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14 results on '"Cheng, Gui-Rong"'

1. Population-attributable fractions of risk factors for all-cause dementia in China rural and urban areas: a cross-sectional study

Author

Hu, Fei-fei, Cheng, Gui-rong, Liu, Dan, Liu, Qian, Gan, Xu-guang, Li, Lin, Wang, Xiao-dan, Zhang, Bo, An, Li-na, Chen, Cong, Zou, Ming-jun, Xu, Lang, Ou, Yang-ming, Chen, Yu-shan, Li, Jin-quan, Wei, Zhen, Wang, Yue-yi, Wu, Qiong, Chen, Xing-xing, Yang, Xi-fei, Wu, Qing-ming, Feng, Lei, Zhang, Jing-jing, Xu, Heng, Yu, Ya-fu, Yang, Meng-liu, Qian, Jin, Lian, Peng-fei, Fu, Li-yan, Duan, Ting-ting, Tian, Yuan, Cheng, Xi, Li, Xin-wen, Yan, Pin-ting, Huang, Guowei, Dong, Hongxin, Ji, Yong, and Zeng, Yan

Published
2022
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2. Association Between Long-Term Exposure to Ambient Air Pollution and the Risk of Mild Cognitive Impairment in a Chinese Urban Area: A Case-Control Study

Author

Xie, Xin-Yan, primary, Huang, Lin-Ya, additional, Cheng, Gui-Rong, additional, Liu, Dan, additional, Hu, Fei-Fei, additional, Zhang, Jing-Jing, additional, Han, Gang-Bin, additional, Liu, Xiao-Chang, additional, Wang, Jun-Yi, additional, Zhou, Juan, additional, Zeng, De-Yang, additional, Liu, Jing, additional, Nie, Qian-Qian, additional, Song, Dan, additional, Yu, Ya-Fu, additional, Hu, Chen-Lu, additional, Fu, Yi-Di, additional, Li, Shi-Yue, additional, Cai, Cheng, additional, Cui, Yu-Yang, additional, Cai, Wan-Ying, additional, Li, Yi-Qing, additional, Fan, Ren-Jia, additional, Wan, Hong, additional, Xu, Lang, additional, Ou, Yang-Ming, additional, Chen, Xing-Xing, additional, Zhou, Yan-Ling, additional, Chen, Yu-Shan, additional, Li, Jin-Quan, additional, Wei, Zhen, additional, Wu, Qiong, additional, Mei, Yu-Fei, additional, Tan, Wei, additional, Song, Shao-Jun, additional, and Zeng, Yan, additional

Published
2024
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4. Prevalence and risk factors for subjective cognitive decline and the correlation with objective cognition among community‐dwelling older adults in China: Results from the Hubei memory and aging cohort study

Author

Cheng, Gui‐Rong, primary, Liu, Dan, additional, Huang, Lin‐Ya, additional, Han, Gang‐Bin, additional, Hu, Fei‐Fei, additional, Wu, Zhao‐Xia, additional, He, Xiao‐Ming, additional, Huang, Yu‐Wei, additional, Yu, Ya‐Fu, additional, Xu, Lang, additional, Li, Jin‐Quan, additional, Chen, Yu‐Shan, additional, Wei, Zhen, additional, Wu, Qiong, additional, Mei, Yu‐Fei, additional, Chen, Xing‐Xing, additional, Ou, Yang‐Ming, additional, Zhang, Jing‐Jing, additional, Yang, Meng‐Liu, additional, Lian, Peng‐Fei, additional, Tan, Wei, additional, Xie, Xin‐Yan, additional, and Zeng, Yan, additional

Published
2023
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6. Population-attributable fractions of risk factors for all-cause dementia in China rural and urban areas: a cross-sectional study

Author

Hu, Fei-fei, primary, Cheng, Gui-rong, additional, Liu, Dan, additional, Liu, Qian, additional, Gan, Xu-guang, additional, Li, Lin, additional, Wang, Xiao-dan, additional, Zhang, Bo, additional, An, Li-na, additional, Chen, Cong, additional, Zou, Ming-jun, additional, Xu, Lang, additional, Ou, Yang-ming, additional, Chen, Yu-shan, additional, Li, Jin-quan, additional, Wei, Zhen, additional, Wang, Yue-yi, additional, Wu, Qiong, additional, Chen, Xing-xing, additional, Yang, Xi-fei, additional, Wu, Qing-ming, additional, Feng, Lei, additional, Zhang, Jing-jing, additional, Xu, Heng, additional, Yu, Ya-fu, additional, Yang, Meng-liu, additional, Qian, Jin, additional, Lian, Peng-fei, additional, Fu, Li-yan, additional, Duan, Ting-ting, additional, Tian, Yuan, additional, Cheng, Xi, additional, Li, Xin-wen, additional, Yan, Pin-ting, additional, Huang, Guowei, additional, Dong, Hongxin, additional, Ji, Yong, additional, and Zeng, Yan, additional

Published
2021
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7. The Hubei Memory and Aging Cohort Study: Study Design, Baseline Characteristics, and Prevalence of Cognitive Impairments

Author

Li, Lin, primary, Cheng, Gui-Rong, additional, Liu, Dan, additional, Hu, Fei-Fei, additional, Gan, Xu-Guang, additional, Zhang, Bo, additional, An, Lina, additional, Chen, Cong, additional, Zou, Ming-Jun, additional, Xu, Lang, additional, Ou, Yang-Ming, additional, Chen, Yu-Shan, additional, Li, Jin-Quan, additional, Wei, Zhen, additional, Wu, Qiong, additional, Chen, Xing-Xing, additional, Guo, Man-Qing, additional, Wu, Qing-Ming, additional, Wang, Ru, additional, and Zeng, Yan, additional

Published
2021
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8. Urban–Rural Disparities in the Association Between Body Mass Index and Cognitive Impairment in Older Adults: A Cross–Sectional Study in Central China

Author

Zhang, Jing-Jing, primary, Li, Lin, additional, Liu, Dan, additional, Hu, Fei-Fei, additional, Cheng, Gui-Rong, additional, Xu, Lang, additional, Yan, Ping-Ting, additional, Tian, Yuan, additional, Hu, Heng, additional, Yu, Ya-Fu, additional, Gan, Xu-Guang, additional, An, Li-Na, additional, Zhang, Bo, additional, Qian, Jin, additional, Fu, Li-Yan, additional, Cheng, Xi, additional, Lian, Peng-Fei, additional, Zou, Ming-Jun, additional, Chen, Cong, additional, Wu, Qing-Ming, additional, and Zeng, Yan, additional

Published
2021
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9. Population-Attributable Fractions for Risk Factors of All-Cause Dementia in Rural and Urban China: A Cross-Sectional Study

Author

Hu, Fei-fei, primary, Cheng, Gui-rong, additional, Liu, Dan, additional, Liu, Qian, additional, Gan, Xu-guang, additional, Li, Lin, additional, Wang, Xiao-dan, additional, Zhang, Bo, additional, An, Li-na, additional, Chen, Chong, additional, Zou, Ming-jun, additional, Xu, Lang, additional, Ou, Yang-ming, additional, Chen, Yu-shan, additional, Li, Jin-quan, additional, Wei, Zhen, additional, Wang, Yue-yi, additional, Wu, Qiong, additional, Chen, Xing-xing, additional, Yang, Xifei, additional, Wu, Qing-ming, additional, Feng, Lei, additional, Zhang, Jing-jing, additional, Xu, Heng, additional, Yu, Ya-fu, additional, Yang, Meng-liu, additional, Qian, Jin, additional, Lian, Peng-fei, additional, Fu, Li-yan, additional, Duan, Ting-ting, additional, Tian, Yuan, additional, Cheng, Xi, additional, Li, Xin-wen, additional, Yan, Pin-ting, additional, Huang, Guowei, additional, Ji, Yong, additional, and Zeng, Yan, additional

Published
2021
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10. ICAM5 as a Novel Target for Treating Cognitive Impairment in Fragile X Syndrome

Author

Pei, Ya-ping, primary, Wang, Yue-yi, additional, Liu, Dan, additional, Lei, Hui-yang, additional, Yang, Zhi-hao, additional, Zhang, Zi-wei, additional, Han, Man, additional, Cheng, Ke, additional, Chen, Yu-shan, additional, Li, Jin-quan, additional, Cheng, Gui-rong, additional, Xu, Lang, additional, Wu, Qing-ming, additional, McClintock, Shawn M., additional, Yang, Ying, additional, Zhang, Yong, additional, and Zeng, Yan, additional

Published
2019
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11. The Hubei Memory and Aging Cohort Study: Study Design, Baseline Characteristics, and Prevalence of Cognitive Impairments.

Author

Li, Lin, Cheng, Gui-Rong, Liu, Dan, Hu, Fei-Fei, Gan, Xu-Guang, Zhang, Bo, An, Lina, Chen, Cong, Zou, Ming-Jun, Xu, Lang, Ou, Yang-Ming, Chen, Yu-Shan, Li, Jin-Quan, Wei, Zhen, Wu, Qiong, Chen, Xing-Xing, Guo, Man-Qing, Wu, Qing-Ming, Wang, Ru, and Zeng, Yan

Subjects
*COGNITION disorders, *AGE factors in memory, *MILD cognitive impairment, *EXPERIMENTAL design, *COHORT analysis, *RESEARCH, *RESEARCH methodology, *DISEASE incidence, *EVALUATION research, *NEUROPSYCHOLOGICAL tests, *COMPARATIVE studies, *DISEASE prevalence, *LOGISTIC regression analysis, *LONGITUDINAL method, *RURAL population
Abstract

Background: Despite the improved access to health services in China, inadequate diagnosis and management of dementia are common issues, especially in rural regions.Objective: The Hubei Memory & Aging Cohort Study was designed as a prospective study in Central China to determine the prevalence, incidence, and risk factors for dementia and mild cognitive impairment (MCI) among urban and rural older adults.Methods: From 2018-2020, participants aged ≥65 years were screened, and data regarding their life behaviors, families, socio-economic status, physical and mental health, social and psychological factors, and cognition were collected. Diagnoses of MCI and dementia were made via consensus diagnosis using the Diagnostic and Statistical Manual of Mental Disorders fourth edition criteria.Results: Of 8,221 individuals who completed their baseline clinical evaluation, 4,449 (54.1%) were women and 3,164 (38.4%) were from remote rural areas (average age: 71.96 years; mean education period: 7.58 years). At baseline, 25.98%(95%confidence interval [CI]: 24.99-26.96) and 7.24%(95%CI: 6.68-7.80) of the participants were diagnosed with MCI and dementia, respectively. Prevalence showed a strong relationship with age. The substantial disparities between rural and urban regions in MCI and dementia prevalence and multiple dementia-related risk factors were revealed. Especially for dementia, the prevalence rate in rural areas was 2.65 times higher than that in urban regions.Conclusion: Our results suggested that public health interventions are urgently needed to achieve equitable diagnosis and management for people living with dementia in the communities across urban and rural areas. [ABSTRACT FROM AUTHOR]

Published
2022
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13. ICAM5 as a Novel Target for Treating Cognitive Impairment in Fragile X Syndrome.

Author

Pei YP, Wang YY, Liu D, Lei HY, Yang ZH, Zhang ZW, Han M, Cheng K, Chen YS, Li JQ, Cheng GR, Xu L, Wu QM, McClintock SM, Yang Y, Zhang Y, and Zeng Y

Subjects
Animals, Cognitive Dysfunction genetics, Dendritic Spines pathology, Fragile X Mental Retardation Protein genetics, Fragile X Mental Retardation Protein metabolism, Fragile X Syndrome complications, Fragile X Syndrome genetics, Male, Mice, Mice, Knockout, Neurogenesis genetics, Cognitive Dysfunction metabolism, Dendritic Spines metabolism, Fragile X Syndrome metabolism, Gene Expression Regulation physiology, Membrane Glycoproteins metabolism, Nerve Tissue Proteins metabolism
Abstract

Fragile X syndrome (FXS) is the most common inherited form of intellectual disability, resulted from the silencing of the Fmr1 gene and the subsequent loss of fragile X mental retardation protein (FMRP). Spine dysgenesis and cognitive impairment have been extensively characterized in FXS; however, the underlying mechanism remains poorly understood. As an important regulator of spine maturation, intercellular adhesion molecule 5 (ICAM5) mRNA may be one of the targets of FMRP and involved in cognitive impairment in FXS. Here we show that in Fmr1 KO male mice, ICAM5 was excessively expressed during the late developmental stage, and its expression was negatively correlated with the expression of FMRP and positively related with the morphological abnormalities of dendritic spines. While in vitro reduction of ICAM5 normalized dendritic spine abnormalities in Fmr1 KO neurons, and in vivo knockdown of ICAM5 in the dentate gyrus rescued the impaired spatial and fear memory and anxiety-like behaviors in Fmr1 KO mice, through both granule cell and mossy cell with a relative rate of 1.32 ± 0.15. Furthermore, biochemical analyses showed direct binding of FMRP with ICAM5 mRNA, to the coding sequence of ICAM5 mRNA. Together, our study suggests that ICAM5 is one of the targets of FMRP and is implicated in the molecular pathogenesis of FXS. ICAM5 could be a therapeutic target for treating cognitive impairment in FXS. SIGNIFICANCE STATEMENT Fragile X syndrome (FXS) is characterized by dendritic spine dysgenesis and cognitive dysfunctions, while one of the FMRP latent targets, ICAM5, is well established for contributing both spine maturation and learning performance. In this study, we examined the potential link between ICAM5 mRNA and FMRP in FXS, and further investigated the molecular details and pathological consequences of ICAM5 overexpression. Our results indicate a critical role of ICAM5 in spine maturation and cognitive impairment in FXS and suggest that ICAM5 is a potential molecular target for the development of medication against FXS., (Copyright © 2020 Pei et al.)

Published
2020
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14. The implication of AMPA receptor in synaptic plasticity impairment and intellectual disability in fragile X syndrome.

Author

Cheng GR, Li XY, Xiang YD, Liu D, McClintock SM, and Zeng Y

Subjects
Animals, Fragile X Syndrome genetics, Humans, Intellectual Disability genetics, Mutation physiology, Protein Transport physiology, Receptors, AMPA genetics, Fragile X Syndrome metabolism, Intellectual Disability metabolism, Neuronal Plasticity physiology, Receptors, AMPA metabolism
Abstract

Fragile X syndrome (FXS) is the most frequently inherited form of intellectual disability and prevalent single-gene cause of autism. A priority of FXS research is to determine the molecular mechanisms underlying the cognitive and social functioning impairments in humans and the FXS mouse model. Glutamate ionotropic alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors (AMPARs) mediate a majority of fast excitatory neurotransmission in the central nervous system and are critically important for nearly all aspects of brain function, including neuronal development, synaptic plasticity, and learning and memory. Both preclinical and clinical studies have indicated that expression, trafficking, and functions of AMPARs are altered and result in altered synapse development and plasticity, cognitive impairment, and poor mental health in FXS. In this review, we discuss the contribution of AMPARs to disorders of FXS by highlighting recent research advances with a specific focus on change in AMPARs expression, trafficking, and dependent synaptic plasticity. Since changes in synaptic strength underlie the basis of learning, development, and disease, we suggest that the current knowledge base of AMPARs has reached a unique point to permit a comprehensive re-evaluation of their roles in FXS.

Published
2017
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