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BackgroundPatients with esophageal cancer often experience clinically relevant deterioration of quality of life (QOL) after esophagectomy owing to malnutrition, lack of physical exercise, and psychological symptoms. ObjectiveThis study aimed to evaluate the feasibility, safety, and efficacy of a comprehensive intervention model using a mobile health system (CIMmH) in patients with esophageal cancer after esophagectomy. MethodsTwenty patients with esophageal cancer undergoing the modified McKeown surgical procedure were invited to join the CIMmH program with both online and offline components for 12 weeks. The participants were assessed before surgery and again at 1 and 3 months after esophagectomy. QOL, depressive symptoms, anxiety, stress, nutrition, and physical fitness were measured. ResultsOf the 20 patients, 16 (80%) completed the program. One month after esophagectomy, patients showed significant deterioration in overall QOL (P=.02), eating (P=.005), reflux (P=.04), and trouble with talking (P

Objective To evaluate the standardized quality management of bedside nursing cart. Methods To standardize the placement of bedside nursing cart and formulate a unified schematic diagram which was hanged on the nursing cart. Specialized personnel was arranged to supervise the maintenance of nursing cart. Results After the standardized management of bedside nursing cart, the total score of nursing cart management and medical items placement increased from (73. 61±6. 10)to(90. 50±8. 60) s. The examination scores of nurse’ familiarity with aseptic items and cleaning products were increased by 19. 65 points (80. 35 to 100. 00) and 23. 11 points (75. 56 to 98. 67) respectively. The time of taking out items from bedside nursing cart was reduced from (6. 51±1. 29) minutes to (4. 15±1. 31) minutes, and the time of fluid replacement was shortened from (18. 76±3. 81) minutes to (13. 43±2. 81) minutes. Conclusion The standardized management of bedside nursing cart can not only meet the requirements of disinfection and isolation, but also make patients get real-time and effective nursing, and reduce the labor intensity of nurses. (目的 探究床边护理车的规范化质量管理实践效果。方法 规范床边护理车的物品摆放, 制定统一的示意图悬挂于护理车上, 专人管理, 定期抽查。记录规范化质量管理活动实施后床边护理车的管理和物品摆放规范性、护士对床边护理车内物品摆放的熟悉情况程度、床边护理车规范前后完成治疗耗时。结果 床边护理车规范管理后, 护理车的管理和车内物品摆放, 总分由之前的(73. 40±6. 10)分提高至(90. 50±8. 60)分, 护士对车内无菌物品的熟悉程度由原来的80. 35分提高至100分, 对车内清洁物品的熟悉程度由原来的75. 56分提高至98. 67分, 取出物品的时间由原来的(6. 51±1. 29)s缩短为(4. 15±1. 31)s, 更换输液的时间由原来的(18. 76±3. 81)s减少至(13. 43±2. 81)s。结论 床边护理车规范管理后, 不仅满足了消毒隔离的要求, 有助于患者得到实时、有效的护理, 而且减轻了护士劳动强度。)

Non‐pharmacological interventions can improve the behavioural and psychological symptoms of dementia (BPSD). However, the optimal non‐pharmacological treatments remain controversial. This study aimed to compare the efficacy of multiple non‐pharmacological methods and identify the optimal therapy for BPSD. Potential randomised controlled trials (RCTs) were searched and selected from 15 databases and sources from the inception of the databases until 1 October 2022. Two independent authors implemented study screening, data extraction, and methodological quality assessment. Primary outcome was reduction of Neuropsychiatric Inventory (NPI). The secondary outcome were changes of Cornell Scale for Depression in Dementia (CSDD), the Cohen‐Mansfield Agitation Inventory (CMAI), the Quality of Life in Alzheimer's Disease (QoL‐AD), the Abilities of Daily Living scale, and the Apathy Evaluation Scale. Meta‐analyses were performed using STATA v15.0 and ADDIS v1.16.8. The GRADE approaches were utilised to evaluate evidence quality. The present study included 43 RCTs with 4978 participants. The global methodological quality of the RCTs was moderate. Regarding NPI reduction, with moderate‐certainty evidence, exercise plus treatment as usual (TAU) outperformed TAU (mean difference [MD]: −7.13; 95% confidence interval [CI]: −13.22, −0.76) and ranked as the optimal treatment. For reduction in CSDD, with low‐ to moderate‐certainty evidence, massage plus TAU (MD: −15.26; 95% CI: −20.13, −10.52) and music plus TAU (MD: −2.40; 95% CI: −4.62, −0.12) were associated with greater reduction compared with TAU. For reduction in CMAI, with moderate‐certainty evidence, aromatherapy plus massage (MD: −15.84; 95% CI: −29.76, −2.42) and massage plus music (MD: −13.12; 95% CI: −25.43, −0.76) were significantly more effective than TAU. For improvement in QoL‐AD, with critically low‐ to low‐certainty evidence, there were no statistical differences between any of non‐pharmacological treatments and TAU. Due to the limited number of included studies, network meta‐analysis was not performed for other outcomes. In conclusion, non‐pharmacological treatments are effective for overall symptoms, depression, and agitation. Exercise plus treatment as usual may be an optimal non‐pharmacological intervention for improving the overall BPSD. This may help to guide patients, doctors, and policymakers. [ABSTRACT FROM AUTHOR]

This study aims to evaluate the biofilm formation of clinical isolates of H. pylori and its impact on antibiotic eradication. Methods: The thickness, morphology, and structure of biofilms derived from nine H. pylori strains were examined using confocal laser scanning microscopy, scanning electron microscopy, and transmission electron microscopy. Subsequently, the susceptibility of both planktonic and biofilm bacteria was assessed through the determination of minimum inhibitory concentration and minimum biofilm eradication concentration for amoxicillin, clarithromycin, levofloxacin, and tetracycline. Results: The results revealed varying biofilm thicknesses and densities among the strains, characterised by the presence of numerous filaments intertwining and connecting bacterial cells. Additionally, several cases exhibited susceptibility based on MIC measurements but resistance according to MBEC measurements, with MBEC indicating a higher resistance rate. Pearson Correlation analysis demonstrated a positive correlation between biofilm thickness and MBEC results (0 < r < 1), notably significant for amoxicillin (r = 0.801, P = 0.009) and tetracycline (r = 0.696, P = 0.037). Conclusion: Different strains of H. pylori exhibit variations in their capacity to release outer membrane vesicles (OMVs) and form biofilms. Biofilm formation can influence the effectiveness of amoxicillin and tetracycline in eradicating susceptible bacterial strains. [ABSTRACT FROM AUTHOR]