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250 results on '"Chen, Zhaoyan"'

6. Reducing brassinosteroid signalling enhances grain yield in semi-dwarf wheat

Author

Song, Long, Liu, Jie, Cao, Beilu, Liu, Bin, Zhang, Xiaoping, Chen, Zhaoyan, Dong, Chaoqun, Liu, Xiangqing, Zhang, Zhaoheng, Wang, Wenxi, Chai, Lingling, Liu, Jing, Zhu, Jun, Cui, Shubin, He, Fei, Peng, Huiru, Hu, Zhaorong, Su, Zhenqi, Guo, Weilong, Xin, Mingming, Yao, Yingyin, Yan, Yong, Song, Yinming, Bai, Guihua, Sun, Qixin, and Ni, Zhongfu

Published
2023
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15. Positional cloning and characterization reveal the role of TaSRN‐3D and TaBSR1 in the regulation of seminal root number in wheat

Author

Chen, Zhaoyan, primary, Li, Xuanshuang, additional, He, Fei, additional, Liu, Bin, additional, Xu, Weiya, additional, Chai, Lingling, additional, Cheng, Xuejiao, additional, Song, Long, additional, Guo, Weilong, additional, Hu, Zhaorong, additional, Su, Zhenqi, additional, Liu, Jie, additional, Xin, Mingming, additional, Peng, Huiru, additional, Yao, Yingyin, additional, Sun, Qixin, additional, Xing, Jiewen, additional, and Ni, Zhongfu, additional

Published
2024
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21. Vitamin D3 reduces hippocampal NR2A and anxiety in nicotine withdrawal mice

Author

Wu Bingxue, Tao Xinrong, Liu Chuanlin, Li Huaixu, Jiang Tao, Chen Zijun, Wang Qi, Liu Fei, Mu Min, and Chen Zhaoyan

Subjects
nicotine withdrawal, anxiety-like behavior, vitamin d3, nr2a, hippocampus, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Nicotine withdrawal symptoms, mainly anxiety, cause high level of relapse rate after quitting smoking. Vitamin D supplementation has shown its potential for the prevention and treatment of anxiety disorders; however, neurobiological studies about the effect of vitamin D on nicotine withdrawal-induced anxiety are limited. To investigate the effect and molecular mechanism of vitamin D3 supplement by dietary on anxiety-like behavior during nicotine withdrawal, male C57/BL6 mice were divided into four groups: vehicle, nicotine only, vitamin D3 only, and nicotine plus vitamin D3. Mice were administrated with nicotine in drinking water (200 µg/mL), and vitamin D3 in feed for 6 weeks. During nicotine withdrawal, vitamin D3-treated mice showed significantly less anxiety-like behavior by an open-field test and marble buried test that performed an increase in the duration of the central zone and a decrease buried marble, respectively. Moreover, vitamin D3 supplementation attenuated the hippocampal NR2A expression on both protein and mRNA levels in nicotine and vitamin D3-treated mice. Our data showed that dietary supplementation with vitamin D3 ameliorated nicotine withdrawal-induced anxiety, which may be related to downregulation of NR2A expression in hippocampus. Vitamin D3 may provide a new dietary intervention with the easy access for smoking cessation.

Published
2021
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33. Natural variations of HvSRN1 modulate the spike rachis node number in barley

Author

Fan, Chaofeng, primary, Xu, Dongdong, additional, Wang, Chunchao, additional, Chen, Zhaoyan, additional, Dou, Tingyu, additional, Qin, Dandan, additional, Guo, Aikui, additional, Zhao, Meng, additional, Pei, Honghong, additional, Zhao, Mengwei, additional, Zhang, Renxu, additional, Wang, Ke, additional, Zhang, Jing, additional, Ni, Zhongfu, additional, and Guo, Ganggang, additional

Published
2023
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38. Model for predicting prognosis and immunotherapy based on CD+8 T cells infiltration in neuroblastoma.

Author

Bao, Wei, Song, Zhiping, Wan, Hao, Yu, Xiaoping, Chen, Zhaoyan, Jiang, Yaqing, Chen, Xiao, and Le, Kai

Subjects
NEUROBLASTOMA, T cells, IMMUNE checkpoint proteins, SYMPATHETIC nervous system, MAJOR histocompatibility complex, IMMUNOTHERAPY
Abstract

Background: Neuroblastoma (NBL) is an extracranial malignant tumor in children deriving from the neural crest in the sympathetic nervous system. Although various immunotherapy interventions have made significant breakthroughs in many adult cancers, the efficacy of these immunotherapies was still limited in NBL. NBL has low immunogenicity which results in a lack of tumor-infiltrating T lymphocytes in the tumor microenvironment (TME). Moreover, tumor cells can wield many immune evasion strategies both in the TME and systemically to impede lymphocyte infiltration and activation. All these factors hamper the anti-tumor effects of CD8+ T cells during immunotherapy and the levels of infiltrating CD8+ T cells correlate with therapy response. Materials and methods: In this study, we utilized multidimensional bioinformatic methods to establish a risk model based on CD8+ T cells -related genes (CD8+ TRGs). Results: We obtained 33 CD8+ TRGs with well-predictive ability for prognosis in both GSE49711 and E-MTAB-8248 cohorts. Then, 12 CD8+ TRGs including HK2, RP2, HPSE, ELL2, GFI1, SLC22A16, FCGR3A, CTSS, SH2D1A, RBP5, ATF5, and ADAM9 were finally identified for risk model construction and validation. This model revealed a stable performance in prognostic prediction of the overall survival (OS) and event-free survival (EFS) in patients with NBL. Additionally, our research indicated that the immune and stromal scores, immune-related pathways, immune cell infiltration, the expression of major histocompatibility complex (MHC) and immune checkpoint molecules, immunotherapy response, and drug susceptibility revealed significant differences between high and low-risk groups. Conclusions: According to our analyses, the constructed CD8+ TRGs-based risk model may be promising for the clinical prediction of anti-tumor therapy responses and prognoses in NBL. [ABSTRACT FROM AUTHOR]

Published
2023
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42. TaACTIN7-Dregulates plant height and grain shape in bread wheat

Author

Li, Xiongtao, Cao, Beilu, Du, Dejie, Song, Long, Tian, Lulu, Xie, Xiaoming, Chen, Zhaoyan, Ding, Yanpeng, Cheng, Xuejiao, Yao, Yingyin, Guo, Weilong, Su, Zhenqi, Sun, Qixin, Ni, Zhongfu, Chai, Lingling, and Liu, Jie

Abstract

Exploitation of new gene resources and genetic networks contributing to the control of crop yield-related traits, such as plant height, grain size, and shape, may enable us to breed modern high-yielding wheat varieties through molecular methods. In this study, via ethylmethanesulfonate mutagenesis, we identify a wheat mutant plant, mu-597, that shows semi-dwarf plant architecture and round grain shape. Through bulked segregant RNA-seq and map-based cloning, the causal gene for the semi-dwarf phenotype of mu-597is located. We find that a single-base mutation in the coding region of TaACTIN7-D(TaACT7-D), leading to a Gly-to-Ser (G65S) amino acid mutation at the 65th residue of the deduced TaACT7-D protein, can explain the semi-dwarfism and round grain shape of mu-597. Further evidence shows that the G65S mutation in TaACT7-D hinders the polymerization of actin from monomeric (G-actin) to filamentous (F-actin) status while attenuates wheat responses to multiple phytohormones, including brassinosteroids, auxin, and gibberellin. Together, these findings not only define a new semi-dwarfing gene resource that can be potentially used to design plant height and grain shape of bread wheat but also establish a direct link between actin structure modulation and phytohormone signal transduction.

Published
2023
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