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7 results on '"Chetty, Palaniappan S."'

6. Role of helices and loops in the ability of apolipophorin-III to interact with native lipoproteins and from discoidal lipoprotein complexes

Author

Chetty, Palaniappan S., Arrese, Estela L., Rodriguez, Veronica, and Soulagues, Jose L.

Subjects
Biochemistry -- Research, Phospholipids -- Research, Proteolipids -- Research, Lipoproteins -- Research, Biological sciences, Chemistry
Abstract

The role of the conformational flexibility of helixes and loops on the lipid binding activity of apolipoprotein was investigated by di sulphide mediated tethering experiments. The ability of the disulfide mutants to interact with phospholipid vesicles, mixed micelles of phosphatidylcholine and cholate, and in vivo with native spherical lipoprotein particles was investigated.

Published
2003

7. In vivo lipoprotein binding assay of the insect exchangeable apolipoprotein, apolipophorin-III.

Author

Chetty PS, Arrese EL, and Soulages JL

Subjects
Animals, Apolipoproteins blood, Apolipoproteins chemistry, Binding Sites, Blotting, Western, Electrophoresis, Polyacrylamide Gel, Lipoproteins blood, Lipoproteins chemistry, Lipoproteins, HDL blood, Lipoproteins, HDL chemistry, Lipoproteins, HDL metabolism, Lipoproteins, LDL blood, Lipoproteins, LDL chemistry, Lipoproteins, LDL metabolism, Ultracentrifugation, Apolipoproteins metabolism, Grasshoppers, Lipoproteins metabolism, Manduca
Abstract

An original method for the study of the lipid binding properties of exchangeable apolipoproteins is reported. Binding of Locusta migratoria apolipophorin-III to Manduca sexta low-density lipophorin (LDLp) and high-density lipophorin (HDLp) was studied in vivo. This assay could be used useful to investigate the effect of mutations in the lipid binding properties of exchangeable apolipoproteins under physiological conditions.

Published
2003
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