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Background and Purpose：Alzheimer’s disease (AD) is a neurodegenerative disease whose main clinical symptoms are cognitive impairment. Synaptic dysfunction is currently a widely accepted pathogenic factor for AD, and this process is closely related to abnormalities in the glutamate receptor /cyclic adenosine monophosphate response element binding protein (NMDAR/CREB) signaling pathway is closely related. The purpose of this study was to identify a new drug for AD treatment. Experimental Approach: PC12 cells, primary neuron model and APPswe/PSEN1dE9(APP/PS1) transgenic mouse model were studied using Aβ1-42 oligomer intervention. Combined with the treatment of AS-IV and NMDAR inhibitors, RT-qPCR, Western-blotting, immunofluorescence and behavioral analysis were performed to explore the pharmacological action and possible mechanism of AS-IV. Key Results: AS-IV significantly improved synaptic damage in AD models and up-regulated the expression of NMDAR (NR1, NR2A, NR2B), CaMKs (CaMKII, CaMKIV), CREB and BDNF. Ultimately, learning, memory, and cognitive impairments in APP/PS1 mice were improved. Inhibition of NMDAR expression significantly attenuated the related protective function of AS-IV. Conclusion and Implications: AS-IV effectively exerts its anti-AD function by activating the NMDAR /CREB signaling pathway. This could help in the development of drugs to treat AD.

In a Laughlin fractional quantum Hall state, one- and two-quasihole states can be obtained by diagonalizing the many-body Hamiltonian with a trapping potential or, for larger systems, from the linear combination of the edge Jack polynomials. The quasihole states live entirely in the subspace of the lowest-energy branch in the energy spectrum with a fixed number of orbits, or a hard-wall confinement. The reduction in the Hilbert space dimension facilitates the study of time evolution of the quasihole states after, say, the removal of the trapping potential. We explore the quench dynamics under a harmonic external potential, which rotates the quasiholes in the droplet, and discuss the effect of long-range interaction and more realistic confinement. Accurate evaluation of the mutual statistics phase of anyons for a wide range of anyon separation can be achieved from the Berry-phase calculation., Comment: 9 pages, 9 figures