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1. Using blood transcriptome analysis for Alzheimer's disease diagnosis and patient stratification

Author

Zhong, Huan, primary, Zhou, Xiaopu, additional, Uhm, Hyebin, additional, Jiang, Yuanbing, additional, Cao, Han, additional, Chen, Yu, additional, Mak, Tiffany T. W., additional, Lo, Ronnie Ming Nok, additional, Wong, Bonnie Wing Yan, additional, Cheng, Elaine Yee Ling, additional, Mok, Kin Y., additional, Chan, Andrew Lung Tat, additional, Kwok, Timothy C. Y., additional, Mok, Vincent C. T., additional, Ip, Fanny C. F., additional, Hardy, John, additional, Fu, Amy K. Y., additional, and Ip, Nancy Y., additional

Published
2024
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3. A blood‐based multi‐pathway biomarker assay for early detection and staging of Alzheimer's disease across ethnic groups

Author

Jiang, Yuanbing, primary, Uhm, Hyebin, additional, Ip, Fanny C., additional, Ouyang, Li, additional, Lo, Ronnie M. N., additional, Cheng, Elaine Y. L., additional, Cao, Xiaoyun, additional, Tan, Clara M. C., additional, Law, Brian C. H., additional, Ortiz‐Romero, Paula, additional, Puig‐Pijoan, Albert, additional, Fernández‐Lebrero, Aida, additional, Contador, José, additional, Mok, Kin Y., additional, Hardy, John, additional, Kwok, Timothy C. Y., additional, Mok, Vincent C. T., additional, Suárez‐Calvet, Marc, additional, Zetterberg, Henrik, additional, Fu, Amy K. Y., additional, and Ip, Nancy Y., additional

Published
2024
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5. Timing of Introduction to Solid Food, Growth, and Nutrition Risk in Later Childhood

Author

Cohn, Ronald, Lau, Eddy, Laupacis, Andreas, Parkin, Patricia C., Salter, Michael, Szatmari, Peter, Weir, Shannon, Anderson, Laura N., Borkhoff, Cornelia M., Kowal, Christine, Mason, Dalah, Abdurrahman, Murtala, Anderson, Kelly, Arbess, Gordon, Baker, Jillian, Barozzino, Tony, Bergeron, Sylvie, Bhagat, Dimple, Bloch, Gary, Bonifacio, Joey, Bowry, Ashna, Calpin, Caroline, Campbell, Douglas, Cheema, Sohail, Cheng, Elaine, Chisamore, Brian, Constantin, Evelyn, Danayan, Karoon, Das, Paul, Derocher, Mary Beth, Do, Anh, Doukas, Kathleen, Egger, Anne, Farber, Allison, Freedman, Amy, Freeman, Sloane, Gazeley, Sharon, Guiang, Charlie, Ha, Dan, Handford, Curtis, Hanson, Laura, Harrington, Leah, Jacobson, Sheila, Jagiello, Lukasz, Jansz, Gwen, Kadar, Paul, Kim, Florence, Kiran, Tara, Knowles, Holly, Kwok, Bruce, Lakhoo, Sheila, Lam-Antoniades, Margarita, Leduc, Denis, Leung, Fok-Han, Li, Alan, Li, Patricia, Malach, Jessica, Male, Roy, Mascoll, Vashti, Meret, Aleks, Mok, Elise, Moodie, Rosemary, Nader, Maya, Nash, Katherine, Naymark, Sharon, Owen, James, Peer, Michael, Pena, Kifi, Perlmutar, Marty, Persaud, Navindra, Pinto, Andrew, Porepa, Michelle, Qi, Vikky, Ramji, Nasreen, Ramji, Noor, Raza, Danyaal, Rosenthal, Alana, Rouleau, Katherine, Ruderman, Caroline, Saunderson, Janet, Schiralli, Vanna, Sgro, Michael, Shuja, Hafiz, Shepherd, Susan, Smiltnieks, Barbara, Srikanthan, Cinntha, Taylor, Carolyn, Treherne, Stephen, Turner, Suzanne, Uddin, Fatima, van den Heuvel, Meta, Vaughan, Joanne, Weisdorf, Thea, Wijayasinghe, Sheila, Wong, Peter, Yaremko, John, Ying, Ethel, Young, Elizabeth, Zajdman, Michael, Bazeghi, Farnaz, Bouchard, Vincent, Bustos, Marivic, Camacho, Charmaine, Dalwadi, Dharma, Koroshegyi, Christine, Malhi, Tarandeep, Thadani, Sharon, Thompson, Julia, Thompson, Laurie, Aglipay, Mary, Bayoumi, Imaan, Carsley, Sarah, Cost, Katherine, Eny, Karen, Kim, Theresa, Kinlin, Laura, Omand, Jessica, Vanderhout, Shelley, Vanderloo, Leigh, Allen, Christopher, Boodhoo, Bryan, Chan, Olivia, Dai, David W.H., Hall, Judith, Juni, Peter, Lebovic, Gerald, Pope, Karen, Thorpe, Kevin, Kandel, Rita, Rodrigues, Michelle, Vandenberghe, Hilde, D'Hollander, Curtis J., Keown-Stoneman, Charles D.G., Birken, Catherine S., O'Connor, Deborah L., and Maguire, Jonathon L.

Published
2021
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6. Prevalence and Clinical Impact of Donor-Specific Alloantibody Among Intestinal Transplant Recipients

Author

Cheng, Elaine Y, Everly, Matthew J, Kaneku, Hugo, Banuelos, Nubia, Wozniak, Laura J, Venick, Robert S, Marcus, Elizabeth A, McDiarmid, Suzanne V, Busuttil, Ronald W, Terasaki, Paul I, and Farmer, Douglas G

Subjects
Biomedical and Clinical Sciences, Immunology, Patient Safety, Prevention, Transplantation, Organ Transplantation, Digestive Diseases, Adolescent, Adult, Allografts, Biomarkers, Child, Child, Preschool, Drug Therapy, Combination, Female, Graft Rejection, Graft Survival, HLA Antigens, Histocompatibility, Histocompatibility Testing, Humans, Immunity, Humoral, Immunosuppressive Agents, Incidence, Intestines, Isoantibodies, Kaplan-Meier Estimate, Los Angeles, Male, Proportional Hazards Models, Retrospective Studies, Risk Factors, Seroepidemiologic Studies, Time Factors, Transplantation Tolerance, Treatment Outcome, Young Adult, Medical and Health Sciences, Surgery, Clinical sciences
Abstract

BackgroundRejection remains the leading cause of allograft loss, and a major barrier to improving long-term outcomes after intestinal transplantation. Our aim is to define the prevalence and investigate the role of donor-specific antibody (DSA) on intestinal graft outcomes.MethodsThe study includes 109 transplants performed in 95 recipients at a single center. Patients were screened for DSA pretransplant, monitored regularly posttransplant and when clinically indicated using the single-antigen bead Luminex assay. Standard induction immunosuppression was with interleukin-2 receptor antagonists, and antithymocyte globulin in high-risk recipients. Maintenance regimens were tacrolimus-based.ResultsPretransplant DSA was detected in 12 (11%) recipients with 50% continuing to have circulating antibodies posttransplant. An additional 24 (25%) patients developed de novo DSA, and of these, 71% had persistent antibodies. Recipients with preformed DSA demonstrated elevated risks of early graft failure, whereas those with de novo DSA experienced accelerated graft loss once DSA was detected, reaching a 28% failure rate within 2 years. HLA-DQ mismatch is a significant risk factor for de novo DSA emergence, whereas the persistence of antibodies is predicted by DSA strength and specificity. Although inclusion of the liver in the intestinal allograft imparts an immunological advantage against rejection-related graft loss, this protective effect was lost among recipients with persistent DSA.ConclusionsThe presence of DSA is associated with inferior graft outcomes among intestinal transplant recipients. An enhanced understanding of the mechanisms by which DSA causes allograft injury, and effective strategies targeting humoral immune reactivity are needed to improve long-term intestinal graft outcomes.

Published
2017

7. Evaluation of Patients With Hepatocellular Carcinomas That Do Not Produce α-Fetoprotein

Author

Agopian, Vatche G, Harlander-Locke, Michael P, Markovic, Daniela, Zarrinpar, Ali, Kaldas, Fady M, Cheng, Elaine Y, Yersiz, Hasan, Farmer, Douglas G, Hiatt, Jonathan R, and Busuttil, Ronald W

Subjects
Digestive Diseases, Rare Diseases, Transplantation, Liver Disease, Organ Transplantation, Cancer, Liver Cancer, Adult, Carcinoma, Hepatocellular, Disease-Free Survival, Female, Humans, Liver Neoplasms, Liver Transplantation, Male, Microvessels, Neoplasm Grading, Neoplasm Invasiveness, Neoplasm Recurrence, Local, Neoplasm Staging, Retrospective Studies, Tumor Burden, alpha-Fetoproteins
Abstract

ImportanceSerum α-fetoprotein (AFP) is a biomarker for hepatocellular carcinomas (HCCs) associated with a more aggressive tumor phenotype and inferior outcomes after a liver transplant (LT). Data on the outcomes for patients with HCCs that do not produce AFP are limited.ObjectiveTo compare characteristics and outcomes among LT recipients with radiographically apparent HCC lesions with AFP-producing tumors or with tumors that do not produce AFP (hereafter referred to as non-AFP-producing tumors), and to identify factors influencing recurrence in LT recipients with non-AFP-producing tumors.Design, setting, and participantsRetrospective analysis at a university transplant center of 665 adults with HCC who underwent an LT during the period from 1989 to 2013. Of the 665 LT recipients, 457 (68.7%) had AFP-producing tumors, and 208 (31.3%) had non-AFP-producing tumors (the maximum AFP level before an LT was ≤10 ng/mL). Dates of study analysis were from August 2015 to June 2016.InterventionLiver transplant.Main outcomes and measuresRecurrence-free survival and recurrence rates.ResultsPatients with non-AFP-producing tumors had radiographic tumor characteristics similar to those of patients with AFP-producing tumors, but, pathologically, they had fewer lesions (25% vs 35% with >2 lesions; P = .03), smaller cumulative tumor diameters (4.2 vs 5.0 cm; P = .02), fewer microvascular (17% vs 22%) and macrovascular (2% vs 9%) invasions (P 2 tumors [HR, 4.98; 95% CI, 1.72-14.4; P = .003]; cumulative diameter [1.70 per log SD; 1.12-2.59; P 2 tumors [4.39; 1.32-14.6; P = .02]; cumulative diameter [2.32 per log SD; 1.43-3.77; P = .001]; microvascular [3.07; 1.02-9.24; P = .05] and macrovascular invasion [8.75; 2.15-35.6; P = .002]).Conclusions and relevanceNearly one-third of patients with radiographically apparent HCC have non-AFP-producing tumors that have more favorable pathologic characteristics, lower posttransplant recurrence, and superior survival compared with patients with AFP-producing tumors. Posttransplant HCC recurrence for patients with non-AFP-producing tumors is predicted by important radiologic and pathologic factors, and is negligible for patients within the Milan criteria. Stratifying patients by AFP status in addition to radiological criteria may improve the selection process for and the prioritization of transplant candidates.

Published
2017

10. A Positive Association Between Dietary Intake of Higher Cow's Milk-Fat Percentage and Non−High-Density Lipoprotein Cholesterol in Young Children

Author

Birken, Catherine S., Maguire, Jonathon L., Cohn, Ronald, Lau, Eddy, Laupacis, Andreas, Parkin, Patricia C., Salter, Michael, Szatmari, Peter, Weir, Shannon, Anderson, Laura N., Borkhoff, Cornelia M., Keown-Stoneman, Charles, Kowal, Christine, Mason, Dalah, Abdurrahman, Murtala, Anderson, Kelly, Arbess, Gordon, Baker, Jillian, Barozzino, Tony, Bergeron, Sylvie, Bhagat, Dimple, Bloch, Gary, Bonifacio, Joey, Bowry, Ashna, Calpin, Caroline, Campbell, Douglas, Cheema, Sohail, Cheng, Elaine, Chisamore, Brian, Constantin, Evelyn, Danayan, Karoon, Das, Paul, Derocher, Mary Beth, Do, Anh, Doukas, Kathleen, Egger, Anne, Farber, Allison, Freedman, Amy, Freeman, Sloane, Gazeley, Sharon, Guiang, Charlie, Ha, Dan, Handford, Curtis, Hanson, Laura, Harrington, Leah, Jacobson, Sheila, Jagiello, Lukasz, Jansz, Gwen, Kadar, Paul, Kim, Florence, Kiran, Tara, Knowles, Holly, Kwok, Bruce, Lakhoo, Sheila, Lam-Antoniades, Margarita, Leduc, Denis, Leung, Fok-Han, Li, Alan, Li, Patricia, Malach, Jessica, Male, Roy, Mascoll, Vashti, Meret, Aleks, Mok, Elise, Moodie, Rosemary, Nader, Maya, Nash, Katherine, Naymark, Sharon, Owen, James, Peer, Michael, Pena, Kifi, Perlmutar, Marty, Persaud, Navindra, Pinto, Andrew, Porepa, Michelle, Qi, Vikky, Ramji, Nasreen, Ramji, Noor, Raza, Danyaal, Rosenthal, Alana, Rouleau, Katherine, Ruderman, Caroline, Saunderson, Janet, Schiralli, Vanna, Sgro, Michael, Shuja, Hafiz, Shepherd, Susan, Smiltnieks, Barbara, Srikanthan, Cinntha, Taylor, Carolyn, Treherne, Stephen, Turner, Suzanne, Uddin, Fatima, van den Heuvel, Meta, Vaughan, Joanne, Weisdorf, Thea, Wijayasinghe, Sheila, Wong, Peter, Yaremko, John, Ying, Ethel, Young, Elizabeth, Zajdman, Michael, Bazeghi, Farnaz, Bouchard, Vincent, Bustos, Marivic, Camacho, Charmaine, Dalwadi, Dharma, Koroshegyi, Christine, Malhi, Tarandeep, Thadani, Sharon, Thompson, Julia, Thompson, Laurie, Aglipay, Mary, Bayoumi, Imaan, Carsley, Sarah, Cost, Katherine, Eny, Karen, Kim, Theresa, Kinlin, Laura, Omand, Jessica, Vanderhout, Shelley, Vanderloo, Leigh, Allen, Christopher, Boodhoo, Bryan, Chan, Olivia, Dai, David W.H., Hall, Judith, Juni, Peter, Lebovic, Gerald, Pope, Karen, Thorpe, Kevin, Kandel, Rita, Rodrigues, Michelle, Vandenberghe, Hilde, Wong, Vincent C.H., Omand, Jessica A., and O'Connor, Deborah L.

Published
2019
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12. Higher Body Mass Index Is Associated with Iron Deficiency in Children 1 to 3 Years of Age

Author

Aglipay, Mary, Anderson, Laura N., Dai, David W.H., Keown-Stoneman, Charles, Kowal, Christine, Mason, Dalah, Abdurrahman, Murtala, Anderson, Barbara, Anderson, Kelly, Arbess, Gordon, Baker, Jillian, Barozzino, Tony, Bayoumi, Imaan, Bergeron, Sylvie, Bhagat, Dimple, Blanchette, Nicholas, Bloch, Gary, Bonifacio, Joey, Bowry, Ashna, Brown, Anne, Bugera, Jennifer, Calpin, Caroline, Campbell, Douglas, Cheema, Sohail, Cheng, Elaine, Chisamore, Brian, Constantin, Evelyn, Culbert, Ellen, Danayan, Karoon, Das, Paul, Derocher, Mary Beth, Do, Anh, Dorey, Michael, Doukas, Kathleen, Egger, Anne, Farber, Allison, Freedman, Amy, Freeman, Sloane, Gazeley, Sharon, Guiang, Charlie, Ha, Dan, Handford, Curtis, Hanson, Laura, Harrington, Leah, Hatch, Hailey, Hughes, Teresa, Jacobson, Sheila, Jagiello, Lukasz, Jansz, Gwen, Jasuja, Mona, Kadar, Paul, Kiran, Tara, Knowles, Holly, Kwok, Bruce, Lakhoo, Sheila, Lam-Antoniades, Margarita, Lau, Eddy, Leduc, Denis, Leung, Fok-Han, Li, Alan, Li, Patricia, Loo, Jennifer, Louis, Joanne, Mahmoud, Sarah, Malach, Jessica, Male, Roy, Mascoll, Vashti, Meret, Aleks, Mok, Elise, Moodie, Rosemary, Morinis, Julia, Nader, Maya, Nash, Katherine, Naymark, Sharon, Owen, James, Parry, Jane, Peer, Michael, Pena, Kifi, Perlmutar, Marty, Persaud, Navindra, Pinto, Andrew, Porepa, Michelle, Qi, Vikky, Ramji, Nasreen, Ramji, Noor, Rana, Jesleen, Raza, Danyaal, Rosenthal, Alana, Rouleau, Katherine, Saunderson, Janet, Saxena, Rahul, Schiralli, Vanna, Sgro, Michael, Shuja, Hafiz, Shepherd, Susan, Smiltnieks, Barbara, Srikanthan, Cinntha, Taylor, Carolyn, Treherne, Stephen, Turner, Suzanne, Uddin, Fatima, van den Heuvel, Meta, Vaughan, Joanne, Weisdorf, Thea, Wijayasinghe, Sheila, Wong, Peter, Wormsbecker, Anne, Yaremko, John, Ying, Ethel, Young, Elizabeth, Zajdman, Michael, Bazeghi, Farnaz, Bouchard, Vincent, Bustos, Marivic, Camacho, Charmaine, Dalwadi, Dharma, Koroshegyi, Christine, Malhi, Tarandeep, Thadani, Sharon, Thompson, Julia, Thompson, Laurie, Sypes, Emma E., Parkin, Patricia C., Birken, Catherine S., Carsley, Sarah, MacArthur, Colin, Maguire, Jonathon L., and Borkhoff, Cornelia M.

Published
2019
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13. The Association of Breastfeeding Duration and Early Childhood Cardiometabolic Risk

Author

Lau, Eddy, Laupacis, Andreas, Salter, Michael, Szatmari, Peter, Weir, Shannon, Camacho, Charmaine, Chandraraj, Arthana, Dalwadi, Dharma, Islam, Ayesha, Jegathesan, Thivia, Malhi, Tarandeep, Smith, Megan, Thompson, Laurie, Allen, Christopher, Boodhoo, Bryan, Hall, Judith, Juni, Peter, Lebovic, Gerald, Pope, Karen, Shim, Jodi, Thorpe, Kevin, Azad, Azar, Abdullah, Kawsari, Ali, Yamna, Bayoumi, Imaan, Borkhoff, Cornelia M., Carsley, Sarah, Chen, Shiyi, Chen, Yang, Darmawikarta, Denise, Dennis, Cindy-Lee, Eny, Karen, Erdle, Stephanie, Furlong, Kayla, Kavikondala, Kanthi, Koroshegyi, Christine, Kowal, Christine, Lee, Grace Jieun, Mason, Dalah, Omand, Jessica, Persaud, Navindra, Plumptre, Lesley, van den Heuvel, Meta, Vanderhout, Shelley, Zabih, Weeda, Abdurrahman, Murtala, Anderson, Barbara, Anderson, Kelly, Arbess, Gordon, Baker, Jillian, Barozzino, Tony, Bergeron, Sylvie, Bhagat, Dimple, Blanchette, Nicholas, Bloch, Gary, Bonifacio, Joey, Bowry, Ashna, Brown, Anne, Bugera, Jennifer, Campbell, Douglas, Cheema, Sohail, Cheng, Elaine, Chisamore, Brian, Culbert, Ellen, Danayan, Karoon, Das, Paul, Derocher, Mary Beth, Do, Anh, Dorey, Michael, Doukas, Kathleen, Egger, Anne, Farber, Allison, Freedman, Amy, Freeman, Sloane, Fung, Keewai, Gazeley, Sharon, Guiang, Charlie, Ha, Dan, Handford, Curtis, Hanson, Laura, Hatch, Hailey, Hughes, Teresa, Jacobson, Sheila, Jagiello, Lukasz, Jansz, Gwen, Kadar, Paul, Kiran, Tara, Kitney, Lauren, Knowles, Holly, Kwok, Bruce, Lakhoo, Sheila, Lam-Antoniades, Margarita, Leung, Fok-Han, Li, Alan, Loo, Jennifer, Louis, Joanne, Mahmoud, Sarah, Male, Roy, Mascoll, Vashti, Moodie, Rosemary, Morinis, Julia, Nader, Maya, Naymark, Sharon, Neelands, Patricia, Owen, James, Parry, Jane, Peer, Michael, Pena, Kifi, Perlmutar, Marty, Pinto, Andrew, Pitt, Tracy, Porepa, Michelle, Qi, Vikky, Ramji, Nasreen, Ramji, Noor, Rana, Jesleen, Rosenthal, Alana, Rouleau, Katherine, Saunderson, Janet, Saxena, Rahul, Schiralli, Vanna, Sgro, Michael, Shuja, Hafiz, Shepherd, Susan, Smiltnieks, Barbara, Srikanthan, Cinntha, Taylor, Carolyn, Turner, Suzanne, Uddin, Fatima, Vaughan, Joanne, Weisdorf, Thea, Wijayasinghe, Sheila, Wormsbecker, Anne, Ying, Ethel, Young, Elizabeth, Zajdman, Michael, Zenlea, Ian, Wong, Peter D., Anderson, Laura N., Dai, David D.W., Parkin, Patricia C., Maguire, Jonathan L., and Birken, Catherine S.

Published
2018
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14. Supplementary Table 3 from Expression Profiling Reveals Novel Pathways in the Transformation of Melanocytes to Melanomas

Author

Hoek, Keith, primary, Rimm, David L., primary, Williams, Kenneth R., primary, Zhao, Hongyu, primary, Ariyan, Stephan, primary, Lin, Aiping, primary, Kluger, Harriet M., primary, Berger, Aaron J., primary, Cheng, Elaine, primary, Trombetta, E. Sergio, primary, Wu, Terence, primary, Niinobe, Michio, primary, Yoshikawa, Kazuaki, primary, Hannigan, Gregory E., primary, and Halaban, Ruth, primary

Published
2023
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15. Supplementary Table 1 from Expression Profiling Reveals Novel Pathways in the Transformation of Melanocytes to Melanomas

Author

Hoek, Keith, primary, Rimm, David L., primary, Williams, Kenneth R., primary, Zhao, Hongyu, primary, Ariyan, Stephan, primary, Lin, Aiping, primary, Kluger, Harriet M., primary, Berger, Aaron J., primary, Cheng, Elaine, primary, Trombetta, E. Sergio, primary, Wu, Terence, primary, Niinobe, Michio, primary, Yoshikawa, Kazuaki, primary, Hannigan, Gregory E., primary, and Halaban, Ruth, primary

Published
2023
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16. Supplementary Table 2 from Expression Profiling Reveals Novel Pathways in the Transformation of Melanocytes to Melanomas

Author

Hoek, Keith, primary, Rimm, David L., primary, Williams, Kenneth R., primary, Zhao, Hongyu, primary, Ariyan, Stephan, primary, Lin, Aiping, primary, Kluger, Harriet M., primary, Berger, Aaron J., primary, Cheng, Elaine, primary, Trombetta, E. Sergio, primary, Wu, Terence, primary, Niinobe, Michio, primary, Yoshikawa, Kazuaki, primary, Hannigan, Gregory E., primary, and Halaban, Ruth, primary

Published
2023
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18. Integrative analysis of epigenetic modulation in melanoma cell response to decitabine: clinical implications.

Author

Halaban, Ruth, Krauthammer, Michael, Pelizzola, Mattia, Cheng, Elaine, Kovacs, Daniela, Sznol, Mario, Ariyan, Stephan, Narayan, Deepak, Bacchiocchi, Antonella, Molinaro, Annette, Kluger, Yuval, Deng, Min, Tran, Nam, Zhang, Wengeng, Picardo, Mauro, and Enghild, Jan J

Subjects
Cell Line, Tumor, Humans, Melanoma, DNA Damage, Azacitidine, Gene Expression Profiling, Computational Biology, Apoptosis, Cell Proliferation, Epigenesis, Genetic, Gene Expression Regulation, Neoplastic, Drug Resistance, Neoplasm, Biomarkers, Tumor, Decitabine, Biomarkers, Tumor, Cell Line, Drug Resistance, Neoplasm, Epigenesis, Genetic, Gene Expression Regulation, Neoplastic, General Science & Technology
Abstract

Decitabine, an epigenetic modifier that reactivates genes otherwise suppressed by DNA promoter methylation, is effective for some, but not all cancer patients, especially those with solid tumors. It is commonly recognized that to overcome resistance and improve outcome, treatment should be guided by tumor biology, which includes genotype, epigenotype, and gene expression profile. We therefore took an integrative approach to better understand melanoma cell response to clinically relevant dose of decitabine and identify complementary targets for combined therapy. We employed eight different melanoma cell strains, determined their growth, apoptotic and DNA damage responses to increasing doses of decitabine, and chose a low, clinically relevant drug dose to perform whole-genome differential gene expression, bioinformatic analysis, and protein validation studies. The data ruled out the DNA damage response, demonstrated the involvement of p21(Cip1) in a p53-independent manner, identified the TGFbeta pathway genes CLU and TGFBI as markers of sensitivity to decitabine and revealed an effect on histone modification as part of decitabine-induced gene expression. Mutation analysis and knockdown by siRNA implicated activated beta-catenin/MITF, but not BRAF, NRAS or PTEN mutations as a source for resistance. The importance of protein stability predicted from the results was validated by the synergistic effect of Bortezomib, a proteasome inhibitor, in enhancing the growth arrest of decitabine in otherwise resistant melanoma cells. Our integrative analysis show that improved therapy can be achieved by comprehensive analysis of cancer cells, identified biomarkers for patient's selection and monitoring response, as well as targets for improved combination therapy.

Published
2009

29. The Association of Breastfeeding Duration and Early Childhood Cardiometabolic Risk

Author

Wong, Peter D., Anderson, Laura N., Dai, David D.W., Parkin, Patricia C., Maguire, Jonathan L., Birken, Catherine S., Lau, Eddy, Laupacis, Andreas, Salter, Michael, Szatmari, Peter, Weir, Shannon, Camacho, Charmaine, Chandraraj, Arthana, Dalwadi, Dharma, Islam, Ayesha, Jegathesan, Thivia, Malhi, Tarandeep, Smith, Megan, Thompson, Laurie, Allen, Christopher, Boodhoo, Bryan, Hall, Judith, Juni, Peter, Lebovic, Gerald, Pope, Karen, Shim, Jodi, Thorpe, Kevin, Azad, Azar, Abdullah, Kawsari, Ali, Yamna, Bayoumi, Imaan, Borkhoff, Cornelia M., Carsley, Sarah, Chen, Shiyi, Chen, Yang, Darmawikarta, Denise, Dennis, Cindy-Lee, Eny, Karen, Erdle, Stephanie, Furlong, Kayla, Kavikondala, Kanthi, Koroshegyi, Christine, Kowal, Christine, Lee, Grace Jieun, Mason, Dalah, Omand, Jessica, Persaud, Navindra, Plumptre, Lesley, van den Heuvel, Meta, Vanderhout, Shelley, Zabih, Weeda, Abdurrahman, Murtala, Anderson, Barbara, Anderson, Kelly, Arbess, Gordon, Baker, Jillian, Barozzino, Tony, Bergeron, Sylvie, Bhagat, Dimple, Blanchette, Nicholas, Bloch, Gary, Bonifacio, Joey, Bowry, Ashna, Brown, Anne, Bugera, Jennifer, Campbell, Douglas, Cheema, Sohail, Cheng, Elaine, Chisamore, Brian, Culbert, Ellen, Danayan, Karoon, Das, Paul, Derocher, Mary Beth, Do, Anh, Dorey, Michael, Doukas, Kathleen, Egger, Anne, Farber, Allison, Freedman, Amy, Freeman, Sloane, Fung, Keewai, Gazeley, Sharon, Guiang, Charlie, Ha, Dan, Handford, Curtis, Hanson, Laura, Hatch, Hailey, Hughes, Teresa, Jacobson, Sheila, Jagiello, Lukasz, Jansz, Gwen, Kadar, Paul, Kiran, Tara, Kitney, Lauren, Knowles, Holly, Kwok, Bruce, Lakhoo, Sheila, Lam-Antoniades, Margarita, Leung, Fok-Han, Li, Alan, Loo, Jennifer, Louis, Joanne, Mahmoud, Sarah, Male, Roy, Mascoll, Vashti, Moodie, Rosemary, Morinis, Julia, Nader, Maya, Naymark, Sharon, Neelands, Patricia, Owen, James, Parry, Jane, Peer, Michael, Pena, Kifi, Perlmutar, Marty, Pinto, Andrew, Pitt, Tracy, Porepa, Michelle, Qi, Vikky, Ramji, Nasreen, Ramji, Noor, Rana, Jesleen, Rosenthal, Alana, Rouleau, Katherine, Saunderson, Janet, Saxena, Rahul, Schiralli, Vanna, Sgro, Michael, Shuja, Hafiz, Shepherd, Susan, Smiltnieks, Barbara, Srikanthan, Cinntha, Taylor, Carolyn, Turner, Suzanne, Uddin, Fatima, Vaughan, Joanne, Weisdorf, Thea, Wijayasinghe, Sheila, Wormsbecker, Anne, Ying, Ethel, Young, Elizabeth, Zajdman, Michael, and Zenlea, Ian

Published
2018
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30. Timing of Introduction to Solid Food, Growth, and Nutrition Risk in Later Childhood

Author

D'Hollander, Curtis J., primary, Keown-Stoneman, Charles D.G., additional, Birken, Catherine S., additional, O'Connor, Deborah L., additional, Maguire, Jonathon L., additional, Cohn, Ronald, additional, Lau, Eddy, additional, Laupacis, Andreas, additional, Parkin, Patricia C., additional, Salter, Michael, additional, Szatmari, Peter, additional, Weir, Shannon, additional, Anderson, Laura N., additional, Borkhoff, Cornelia M., additional, Kowal, Christine, additional, Mason, Dalah, additional, Abdurrahman, Murtala, additional, Anderson, Kelly, additional, Arbess, Gordon, additional, Baker, Jillian, additional, Barozzino, Tony, additional, Bergeron, Sylvie, additional, Bhagat, Dimple, additional, Bloch, Gary, additional, Bonifacio, Joey, additional, Bowry, Ashna, additional, Calpin, Caroline, additional, Campbell, Douglas, additional, Cheema, Sohail, additional, Cheng, Elaine, additional, Chisamore, Brian, additional, Constantin, Evelyn, additional, Danayan, Karoon, additional, Das, Paul, additional, Derocher, Mary Beth, additional, Do, Anh, additional, Doukas, Kathleen, additional, Egger, Anne, additional, Farber, Allison, additional, Freedman, Amy, additional, Freeman, Sloane, additional, Gazeley, Sharon, additional, Guiang, Charlie, additional, Ha, Dan, additional, Handford, Curtis, additional, Hanson, Laura, additional, Harrington, Leah, additional, Jacobson, Sheila, additional, Jagiello, Lukasz, additional, Jansz, Gwen, additional, Kadar, Paul, additional, Kim, Florence, additional, Kiran, Tara, additional, Knowles, Holly, additional, Kwok, Bruce, additional, Lakhoo, Sheila, additional, Lam-Antoniades, Margarita, additional, Leduc, Denis, additional, Leung, Fok-Han, additional, Li, Alan, additional, Li, Patricia, additional, Malach, Jessica, additional, Male, Roy, additional, Mascoll, Vashti, additional, Meret, Aleks, additional, Mok, Elise, additional, Moodie, Rosemary, additional, Nader, Maya, additional, Nash, Katherine, additional, Naymark, Sharon, additional, Owen, James, additional, Peer, Michael, additional, Pena, Kifi, additional, Perlmutar, Marty, additional, Persaud, Navindra, additional, Pinto, Andrew, additional, Porepa, Michelle, additional, Qi, Vikky, additional, Ramji, Nasreen, additional, Ramji, Noor, additional, Raza, Danyaal, additional, Rosenthal, Alana, additional, Rouleau, Katherine, additional, Ruderman, Caroline, additional, Saunderson, Janet, additional, Schiralli, Vanna, additional, Sgro, Michael, additional, Shuja, Hafiz, additional, Shepherd, Susan, additional, Smiltnieks, Barbara, additional, Srikanthan, Cinntha, additional, Taylor, Carolyn, additional, Treherne, Stephen, additional, Turner, Suzanne, additional, Uddin, Fatima, additional, van den Heuvel, Meta, additional, Vaughan, Joanne, additional, Weisdorf, Thea, additional, Wijayasinghe, Sheila, additional, Wong, Peter, additional, Yaremko, John, additional, Ying, Ethel, additional, Young, Elizabeth, additional, Zajdman, Michael, additional, Bazeghi, Farnaz, additional, Bouchard, Vincent, additional, Bustos, Marivic, additional, Camacho, Charmaine, additional, Dalwadi, Dharma, additional, Koroshegyi, Christine, additional, Malhi, Tarandeep, additional, Thadani, Sharon, additional, Thompson, Julia, additional, Thompson, Laurie, additional, Aglipay, Mary, additional, Bayoumi, Imaan, additional, Carsley, Sarah, additional, Cost, Katherine, additional, Eny, Karen, additional, Kim, Theresa, additional, Kinlin, Laura, additional, Omand, Jessica, additional, Vanderhout, Shelley, additional, Vanderloo, Leigh, additional, Allen, Christopher, additional, Boodhoo, Bryan, additional, Chan, Olivia, additional, Dai, David W.H., additional, Hall, Judith, additional, Juni, Peter, additional, Lebovic, Gerald, additional, Pope, Karen, additional, Thorpe, Kevin, additional, Kandel, Rita, additional, Rodrigues, Michelle, additional, and Vandenberghe, Hilde, additional

Published
2022
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34. Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

Author

Krauthammer, Michael, Kong, Yong, Ha, Byung Hak, Evans, Perry, Bacchiocchi, Antonella, McCusker, Jamie P, Cheng, Elaine, Davis, Matthew J, Goh, Gerald, Choi, Murim, Ariyan, Stephan, Narayan, Deepak, Dutton-Regester, Ken, Capatana, Ana, Holman, Edna C, Bosenberg, Marcus, Sznol, Mario, Kluger, Harriet M, Brash, Douglas E, Stern, David F, Materin, Miguel A, Lo, Roger S, Mane, Shrikant, Ma, Shuangge, Kidd, Kenneth K, Hayward, Nicholas K, Lifton, Richard P, Schlessinger, Joseph, Boggon, Titus J, and Halaban, Ruth

Published
2012
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41. Additional file 2 of Detecting copy number status and uncovering subclonal markers in heterogeneous tumor biopsies

Author

Parisi, Fabio, Ariyan, Stephan, Narayan, Deepak, Bacchiocchi, Antonella, Hoyt, Kathleen, Cheng, Elaine, Xu, Fang, Peining Li, Halaban, Ruth, and Kluger, Yuval

Abstract

Additional file 2:Evidence of subclonal heterogeneity from RNA-Seq data across a collection of melanoma samples. Allelic imbalance along each gene demonstrates subclonal heterogeneity. The score of the non-reference nucleotide has been calculated as 0.5- | 0.5 - (#B/(#B+#A)) |, where #A and #B are the numbers of reads hosting the reference and non-reference nucleotide respectively. However, all the reported genes have a multimodal distribution of B-allele frequencies along at least one exon. The B-allele frequencies close to 0.5 have been marked in grey, B-alleles that significantly deviate from this cluster are considered acquired somatic mutations (black) and can be explained by subclonal heterogeneity. Vertical bars represent 95% confidence intervals. All non-reference nucleotides shown are supported by at least 100 reads. Vertical dashed lines mark the boundaries between exons in the transcript. (PDF 46 KB)

Published
2020
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42. Additional file 1 of Detecting copy number status and uncovering subclonal markers in heterogeneous tumor biopsies

Author

Parisi, Fabio, Ariyan, Stephan, Narayan, Deepak, Bacchiocchi, Antonella, Hoyt, Kathleen, Cheng, Elaine, Xu, Fang, Peining Li, Halaban, Ruth, and Kluger, Yuval

Abstract

Additional file 1:Detecting copy number status and uncovering subclonal markers in heterogeneous tumor biopsies. Comparing the M-Measure-based approach to a state-of-the-art CNA algorithm by testing their ability to identify de novo aberrations in SNP-array signals from an evolving tumor at two time points. (DOC 820 KB)

Published
2020
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44. A Pentacyclic Triterpene from Ligustrum lucidum Targets γ-Secretase

Author

Luo, Wenjie, primary, Ip, Fanny C. F., additional, Fu, Guangmiao, additional, Cheung, Kit, additional, Tian, Yuan, additional, Hu, Yueqing, additional, Sinha, Anjana, additional, Cheng, Elaine Y. L., additional, Wu, Xianzhong, additional, Bustos, Victor, additional, Greengard, Paul, additional, Li, Yue-Ming, additional, Sinha, Subhash C., additional, and Ip, Nancy Y., additional

Published
2020
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45. Perforated Carcinoid Tumor of the Appendix: Need for Guidelines for Management With Respect to Prognostic Factors

Author

McCann, Charles, Schwartz, Jandie, Perry, Luke, and Cheng, Elaine

Abstract

Carcinoid tumors, one of the most common malignant lesions involving the appendix, are typically found incidentally during routine appendectomies. While up to 20% of acute appendicitis cases present with perforation, the incidence of perforation among patients with undiagnosed carcinoid tumors of the appendix is unknown. In addition, there is no consensus on the management of carcinoid tumors in the perforated appendix or its impact on prognosis. We present a case of a 42-year-old woman presented with perforated appendicitis. Final pathology demonstrated the presence of a 1.1 cm, well-differentiated grade 1 neuroendocrine tumor at the tip of the appendix extending into the subserosa, without evidence for lymphovascular invasion. Given the depth of tumor invasion and the relatively young age of the patient, the decision was made to perform an interval completion right hemicolectomy for lymph node sampling. Only a few cases have been reported in the available literature, and it remains unclear whether appendiceal perforation represents an independent negative prognostic factor for patient survival. Additional data from cohort studies are needed to determine the true incidence, prognosis, and optimal management of newly diagnosed carcinoid tumors in the perforated appendix. Furthermore, clear consensus guidelines are needed to identify the subgroup of patients who would benefit from interval or primary right hemicolectomy.

Published
2023
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47. A Positive Association Between Dietary Intake of Higher Cow's Milk-Fat Percentage and Non−High-Density Lipoprotein Cholesterol in Young Children

Author

Wong, Vincent C.H., primary, Maguire, Jonathon L., additional, Omand, Jessica A., additional, Dai, David W.H., additional, Lebovic, Gerald, additional, Parkin, Patricia C., additional, O'Connor, Deborah L., additional, Birken, Catherine S., additional, Cohn, Ronald, additional, Lau, Eddy, additional, Laupacis, Andreas, additional, Salter, Michael, additional, Szatmari, Peter, additional, Weir, Shannon, additional, Anderson, Laura N., additional, Borkhoff, Cornelia M., additional, Keown-Stoneman, Charles, additional, Kowal, Christine, additional, Mason, Dalah, additional, Abdurrahman, Murtala, additional, Anderson, Kelly, additional, Arbess, Gordon, additional, Baker, Jillian, additional, Barozzino, Tony, additional, Bergeron, Sylvie, additional, Bhagat, Dimple, additional, Bloch, Gary, additional, Bonifacio, Joey, additional, Bowry, Ashna, additional, Calpin, Caroline, additional, Campbell, Douglas, additional, Cheema, Sohail, additional, Cheng, Elaine, additional, Chisamore, Brian, additional, Constantin, Evelyn, additional, Danayan, Karoon, additional, Das, Paul, additional, Derocher, Mary Beth, additional, Do, Anh, additional, Doukas, Kathleen, additional, Egger, Anne, additional, Farber, Allison, additional, Freedman, Amy, additional, Freeman, Sloane, additional, Gazeley, Sharon, additional, Guiang, Charlie, additional, Ha, Dan, additional, Handford, Curtis, additional, Hanson, Laura, additional, Harrington, Leah, additional, Jacobson, Sheila, additional, Jagiello, Lukasz, additional, Jansz, Gwen, additional, Kadar, Paul, additional, Kim, Florence, additional, Kiran, Tara, additional, Knowles, Holly, additional, Kwok, Bruce, additional, Lakhoo, Sheila, additional, Lam-Antoniades, Margarita, additional, Leduc, Denis, additional, Leung, Fok-Han, additional, Li, Alan, additional, Li, Patricia, additional, Malach, Jessica, additional, Male, Roy, additional, Mascoll, Vashti, additional, Meret, Aleks, additional, Mok, Elise, additional, Moodie, Rosemary, additional, Nader, Maya, additional, Nash, Katherine, additional, Naymark, Sharon, additional, Owen, James, additional, Peer, Michael, additional, Pena, Kifi, additional, Perlmutar, Marty, additional, Persaud, Navindra, additional, Pinto, Andrew, additional, Porepa, Michelle, additional, Qi, Vikky, additional, Ramji, Nasreen, additional, Ramji, Noor, additional, Raza, Danyaal, additional, Rosenthal, Alana, additional, Rouleau, Katherine, additional, Ruderman, Caroline, additional, Saunderson, Janet, additional, Schiralli, Vanna, additional, Sgro, Michael, additional, Shuja, Hafiz, additional, Shepherd, Susan, additional, Smiltnieks, Barbara, additional, Srikanthan, Cinntha, additional, Taylor, Carolyn, additional, Treherne, Stephen, additional, Turner, Suzanne, additional, Uddin, Fatima, additional, van den Heuvel, Meta, additional, Vaughan, Joanne, additional, Weisdorf, Thea, additional, Wijayasinghe, Sheila, additional, Wong, Peter, additional, Yaremko, John, additional, Ying, Ethel, additional, Young, Elizabeth, additional, Zajdman, Michael, additional, Bazeghi, Farnaz, additional, Bouchard, Vincent, additional, Bustos, Marivic, additional, Camacho, Charmaine, additional, Dalwadi, Dharma, additional, Koroshegyi, Christine, additional, Malhi, Tarandeep, additional, Thadani, Sharon, additional, Thompson, Julia, additional, Thompson, Laurie, additional, Aglipay, Mary, additional, Bayoumi, Imaan, additional, Carsley, Sarah, additional, Cost, Katherine, additional, Eny, Karen, additional, Kim, Theresa, additional, Kinlin, Laura, additional, Omand, Jessica, additional, Vanderhout, Shelley, additional, Vanderloo, Leigh, additional, Allen, Christopher, additional, Boodhoo, Bryan, additional, Chan, Olivia, additional, Hall, Judith, additional, Juni, Peter, additional, Pope, Karen, additional, Thorpe, Kevin, additional, Kandel, Rita, additional, Rodrigues, Michelle, additional, and Vandenberghe, Hilde, additional

Published
2019
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50. Evaluation of intraperitoneal vancomycin in peritoneal dialysis-associated peritonitis

Author

Chang, Wui Ming, Cheng, Elaine, Shalansky, Karen, and Singh, Suneet R

Abstract

Background: Intraperitoneal (IP) vancomycin is recommended as one of the treatment options for gram-positive coverage in the management of peritoneal dialysis (PD)-associated peritonitis. There is a lack of literature supporting the optimal dose and approach to vancomycin therapeutic drug-level monitoring.Methods: A retrospective chart review was conducted using the BC Renal Agency PROMIS Database and our hospital records from 1 June 2011 to 1 July 2019. Adult patients with PD-associated peritonitis who received IP vancomycin and had at least one serum vancomycin level drawn were included. All patients received a loading dose of 30 mg/kg, which was repeated every 3–5 days depending on PD modality. Serum vancomycin levels were drawn prior to the second vancomycin dose, then at the discretion of the prescriber. The primary end point was the rate of therapeutic serum vancomycin levels ≥15 mg/L.Results: Twenty-three episodes of PD-associated peritonitis in 20 patients met the eligibility criteria. Only 15/23 serum vancomycin levels were drawn appropriately after the first dose. Sixty per cent of these levels were subtherapeutic at <15 mg/L. All subsequent serum vancomycin levels were above the therapeutic target. Most peritonitis episodes (78%) achieved resolution of infection. Residual kidney function was not significantly correlated with serum vancomycin levels (p= 0.19).Conclusions: An IP vancomycin regimen of 30 mg/kg every 3–5 days resulted in subtherapeutic serum vancomycin levels in most patients following the loading dose but therapeutic levels thereafter. A large percentage of vancomycin levels were drawn inappropriately due to misalignment of outpatient follow-up visits and timing of blood work.

Published
2022
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