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1. Genome-wide association study of early-onset bipolar I disorder in the Han Taiwanese population.

Author

Wu, Lawrence Shih-Hsin, Huang, Ming-Chyi, Fann, Cathy Shen-Jang, Lane, Hsien-Yuan, Kuo, Chian-Jue, Chiu, Wei-Che, Kwok, Pui-Yan, and Cheng, Andrew Tai-Ann

Subjects
Clinical Sciences, Public Health and Health Services, Psychology
Abstract

The search for susceptibility genes underlying the heterogeneous bipolar disorder has been inconclusive, often with irreproducible results. There is a hope that narrowing the phenotypes will increase the power of genetic analysis. Early-onset bipolar disorder is thought to be a genetically homogeneous subtype with greater symptom severity. We conducted a genome-wide association study (GWAS) for this subtype in bipolar I (BPI) disorder. Study participants included 1779 patients of Han Chinese descent with BPI disorder recruited by the Taiwan Bipolar Consortium. We conducted phenotype assessment using the Chinese version of the Schedules for Clinical Assessment in Neuropsychiatry and prepared a life chart with graphic depiction of lifetime clinical course for each of the BPI patient recruited. The assessment of onset age was based on this life chart with early onset defined as ≤20 years of age. We performed GWAS in a discovery group of 516 early-onset and 790 non-early-onset BPI patients, followed by a replication study in an independent group of 153 early-onset and 320 non-early-onset BPI patients and a meta-analysis with these two groups. The SNP rs11127876, located in the intron of CADM2, showed association with early-onset BPI in the discovery cohort (P = 7.04 × 10-8) and in the test of replication (P = 0.0354). After meta-analysis, this SNP was demonstrated to be a new genetic locus in CADM2 gene associated with early-onset BPI disorder (P = 5.19 × 10-8).

Published
2021

4. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

Author

Lim, Stephen S, Vos, Theo, Flaxman, Abraham D, Danaei, Goodarz, Shibuya, Kenji, Adair-Rohani, Heather, AlMazroa, Mohammad A, Amann, Markus, Anderson, H Ross, Andrews, Kathryn G, Aryee, Martin, Atkinson, Charles, Bacchus, Loraine J, Bahalim, Adil N, Balakrishnan, Kalpana, Balmes, John, Barker-Collo, Suzanne, Baxter, Amanda, Bell, Michelle L, Blore, Jed D, Blyth, Fiona, Bonner, Carissa, Borges, Guilherme, Bourne, Rupert, Boussinesq, Michel, Brauer, Michael, Brooks, Peter, Bruce, Nigel G, Brunekreef, Bert, Bryan-Hancock, Claire, Bucello, Chiara, Buchbinder, Rachelle, Bull, Fiona, Burnett, Richard T, Byers, Tim E, Calabria, Bianca, Carapetis, Jonathan, Carnahan, Emily, Chafe, Zoe, Charlson, Fiona, Chen, Honglei, Chen, Jian Shen, Cheng, Andrew Tai-Ann, Child, Jennifer Christine, Cohen, Aaron, Colson, K Ellicott, Cowie, Benjamin C, Darby, Sarah, Darling, Susan, Davis, Adrian, Degenhardt, Louisa, Dentener, Frank, Jarlais, Don C Des, Devries, Karen, Dherani, Mukesh, Ding, Eric L, Dorsey, E Ray, Driscoll, Tim, Edmond, Karen, Ali, Suad Eltahir, Engell, Rebecca E, Erwin, Patricia J, Fahimi, Saman, Falder, Gail, Farzadfar, Farshad, Ferrari, Alize, Finucane, Mariel M, Flaxman, Seth, Fowkes, Francis Gerry R, Freedman, Greg, Freeman, Michael K, Gakidou, Emmanuela, Ghosh, Santu, Giovannucci, Edward, Gmel, Gerhard, Graham, Kathryn, Grainger, Rebecca, Grant, Bridget, Gunnell, David, Gutierrez, Hialy R, Hall, Wayne, Hoek, Hans W, Hogan, Anthony, Hosgood, H Dean, Hoy, Damian, Hu, Howard, Hubbell, Bryan J, Hutchings, Sally J, Ibeanusi, Sydney E, Jacklyn, Gemma L, Jasrasaria, Rashmi, Jonas, Jost B, Kan, Haidong, Kanis, John A, Kassebaum, Nicholas, Kawakami, Norito, Khang, Young-Ho, Khatibzadeh, Shahab, Khoo, Jon-Paul, and Kok, Cindy

Subjects
Tobacco Smoke and Health, Prevention, Tobacco, Burden of Illness, Nutrition, Pediatric, 2.2 Factors relating to the physical environment, 2.3 Psychological, social and economic factors, Aetiology, Respiratory, Cardiovascular, Good Health and Well Being, Clean Water and Sanitation, Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Global Health, Humans, Infant, Infant, Newborn, Male, Middle Aged, Mortality, Quality-Adjusted Life Years, Risk Assessment, Risk Factors, Sex Factors, Young Adult, Medical and Health Sciences, General & Internal Medicine
Abstract

BackgroundQuantification of the disease burden caused by different risks informs prevention by providing an account of health loss different to that provided by a disease-by-disease analysis. No complete revision of global disease burden caused by risk factors has been done since a comparative risk assessment in 2000, and no previous analysis has assessed changes in burden attributable to risk factors over time.MethodsWe estimated deaths and disability-adjusted life years (DALYs; sum of years lived with disability [YLD] and years of life lost [YLL]) attributable to the independent effects of 67 risk factors and clusters of risk factors for 21 regions in 1990 and 2010. We estimated exposure distributions for each year, region, sex, and age group, and relative risks per unit of exposure by systematically reviewing and synthesising published and unpublished data. We used these estimates, together with estimates of cause-specific deaths and DALYs from the Global Burden of Disease Study 2010, to calculate the burden attributable to each risk factor exposure compared with the theoretical-minimum-risk exposure. We incorporated uncertainty in disease burden, relative risks, and exposures into our estimates of attributable burden.FindingsIn 2010, the three leading risk factors for global disease burden were high blood pressure (7·0% [95% uncertainty interval 6·2-7·7] of global DALYs), tobacco smoking including second-hand smoke (6·3% [5·5-7·0]), and alcohol use (5·5% [5·0-5·9]). In 1990, the leading risks were childhood underweight (7·9% [6·8-9·4]), household air pollution from solid fuels (HAP; 7·0% [5·6-8·3]), and tobacco smoking including second-hand smoke (6·1% [5·4-6·8]). Dietary risk factors and physical inactivity collectively accounted for 10·0% (95% UI 9·2-10·8) of global DALYs in 2010, with the most prominent dietary risks being diets low in fruits and those high in sodium. Several risks that primarily affect childhood communicable diseases, including unimproved water and sanitation and childhood micronutrient deficiencies, fell in rank between 1990 and 2010, with unimproved water and sanitation accounting for 0·9% (0·4-1·6) of global DALYs in 2010. However, in most of sub-Saharan Africa childhood underweight, HAP, and non-exclusive and discontinued breastfeeding were the leading risks in 2010, while HAP was the leading risk in south Asia. The leading risk factor in Eastern Europe, most of Latin America, and southern sub-Saharan Africa in 2010 was alcohol use; in most of Asia, North Africa and Middle East, and central Europe it was high blood pressure. Despite declines, tobacco smoking including second-hand smoke remained the leading risk in high-income north America and western Europe. High body-mass index has increased globally and it is the leading risk in Australasia and southern Latin America, and also ranks high in other high-income regions, North Africa and Middle East, and Oceania.InterpretationWorldwide, the contribution of different risk factors to disease burden has changed substantially, with a shift away from risks for communicable diseases in children towards those for non-communicable diseases in adults. These changes are related to the ageing population, decreased mortality among children younger than 5 years, changes in cause-of-death composition, and changes in risk factor exposures. New evidence has led to changes in the magnitude of key risks including unimproved water and sanitation, vitamin A and zinc deficiencies, and ambient particulate matter pollution. The extent to which the epidemiological shift has occurred and what the leading risks currently are varies greatly across regions. In much of sub-Saharan Africa, the leading risks are still those associated with poverty and those that affect children.FundingBill & Melinda Gates Foundation.

Published
2012

5. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

Author

Vos, Theo, Flaxman, Abraham D, Naghavi, Mohsen, Lozano, Rafael, Michaud, Catherine, Ezzati, Majid, Shibuya, Kenji, Salomon, Joshua A, Abdalla, Safa, Aboyans, Victor, Abraham, Jerry, Ackerman, Ilana, Aggarwal, Rakesh, Ahn, Stephanie Y, Ali, Mohammed K, AlMazroa, Mohammad A, Alvarado, Miriam, Anderson, H Ross, Anderson, Laurie M, Andrews, Kathryn G, Atkinson, Charles, Baddour, Larry M, Bahalim, Adil N, Barker-Collo, Suzanne, Barrero, Lope H, Bartels, David H, Basáñez, Maria-Gloria, Baxter, Amanda, Bell, Michelle L, Benjamin, Emelia J, Bennett, Derrick, Bernabé, Eduardo, Bhalla, Kavi, Bhandari, Bishal, Bikbov, Boris, Bin Abdulhak, Aref, Birbeck, Gretchen, Black, James A, Blencowe, Hannah, Blore, Jed D, Blyth, Fiona, Bolliger, Ian, Bonaventure, Audrey, Boufous, Soufiane, Bourne, Rupert, Boussinesq, Michel, Braithwaite, Tasanee, Brayne, Carol, Bridgett, Lisa, Brooker, Simon, Brooks, Peter, Brugha, Traolach S, Bryan-Hancock, Claire, Bucello, Chiara, Buchbinder, Rachelle, Buckle, Geoffrey, Budke, Christine M, Burch, Michael, Burney, Peter, Burstein, Roy, Calabria, Bianca, Campbell, Benjamin, Canter, Charles E, Carabin, Hélène, Carapetis, Jonathan, Carmona, Loreto, Cella, Claudia, Charlson, Fiona, Chen, Honglei, Cheng, Andrew Tai-Ann, Chou, David, Chugh, Sumeet S, Coffeng, Luc E, Colan, Steven D, Colquhoun, Samantha, Colson, K Ellicott, Condon, John, Connor, Myles D, Cooper, Leslie T, Corriere, Matthew, Cortinovis, Monica, de Vaccaro, Karen Courville, Couser, William, Cowie, Benjamin C, Criqui, Michael H, Cross, Marita, Dabhadkar, Kaustubh C, Dahiya, Manu, Dahodwala, Nabila, Damsere-Derry, James, Danaei, Goodarz, Davis, Adrian, De Leo, Diego, Degenhardt, Louisa, Dellavalle, Robert, Delossantos, Allyne, Denenberg, Julie, Derrett, Sarah, Jarlais, Don C Des, and Dharmaratne, Samath D

Subjects
Epidemiology, Biomedical and Clinical Sciences, Public Health, Health Sciences, Pain Research, Mental Health, Infectious Diseases, Prevention, Rare Diseases, Aetiology, 2.2 Factors relating to the physical environment, 2.4 Surveillance and distribution, Good Health and Well Being, Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Global Health, Health Status, Humans, Incidence, Infant, Infant, Newborn, Male, Middle Aged, Prevalence, Quality-Adjusted Life Years, Sex Factors, Wounds and Injuries, Young Adult, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundNon-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and 2000 have been the only studies to quantify non-fatal health outcomes across an exhaustive set of disorders at the global and regional level. Neither effort quantified uncertainty in prevalence or years lived with disability (YLDs).MethodsOf the 291 diseases and injuries in the GBD cause list, 289 cause disability. For 1160 sequelae of the 289 diseases and injuries, we undertook a systematic analysis of prevalence, incidence, remission, duration, and excess mortality. Sources included published studies, case notification, population-based cancer registries, other disease registries, antenatal clinic serosurveillance, hospital discharge data, ambulatory care data, household surveys, other surveys, and cohort studies. For most sequelae, we used a Bayesian meta-regression method, DisMod-MR, designed to address key limitations in descriptive epidemiological data, including missing data, inconsistency, and large methodological variation between data sources. For some disorders, we used natural history models, geospatial models, back-calculation models (models calculating incidence from population mortality rates and case fatality), or registration completeness models (models adjusting for incomplete registration with health-system access and other covariates). Disability weights for 220 unique health states were used to capture the severity of health loss. YLDs by cause at age, sex, country, and year levels were adjusted for comorbidity with simulation methods. We included uncertainty estimates at all stages of the analysis.FindingsGlobal prevalence for all ages combined in 2010 across the 1160 sequelae ranged from fewer than one case per 1 million people to 350,000 cases per 1 million people. Prevalence and severity of health loss were weakly correlated (correlation coefficient -0·37). In 2010, there were 777 million YLDs from all causes, up from 583 million in 1990. The main contributors to global YLDs were mental and behavioural disorders, musculoskeletal disorders, and diabetes or endocrine diseases. The leading specific causes of YLDs were much the same in 2010 as they were in 1990: low back pain, major depressive disorder, iron-deficiency anaemia, neck pain, chronic obstructive pulmonary disease, anxiety disorders, migraine, diabetes, and falls. Age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010. Regional patterns of the leading causes of YLDs were more similar compared with years of life lost due to premature mortality. Neglected tropical diseases, HIV/AIDS, tuberculosis, malaria, and anaemia were important causes of YLDs in sub-Saharan Africa.InterpretationRates of YLDs per 100,000 people have remained largely constant over time but rise steadily with age. Population growth and ageing have increased YLD numbers and crude rates over the past two decades. Prevalences of the most common causes of YLDs, such as mental and behavioural disorders and musculoskeletal disorders, have not decreased. Health systems will need to address the needs of the rising numbers of individuals with a range of disorders that largely cause disability but not mortality. Quantification of the burden of non-fatal health outcomes will be crucial to understand how well health systems are responding to these challenges. Effective and affordable strategies to deal with this rising burden are an urgent priority for health systems in most parts of the world.FundingBill & Melinda Gates Foundation.

Published
2012

15. Variant GADL1 and Response to Lithium Therapy in Bipolar I Disorder

Author

Chen, Chien-Hsiun, Lee, Chau-Shoun, Lee, Ming-Ta Michael, Ouyang, Wen-Chen, Chen, Chiao-Chicy, Chong, Mian-Yoon, Wu, Jer-Yuarn, Tan, Happy Kuy-Lok, Lee, Yi-Ching, Chuo, Liang-Jen, Chiu, Nan-Ying, Tsang, Hin-Yeung, Chang, Ta-Jen, Lung, For-Wey, Chiu, Chen-Huan, Chang, Cheng-Ho, Chen, Ying-Sheue, Hou, Yuh-Ming, Chen, Cheng-Chung, Lai, Te-Jen, Tung, Chun-Liang, Chen, Chung-Ying, Lane, Hsien-Yuan, Su, Tung-Ping, Feng, Jung, Lin, Jin-Jia, Chang, Ching-Jui, Teng, Po-Ren, Liu, Chia-Yih, Chen, Chih-Ken, Liu, I-Chao, Chen, Jiahn-Jyh, Lu, Ti, Fan, Chun-Chieh, Wu, Ching-Kuan, Li, Chang-Fang, Wang, Kathy Hsiao-Tsz, Wu, Lawrence Shih-Hsin, Peng, Hsin-Ling, Chang, Chun-Ping, Lu, Liang-Suei, Chen, Yuan-Tsong, and Cheng, Andrew Tai-Ann

Published
2014
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16. Association between morningness-eveningness and behavioral/emotional problems among adolescents

Author

Gau, Susan Shur-Fen, Shang, Chi-Yung, Merikangas, Kathleen R., Chiu, Yen-Nan, Soong, Wei-Tsuen, and Cheng, Andrew Tai-Ann

Subjects
Suicidal behavior -- Analysis -- Research -- Genetic aspects, Human acts -- Research -- Psychological aspects -- Genetic aspects -- Analysis, Genetic psychology -- Analysis -- Psychological aspects -- Research, Teenagers -- Research -- Psychological aspects -- Analysis, Youth -- Research -- Psychological aspects -- Analysis, Circadian rhythms -- Research -- Analysis -- Genetic aspects -- Psychological aspects, Substance abusers -- Research -- Analysis -- Psychological aspects, Human behavior -- Research -- Psychological aspects -- Genetic aspects -- Analysis, Biological sciences, Psychological aspects, Analysis, Research, Genetic aspects
Abstract

Abstract Adolescent eveningness is associated with age, parental monitoring, daytime sleepiness, sleep problems, moodiness, and the use of coffee. This study investigated the association between adolescent morningness-eveningness and psychopathology, substance [...]

Published
2007

17. Executive function in adolescence among children with attention-deficit/hyperactivity disorder in Taiwan

Author

Gau, Susan Shur-Fen, Chiu, Chui-De, Shang, Chi-Yung, Cheng, Andrew Tai-Ann, and Soong, Wei-Tsuen

Subjects
Executive function (Psychology) -- Demographic aspects, Executive function (Psychology) -- Research, Attention-deficit hyperactivity disorder -- Research, Methylphenidate -- Dosage and administration, Methylphenidate -- Research, Methylphenidate hydrochloride -- Dosage and administration, Methylphenidate hydrochloride -- Research, Education, Health, Psychology and mental health
Published
2009

21. Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report

Author

Manchia, Mirko, primary, Adli, Mazda, additional, Akula, Nirmala, additional, Ardau, Raffaella, additional, Aubry, Jean-Michel, additional, Backlund, Lena, additional, Banzato, Claudio EM., additional, Baune, Bernhard T., additional, Bellivier, Frank, additional, Bengesser, Susanne, additional, Biernacka, Joanna M., additional, Brichant-Petitjean, Clara, additional, Bui, Elise, additional, Calkin, Cynthia V., additional, Cheng, Andrew Tai Ann, additional, Chillotti, Caterina, additional, Cichon, Sven, additional, Clark, Scott, additional, Czerski, Piotr M., additional, Dantas, Clarissa, additional, Zompo, Maria Del, additional, DePaulo, J. Raymond, additional, Detera-Wadleigh, Sevilla D., additional, Etain, Bruno, additional, Falkai, Peter, additional, Frisén, Louise, additional, Frye, Mark A., additional, Fullerton, Jan, additional, Gard, Sébastien, additional, Garnham, Julie, additional, Goes, Fernando S., additional, Grof, Paul, additional, Gruber, Oliver, additional, Hashimoto, Ryota, additional, Hauser, Joanna, additional, Heilbronner, Urs, additional, Hoban, Rebecca, additional, Hou, Liping, additional, Jamain, Stéphane, additional, Kahn, Jean-Pierre, additional, Kassem, Layla, additional, Kato, Tadafumi, additional, Kelsoe, John R., additional, Kittel-Schneider, Sarah, additional, Kliwicki, Sebastian, additional, Kuo, Po-Hsiu, additional, Kusumi, Ichiro, additional, Laje, Gonzalo, additional, Lavebratt, Catharina, additional, Leboyer, Marion, additional, Leckband, Susan G., additional, López Jaramillo, Carlos A., additional, Maj, Mario, additional, Malafosse, Alain, additional, Martinsson, Lina, additional, Masui, Takuya, additional, Mitchell, Philip B., additional, Mondimore, Frank, additional, Monteleone, Palmiero, additional, Nallet, Audrey, additional, Neuner, Maria, additional, Novák, Tomás, additional, O’Donovan, Claire, additional, Ösby, Urban, additional, Ozaki, Norio, additional, Perlis, Roy H., additional, Pfennig, Andrea, additional, Potash, James B., additional, Reich-Erkelenz, Daniela, additional, Reif, Andreas, additional, Reininghaus, Eva, additional, Richardson, Sara, additional, Rouleau, Guy A., additional, Rybakowski, Janusz K., additional, Schalling, Martin, additional, Schofield, Peter R., additional, Schubert, Oliver K., additional, Schweizer, Barbara, additional, Seemüller, Florian, additional, Grigoroiu-Serbanescu, Maria, additional, Severino, Giovanni, additional, Seymour, Lisa R., additional, Slaney, Claire, additional, Smoller, Jordan W., additional, Squassina, Alessio, additional, Stamm, Thomas, additional, Steele, Jo, additional, Stopkova, Pavla, additional, Tighe, Sarah K., additional, Tortorella, Alfonso, additional, Turecki, Gustavo, additional, Wray, Naomi R., additional, Wright, Adam, additional, Zandi, Peter P., additional, Zilles, David, additional, Bauer, Michael, additional, Rietschel, Marcella, additional, McMahon, Francis J., additional, Schulze, Thomas G., additional, and Alda, Martin, additional

Published
2013
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23. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

Author

Murray, Christopher J L, primary, Vos, Theo, additional, Lozano, Rafael, additional, Naghavi, Mohsen, additional, Flaxman, Abraham D, additional, Michaud, Catherine, additional, Ezzati, Majid, additional, Shibuya, Kenji, additional, Salomon, Joshua A, additional, Abdalla, Safa, additional, Aboyans, Victor, additional, Abraham, Jerry, additional, Ackerman, Ilana, additional, Aggarwal, Rakesh, additional, Ahn, Stephanie Y, additional, Ali, Mohammed K, additional, AlMazroa, Mohammad A, additional, Alvarado, Miriam, additional, Anderson, H Ross, additional, Anderson, Laurie M, additional, Andrews, Kathryn G, additional, Atkinson, Charles, additional, Baddour, Larry M, additional, Bahalim, Adil N, additional, Barker-Collo, Suzanne, additional, Barrero, Lope H, additional, Bartels, David H, additional, Basáñez, Maria-Gloria, additional, Baxter, Amanda, additional, Bell, Michelle L, additional, Benjamin, Emelia J, additional, Bennett, Derrick, additional, Bernabé, Eduardo, additional, Bhalla, Kavi, additional, Bhandari, Bishal, additional, Bikbov, Boris, additional, Abdulhak, Aref Bin, additional, Birbeck, Gretchen, additional, Black, James A, additional, Blencowe, Hannah, additional, Blore, Jed D, additional, Blyth, Fiona, additional, Bolliger, Ian, additional, Bonaventure, Audrey, additional, Boufous, Soufiane, additional, Bourne, Rupert, additional, Boussinesq, Michel, additional, Braithwaite, Tasanee, additional, Brayne, Carol, additional, Bridgett, Lisa, additional, Brooker, Simon, additional, Brooks, Peter, additional, Brugha, Traolach S, additional, Bryan-Hancock, Claire, additional, Bucello, Chiara, additional, Buchbinder, Rachelle, additional, Buckle, Geoffrey, additional, Budke, Christine M, additional, Burch, Michael, additional, Burney, Peter, additional, Burstein, Roy, additional, Calabria, Bianca, additional, Campbell, Benjamin, additional, Canter, Charles E, additional, Carabin, Hélène, additional, Carapetis, Jonathan, additional, Carmona, Loreto, additional, Cella, Claudia, additional, Charlson, Fiona, additional, Chen, Honglei, additional, Cheng, Andrew Tai-Ann, additional, Chou, David, additional, Chugh, Sumeet S, additional, Coffeng, Luc E, additional, Colan, Steven D, additional, Colquhoun, Samantha, additional, Colson, K Ellicott, additional, Condon, John, additional, Connor, Myles D, additional, Cooper, Leslie T, additional, Corriere, Matthew, additional, Cortinovis, Monica, additional, de Vaccaro, Karen Courville, additional, Couser, William, additional, Cowie, Benjamin C, additional, Criqui, Michael H, additional, Cross, Marita, additional, Dabhadkar, Kaustubh C, additional, Dahiya, Manu, additional, Dahodwala, Nabila, additional, Damsere-Derry, James, additional, Danaei, Goodarz, additional, Davis, Adrian, additional, Leo, Diego De, additional, Degenhardt, Louisa, additional, Dellavalle, Robert, additional, Delossantos, Allyne, additional, Denenberg, Julie, additional, Derrett, Sarah, additional, Des Jarlais, Don C, additional, Dharmaratne, Samath D, additional, Dherani, Mukesh, additional, Diaz-Torne, Cesar, additional, Dolk, Helen, additional, Dorsey, E Ray, additional, Driscoll, Tim, additional, Duber, Herbert, additional, Ebel, Beth, additional, Edmond, Karen, additional, Elbaz, Alexis, additional, Ali, Suad Eltahir, additional, Erskine, Holly, additional, Erwin, Patricia J, additional, Espindola, Patricia, additional, Ewoigbokhan, Stalin E, additional, Farzadfar, Farshad, additional, Feigin, Valery, additional, Felson, David T, additional, Ferrari, Alize, additional, Ferri, Cleusa P, additional, Fèvre, Eric M, additional, Finucane, Mariel M, additional, Flaxman, Seth, additional, Flood, Louise, additional, Foreman, Kyle, additional, Forouzanfar, Mohammad H, additional, Fowkes, Francis Gerry R, additional, Fransen, Marlene, additional, Freeman, Michael K, additional, Gabbe, Belinda J, additional, Gabriel, Sherine E, additional, Gakidou, Emmanuela, additional, Ganatra, Hammad A, additional, Garcia, Bianca, additional, Gaspari, Flavio, additional, Gillum, Richard F, additional, Gmel, Gerhard, additional, Gonzalez-Medina, Diego, additional, Gosselin, Richard, additional, Grainger, Rebecca, additional, Grant, Bridget, additional, Groeger, Justina, additional, Guillemin, Francis, additional, Gunnell, David, additional, Gupta, Ramyani, additional, Haagsma, Juanita, additional, Hagan, Holly, additional, Halasa, Yara A, additional, Hall, Wayne, additional, Haring, Diana, additional, Haro, Josep Maria, additional, Harrison, James E, additional, Havmoeller, Rasmus, additional, Hay, Roderick J, additional, Higashi, Hideki, additional, Hill, Catherine, additional, Hoen, Bruno, additional, Hoffman, Howard, additional, Hotez, Peter J, additional, Hoy, Damian, additional, Huang, John J, additional, Ibeanusi, Sydney E, additional, Jacobsen, Kathryn H, additional, James, Spencer L, additional, Jarvis, Deborah, additional, Jasrasaria, Rashmi, additional, Jayaraman, Sudha, additional, Johns, Nicole, additional, Jonas, Jost B, additional, Karthikeyan, Ganesan, additional, Kassebaum, Nicholas, additional, Kawakami, Norito, additional, Keren, Andre, additional, Khoo, Jon-Paul, additional, King, Charles H, additional, Knowlton, Lisa Marie, additional, Kobusingye, Olive, additional, Koranteng, Adofo, additional, Krishnamurthi, Rita, additional, Laden, Francine, additional, Lalloo, Ratilal, additional, Laslett, Laura L, additional, Lathlean, Tim, additional, Leasher, Janet L, additional, Lee, Yong Yi, additional, Leigh, James, additional, Levinson, Daphna, additional, Lim, Stephen S, additional, Limb, Elizabeth, additional, Lin, John Kent, additional, Lipnick, Michael, additional, Lipshultz, Steven E, additional, Liu, Wei, additional, Loane, Maria, additional, Ohno, Summer Lockett, additional, Lyons, Ronan, additional, Mabweijano, Jacqueline, additional, MacIntyre, Michael F, additional, Malekzadeh, Reza, additional, Mallinger, Leslie, additional, Manivannan, Sivabalan, additional, Marcenes, Wagner, additional, March, Lyn, additional, Margolis, David J, additional, Marks, Guy B, additional, Marks, Robin, additional, Matsumori, Akira, additional, Matzopoulos, Richard, additional, Mayosi, Bongani M, additional, McAnulty, John H, additional, McDermott, Mary M, additional, McGill, Neil, additional, McGrath, John, additional, Medina-Mora, Maria Elena, additional, Meltzer, Michele, additional, Memish, Ziad A, additional, Mensah, George A, additional, Merriman, Tony R, additional, Meyer, Ana-Claire, additional, Miglioli, Valeria, additional, Miller, Matthew, additional, Miller, Ted R, additional, Mitchell, Philip B, additional, Mock, Charles, additional, Mocumbi, Ana Olga, additional, Moffitt, Terrie E, additional, Mokdad, Ali A, additional, Monasta, Lorenzo, additional, Montico, Marcella, additional, Moradi-Lakeh, Maziar, additional, Moran, Andrew, additional, Morawska, Lidia, additional, Mori, Rintaro, additional, Murdoch, Michele E, additional, Mwaniki, Michael K, additional, Naidoo, Kovin, additional, Nair, M Nathan, additional, Naldi, Luigi, additional, Narayan, K M Venkat, additional, Nelson, Paul K, additional, Nelson, Robert G, additional, Nevitt, Michael C, additional, Newton, Charles R, additional, Nolte, Sandra, additional, Norman, Paul, additional, Norman, Rosana, additional, O'Donnell, Martin, additional, O'Hanlon, Simon, additional, Olives, Casey, additional, Omer, Saad B, additional, Ortblad, Katrina, additional, Osborne, Richard, additional, Ozgediz, Doruk, additional, Page, Andrew, additional, Pahari, Bishnu, additional, Pandian, Jeyaraj Durai, additional, Rivero, Andrea Panozo, additional, Patten, Scott B, additional, Pearce, Neil, additional, Padilla, Rogelio Perez, additional, Perez-Ruiz, Fernando, additional, Perico, Norberto, additional, Pesudovs, Konrad, additional, Phillips, David, additional, Phillips, Michael R, additional, Pierce, Kelsey, additional, Pion, Sébastien, additional, Polanczyk, Guilherme V, additional, Polinder, Suzanne, additional, Pope, C Arden, additional, Popova, Svetlana, additional, Porrini, Esteban, additional, Pourmalek, Farshad, additional, Prince, Martin, additional, Pullan, Rachel L, additional, Ramaiah, Kapa D, additional, Ranganathan, Dharani, additional, Razavi, Homie, additional, Regan, Mathilda, additional, Rehm, Jürgen T, additional, Rein, David B, additional, Remuzzi, Guiseppe, additional, Richardson, Kathryn, additional, Rivara, Frederick P, additional, Roberts, Thomas, additional, Robinson, Carolyn, additional, De Leòn, Felipe Rodriguez, additional, Ronfani, Luca, additional, Room, Robin, additional, Rosenfeld, Lisa C, additional, Rushton, Lesley, additional, Sacco, Ralph L, additional, Saha, Sukanta, additional, Sampson, Uchechukwu, additional, Sanchez-Riera, Lidia, additional, Sanman, Ella, additional, Schwebel, David C, additional, Scott, James Graham, additional, Segui-Gomez, Maria, additional, Shahraz, Saeid, additional, Shepard, Donald S, additional, Shin, Hwashin, additional, Shivakoti, Rupak, additional, Silberberg, Donald, additional, Singh, David, additional, Singh, Gitanjali M, additional, Singh, Jasvinder A, additional, Singleton, Jessica, additional, Sleet, David A, additional, Sliwa, Karen, additional, Smith, Emma, additional, Smith, Jennifer L, additional, Stapelberg, Nicolas JC, additional, Steer, Andrew, additional, Steiner, Timothy, additional, Stolk, Wilma A, additional, Stovner, Lars Jacob, additional, Sudfeld, Christopher, additional, Syed, Sana, additional, Tamburlini, Giorgio, additional, Tavakkoli, Mohammad, additional, Taylor, Hugh R, additional, Taylor, Jennifer A, additional, Taylor, William J, additional, Thomas, Bernadette, additional, Thomson, W Murray, additional, Thurston, George D, additional, Tleyjeh, Imad M, additional, Tonelli, Marcello, additional, Towbin, Jeffrey A, additional, Truelsen, Thomas, additional, Tsilimbaris, Miltiadis K, additional, Ubeda, Clotilde, additional, Undurraga, Eduardo A, additional, van der Werf, Marieke J, additional, van Os, Jim, additional, Vavilala, Monica S, additional, Venketasubramanian, N, additional, Wang, Mengru, additional, Wang, Wenzhi, additional, Watt, Kerrianne, additional, Weatherall, David J, additional, Weinstock, Martin A, additional, Weintraub, Robert, additional, Weisskopf, Marc G, additional, Weissman, Myrna M, additional, White, Richard A, additional, Whiteford, Harvey, additional, Wiebe, Natasha, additional, Wiersma, Steven T, additional, Wilkinson, James D, additional, Williams, Hywel C, additional, Williams, Sean RM, additional, Witt, Emma, additional, Wolfe, Frederick, additional, Woolf, Anthony D, additional, Wulf, Sarah, additional, Yeh, Pon-Hsiu, additional, Zaidi, Anita KM, additional, Zheng, Zhi-Jie, additional, Zonies, David, additional, and Lopez, Alan D, additional

Published
2012
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24. Life Attitude Schedule--Chinese Version

Author

Chang, Hsiu-Ju, primary, Wu, Chiung-Jane, additional, Chen, Tzen Wen, additional, Cheng, Andrew Tai Ann, additional, Lin, Kuan-Chia, additional, Rong, Jiin-Ru, additional, and Lee, Hsin-Chien, additional

Published
2011
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28. Psychopathology and symptom remission at adolescence among children with attention-deficit–hyperactivity disorder.

Author

Gau, Susan Shur-Fen, Yu-Ju Lin, Cheng, Andrew Tai-Ann, Yen-Nan Chiu, Wen-Che Tsai, and Wei-Tsuen Soong

Subjects
ATTENTION-deficit hyperactivity disorder, BEHAVIOR disorders in children, PATHOLOGICAL psychology, COMORBIDITY, EPIDEMIOLOGY
Abstract

Objective: The aim of the present study was to examine changes of attention-deficit–hyperactivity disorder (ADHD) symptoms and psychiatric comorbidities at adolescence, and mother-child agreement on reports of ADHD symptoms among children with ADHD as compared to unaffected controls. Methods: The participants included 93 patients (male, 82.8%) aged 11–16, who were clinically diagnosed with ADHD at the mean age of 7.3 ± 2.8 years, and 93 age-, sex-, and parental education-matched school controls. The participants and their mothers were frist interviewed separately for baseline psychopathology at childhood, followed by current psychopathology using the Chinese Kiddie Epidemiologic version of the Schedule for Affective Disorders and Schizophrenia. Results: At adolescence, 46 patients (49.5%) met full DSM-IV ADHD criteria, 31 (33.3%) had subthreshold ADHD, and 16 (17.2%) had recovered from ADHD. We found a significant progressive decline in the three ADHD core symptoms for the ADHD group: hyperactivity had the greatest effect size, followed by inattention, and then impulsivity. Children with ADHD tended to report less severe ADHD symptoms at childhood and adolescence than their mothers. They were more likely than the controls to have oppositional defiant disorder (odds ratio (OR)=18.0; 95% confidence interval (CI)=8.3–38.9), conduct disorder (OR=23.1, 95%CI =5.3–100.2), mood disorders (OR=3.8, 95%CI = 1.5–9.4), bipolar disorders (Fisher's exact p < 0.001), and sleep disorders (OR=3.1, 95%CI = 1.6–6.0) at adolescence. Conclusions: The present findings are similar to those of Western studies, regarding the patterns of comorbidity, stability of core symptoms, and mother–child differences on symptom reports. [ABSTRACT FROM AUTHOR]

Published
2010
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29. Association between Morningness-Eveningness and Behavioral/Emotional Problems among Adolescents.

Author

Shur-Fen Gau, Susan, Shang, Chi-Yung, Merikangas, Kathleen R., Yen-Nan Chiu, Wei-Tsuen Soong, and Cheng, Andrew Tai-Ann

Subjects
SLEEP disorders, PATHOLOGICAL psychology, SUBSTANCE abuse, SUICIDAL behavior, CHILD psychology, MENTAL health
Abstract

Adolescent eveningness is associated with age, parental monitoring, daytime sleepiness, sleep problems, moodiness, and the use of coffee. This study investigated the association between adolescent morningness-eveningness and psychopathology, substance use, and suicidality in 1332 students ages 12 to 13. Each student-participant completed the Chinese version of the Child Morningness/Eveningness Scale (CMES), the Pubertal Development Scale, and a questionnaire about their sleep schedule, trouble sleeping, habitual substance use, and suicidality. Their mothers completed the Child Behavioral Checklist and Chinese Health Questionnaire. The morning (n = 412), intermediate (n = 740), and evening (n = 180) groups were operationally defined by the CMES t scores. The mixed model was used for data analysis. The evening group had shorter weekday sleep time, longer weekend sleep time, more daytime napping, and greater sleep compensation on weekends and was more likely than the other 2 groups to have behavioral/emotional problems, suicidality, and habitual substance use. Internalizing and externalizing problems partially explained the association between eveningness, substance use, and suicidality. The findings suggest that eveningness may be an indicator for adolescents with behavioral/emotional problems and risky behaviors and suggest an investigation for possible intervention. [ABSTRACT FROM AUTHOR]

Published
2007
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30. Association study of novel human serotonin 5-HT1B polymorphisms with alcohol dependence in taiwanese han

Author

Sun, Hsiao-Fang Sunny, Chang, Yuh-Terng, Fann, Cathy Shen-Jang, Chang, Ching-Jui, Chen, Yi-Hsin, Hsu, Yun-Pung, Yu, Wu-Yang, and Cheng, Andrew Tai-Ann

Subjects
*SEROTONINERGIC mechanisms, *NEUROPSYCHIATRY, *AFFECTIVE disorders
Abstract

Background: Abnormal serotonergic pathways are implicated in numerous neuropsychiatric disorders, such as depression, anxiety, migraine, substance abuse, and alcoholism. The human serotonin receptor 1B, encoded by the HTR1B gene, is a presynaptic serotonin autoreceptor that plays a role in regulating serotonin synthesis and release. Because the linkage of antisocial alcoholism to the HTR1B gene was recently reported in two populations, it was of interest to identify genetic variants at the HTR1B locus and study their association with alcoholism in the Taiwanese Han population.Methods: We sequenced DNA from Taiwanese Han to screen for genetic variation in the coding, promoter, and partial 3′ untranslated regions of the HTR1B locus of 158 alcohol-dependent cases with withdrawal symptoms and 149 control subjects, who either never drank or drank only occasionally and in low quantities.Results: Seven variants were identified. Positive associations were found between variant A-161T and alcohol dependence at both the allelic and genotypic level. In addition, an expression study showed that the A-161T variant affected reporter gene activity.Conclusions: Our results support an association between HTR1B and alcohol dependence. The HTR1B A-161T polymorphism may be valuable both as a functional and as an anonymous genetic marker for HTR1B. [ABSTRACT FROM AUTHOR]

Published
2002
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31. GADL1 variant and medication adherence in predicting response to lithium maintenance treatment in bipolar I disorder.

Author

Chen CK, Lee CS, Chen HY, Wu LS, Chang JC, Liu CY, and Cheng AT

Abstract

Background: Genetic variants and medication adherence have been identified to be the main factors contributing to lithium treatment response in bipolar disorders., Aims: To simultaneously examine effects of variant glutamate decarboxylase-like protein 1 ( GADL1 ) and medication adherence on response to lithium maintenance treatment in Han Chinese patients with bipolar I (BPI) disorder., Method: Frequencies of manic and depressive episodes between carriers and non-carriers of the effective GADL1 rs17026688 T allele during the cumulative periods of off-lithium, poor adherence to lithium treatment and good adherence to lithium treatment were compared in Han Chinese patients with BPI disorder ( n =215)., Results: GADL1 rs17026688 T carriers had significantly lower frequencies of recurrent affective episodes than non-T carriers during the cumulative period of good adherence, but not during those of poor adherence., Conclusions: GADL1 rs17026688 and medication adherence jointly predict response to lithium maintenance treatment in Han Chinese BPI patients., Declaration of Interest: None., Copyright and Usage: © The Royal College of Psychiatrists 2016. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) license.

Published
2016
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