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20 results on '"Cheng, Jennifer J."'

2. Virtual stimulation of the interictal EEG network localizes the EZ as a measure of cortical excitability.

Author

Zhai, Sophia R., Sarma, Sridevi V., Gunnarsdottir, Kristin, Crone, Nathan E., Rouse, Adam G., Cheng, Jennifer J., Kinsman, Michael J., Landazuri, Patrick, Uysal, Utku, Ulloa, Carol M., Cameron, Nathaniel, Inati, Sara, Zaghloul, Kareem A., Boerwinkle, Varina L., Wyckoff, Sarah, Barot, Niravkumar, González-Martínez, Jorge A., Joon Y. Kang, and Smith, Rachel June

Subjects
EPILEPSY, ELECTRIC stimulation, ELECTROENCEPHALOGRAPHY, SEIZURES (Medicine), NEURAL stimulation
Abstract

Introduction: For patients with drug-resistant epilepsy, successful localization and surgical treatment of the epileptogenic zone (EZ) can bring seizure freedom. However, surgical success rates vary widely because there are currently no clinically validated biomarkers of the EZ. Highly epileptogenic regions often display increased levels of cortical excitability, which can be probed using single-pulse electrical stimulation (SPES), where brief pulses of electrical current are delivered to brain tissue. It has been shown that high-amplitude responses to SPES can localize EZ regions, indicating a decreased threshold of excitability. However, performing extensive SPES in the epilepsy monitoring unit (EMU) is time-consuming. Thus, we built patient-specific in silico dynamical network models from interictal intracranial EEG (iEEG) to test whether virtual stimulation could reveal information about the underlying network to identify highly excitable brain regions similar to physical stimulation of the brain. Methods: We performed virtual stimulation in 69 patients that were evaluated at five centers and assessed for clinical outcome 1 year post surgery. We further investigated differences in observed SPES iEEG responses of 14 patients stratified by surgical outcome. Results: Clinically-labeled EZ cortical regions exhibited higher excitability from virtual stimulation than non-EZ regions with most significant differences in successful patients and little difference in failure patients. These trends were also observed in responses to extensive SPES performed in the EMU. Finally, when excitability was used to predict whether a channel is in the EZ or not, the classifier achieved an accuracy of 91%. Discussion: This study demonstrates how excitability determined via virtual stimulation can capture valuable information about the EZ from interictal intracranial EEG. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Consistent linear and non-linear responses to invasive electrical brain stimulation across individuals and primate species with implanted electrodes

Author

Basu, Ishita, Robertson, Madeline M., Crocker, Britni, Peled, Noam, Farnes, Kara, Vallejo-Lopez, Deborah I., Deng, Helen, Thombs, Matthew, Martinez-Rubio, Clarissa, Cheng, Jennifer J., McDonald, Eric, Dougherty, Darin D., Eskandar, Emad N., Widge, Alik S., Paulk, Angelique C., and Cash, Sydney S.

Published
2019
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6. Source-sink connectivity: a novel interictal EEG marker for seizure localization

Author

Gunnarsdottir, Kristin M, primary, Li, Adam, additional, Smith, Rachel J, additional, Kang, Joon-Yi, additional, Korzeniewska, Anna, additional, Crone, Nathan E, additional, Rouse, Adam G, additional, Cheng, Jennifer J, additional, Kinsman, Michael J, additional, Landazuri, Patrick, additional, Uysal, Utku, additional, Ulloa, Carol M, additional, Cameron, Nathaniel, additional, Cajigas, Iahn, additional, Jagid, Jonathan, additional, Kanner, Andres, additional, Elarjani, Turki, additional, Bicchi, Manuel Melo, additional, Inati, Sara, additional, Zaghloul, Kareem A, additional, Boerwinkle, Varina L, additional, Wyckoff, Sarah, additional, Barot, Niravkumar, additional, Gonzalez-Martinez, Jorge, additional, and Sarma, Sridevi V, additional

Published
2022
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9. sEEG for expansion of a surgical epilepsy program: Safety and efficacy in 152 consecutive cases

Author

Miller, Christopher, primary, Schatmeyer, Bryan, additional, Landazuri, Patrick, additional, Uysal, Utku, additional, Nazzaro, Jules, additional, Kinsman, Michael J., additional, Camarata, Paul J., additional, Ulloa, Carol M., additional, Hammond, Nancy, additional, Pearson, Caleb, additional, Shah, Vishal, additional, and Cheng, Jennifer J., additional

Published
2021
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10. Source-sink connectivity: A novel interictal EEG marker for seizure localization

Author

Gunnarsdottir, Kristin M., primary, Li, Adam, additional, Smith, Rachel J., additional, Kang, Joon-Yi, additional, Korzeniewska, Anna, additional, Crone, Nathan E., additional, Rouse, Adam G., additional, Cheng, Jennifer J., additional, Kinsman, Michael J., additional, Landazuri, Patrick, additional, Uysal, Utku, additional, Ulloa, Carol M., additional, Cameron, Nathaniel, additional, Cajigas, Iahn, additional, Jagid, Jonathan, additional, Kanner, Andres, additional, Elarjani, Turki, additional, Bicchi, Manuel Melo, additional, Inati, Sara, additional, Zaghloul, Kareem A., additional, Boerwinkle, Varina L., additional, Wyckoff, Sarah, additional, Barot, Niravkumar, additional, Gonzalez-Martinez, Jorge, additional, and Sarma, Sridevi V., additional

Published
2021
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16. The detection of immortal DNA strand co-segregation as a method of adult stem cell identification

Author

James L. Sherley., Massachusetts Institute of Technology. Biological Engineering Division., Cheng, Jennifer J. (Jennifer Jay), 1979, James L. Sherley., Massachusetts Institute of Technology. Biological Engineering Division., and Cheng, Jennifer J. (Jennifer Jay), 1979

Abstract

Thesis (S.M.)--Massachusetts Institute of Technology, Biological Engineering Division, 2004., Includes bibliographical references (leaves 35-40)., The study of stem cells is one of the most fascinating topics in biology. Adult stem cells (ASC), which play the prime role in the maintenance and restoration of tissues, are thought to hold great potential for the advancement of medicine. It has been postulated that adult stem cells are able to retain "immortal" DNA template strands over successive generations by non-random chromosome co-segregation, and in so doing, to protect the long-term genomic fidelity of whole tissue compartments. The investigation of this theory may yield insights into areas such as the development of cancer and the process of aging. In addition, it may lead to the discovery of an effective method for the unique identification of adult stem cells, the study of which has thus far suffered from the lack of unique identifiers. Thus, the goal of this research was to develop an assay for the detection of immortal DNA strand co-segregation that could be applied to the detection and analysis of adult stem cells. It is proposed that such an assay may in itself serve as a unique identification method for adult stem cells. In this thesis, the development of such an assay is described. This assay, referred to as the label release assay, has provided further evidence for the existence of immortal strand co-segregation in model cell lines, and will potentially be useful in the study of adult stem cells in tissues., by Jennifer J. Cheng., S.M.

Published
2005

17. Percutaneous computed tomography fluoroscopy–guided conformal ultrasonic ablation of vertebral tumors in a rabbit tumor model

Author

Sciubba, Daniel M., primary, Burdette, E. Clif, additional, Cheng, Jennifer J., additional, Pennant, William A., additional, Noggle, Joseph C., additional, Petteys, Rory J., additional, Alix, Christopher, additional, Diederich, Chris J., additional, Fichtinger, Gabor, additional, Gokaslan, Ziya L., additional, and Murphy, Kieran P., additional

Published
2010
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