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Your search keyword '"Cheng, Zhong-Jian"' showing total 17 results
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17 results on '"Cheng, Zhong-Jian"'

2. Vascular dysfunction in type 2 diabetic TallyHo mice: role for an increase in the contribution of PG[H.sub.2]/Tx[A.sub.2] receptor activation and cytochrome p450 products (1)

Author

Cheng, Zhong Jian, Jiang, Yan-Fen, Ding, Hong, Severson, David, and Triggle, Chris R.

Subjects
Vascular endothelium -- Properties -- Health aspects -- Physiological aspects, Thromboxanes -- Physiological aspects -- Health aspects -- Complications and side effects, Prostaglandins -- Physiological aspects -- Health aspects -- Complications and side effects, Type 2 diabetes -- Complications and side effects -- Risk factors -- Development and progression, Blood circulation disorders -- Development and progression -- Risk factors -- Complications and side effects, Biological sciences, Complications and side effects, Physiological aspects, Development and progression, Risk factors, Properties, Health aspects
Abstract

Abstract: In this study, we tested the hypothesis that spontaneously diabetic TallyHo (TH) mice, a novel polygenic model for type 2 diabetes, will exhibit endothelial dysfunction associated with an increased [...]

Published
2007

10. Vascular dysfunction in type 2 diabetic TallyHo mice: role for an increase in the contribution of PGH2/TxA2 receptor activation and cytochrome p450 productsThis paper is one of a selection of papers published in this Special Issue, entitled The Cellular and Molecular Basis of Cardiovascular Dysfunction, Dhalla 70th Birthday Tribute.

Author

Cheng, Zhong Jian, primary, Jiang, Yan-Fen, additional, Ding, Hong, additional, Severson, David, additional, and Triggle, Chris R., additional

Published
2007
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14. Entacapone protects from angiotensin II-induced inflammation and renal injury

Author

Helkamaa, Teemu, primary, Finckenberg, Piet, additional, Louhelainen, Marjut, additional, Merasto, Saara, additional, Rauhala, Pekka, additional, Lapatto, Risto, additional, Cheng, Zhong Jian, additional, Reenil??, Ilkka, additional, M??nnist??, Pekka, additional, M??ller, Dominik N, additional, Luft, Friedrich C, additional, and Mervaala, Eero MA, additional

Published
2003
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15. Endothelial Dysfunction and Xanthine Oxidoreductase Activity in Rats With Human Renin and Angiotensinogen Genes

Author

Mervaala, Eero M. A., primary, Cheng, Zhong Jian, additional, Tikkanen, Ilkka, additional, Lapatto, Risto, additional, Nurminen, Kaisa, additional, Vapaatalo, Heikki, additional, Müller, Dominik N., additional, Fiebeler, Anette, additional, Ganten, Ursula, additional, Ganten, Detlev, additional, and Luft, Friedrich C., additional

Published
2001
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17. Angiotensin II and vascular inflammation.

Author

Cheng ZJ, Vapaatalo H, and Mervaala E

Subjects
Animals, Capillary Permeability, Cyclooxygenase 2, Endothelin-1 physiology, Humans, Membrane Proteins, Nitric Oxide physiology, Prostaglandin-Endoperoxide Synthases metabolism, Signal Transduction, Angiotensin II physiology, Blood Vessels physiopathology, Inflammation physiopathology
Abstract

Vascular inflammation is involved in the initiation and progression of atherosclerosis, and is also present in hypertension- and diabetes-induced vascular complications. Angiotensin II (Ang II), the key effector of the renin-angiotensin system (RAS), plays a central role in the regulation of blood pressure and electrolyte homeostasis. There is accumulating evidence to indicate that Ang II is also capable of inducing inflammatory response in the vascular wall. This review summarizes the current understanding of the molecular mechanisms and signal transduction pathways of Ang II-induced vascular inflammation. The roles of modulators of Ang II-induced inflammatory response, such as nitric oxide (NO), bradykinin, cyclooxygenase-2 (COX-2), endothelin-1 (ET-1), and epoxyeicosatrienoic acids (EETs), are also discussed. The current data suggest that Ang II modifies several steps of inflammatory response, such as increase of vascular permeability, leukocyte infiltration, tissue hypertrophy/proliferation, and fibrosis. Ang II, via the type 1 (AT1) receptors, enhances the production of reactive oxygen species (ROS) through stimulation of NAD(P)H oxidase in the vascular wall. Increased oxidative stress contributes to endothelial dysfunction and to vascular inflammation by stimulating the redox-sensitive transcription factors (NF-kappaB) and by upregulating adhesion molecules, cytokines, and chemokines. The pro-inflammatory action of Ang II may help us to understand the molecular mechanisms of hypertension- and diabetes-induced vascular complication as well as the pleiotropic actions of drugs interfering with RAS.

Published
2005

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