Search

Abstract The role of mast cells (MCs) in ulcerative colitis (UC) development is controversial. FcεRI, the IgE high-affinity receptor, is known to activate MCs. However, its role in UC remains unclear. In our study, Anti-FcεRI showed highly diagnostic value for UC. FcεRIα knockout in mice ameliorated DSS-induced colitis in a gut microbiota-dependent manner. Increased Lactobacillus abundance in FcεRIα deficient mice showed strongly correlation with the remission of colitis. RNA sequencing indicated activation of the NLRP6 inflammasome pathway in FcεRIα knockout mice. Additionally, Lactobacillus plantarum supplementation protected against inflammatory injury and goblet cell loss, with activation of the NLRP6 inflammasome during colitis. Notably, this effect was absent when the strain is unable to produce lactic acid. In summary, colitis was mitigated in FcεRIα deficient mice, which may be attributed to the increased abundance of Lactobacillus. These findings contribute to a better understanding of the relationship between allergic reactions, microbiota, and colitis.

Background: The triglyceride-glucose (TyG) index has been recommended as a practical surrogate of insulin resistance (IR). However, the association between the TyG index and hyperuricemia among adults with hypertension remains to be elucidated. Methods: We included and analyzed 3134 HTN patients and 4233 non-HTN participants from the cross-sectional 2013–2018 U.S. National Health and Nutrition Examination Surveys (NHANES). Multivariable logistic regression and restricted cubic splines (RCS) were used to explore the association between the TyG index and hyperuricemia. Stratifed analyses were performed to assess the association in populations with different subgroups of hypertension. Results: The prevalence of hyperuricemia was higher in HTN patients (28.00 %) than in non-HTN participants (12.47 %). The multivariable logistic regression showed that the TyG index was significantly associated with hyperuricemia. After multivariable adjustment, higher TyG index levels were found to be associated with a higher prevalence of hyperuricemia in HTN patients (OR: 2.39, 95 % CI: 1.37–4.17, Ptrend 0.05). In the subgroup analysis suggested that the positive association seemed to be strong among male, alcohol use, and diabetes group (P for interaction

Workload (WL) measurement is a crucial foundation for human–machine collaboration, particularly in high-stress multitasking environments such as manned vehicle operations during emergencies, where operators often experience High Workload (HWL) levels, increasing the risk of human error. To address this challenge, this study introduces a novel WL measurement method that combines Task Demand Load (TDL) and Subject Load Capacity (SLC) to quantitatively assess operator workload. This method was validated through experiments with 45 subjects using the Environmental Control and Atmospheric Regeneration (ECAR) system. The statistical results showed that as the designed WL levels increased, the Average Workload (AWL), the NASA-TLX score, and the work time percentage increased significantly, while the task accuracy and the fixation duration decreased significantly. These results also revealed the impact of WL levels on human responses (such as subjective feeling, work performance, and eye movement). In addition, very strong correlations were found between AWL measurements and NASA-TLX scores (r = 0.75, p < 0.01), task accuracy (r = −0.73, p < 0.01), and work time percentage (r = 0.97, p < 0.01). Overall, these results proved the effectiveness of the proposed method for measuring WL. On this basis, this study defined WL thresholds by integrating task accuracy with AWL calculations, providing a framework for the dynamic management of task allocation between humans and machines to maintain operators within optimal WL ranges.

Individuals exposed to elevated noise levels experience heightened emotional intensity, leading to increased cognitive disruption and a higher likelihood of accidents. This study seeks to investigate the impact of noise exposure on human cognitive performance, and the moderating role of emotion. Twelve healthy male college-age students underwent exposure to three noise conditions, each characterized by different sound pressure levels and sharpness. Each condition included an initial acoustic/thermal adaption period lasting approximately 40 min, followed by intermittent questionnaire tests and a battery of computerized cognitive tests. Statistical analysis revealed that reducing noise levels proved advantageous, enhancing perceived sound quality, positive emotions, and auditory perception abilities, while concurrently reducing false alerts and accelerating execution speed. Many of these effects were found to be counteracted by elevated sharpness. Correlation analyses and partial least squares structural equation modeling (PLS-SEM) results suggested that human emotions mediate the relationship between noise exposure and cognitive performance. The potential underlying mechanism suggests that negative feelings towards noise contribute to poor emotional states, subsequently influencing cognitive processes and impairing executive function. The outcomes of this study provide valuable insights into the mechanism of noise exposure and its effects on human cognition and subjective perceptions.

Twelve healthy male college-age students were recruited to investigate the effects of different noise exposure conditions on complex task performance and vigilance. During each noise exposure, the Multi-Attribute Task Battery (MATB) with low, medium, and high mental workloads were conducted in the order designated by the Latin square method. Meanwhile, a psychomotor vigilance test (PVT) was used to evaluate human vigilance. Heart rate variability (HRV) signals were also collected while participants performed the tasks. The generalized additive mixed-effect model (GAMM) results showed that the increased mental workload had an inverted U-shaped effect on MATB task performance. Noise exposure had no significant impact on the overall performance of MATB tasks. However, when exposed to increased noise sharpness at low mental workloads, Tracking Task (TRA) performance significantly decreased, whereas the System Monitoring Task (SYS) performance was significantly improved. In addition, higher noise sound pressure level and sharpness would impair human vigilance, which was reflected in a lower mean sample entropy of HRV and worse performance on the PVT. The results indicated that noise control in the workplace should consider both sound pressure level and sharpness.

Both the Wenchuan earthquake on May 12, 2008, and the Lushan earthquake on April 12, 2013, produced many coseismic landslides along the Nanya River in Shimian City. Subsequent debris flows that initiated from these landslides and are triggered by intense rainfall become the secondary hazard in the years after the earthquake; in particular, some debris flows led to a serious river blocking event. For example, the Guangyuanbao debris flow which occurred on July 04, 2013, partly blocked the Nanya River, presenting a major threat to the national highway and residential areas. To analyze the pattern of landslide damming, we analyzed numerical simulations of the movement characteristics of the Guangyuanbao debris flow using rainfall intensities with varying recurrence periods of 5, 20, and 50 years. The accuracy of the spreading of the numerical simulation is about 90%. The simulation indicated a small volume of sediment entering the river for a rainfall under 5-year return period. A debris flow induced by rainfall under 20-year return period partly blocked the river, while rainfall under 50-year return period has potential to block the river completely. This proposed analysis of river blocking induced by a debris flow could be used for disaster prevention in earthquake-stricken area.