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42 results on '"Cheng, Ningbo"'

8. Incidence, mortality, and predictive factors associated with acute respiratory distress syndrome in multiple trauma patients living in high-altitude areas: a retrospective study in Shigatse.

Author

Tu, Dan, Ji, Lv, Cao, Qiang, Ley, Tin, Duo, Suolangpian, Cheng, Ningbo, Lin, Wenjing, Zhang, Jianlei, Yu, Weifeng, Pan, Zhiying, and Wang, Xiaoqiang

Subjects
ADULT respiratory distress syndrome, DISEASE risk factors, INTENSIVE care units, HOSPITAL mortality, LOGISTIC regression analysis
Abstract

Background: Acute respiratory distress syndrome (ARDS) is a severe complication that can lead to fatalities in multiple trauma patients. Nevertheless, the incidence rate and early prediction of ARDS among multiple trauma patients residing in high-altitude areas remain unknown. Methods: This study included a total of 168 multiple trauma patients who received treatment at Shigatse People's Hospital Intensive Care Unit (ICU) between January 1, 2019 and December 31, 2021. The clinical characteristics of the patients and the incidence rate of ARDS were assessed. Univariable and multivariable logistic regression models were employed to identify potential risk factors for ARDS, and the predictive effects of these risk factors were analyzed. Results: In the high-altitude area, the incidence of ARDS among multiple trauma patients was 37.5% (63/168), with a hospital mortality rate of 16.1% (27/168). Injury Severity Score (ISS) and thoracic injuries were identified as significant predictors for ARDS using the logistic regression model, with an area under the curve (AUC) of 0.75 and 0.75, respectively. Furthermore, a novel predictive risk score combining ISS and thoracic injuries demonstrated improved predictive ability, achieving an AUC of 0.82. Conclusions: This study presents the incidence of ARDS in multiple trauma patients residing in the Tibetan region, and identifies two critical predictive factors along with a risk score for early prediction of ARDS. These findings have the potential to enhance clinicians' ability to accurately assess the risk of ARDS and proactively prevent its onset. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Transparent Nanofibrous Membranes with Optimized Optical Channel Structure for Window Screens.

Author

Sun, Feifei, Lin, Yanyan, Li, Xueqin, Wang, Chao, Cheng, Ningbo, Meng, Na, Wang, Xianfeng, Yu, Jianyong, and Ding, Bin

Subjects
OPTICAL reflection, LIGHT transmission, LIGHT scattering, PRESSURE drop (Fluid dynamics), PERMEABILITY
Abstract

Nanofibrous membranes, characterized by their flexibility, high porosity, and tunable structure, are emerging as a promising contender for advanced transparent materials with sufficient breathability and pliability. However, the considerable surface light reflection and internal light scattering of nanofibrous membranes pose a challenging task in achieving transparency. In this study, transparent nanofibrous membranes are fabricated by constructing a topological structure with optimized optical transmission channels, which provide the minimum equivalent thickness to minimize light loss in nanofibrous membranes. The resultant fabricated membrane exhibits a high light transmittance of up to 81%, along with a sufficient porosity of 84% and flexibility. Additionally, the membrane demonstrated effective PM0.3–10 removal efficiency (>91%), low air pressure drops (<110 Pa), high air permeability (≈104 mm s−1), and good waterproof performance. Therefore, the prepared transparent nanofibrous membrane may serve as a transparent air filtration window screen to enhance indoor comfort for people. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Bioinspired electrospun fibrous materials for directional water transport.

Author

Miao, Dongyang, Cheng, Ningbo, Wang, Xianfeng, and Yu, Jianyong

Abstract

Directional water transport behavior of living creatures is an emerging class in natural biology. Biomimetic fibrous materials with wettability gradient have attracted increasing attention from scientists because of their potential applications in controllable water manipulation. The combination of surface chemistry and the hierarchically porous structure is crucial for the preparation of fibrous materials with wettability gradient. Among various manufacturing techniques, electrospinning has been proven to be a versatile method that can be used to design and prepare fibrous materials with specific chemical compositions and surface wettability. Here we first introduce the typical directional water transport behaviors and mechanisms of natural creatures with special wettability, including spider silk, cactus spine, desert beetle, and shorebird beak. Then, we systematically describe the state-of-the-art method for the preparation of electrospun fibrous materials with directional water transport behavior from the perspective of one-dimensional fibers, two-dimensional surfaces, and three-dimensional aggregates. Finally, the remaining challenges in the field of directional water transport are highlighted, and the future development trends are summarized. [ABSTRACT FROM AUTHOR]

Published
2023
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28. Anti-inflammatory labdane diterpenoids from Leonurus japonicus Houtt

Author

Su Zhenzhen, Cao Zeyu, Cao Liang, Cheng Ningbo, Biao Yang, Wei Xiao, Zhong Yan, Wen-Zhe Huang, Hu Yumei, and Zhenzhong Wang

Subjects
Magnetic Resonance Spectroscopy, Molecular Structure, biology, Stereochemistry, medicine.drug_class, Anti-Inflammatory Agents, Leonurus japonicus, Positive control, Plant Science, General Medicine, Horticulture, biology.organism_classification, Biochemistry, Anti-inflammatory, Labdane, chemistry.chemical_compound, Leonurus, chemistry, medicine, Ic50 values, lipids (amino acids, peptides, and proteins), Diterpenes, Molecular Biology, Two-dimensional nuclear magnetic resonance spectroscopy
Abstract

Seven undescribed labdane diterpenoids, japonicones A-G, were isolated from the aerial parts of Leonurus japonicus Houtt. Japonicones C-G contained two keto carbonyl groups in their structures attached to C-3 and C-7, which are rare for labdane diterpenoids. The structures and absolute configurations of japonicones A-G were established by means of spectroscopic analyses (HRESIMS, 1D and 2D NMR, and ECD). Their anti-inflammatory activities were evaluated by measuring their inhibitory effects on PGE2 production in LPS-stimulated RAW264.7 macrophages. Japonicones A-D and G showed inhibition of PGE2 production with IC50 values in the range of 8.62–30.71 μM (the positive control paracetamol showed an IC50 = 5.79 μM).

Published
2020

29. Two new labdane diterpenoids from aerial parts of Leonurus japonicus and their anti-inflammatory activity

Author

Li Mengxuan, Hu Yumei, Wen-Zhe Huang, Hua-Xu Zhu, Zhenzhong Wang, Wei Xiao, Wen-Jun Liu, Jiang Tao, Hai-Bo Li, and Cheng Ningbo

Subjects
Leojaponin, biology, Traditional medicine, 010405 organic chemistry, medicine.drug_class, Organic Chemistry, Leonurus japonicus, Plant Science, biology.organism_classification, 01 natural sciences, Biochemistry, Anti-inflammatory, 0104 chemical sciences, Analytical Chemistry, Dried herb, Labdane, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, chemistry, medicine, Lamiaceae
Abstract

Two new labdane diterpenoids, Leojaponin E (1) and F (2), together with three known compounds were isolated from the dried herb of Leonurus japonicus Houtt., Lamiaceae. Their structures were determined based on extensive spectroscopic analyses. The absolute configurations of 1 and 2 were elucidated on the basis of experimental and calculated electronic circular dichroism spectra. In addition, compounds 1 and 2 exerted inhibition of LPS-induced PGE2 production in a dose-dependent manner at concentrations ranging from 5 to 20 μM.

Published
2018
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30. Research on Chinese medicine pairs effects of Panax notoginseng and Bletilla striata before and after compatibility on contents of notoginsenosides

Author

Wen-Zhe Huang, Zhaoqing Meng, Fei Hongqiang, Wenjun Liu, Wang Yuesheng, Zhen-Zhong Wang, Cheng Ningbo, Wei Xiao, and Lin Sun

Subjects
0301 basic medicine, food.ingredient, Saponin, Panax notoginseng, Decoction, Traditional Chinese medicine, Plant Roots, 03 medical and health sciences, Ginseng, 0302 clinical medicine, food, Bletilla striata, Pharmacology (medical), General Pharmacology, Toxicology and Pharmaceutics, Orchidaceae, Chromatography, High Pressure Liquid, chemistry.chemical_classification, Plants, Medicinal, biology, Traditional medicine, Chemistry, Saponins, biology.organism_classification, 030104 developmental biology, Complementary and alternative medicine, 030220 oncology & carcinogenesis, Herb, Lipase inhibitors, Drugs, Chinese Herbal
Abstract

To discuss the synergistic mechanism of compatible use of two medicinal herbs,Panax notoginseng and Bletilla striata, an HPLC was established to determine two ginseng saponins (20S)-ginseng saponin Rg₃ and ginseng saponin Rh₄ contained in single decoction of Panax notoginseng as well as in compound decoction of Panax notoginseng and Bletillastriata in different compatibility ratio (1∶0.5, 1∶1, 1∶2), followed by analyzing the impact of amount of notoginsenosides after compatibility. As a result, compared with the single decoction of Panax notoginseng, the contents of ginseng saponin Rg₃ and ginseng saponin Rh₄ in the compound decoction of Panax notoginseng and Bletillastriata were on the rise as the increasement of the amount of Bletillastriata. The contents of the notoginsengsaponin R₁, ginseng saponin Rg₁ and ginseng saponin Rb₁ of Panax notoginseng single decoction were significantly decreased after compatibility. Therefore, after compatibility, it was more easy to produce (20S)-ginseng saponin Rg₃ and ginseng saponin Rh₄.This study can extend to a method of preparation of (20S)-ginseng saponin Rg₃ and ginseng saponin Rh₄. Furthermore, after compatibility, two ginseng saponins which had lipase inhibitory effect were both increased significantly, indicating that the compatibility of these two herb medicines may have effect on losing weight.

Published
2016

31. Relationship between molecular weight, monosaccharide composition and immunobiologic activity of Astragalus polysaccharides

Author

Gang Ding, Wen-Zhe Huang, Kai Gao, Wei Xiao, Wenjun Liu, Zhenzhong Wang, Cheng Ningbo, Na Li, Qi Xiaohui, and Yiping Jiang

Subjects
0301 basic medicine, Arabinose, Rhamnose, 02 engineering and technology, Lymphocyte proliferation, Polysaccharide, Biochemistry, Gel permeation chromatography, 03 medical and health sciences, chemistry.chemical_compound, Mice, Polysaccharides, Carbohydrate Conformation, Monosaccharide, Animals, Lymphocytes, Molecular Biology, Ethanol precipitation, Cell Proliferation, chemistry.chemical_classification, Mice, Inbred BALB C, Chromatography, Chemistry, Monosaccharides, Cell Biology, Astragalus Plant, 021001 nanoscience & nanotechnology, 030104 developmental biology, Galactose, Female, 0210 nano-technology
Abstract

Four Astragalus polysaccharides (APS1-APS4) were isolated from the water extract of Radix Astragali and purified through ethanol precipitation with 20 %, 40 %, 60 % and 80 % ethanol, respectively. The total sugar content was measured by sulfuric acid-phenol method. Their molecular weight was determined using high performance gel permeation chromatography (HPGPC) and their monosaccharide composition was analyzed by reversed-phase high performance liquid chromatography (HPLC) after pre-column derivatization. Then the immunobiologic activity of APS was evaluated by the experiment of spleen lymphocytes proliferation in vitro. The data suggested that precipitation by different concentration of ethanol will obtain different molecular weight APS, the higher concentration of ethanol the smaller molecular weight for APS. The molecular weights of four APS were 257.7 kDa, 40.1 kDa, 15.3 kDa and 3.2 kDa. Monosaccharide composition analysis indicated that APS1 consisted of glucose only, and APS2 all consisted of arabinose. APS3 consisted of rhamnose, glucose, galactose and arabinose and APS4 consisted of galactose and arabinose, in a molar ratio of 1:10.76:6.55:12 and 3.02:1. The result of immunobiologic activity assay showed that both APS2 and APS3 can effectively stimulate normal spleen lymphocyte proliferation in vitro. Apart from this, the effect of APS2 also showed dose dependent tendency from 6.25 μg/mL to 800 μg/mL. The result of this research indicated that Astragalus polysaccharides, which consist of arabinose and their molecular weight between 15.2 kDa to 40.1 kDa, neither too high nor too low, had significant immune activity.

Published
2016

37. Research on Route Optimization for Laser Beam Alignment at Target Area of an ICF Laser Facility

Author

魏晓峰 Wei Xiaofeng, 冯斌 Feng Bin, 贾怀庭 Jia Huaiting, 向勇 Xiang Yong, 程宁波 Cheng Ningbo, and 李富全 Li Fuquan

Subjects
Materials science, Optics, law, business.industry, Electrical and Electronic Engineering, Laser, business, Atomic and Molecular Physics, and Optics, Laser beams, Electronic, Optical and Magnetic Materials, law.invention
Published
2015

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