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173 results on '"Chiang, Shang-Lun"'

4. Supplementary Figures 1-2, Tables 1-2 from Up-regulation of Inflammatory Signalings by Areca Nut Extract and Role of Cyclooxygenase-2 −1195G>A Polymorphism Reveal Risk of Oral Cancer

Author

Chiang, Shang-Lun, primary, Chen, Ping-Ho, primary, Lee, Chien-Hung, primary, Ko, Albert Min-Shan, primary, Lee, Ka-Wo, primary, Lin, Ying-Chu, primary, Ho, Pei-Shan, primary, Tu, Hung-Pin, primary, Wu, Deng-Chyang, primary, Shieh, Tien-Yu, primary, and Ko, Ying-Chin, primary

Published
2023
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5. Supplementary Tables 1 - 3 from miRNA-491-5p and GIT1 Serve as Modulators and Biomarkers for Oral Squamous Cell Carcinoma Invasion and Metastasis

Author

Huang, Wei-Chieh, primary, Chan, Shih-Hsuan, primary, Jang, Te-Hsuan, primary, Chang, Jer-Wei, primary, Ko, Ying-Chin, primary, Yen, Tzu-Chen, primary, Chiang, Shang-Lun, primary, Chiang, Wei-Fan, primary, Shieh, Tien-Yu, primary, Liao, Chun-Ta, primary, Juang, Jyh-Lyh, primary, Wang, Hsueh-Chun, primary, Cheng, Ann-Joy, primary, Lu, Ya-Ching, primary, and Wang, Lu-Hai, primary

Published
2023
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6. Data from miRNA-491-5p and GIT1 Serve as Modulators and Biomarkers for Oral Squamous Cell Carcinoma Invasion and Metastasis

Author

Huang, Wei-Chieh, primary, Chan, Shih-Hsuan, primary, Jang, Te-Hsuan, primary, Chang, Jer-Wei, primary, Ko, Ying-Chin, primary, Yen, Tzu-Chen, primary, Chiang, Shang-Lun, primary, Chiang, Wei-Fan, primary, Shieh, Tien-Yu, primary, Liao, Chun-Ta, primary, Juang, Jyh-Lyh, primary, Wang, Hsueh-Chun, primary, Cheng, Ann-Joy, primary, Lu, Ya-Ching, primary, and Wang, Lu-Hai, primary

Published
2023
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7. Supplementary Figure Legend from miRNA-491-5p and GIT1 Serve as Modulators and Biomarkers for Oral Squamous Cell Carcinoma Invasion and Metastasis

Author

Huang, Wei-Chieh, primary, Chan, Shih-Hsuan, primary, Jang, Te-Hsuan, primary, Chang, Jer-Wei, primary, Ko, Ying-Chin, primary, Yen, Tzu-Chen, primary, Chiang, Shang-Lun, primary, Chiang, Wei-Fan, primary, Shieh, Tien-Yu, primary, Liao, Chun-Ta, primary, Juang, Jyh-Lyh, primary, Wang, Hsueh-Chun, primary, Cheng, Ann-Joy, primary, Lu, Ya-Ching, primary, and Wang, Lu-Hai, primary

Published
2023
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8. Supplementary Methods from miRNA-491-5p and GIT1 Serve as Modulators and Biomarkers for Oral Squamous Cell Carcinoma Invasion and Metastasis

Author

Huang, Wei-Chieh, primary, Chan, Shih-Hsuan, primary, Jang, Te-Hsuan, primary, Chang, Jer-Wei, primary, Ko, Ying-Chin, primary, Yen, Tzu-Chen, primary, Chiang, Shang-Lun, primary, Chiang, Wei-Fan, primary, Shieh, Tien-Yu, primary, Liao, Chun-Ta, primary, Juang, Jyh-Lyh, primary, Wang, Hsueh-Chun, primary, Cheng, Ann-Joy, primary, Lu, Ya-Ching, primary, and Wang, Lu-Hai, primary

Published
2023
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9. Supplementary Figures 1 - 11 from miRNA-491-5p and GIT1 Serve as Modulators and Biomarkers for Oral Squamous Cell Carcinoma Invasion and Metastasis

Author

Huang, Wei-Chieh, primary, Chan, Shih-Hsuan, primary, Jang, Te-Hsuan, primary, Chang, Jer-Wei, primary, Ko, Ying-Chin, primary, Yen, Tzu-Chen, primary, Chiang, Shang-Lun, primary, Chiang, Wei-Fan, primary, Shieh, Tien-Yu, primary, Liao, Chun-Ta, primary, Juang, Jyh-Lyh, primary, Wang, Hsueh-Chun, primary, Cheng, Ann-Joy, primary, Lu, Ya-Ching, primary, and Wang, Lu-Hai, primary

Published
2023
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36. Prognostic factors associated with the survival of oral and pharyngeal carcinoma in Taiwan

Author

Lin Ying-Chu, Yang Yi-Hsin, Tsai Chi-Cheng, Ho Pei-Shan, Shieh Tien-Yu, Chen Ping-Ho, Ko Min-Shan, Tsai Pei-Chien, Chiang Shang-Lun, Tu Hung-Pin, and Ko Ying-Chin

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background In Taiwan, a distinct ethnic group variation in incidence and mortality rates has been suggested for most carcinomas. Our aim is to identify the role of prognostic factors associated with the survival of oral and pharyngeal carcinoma in Taiwan. Methods Taiwan Cancer Registry records of 9039 subjects diagnosed with oral and pharyngeal carcinoma were analyzed. The population was divided into three ethnic groups by residence, which were Taiwanese aborigines, Hakka and Hokkien communities. Five-year survival rates were estimated by Kaplan-Meier methods. Ethnic curves differed significantly by log-rank test; therefore separate models for Taiwanese aborigines, Hakka and Hokkien were carried out. The Cox multivariate proportional hazards model was used to examine the role of prognostic factors on ethnic survival. Results The five-year survival rates of oral and pharyngeal carcinoma were significantly poorer for Hokkien community (53.9%) and Taiwanese aborigines community (58.1%) compared with Hakka community (60.5%). The adjusted hazard ratio of Taiwanese aborigines versus Hakka was 1.07 (95%CI, 0.86–1.33) for oral and pharyngeal carcinoma mortality, and 1.16 (95%CI, 1.01–1.33) for Hokkien versus Hakka. Males had significantly poor prognosis than females. Subjects with tongue and/or mouth carcinoma presented the worst prognosis, whereas lip carcinoma had the best prognosis. Subjects with verrucous carcinoma had better survival than squamous cell carcinoma. Prognosis was the worst in elderly subjects, and subjects who underwent surgery had the highest survival rate. Conclusion Our study presented that predictive variables in oral and pharyngeal carcinoma survival have been: ethnic groups, period of diagnosis, gender, diagnostic age, anatomic site, morphologic type, and therapy.

Published
2007
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37. Corrigendum: ALPK1 phosphorylates myosin IIA modulating TNF-α trafficking in gout flares

Author

Lee, Chi-Pin, Chiang, Shang-Lun, Ko, Albert Min-Shan, Liu, Yu-Fan, Ma, Che, Lu, Chi-Yu, Huang, Chung-Ming, Chang, Jan-Gowth, Kuo, Tzer-Min, Chen, Chia-Lin, Tsai, Eing-Mei, and Ko, Ying-Chin

Subjects
Gout, Tumor Necrosis Factor-alpha, Nonmuscle Myosin Type IIA, Genetic Vectors, Down-Regulation, Corrigenda, Models, Biological, Monocytes, Protein Structure, Secondary, Cell Line, Uric Acid, HEK293 Cells, Protein Domains, Gene Knockdown Techniques, Cytokines, Humans, Amino Acid Sequence, Phosphorylation, Colchicine, Protein Kinases, Protein Binding
Abstract

Gout is characterized by the monosodium urate monohydrate (MSU)-induced arthritis. Alpha kinase-1 (ALPK1) has shown to be associated with MSU-induced inflammation and gout. Here, we used bioinformatics, proteomics, cell models, and twenty in vitro human assays to clarify some of its role in the inflammatory response to MSU. We found myosin IIA to be a frequent interacting protein partner of ALPK1, binding to its N-terminal and forming a protein complex with calmodulin and F-actin, and that MSU-induced ALPK1 phosphorylated the myosin IIA. A knockdown of endogenous ALPK1 or myosin IIA significantly reduced the MSU-induced secretion of tumour necrosis factor (TNF)-α. Furthermore, all gouty patients expressed higher basal protein levels of ALPK1, myosin IIA, and plasma TNF-α, however those medicated with colchicine has shown reduced myosin IIA and TNF-α but not ALPK1. The findings suggest ALPK1 is a kinase that participates in the regulation of Golgi-derived TNF-α trafficking through myosin IIA phosphorylation in the inflammation of gout. This novel pathway could be blocked at the level of myosin by colchicine in gout treatment.

Published
2016

38. Preventive effect of celecoxib use against cancer progression and occurrence of oral squamous cell carcinoma

Author

Chiang, Shang-Lun, primary, Velmurugan, Bharath Kumar, additional, Chung, Chia-Min, additional, Lin, Shu-Hui, additional, Wang, Zhi-Hong, additional, Hua, Chun-Hung, additional, Tsai, Ming-Hsui, additional, Kuo, Tzer-Min, additional, Yeh, Kun-Tu, additional, Chang, Pei-Ying, additional, Yang, Yi-Hsin, additional, and Ko, Ying-Chin, additional

Published
2017
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41. Correction: Corrigendum: Somatic Mutations and Genetic Variants of NOTCH1 in Head and Neck Squamous Cell Carcinoma Occurrence and Development

Author

Liu, Yu-Fan, primary, Chiang, Shang-Lun, additional, Lin, Chien-Yu, additional, Chang, Jan-Gowth, additional, Chung, Chia-Min, additional, Ko, Albert Min-Shan, additional, Lin, You-Zhe, additional, Lee, Chien-Hung, additional, Lee, Ka-Wo, additional, Chen, Mu-Kuan, additional, Hua, Chun-Hung, additional, Tsai, Ming-Hsui, additional, Chen, Yuan-Chien, additional, and Ko, Ying-Chin, additional

Published
2016
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44. Somatic Mutations and Genetic Variants of NOTCH1 in Head and Neck Squamous Cell Carcinoma Occurrence and Development

Author

Liu, Yu-Fan, primary, Chiang, Shang-Lun, additional, Lin, Chien-Yu, additional, Chang, Jan-Gowth, additional, Chung, Chia-Min, additional, Ko, Albert Min-Shan, additional, Lin, You-Zhe, additional, Lee, Chien-Hung, additional, Lee, Ka-Wo, additional, Chen, Mu-Kuan, additional, Hua, Chun-Hung, additional, Tsai, Ming-Hsui, additional, Chen, Yuan-Chien, additional, and Ko, Ying-Chin, additional

Published
2016
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45. Acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) association with lymph node metastasis predicts poor survival in oral squamous cell carcinoma patients

Author

Velmurugan, Bharath Kumar, primary, Yeh, Kun-Tu, additional, Lee, Chien-Hung, additional, Lin, Shu-Hui, additional, Chin, Mei-Chung, additional, Chiang, Shang-Lun, additional, Wang, Zhi-Hong, additional, Hua, Chun-Hung, additional, Tsai, Ming-Hsui, additional, Chang, Jan-Gowth, additional, and Ko, Ying-Chin, additional

Published
2016
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48. PP2A deactivation is a common event in oral cancer and reactivation by FTY720 shows promising therapeutic potential.

Author

Velmurugan, Bharath K., Lee, Chien‐Hung, Chiang, Shang‐Lun, Hua, Chun‐Hung, Chen, Mei‐Chung, Lin, Shu‐Hui, Yeh, Kun‐Tu, and Ko, Ying‐Chin

Subjects
ORAL cancer, PHOSPHOPROTEIN phosphatases, TUMOR suppressor genes, SQUAMOUS cell carcinoma, MOLECULAR oncology, POST-translational modification
Abstract

Protein phosphatase 2A (PP2A) is a tumor suppressor gene, that has been frequently deactivated in many types of cancer. However, its molecular and clinical relevance in oral squamous cell carcinoma (OSCC) remain unclear. Here we show that, PP2A deactivation is a common event in oral cancer cells and hyperphosphorylation in its tyrosine-307 (Y307) residue contributes to PP2A deactivation. PP2A restoration by FTY720 treatment reduced cell growth and decreased GSK-3β phosphorylation without significantly altering other PP2A targets. We further detected PP2A phosphorylation in 262 OSCC tissues. Increased expression of p-PP2A in the tumor tissues was significantly correlated with higher N2/N3-stage (aOR = 2.1, 95%CI: 1.2-3.8). Patients with high p-PP2A expression had lower overall survival rates than those with low expression. Hazard ratio analysis showed that, high p-PP2A expression was significantly associated with mortality density (aOR = 2.2, 95%CI: 1.2-4.0) and lower 10-year overall survival (p = 0.027) in lymph node metastasis. However, no interaction was observed between p-PP2A expression and lymph node metastasis. All our results suggest that PP2A is frequently deactivated is oral cancer and determines poor outcome, restoring its expression by FTY720 can be an alternative therapeutic approach in OSCC. [ABSTRACT FROM AUTHOR]

Published
2018
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