1. Correlation between the miR‐618 rs2682818 C>A polymorphism and venous malformation susceptibility.
- Author
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Lin, Xi, Chen, Zijian, Wu, Guitao, Jiang, Hua, and Liu, Zhenyin
- Abstract
Venous malformations are the most common congenital vascular malformations, and the incidence rate is high. Previous studies have confirmed that a variety of polymorphisms within the miRNA functional region are associated with tumor susceptibility. We examined the correlation between
miR‐618 rs2682818 C>A and risk of developing venous malformation in a southern Chinese population (1113 patients and 1158 controls). TaqMan genotyping ofmiR‐618 rs2682818 C>A was conducted utilizing real‐time fluorescent quantitative PCR. ThemiR‐618 rs2682818 polymorphism was not correlated with susceptibility to venous malformation (CA/AA vs. CC: adjusted odds ratio [AOR] = 1.00, 95% confidence interval [CI] = 0.81–1.25,p = 0.994; AA vs. CC/CA: AOR = 1.10, 95% CI = 0.73–1.65,p = 0.646). Stratified analysis of different subtypes of venous malformation revealed that there was no significant difference in the rs2682818 C>A polymorphism genotypes across these subtypes. Our results indicate thatmiR‐618 rs2682818 C>A polymorphism is not correlated with the susceptibility to venous malformation. [ABSTRACT FROM AUTHOR]- Published
- 2024
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