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8. TNF-block genotypes influence susceptibility to HIV-associated sensory neuropathy in Indonesians and South Africans

Author

Gaff, Jessica, Octaviana, Fitri, Pillay, Prinisha, Mbenda, Huguette Gaelle Ngassa, Ariyanto, Ibnu A., Gan, June Ann, Cherry, Catherine L., Kamerman, Peter, Laws, Simon M., Price, Patricia, Gaff, Jessica, Octaviana, Fitri, Pillay, Prinisha, Mbenda, Huguette Gaelle Ngassa, Ariyanto, Ibnu A., Gan, June Ann, Cherry, Catherine L., Kamerman, Peter, Laws, Simon M., and Price, Patricia

Abstract

HIV-associated sensory neuropathy (HIV-SN) is a disabling complication of HIV disease and antiretroviral therapies (ART). Since stavudine was removed from recommended treatment schedules, the prevalence of HIV-SN has declined and associated risk factors have changed. With stavudine, rs1799964*C (TNF-1031) associated with HIV-SN in Caucasians and Indonesians but not in South Africans. Here, we investigate associations between HIV-SN and rs1799964*C and 12 other polymorphisms spanning TNF and seven neighboring genes (the TNF-block) in Indonesians (n = 202; 34/168 cases) and South Africans (n = 75; 29/75 cases) treated without stavudine. Haplotypes were derived using fastPHASE and haplotype networks built with PopART. There were no associations with rs1799964*C in either population. However, rs9281523*C in intron 10 of BAT1 (alternatively DDX39B) independently associated with HIV-SN in Indonesians after correcting for lower CD4 T-cell counts and >500 copies of HIV RNA/mL (model p = 0.0011, Pseudo R2 = 0.09). rs4947324*T (between NFKBIL1 and LTA) independently associated with reduced risk of HIV-SN and shared haplotype 1 (containing no minor alleles) associated with increased risk of HIV-SN after correcting for greater body weight, a history of tuberculosis and nadir CD4 T-cell counts (model: p = 0.0003, Pseudo R2 = 0.22). These results confirm TNF-block genotypes influence susceptibility of HIV-SN. However, critical genotypes differ between ethnicities and with stavudine use.

Published
2020

9. Tissue-specific associations between mitochondrial DNA levels and current treatment status in HIV-infected individuals

Author

Cherry, Catherine L., James Ian R., Nolan, David, McKinnon, Elizabeth J., Mallal, Simon A., Gahan, Michelle E., Lal, Luxshimi, McArthur, Justin C., and Wesselingh, Steven L.

Subjects
Mitochondrial DNA -- Research, Tissue specific antigens -- Research, HIV infection -- Care and treatment, Health
Abstract

The mitochondrial DNA (mtDNA) levels in matched samples of peripheral blood mononuclear cells (PBMCs) and subcutaneous fat from a large Australian cohort were studied to examine treatment, clinical, and demographic association with mtDNA depletion. The results confirm a tissue- and drug-specific association between nucleoside reverse transcriptase inhibitor (NRTI) exposure and mtDNA levels and there was no effect of the duration of therapy, suggesting that mtDNA depletion occurs rapidly when NRTIs are commenced.

Published
2006

10. Adverse effects of antiretroviral drugs on HIV-1-infected and -uninfected human monocyte-derived macrophages

Author

Azzam, Rula, Lal, Luxshimi, Suet-Ling Goh, Kedzierska, Katherine, Jaworowski, Anthony, Wesselingh, Steven L., Naim, Eman, Mills, John, Crowe, Suzanne M., and Cherry, Catherine L.

Subjects
Antiviral agents -- Complications and side effects, Reverse transcriptase inhibitors -- Complications and side effects, HIV infection -- Drug therapy, Health
Abstract

A study was conducted to investigate the effects of nucleoside reverse transcriptase inhibitors (NRTIs) on the viability and function of HIV-1-infected and -uninfected human monocyte-derived macrophages (MDMs) associated with reduced phagocytic capacity of macrophages, a crucial function in host surveillance and immunity. Results have important implications for use of these antiretroviral drugs in immunocomprised individuals.

Published
2006

11. Increased adipocyte apoptosis in lipoatrophy improves within 48 weeks of switching patient therapy from stavudine to abacavir or zidovudine

Author

Cherry, Catherine L., Lal, Luxshimi, Thompson, Katherine A., McComsey, Grace, McLean, Catriona A., Wesselingh, Steven L., Ross, Lisa L., and Hernandez, Jaime

Subjects
Lipodystrophy -- Drug therapy, Apoptosis -- Research, Nucleoside analogs -- Research, Health
Abstract

The degree and reversibility of adipocyte apoptosis in patients with lipoatrophy before and 48 weeks after substituting abacavir or zidovudine for stavudine is assessed. It is concluded that increased apoptosis is present in fat samples from patients with lipoatrophy treated with stavudine.

Published
2005

13. Exposure to dideoxynucleosides is reflected in lowered mitochondrial DNA in subcutaneous fat

Author

Cherry, Catherine L., Gahan, Michelle E., McArthur, Justin C., Lewin, Sharon R., Hoy, Jennifer F., and Wesselingh, Steven L.

Subjects
Epidemiology -- Statistics, Epidemiology -- Research, HIV patients -- Health aspects, HIV patients -- Care and treatment, HIV infection -- Prevention, HIV infection -- Research, HIV infection -- Health aspects, Mitochondrial DNA -- Genetic aspects, Adipose tissues -- Genetic aspects, Adipose tissues -- Physiological aspects, Health
Abstract

Research has been conducted on dideoxynucleoside analogues used in HIV treatment. The correlation of the tissue mitochondrial DNA quantification in HIV-infected patients with the exposure to nucleoside analog has been studied and the results are reported.

Published
2002

29. Producing an evidence‐based treatment information website in partnership with people affected by multiple sclerosis

Author

Osborne, Richard, Synnot, Anneliese J., Hawkins, Melanie, Merner, Bronwen A., Summers, Michael P., Filippini, Graziella, Shapland, Sue D.P., Cherry, Catherine L., Stuckey, Rwth, Milne, Catherine A., Mosconi, Paola, Colombo, Cinzia, Hill, Sophie J., Osborne, Richard, Synnot, Anneliese J., Hawkins, Melanie, Merner, Bronwen A., Summers, Michael P., Filippini, Graziella, Shapland, Sue D.P., Cherry, Catherine L., Stuckey, Rwth, Milne, Catherine A., Mosconi, Paola, Colombo, Cinzia, and Hill, Sophie J.

Published
2018

32. Polymorphism rs1385129 Within Glut1 Gene SLC2A1 Is Linked to Poor CD4+ T Cell Recovery in Antiretroviral-Treated HIV+ Individuals

Author

Masson, Jesse J. R., primary, Cherry, Catherine L., additional, Murphy, Nicholas M., additional, Sada-Ovalle, Isabel, additional, Hussain, Tabinda, additional, Palchaudhuri, Riya, additional, Martinson, Jeffrey, additional, Landay, Alan L., additional, Billah, Baki, additional, Crowe, Suzanne M., additional, and Palmer, Clovis S., additional

Published
2018
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33. Producing an evidence-based treatment information website in partnership with people affected by multiple sclerosis

Author

Synnot, Anneliese J., primary, Hawkins, Melanie, additional, Merner, Bronwen A., additional, Summers, Michael P., additional, Filippini, Graziella, additional, Osborne, Richard H., additional, Shapland, Sue D.P., additional, Cherry, Catherine L., additional, Stuckey, Rwth, additional, Milne, Catherine A., additional, Mosconi, Paola, additional, Colombo, Cinzia, additional, and Hill, Sophie J., additional

Published
2018
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35. A Longitudinal Study of the Effects of ART on Plasma Chemokine Levels in Malaysian HIV Patients

Author

Chew, Constance S. N., Cherry, Catherine L., Kamarulzaman, Adeeba, Yien, Tan Hong, Aghafar, Zayd, and Price, Patricia

Subjects
Genotype, Immune Reconstitution Disease, Anti-HIV Agents, Clinical Biochemistry, HIV Infections, nucleoside analogue reverse transcriptase inhibitor sensory neuropathy, Polymorphism, Single Nucleotide, Statistics, Nonparametric, Interferon-gamma, Polyneuropathies, Gene Frequency, Immune Reconstitution Inflammatory Syndrome, parasitic diseases, Genetics, HIV sensory neuropathy, Humans, Longitudinal Studies, Chemokine CCL5, Molecular Biology, Chemokine CCL2, lcsh:R5-920, CCL5, CXCL10, Biochemistry (medical), Malaysia, General Medicine, Chemokine CXCL10, Case-Control Studies, Other, lcsh:Medicine (General), Biomarkers
Abstract

Objectives: Chemokines influence the migration of leukocytes to secondary lymphoid tissue and sites of inflammation. In HIV patients, they are implicated in inflammatory complications of antiretroviral therapy (ART), notably Immune Reconstitution Disease (IRD) and Sensory Neuropathy (SN). However most chemokines have not been monitored as patients begin ART or correlated with IRD and SN.Methods: Plasma chemokine levels were assessed longitudinally using commercial ELISAs in 69 patients treated in Kuala Lumpur, Malaysia. Plasma was available at baseline and after 6, 12, 24 and 48 weeks on ART. Chemokine genotypes were assessed using allele-specific fluorescent probes. IRD were diagnosed in 15 patients. 30 patients were screened for SN using the ACTG BPNS tool after six months on ART. SN was detected in 8 patients.Results: Plasma CXCL10 levels decreased on ART compared to baseline (p= 0.002–0.0001), but remain higher than healthy controls (p≤ 0.0001). The decline was clearer in patients without IRD. CCL5 levels rose on ART but remained similar to controls. CCL2 levels were higher in patients than controls after week 12. Plasma chemokine levels were not affected by CD4+ T-cell counts or any genotypes tested. Several patients with SN displayed higher CCL5 levels throughout therapy compared to patients without neuropathy. Levels of other chemokines and chemokine genotypes were not associated with SN.Conclusions: Chemokines are differentially affected by ART. CXCL10 and CCL5 may influence IRD and CCL5 warrants further investigation for an effect in SN. These trends are not influenced by chemokine genotypes investigated here.

Published
2011

45. First Molecular Epidemiology Study of Mycobacterium tuberculosis in Kiribati

Author

Aleksic, Eman, primary, Merker, Matthias, additional, Cox, Helen, additional, Reiher, Bereka, additional, Sekawi, Zamberi, additional, Hearps, Anna C., additional, Ryan, Claire E., additional, Lee, Adele V., additional, Goursaud, Regis, additional, Malau, Clement, additional, O'Connor, Janet, additional, Cherry, Catherine L., additional, Niemann, Stefan, additional, and Crowe, Suzanne M., additional

Published
2013
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