8,279 results on '"Chiarello, A"'
Search Results
2. Existence result for a 2 x 2 system of conservation laws with discontinuous flux and applications
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Chiarello, Felisia Angela, Fagioli, Simone, and Rosini, Massimiliano Daniele
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Mathematics - Analysis of PDEs ,Primary: 35L65, 35B40, Secondary: 35D30, 35Q70, 35L45 - Abstract
This paper analyzes a two-by-two Temple-type system of conservation laws with discontinuous flux, focusing on applications in traffic modeling. We prove the existence of entropy solutions for initial data with sufficiently small total variation. Additionally, we explicitly construct the corresponding Riemann solver and examine its key properties. To illustrate the impact of the discontinuous flux on the solution, we also present numerical simulations.
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- 2024
3. Euler-flocking system with nonlocal dissipation in 1D: periodic entropy solutions
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Amadori, D., Chiarello, F. A., and Christoforou, C.
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Mathematics - Analysis of PDEs ,Primary: 35L65, 35B40, Secondary: 35D30, 35Q70, 35L45 - Abstract
We consider a hydrodynamic model of flocking-type with all-to-all interaction kernel in a periodic domain in one-space dimension with linear pressure term. The main result is the global existence of periodic entropy weak solutions, for periodic initial data having finite total variation and initial density bounded away from zero.
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- 2024
4. Linearly Multiplexed Photon Number Resolving Single-photon Detectors Array
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Limongi, Leonardo, Martini, Francesco, Dao, Thu Ha, Gaggero, Alessandro, Hasnaoui, Hamza, Lopez-Gonzalez, Igor, Chiarello, Fabio, de Matteis, Fabio, Quaranta, Alberto, Salamon, Andrea, Mattioli, Francesco, Bernard, Martino, and Lobino, Mirko
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Quantum Physics - Abstract
Photon Number Resolving Detectors (PNRDs) are devices capable of measuring the number of photons present in an incident optical beam, enabling light sources to be measured and characterized at the quantum level. In this paper, we explore the performance and design considerations of a linearly multiplexed photon number-resolving single-photon detector array, integrated on a single mode waveguide. Our investigation focus on defining and analyzing the fidelity of such an array under various conditions and proposing practical designs for its implementation. Through theoretical analysis and numerical simulations, we show how propagation losses and dark counts may have a strong impact on the performance of the system and highlight the importance of mitigating these effects in practical implementations.
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- 2024
5. The end-to-end simulator of the ATHENA X-IFU Cryogenic AntiCoincidence detector (CryoAC)
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D'Andrea, Matteo, Macculi, Claudio, Lotti, Simone, Piro, Luigi, Argan, Andrea, Minervini, Gabriele, Torrioli, Guido, Chiarello, Fabio, Barusso, Lorenzo Ferrari, Gatti, Flavio, and Rigano, Manuela
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The X-IFU is one of the two instruments of ATHENA, the next ESA large X-ray observatory. It is a cryogenic spectrometer based on an array of TES microcalorimeters. To reduce the particle background, the TES array works in combination with a Cryogenic AntiCoincidence detector (CryoAC). The CryoAC is a 4-pixel detector, based on ~1 cm2 silicon absorbers sensed by Ir/Au TES. It is required to have a wide energy bandwidth (from 20 keV to ~1 MeV), high efficiency (< 0.014% missed particles), low dead-time (< 1%) and good time-tagging accuracy (10 us at 1 sigma). An end-to-end simulator of the CryoAC detector has been developed both for design and performance assessment, consisting of several modules. First, the in-flight flux of background particles is evaluated by Geant4 simulations. Then, the current flow in the TES is evaluated by solving the electro-thermal equations of microcalorimeters, and the detector output signal is generated by simulating the SQUID FLL dynamics. Finally, the output is analyzed by a high-efficiency trigger algorithm, producing the simulated CryoAC telemetry. Here, we present in detail this end-to-end simulator, and how we are using it to define the new CryoAC baseline configuration in the new Athena context., Comment: Proceeding of the SPIE Astronomical Telescopes + Instrumentation 2024
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- 2024
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6. A retrospective multicenter study of WHO 2021 classification-diagnosed solitary fibrous tumor of the CNS in a population from Lombardy, Italy
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Salmaggi, Andrea, Domina, Elisabetta, Piparo, Maurizio, Billo, Paola, Schembari, Silvia, Spena, Giannantonio, Viglio, Alessandra, Caroli, Manuela, Lopez, Gianluca, Demertzis, Dimitrios, Bramerio, Manuela Adele, Imbesi, Francesca, Cenzato, Marco, Rigoli, Elena, Lanterna, Andrea, Bernucci, Claudio, Zanella, Stefano, Polosa, Maria, Stefanoni, Giovanni, Chiarello, Gaia, Di Cristofori, Andrea, Milani, Riccardo, Martinelli-Boneschi, Filippo, and Dainese, Emanuele
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- 2025
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7. Thermomechanical analysis and additive manufacturing of a target for nuclear physics
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Benmansour, H., Cavoto, G., Chiarello, G., del Maso, G., Meucci, M., Milana, S., Papa, A., Pettinacci, V., Renga, F., Schwendimann, P., Vitali, B., and Voena, C.
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- 2025
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8. The impact of SARS-CoV-2 (COVID-19) pandemic on educational and professional growth of young Italian epileptologists: a survey of the Young Epilepsy Section-Italian chapter
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Masnada, Silvia, Spagnoli, Carlotta, Duca, Maddalena, Chiarello, Daniela, Lo Barco, Tommaso, and Nucera, Bruna
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- 2025
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9. Towards Personalized Educational Materials: Mapping Student Knowledge Through Natural Language Processing
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Domenichini, Diana, Giordano, Vito, Fantoni, Gualtiero, Chiarello, Filippo, Ghosh, Ashish, Editorial Board Member, Meo, Rosa, editor, and Silvestri, Fabrizio, editor
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- 2025
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10. The ChatGPT and Education Tweets Dataset
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Barandoni, Simone, Chiarello, Filippo, Giordano, Vito, Fantoni, Gualtiero, Ghosh, Ashish, Editorial Board Member, Meo, Rosa, editor, and Silvestri, Fabrizio, editor
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- 2025
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11. Automating Customer Needs Analysis: A Comparative Study of Large Language Models in the Travel Industry
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Barandoni, Simone, Chiarello, Filippo, Cascone, Lorenzo, Marrale, Emiliano, and Puccio, Salvatore
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Computer Science - Computation and Language ,Computer Science - Artificial Intelligence ,Computer Science - Human-Computer Interaction - Abstract
In the rapidly evolving landscape of Natural Language Processing (NLP), Large Language Models (LLMs) have emerged as powerful tools for many tasks, such as extracting valuable insights from vast amounts of textual data. In this study, we conduct a comparative analysis of LLMs for the extraction of travel customer needs from TripAdvisor posts. Leveraging a diverse range of models, including both open-source and proprietary ones such as GPT-4 and Gemini, we aim to elucidate their strengths and weaknesses in this specialized domain. Through an evaluation process involving metrics such as BERTScore, ROUGE, and BLEU, we assess the performance of each model in accurately identifying and summarizing customer needs. Our findings highlight the efficacy of opensource LLMs, particularly Mistral 7B, in achieving comparable performance to larger closed models while offering affordability and customization benefits. Additionally, we underscore the importance of considering factors such as model size, resource requirements, and performance metrics when selecting the most suitable LLM for customer needs analysis tasks. Overall, this study contributes valuable insights for businesses seeking to leverage advanced NLP techniques to enhance customer experience and drive operational efficiency in the travel industry.
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- 2024
12. White Coat Crime
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Chiarello, Elizabeth
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Cases ,Company legal issue ,Physicians -- Cases ,White collar crime -- Cases ,White collar crimes -- Cases - Abstract
She murdered her patients. At least, that's what the prosecutors said. All it took to get powerful opioids from California internist Lisa Tseng was a brief conversation. No X-rays. No [...]
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- 2024
13. Genuine Memory Deficits as Assessed by the Free and Cued Selective Reminding Test (FCSRT) in the Behavioural Variant of Frontotemporal Dementia. A Systematic Review and Meta-analysis Study
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Macchitella, Luigi, Tosi, Giorgia, Giaquinto, Francesco, Iaia, Marika, Rizzi, Ezia, Chiarello, Ylenia, Bertoux, Maxime, Angelelli, Paola, and Romano, Daniele Luigi
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- 2024
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14. Characterization of a Transmon Qubit in a 3D Cavity for Quantum Machine Learning and Photon Counting
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D'Elia, Alessandro, Alfakes, Boulos, Alkhazaleh, Anas, Banchi, Leonardo, Beretta, Matteo, Carrazza, Stefano, Chiarello, Fabio, Di Gioacchino, Daniele, Giachero, Andrea, Henrich, Felix, Komnang, Alex Stephane Piedjou, Ligi, Carlo, Maccarrone, Giovanni, Macucci, Massimo, Palumbo, Emanuele, Pasquale, Andrea, Piersanti, Luca, Ravaux, Florent, Rettaroli, Alessio, Robbiati, Matteo, Tocci, Simone, and Gatti, Claudio
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Quantum Physics ,High Energy Physics - Phenomenology - Abstract
In this paper we report the use of superconducting transmon qubit in a 3D cavity for quantum machine learning and photon counting applications. We first describe the realization and characterization of a transmon qubit coupled to a 3D resonator, providing a detailed description of the simulation framework and of the experimental measurement of important parameters, like the dispersive shift and the qubit anharmonicity. We then report on a Quantum Machine Learning application implemented on the single-qubit device to fit the u-quark parton distribution function of the proton. In the final section of the manuscript we present a new microwave photon detection scheme based on two qubits coupled to the same 3D resonator. This could in principle decrease the dark count rate, favouring applications like axion dark matter searches., Comment: 22 pages, 10 figures, accepted in Applied Sciences, code available at https://qibo.science
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- 2024
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15. The TES-based Cryogenic AntiCoincidence Detector (CryoAC) of ATHENA X-IFU: a large area silicon microcalorimeter for background particles detection
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D'Andrea, M., Macculi, C., Lotti, S., Piro, L., Argan, A., Minervini, G., Torrioli, G., Chiarello, F., Barusso, L. Ferrari, Celasco, E., Gallucci, G., Gatti, F., Grosso, D., Rigano, M., Brienza, D., Cavazzuti, E., and Volpe, A.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Physics - Instrumentation and Detectors - Abstract
We are developing the Cryogenic AntiCoincidence detector (CryoAC) of the ATHENA X-IFU spectrometer. It is a TES-based particle detector aimed to reduce the background of the instrument. Here, we present the result obtained with the last CryoAC single-pixel prototype. It is based on a 1 cm2 silicon absorber sensed by a single 2mm x 1mm Ir/Au TES, featuring an on-chip heater for calibration and diagnostic purposes. We have illuminated the sample with 55Fe (6 keV line) and 241Am (60 keV line) radioactive sources, thus studying the detector response and the heater calibration accuracy at low energy. Furthermore, we have operated the sample in combination with a past-generation CryoAC prototype. Here, by analyzing the coincident detections between the two detectors, we have been able to characterize the background spectrum of the laboratory environment and disentangle the primary (i.e. cosmic muons) and secondaries (mostly secondary photons and electrons) signatures in the spectral shape., Comment: Accepted for publication in the Journal of Low Temperature Physics for LTD-20 special issue
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- 2024
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16. Insulin-Related Skin Lipohypertrophy in Type Two Diabetes: A Clinical Study of a Case Series, with Ultrasonographic and Histopathologic Implications
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Sandro Gentile, Felice Strollo, Giuseppina Guarino, Andrea Ronchi, Ersilia Satta, Teresa Della-Corte, Elisabetta Fulgione, Graziella Babino, Edi Mattera, Emilia Martedì, Roberta Di Martino, Raffaella Fiorentino, Roberta Porcini, Carmine Romano, Maria Chiarello, Giuseppe Caccavale, Renato Franco, and Giuseppe Argenziano
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insulin-induced lipohypertrophy ,histopathology ,diabetes complications ,insulin-derived amyloidosis ,injection technique ,Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
Introduction: The most frequent local complication of insulin injection is the occurrence of subcutaneous nodules due to incorrect injection technique. Injection into nodules negatively impacts metabolic compensation and the requirement for greater insulin doses due to its partial and erratic absorption. Despite these concepts being accepted by the scientific community, it is not yet clear whether injection into nodules is causally related to worsening chronic diabetes (DM) complications and the morphological nature of such nodules. Aim: This multicenter study aimed to evaluate the associations between structural characteristics of skin nodules and chronic DM complications. A secondary endpoint was to evaluate the histological structure of those nodules, looking for differences between lipohypertrophies (LH) and amyloid nodules (LIDA). Methods: For this purpose, 816 DM patients with LH and 1033 without LH underwent a clinical and ultrasound study comparing metabolic data, injection habits, and frequency of complications. Excisional biopsies of the skin nodules were performed in a small series of eight subjects. Results: Data observed confirm a strong relationship between LH and diabetes chronic complications other than poor glycemic control. Histology of biopsies from the skin nodules showed mild foreign-body-like inflammation, prevailing mega-adipocytes (65%), apoptosis, and fibrosis but could not detect any amyloid fibrils. In four cases, intra-nodular fluid was present with an insulin concentration several times higher than in blood. Conclusions: We confirmed LHs to be significantly associated with insulin administration errors, duration of insulin therapy, greater daily doses and duration of insulin administration, and the presence of micro- and macro-vascular DM complications. LH nodules displayed no typical morphological features and were indistinguishable from LIDA nodules with which they shared several histologic similarities, albeit within the frame of a general picture of LIDA inhomogeneity. Further targeted studies are warranted to clarify the remaining doubts.
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- 2024
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17. A search for $\mu^+\to e^+\gamma$ with the first dataset of the MEG II experiment
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MEG II collaboration, Afanaciev, K., Baldini, A. M., Ban, S., Baranov, V., Benmansour, H., Biasotti, M., Boca, G., Cattaneo, P. W., Cavoto, G., Cei, F., Chiappini, M., Chiarello, G., Corvaglia, A., Cuna, F., Maso, G. Dal, De Bari, A., De Gerone, M., Barusso, L. Ferrari, Francesconi, M., Galli, L., Gallucci, G., Gatti, F., Gerritzen, L., Grancagnolo, F., Grandoni, E. G., Grassi, M., Grigoriev, D. N., Hildebrandt, M., Ieki, K., Ignatov, F., Ikeda, F., Iwamoto, T., Karpov, S., Kettle, P. -R., Khomutov, N., Kobayashi, S., Kolesnikov, A., Kravchuk, N., Krylov, V., Kuchinskiy, N., Kyle, W., Libeiro, T., Malyshev, V., Matsushita, A., Meucci, M., Mihara, S., Molzon, W., Mori, Toshinori, Nakao, M., Nicolò, D., Nishiguchi, H., Ochi, A., Ogawa, S., Onda, R., Ootani, W., Oya, A., Palo, D., Panareo, M., Papa, A., Pettinacci, V., Popov, A., Renga, F., Ritt, S., Rossella, M., Rozhdestvensky, A., Schwendimann, P., Shimada, K., Signorelli, G., Takahashi, M., Tassielli, G. F., Toyoda, K., Uchiyama, Y., Usami, M., Venturini, A., Vitali, B., Voena, C., Yamamoto, K., Yanai, K., Yonemoto, T., Yoshida, K., and Yudin, Yu. V.
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High Energy Physics - Experiment - Abstract
The MEG II experiment, based at the Paul Scherrer Institut in Switzerland, reports the result of a search for the decay $\mu^+\to e^+\gamma$ from data taken in the first physics run in 2021. No excess of events over the expected background is observed, yielding an upper limit on the branching ratio of B($\mu^+\to e^+\gamma$) < $7.5 \times 10^{-13}$ (90% C.L.). The combination of this result and the limit obtained by MEG gives B($\mu^+\to e^+\gamma$) < $3.1 \times 10^{-13}$ (90% C.L.), which is the most stringent limit to date. A ten-fold larger sample of data is being collected during the years 2022-2023, and data-taking will continue in the coming years., Comment: 10 pages, 6 figures. To be published in EPJC
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- 2023
18. Performances of a new generation tracking detector: the MEG II cylindrical drfit chamber
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Baldini, A. M., Benmansour, H., Boca, G., Cavoto, G., Cei, F., Chiappini, M., Chiarello, G., Corvaglia, A., Cuna, F., Francesconi, M., Galli, L., Grancagnolo, F., Grandoni, E. G., Grassi, M., Hildebrandt, M., Ignatov, F., Meucci, M., Molzon, W., Nicolo', D., Oya, A., Palo, D., Panareo, M., Papa, A., Raffaelli, F., Renga, F., Signorelli, G., Tassielli, G. F., Uchiyama, Y., Venturini, A., Vitali, B., and Voena, C.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment - Abstract
The cylindrical drift chamber is the most innovative part of the MEG~II detector, the upgraded version of the MEG experiment. The MEG~II chamber differs from the MEG one because it is a single volume cylindrical structure, instead of a segmented one, chosen to improve its resolutions and efficiency in detecting low energy positrons from muon decays at rest. In this paper, we show the characteristics and performances of this fundamental part of the MEG~II apparatus and we discuss the impact of its higher resolution and efficiency on the sensitivity of the MEG~II experiment. Because of its innovative structure and high quality resolution and efficiency the MEG~II cylindrical drift chamber will be a cornerstone in the development of an ideal tracking detector for future positron-electron collider machines., Comment: 27 pages, 42 figures, published on EPJC 84(2024)5,473
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- 2023
19. Operation and performance of MEG II detector
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MEG II Collaboration, Afanaciev, K., Baldini, A. M., Ban, S., Baranov, V., Benmansour, H., Biasotti, M., Boca, G., Cattaneo, P. W., Cavoto, G., Cei, F., Chiappini, M., Chiarello, G., Corvaglia, A., Cuna, F., Maso, G. Dal, De Bari, A., De Gerone, M., Barusso, L. Ferrari, Francesconi, M., Galli, L., Gallucci, G., Gatti, F., Gerritzen, L., Grancagnolo, F., Grandoni, E. G., Grassi, M., Grigoriev, D. N., Hildebrandt, M., Ieki, K., Ignatov, F., Ikeda, F., Iwamoto, T., Karpov, S., Kettle, P. -R., Khomutov, N., Kobayashi, S., Kolesnikov, A., Kravchuk, N., Krylov, V., Kuchinskiy, N., Kyle, W., Libeiro, T., Malyshev, V., Matsushita, A., Meucci, M., Mihara, S., Molzon, W., Mori, Toshinori, Morsani, F., Nakao, M., Nicolò, D., Nishiguchi, H., Ochi, A., Ogawa, S., Onda, R., Ootani, W., Oya, A., Palo, D., Panareo, M., Papa, A., Pettinacci, V., Popov, A., Raffaelli, F., Renga, F., Ritt, S., Rossella, M., Rozhdestvensky, A., Schwendimann, P., Shimada, K., Signorelli, G., Stoykov, A., Takahashi, M., Tassielli, G. F., Toyoda, K., Uchiyama, Y., Usami, M., Venturini, A., Vitali, B., Voena, C., Yamamoto, K., Yanai, K., Yonemoto, T., Yoshida, K., and Yudin, Yu. V.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment - Abstract
The MEG II experiment, located at the Paul Scherrer Institut (PSI) in Switzerland, is the successor to the MEG experiment, which completed data taking in 2013. MEG II started fully operational data taking in 2021, with the goal of improving the sensitivity of the mu+ -> e+ gamma decay down to 6e-14 almost an order of magnitude better than the current limit. In this paper, we describe the operation and performance of the experiment and give a new estimate of its sensitivity versus data acquisition time., Comment: 42 pages, 55 figures. Submitted to EPJC
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- 2023
20. Design and simulation of a transmon qubit chip for Axion detection
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Moretti, Roberto, Corti, Hervè Atsè, Labranca, Danilo, Ahrens, Felix, Avallone, Guerino, Babusci, Danilo, Banchi, Leonardo, Barone, Carlo, Beretta, Matteo Mario, Borghesi, Matteo, Buonomo, Bruno, Calore, Enrico, Carapella, Giovanni, Chiarello, Fabio, Cian, Alessandro, Cidronali, Alessando, Costa, Filippo, Cuccoli, Alessandro, D'Elia, Alessandro, Di Gioacchino, Daniele, Di Pascoli, Stefano, Falferi, Paolo, Fanciulli, Marco, Faverzani, Marco, Felici, Giulietto, Ferri, Elena, Filatrella, Giovanni, Foggetta, Luca Gennaro, Gatti, Claudio, Giachero, Andrea, Giazotto, Francesco, Giubertoni, Damiano, Granata, Veronica, Guarcello, Claudio, Lamanna, Gianluca, Ligi, Carlo, Maccarrone, Giovanni, Macucci, Massimo, Manara, Giuliano, Mantegazzini, Federica, Marconcini, Paolo, Margesin, Benno, Mattioli, Francesco, Miola, Andrea, Nucciotti, Angelo, Origo, Luca, Pagano, Sergio, Paolucci, Federico, Piersanti, Luca, Rettaroli, Alessio, Sanguinetti, Stefano, Schifano, Sebastiano Fabio, Spagnolo, Paolo, Tocci, Simone, Toncelli, Alessandra, Torrioli, Guido, and Vinante, Andrea
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Quantum Physics - Abstract
Quantum Sensing is a rapidly expanding research field that finds one of its applications in Fundamental Physics, as the search for Dark Matter. Devices based on superconducting qubits have already been successfully applied in detecting few-GHz single photons via Quantum Non-Demolition measurement (QND). This technique allows us to perform repeatable measurements, bringing remarkable sensitivity improvements and dark count rate suppression in experiments based on high-precision microwave photon detection, such as for Axions and Dark Photons search. In this context, the INFN Qub-IT project goal is to realize an itinerant single-photon counter based on superconducting qubits that will exploit QND for enhancing Axion search experiments. In this study, we present Qub-IT's status towards the realization of its first superconducting qubit device, illustrating design and simulation procedures and the characterization of fabricated Coplanar Waveguide Resonators (CPWs) for readout. We match target qubit parameters and assess a few-percent level agreement between lumped and distributed element simulation models. We reach a maximum internal quality factor of 9.2x10^5 for -92 dBm on-chip readout power.
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- 2023
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21. On the singular limit problem in nonlocal balance laws: Applications to nonlocal lane-changing traffic flow models
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Chiarello, Felisia Angela and Keimer, Alexander
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Mathematics - Analysis of PDEs ,35L65, 90B20 - Abstract
We present a convergence result from nonlocal to local behavior for a system of nonlocal balance laws. The velocity field of the underlying conservation laws is diagonal. In contrast, the coupling to the remaining balance laws involves a nonlinear right-hand side that depends on the solution, nonlocal term, and other factors. The nonlocal operator integrates the density around a specific spatial point, which introduces nonlocality into the problem. Inspired by multi-lane traffic flow modeling and lane-changing, the nonlocal kernel is discontinuous and only looks downstream. In this paper, we prove the convergence of the system to the local entropy solutions when the nonlocal operator (chosen to be of an exponential type for simplicity) converges to a Dirac distribution. Numerical illustrations that support the main results are also presented., Comment: 20 pages, 3 figures
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- 2023
22. Artificial intelligence in the diagnosis and treatment of acute appendicitis: a narrative review
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Bianchi, Valentina, Giambusso, Mauro, De Iacob, Alessandra, Chiarello, Maria Michela, and Brisinda, Giuseppe
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- 2024
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23. A non-local traffic flow model for 1-to-1 junctions with buffer
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Chiarello, F. A., Friedrich, J., and GÖttlich, S.
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Mathematics - Analysis of PDEs ,35L65, 65M08, 76A30 - Abstract
Inthispaper,weintroduceanon-localPDE-ODEtrafficmodeldevotedtothedescriptionof a 1-to-1 junction with buffer. We present an existence result in the free flow case as well as a numerical method to approximate weak solutions in the general case. In addition, we show a maximum principle which is uniform in the non-local interaction range. Further, we exploit the limit models as the support of the kernel tends to zero and to infinity. We compare them with other already existing models for traffic and production flow and present numerical examples.
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- 2023
24. Epilepsy surgery below the age of 5 years: Are we still in time to preserve developmental and intellectual functions?
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Simona Cappelletti, Cinzia Correale, Mattia Mercier, Giusy Carfi Pavia, Chiara Falamesca, Alessandro De Benedictis, Carlo Efisio Marras, Chiara Quintavalle, Concetta Luisi, Chiara Pepi, Daniela Chiarello, Federico Vigevano, Luca De Palma, and Nicola Specchio
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developmental and intellectual outcomes ,developmental quotient ,drug‐resistant epilepsy ,intelligence quotient ,pediatric epilepsy surgery ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Objective The aim of this study is to describe the pre‐ and post‐operative developmental and intellectual functions in a cohort of patients who underwent surgery for drug‐resistant epilepsy (DRE) before the age of 5 years. Method We retrospectively reviewed the medical records and neurodevelopmental assessments of a cohort of 80 surgically treated pediatric patients with DRE. We included patients if they had at least one pre‐ and one post‐surgical neuropsychological assessments; 27 met the inclusion criteria. We evaluated Developmental Quotient (DQ) and Intelligence Quotient (IQ) before and after surgery. We identified two groups based on psychological evaluation outcome: Group 1, with stable or improved developmental and intellectual functions, and Group 2, experiencing developmental and intellectual loss. Results The mean age at seizure onset was 1.2 ± 1.0 years, and the mean age at surgery was 2.9 ± 1.2 years. At the last follow‐up (mean 4 years, SD ± 2), 19/27 (70%) patients were seizure‐ and drug‐free; 18/27 patients (67%) fit in Group 1, and 9/27 (33%) fit in Group 2. The mean age at surgery was 2.6 years (SD ± 1.1; range 1.2–5.1) in Group 1 and 3.4 years in Group 2 (SD ± 1.1; range 1.6–5.0). Group 1 had a lower pre‐operative DQ/IQ total score than Group 2 (median DQ/IQ respectively 82 vs 108, p = 0.05). Between pre‐ and post‐assessments, we found that in Group 1, Performance scores improved (82.7 vs 102, p = 0.001), while in Group 2, the Total and Verbal scores worsened (respectively 108 vs 75, p = 0.008, and 100 vs 76, p = 0.021). Significance Our study's results emphasize the positive impact of surgery before the age of 5 years on developmental and intellectual outcomes. Despite limitations such as a small sample size, lack of a control group, and diverse etiologies, our findings support the crucial role of early intervention in preserving or enhancing developmental and intellectual functions in young patients with DRE. Plain Language Summary This retrospective study, conducted at the Bambino Gesù Children Hospital in Italy, reports neuropsychological and developmental and/or cognitive data for children undergoing early epilepsy surgery (before the age of 5). It found that children with lower developmental or cognitive profiles gained the highest scores on post‐operative neuropsychological evaluations. This study provides information on the potential benefits of early surgery in shortening the duration of epilepsy, preventing or arresting deterioration, and enhancing plasticity and recovery.
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- 2024
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25. Tracing Topic Evolution in Higher Education: A Text Mining Study on Italian Universities
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Irene Spada, Vito Giordano, Filippo Chiarello, Marco Abate, Francesca M. Dovetto, and Gualtiero Fantoni
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In the last decade, the fast technological and social transformations have been placing new demands on Higher Education (HE) systems to update their educational offers. Grounded in the broader discourse on the impact of such transformation on HE, this article relies on Text Mining (TM). We consider as a case study the Italian HE system, providing an overview of the university education in the last 10 Academic Years. We automatically analyse 54,535 learning outcomes of degree programmes to identify the relevant topics with Named Entity Recognition, a technique of TM. For each topic, we measured its trend in time and coverage on a geographical basis and in the disciplinary fields. We detected 6062 different topics, among these the most growing are artificial intelligence, sustainability, rare diseases, and ethics. The findings reveal that topics related to hard sciences register higher occurrence than the ones concerning humanities and social sciences. Furthermore, we observed that universities are overcoming the boundaries of disciplinary fields, promoting knowledge contamination and vertical specialisation. The proposed approach can advance studies in HE literature for effective and efficient analysis. The findings can inform policies and practices in HE on evolving learning outcomes and educational offerings, even across different countries and disciplines.
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- 2024
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26. Hydrodynamic traffic flow models including random accidents: A kinetic derivation
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Chiarello, Felisia Angela, Göttlich, Simone, Schilliger, Thomas, and Tosin, Andrea
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Mathematical Physics ,Condensed Matter - Statistical Mechanics ,Mathematics - Analysis of PDEs ,Physics - Physics and Society ,35Q20, 35Q70, 90B20 - Abstract
We present a formal kinetic derivation of a second order macroscopic traffic model from a stochastic particle model. The macroscopic model is given by a system of hyperbolic partial differential equations (PDEs) with a discontinuous flux function, in which the traffic density and the headway are the averaged quantities. A numerical study illustrates the performance of the second order model compared to the particle approach. We also analyse numerically uncertain traffic accidents by considering statistical measures of the solution to the PDEs.
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- 2023
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27. Cluster counting algorithms for particle identification at future colliders
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D'Anzi, Brunella, Chiarello, Gianluigi, Corvaglia, Alessandro, De Filippis, Nicola, Elmetenawee, Walaa, De Santis, Francesco, Gorini, Edoardo, Grancagnolo, Francesco, Maggi, Marcello, Miccoli, Alessandro, Panareo, Marco, Primavera, Margherita, Ventura, Andrea, Xin, Shuiting, Guo, Fangyi, and Liu, Shuaiyi
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High Energy Physics - Experiment ,Physics - Instrumentation and Detectors - Abstract
Recognition of electron peaks and primary ionization clusters in real data-driven waveform signals is the main goal of research for the usage of the cluster counting technique in particle identification at future colliders. The state-of-the-art open-source algorithms fail in finding the cluster distribution Poisson behavior even in low-noise conditions. In this work, we present cutting-edge algorithms and their performance to search for electron peaks and identify ionization clusters in experimental data using the latest available computing tools and physics knowledge., Comment: 6 pages, 12 figures, Proceedings of: ACAT2022
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- 2023
28. Optimal Amplitude Multiplexing of a Series of Superconducting Nanowire Single Photon Detectors
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Chiarello, Fabio, Leoni, Roberto, Martini, Francesco, Mattioli, Francesco, and Gaggero, Alessandro
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Quantum Physics ,Condensed Matter - Superconductivity - Abstract
Integrated arrays of Superconducting Nanowire Single Photon Detectors (SNSPDs) have shown capabilities such as Photon Number Resolution, single photon imaging and coincidences detection, and can be effectively used also in other different applications related to quantum optics. The growing complexity of such applications requires the use of multiplexing schemes for the simultaneous readout of different detectors. A simple multiplexing scheme can be realized by arranging a series of SNSPDs elements, shunted by appropriate resistances. The goal of this work is to investigate and optimize this scheme, developing a general method able to identify the optimal sets of shunting resistences for any different application. The methodology obtained is very general, and can be extended to other detection systems.
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- 2023
29. Impact of Granulocyte Colony-Stimulating Factor (G-CSF) on Clinical Outcomes in Allogeneic Hematopoietic Cell Transplantation: Does Speeding Up Neutrophil Engraftment Make a Difference?
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Ahmed Alnughmush, MD, Ayman Sayyed, MD, Mats Remberger, PhD, Eshrak AL-Shaibani, MD, Carol Chen, BSc, Caden Chiarello, Ivan Pasic, MD, Igor Novitzky-Basso, MD, Arjun Datt Law, MD, Wilson Lam, MD, Dennis (Dong Hwan) Kim, MD, Armin Gerbitz, MD, Auro Viswabandya, MD, Rajat Kumar, MD, Fotios V. Michelis, MD, and Jonas Mattsson, MD, PhD
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Surgery ,RD1-811 - Abstract
Background. Despite decades of post–allogeneic hematopoietic cell transplantation (HCT) growth factor utilization, its role remains undefined, leading to ongoing debates and research. The theoretical impacts of growth factors have been challenged in numerous studies. Methods. In this retrospective cohort study conducted at the Princess Margaret Cancer Centre, we analyzed the clinical outcomes of 509 patients who underwent allogeneic HCT between May 1, 2019, and May 31, 2022. This study aimed to assess the impact of granulocyte colony-stimulating factor (G-CSF) administration posttransplantation on neutrophil and platelet engraftment, incidence of bloodstream infections (BSIs), graft-versus-host disease, engraftment syndrome (ES), and survival metrics including overall survival, nonrelapse mortality, and graft-versus-host disease–free/relapse-free survival. Results. Our findings indicate that G-CSF administration expedited neutrophil engraftment (16 versus 18 d, P = 0.009) and was associated with a decreased incidence of BSI (9.4% versus 31.3%, P = 0.014). However, this benefit was counterbalanced by a significant delay in platelet engraftment (21 versus 17 d, P
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- 2025
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30. Trained innate immunity as a potential link between preeclampsia and future cardiovascular disease
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Ivo Carrasco-Wong, Javiera M. Sanchez, Jaime A. Gutierrez, and Delia I. Chiarello
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preeclampsia ,maternal cardiovascular health ,long-lasting effects ,trained immunity ,DAMPs (damage-associated molecular pattern molecules) ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Preeclampsia (PE) is a complex pregnancy syndrome characterized by hypertension with or without proteinuria, affecting 2–6% of pregnancies globally. PE is characterized by excessive release of damage-associated molecular patterns (DAMPs) into the maternal circulation. This DAMP-rich milieu acts on innate immune cells, inducing a proinflammatory state characterized by elevated cytokines such as IL-1β and IL-18. This proinflammatory state in the mother and placenta results in the endothelial dysfunction strongly associated with cardiovascular disorders. While the immediate maternal and fetal risks of PE are well-documented, accumulating evidence indicates that PE also confers long-term cardiovascular risks to the mother, including hypertension, coronary heart disease, stroke, and heart failure. The underlying mechanisms connecting PE to these chronic cardiovascular conditions remain unclear. This article explores the potential role of trained innate immunity (TRIM) as a mechanistic link between PE and increased long-term cardiovascular risk. We propose that the persistent exposure to DAMPs during PE may epigenetically reprogram maternal innate immune cells and their progenitors, leading to TRIM. This reprogramming enhances the inflammatory response to subsequent stimuli, potentially contributing to endothelial dysfunction and chronic inflammation that predispose women to cardiovascular diseases later in life. Understanding the role of TRIM in PE could provide novel insights into the pathophysiology of PE-related cardiovascular complications and identify potential targets for therapeutic intervention. Further research is warranted to investigate the epigenetic and metabolic alterations in innate immune cells induced by PE and to determine how these changes may influence long-term maternal cardiovascular health.
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- 2024
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31. Stepping closer to pulsed single microwave photon detectors for axions search
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D'Elia, A., Rettaroli, A., Tocci, S., Babusci, D., Barone, C., Beretta, M., Buonomo, B., Chiarello, F., Chikhi, N., Di Gioacchino, D., Felici, G., Filatrella, G., Fistul, M., Foggetta, L. G., Gatti, C., Il'ichev, E., Ligi, C., Lisitskiy, M., Maccarrone, G., Mattioli, F., Oelsner, G., Pagano, S., Piersanti, L., Ruggiero, B., Torrioli, G., and Zagoskin, A.
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Quantum Physics ,Physics - Instrumentation and Detectors - Abstract
Axions detection requires the ultimate sensitivity down to the single photon limit. In the microwave region this corresponds to energies in the yJ range. This extreme sensitivity has to be combined with an extremely low dark count rate, since the probability of axions conversion into microwave photons is supposed to be very low. To face this complicated task, we followed two promising approaches that both rely on the use of superconducting devices based on the Josephson effect. The first one is to use a single Josephson junction (JJ) as a switching detector (i.e. exploiting the superconducting to normal state transition in presence of microwave photons). We designed a device composed of a coplanar waveguide terminated on a current biased Josephson junction. We tested its efficiency to pulsed (pulse duration 10 ns) microwave signals, since this configuration is closer to an actual axions search experiment. We show how our device is able to reach detection capability of the order of 10 photons with frequency 8 GHz. The second approach is based on an intrinsically quantum device formed by two resonators coupled only via a superconducting qubit network (SQN). This approach relies on quantum nondemolition measurements of the resonator photons. We show that injecting RF power into the resonator, the frequency position of the resonant drop in the transmission coefficient (S21) can be modulated up to 4 MHz. We anticipate that, once optimized, both the devices have the potential to reach single photon sensitivity.
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- 2023
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32. Stability estimates for nonlocal balance laws arising in traffic modelling
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Chiarello, Felisia Angela and Contreras, Harold Deivi
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Mathematics - Analysis of PDEs ,35L65, 35L60, 35L04, 90B20 - Abstract
This paper focuses on the proof of the stability of entropy weak solutions of a nonlocal balance law modeling vehicular traffic flow on a road with on- and off-ramps. The stability is obtained with respect to a kernel function in the source term. We get an estimate of the L1-dependence of the solution with respect to the initial datum, the on-ramp rate, the off-ramp rate and the mentioned kernel function. We also show numerical experiments in order to perform an optimization problem in traffic flow with on-ramps.
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- 2023
33. A novel molecule reduces cocoon production loss in BmNPV-infected Bombyx mori larvae
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De La Cruz Cisneros, Jully Jesus, Cabral, Lucas Costa, Caligari, Daniel, Silva, Alessandra Aparecida, Chiarello, Alex Sandro Gularte, de Fátima Chasko Ribeiro, Lucinéia, Costa, Rose Meire, Gigliolli, Adriana Aparecida Sinópolis, Lapenta, Ana Silvia, Ramos, Anelise Cardoso, Seixas, Flávio Augusto Vicente, and Fernandez, Maria Aparecida
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- 2024
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34. Adult-Onset Case of Female Idiopathic Hypogonadotropic Hypogonadism and Ataxia: Genetic Background
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Paola Chiarello, Giuseppe Seminara, Sabrina Bossio, Valentina Rocca, Emma Colao, Rodolfo Iuliano, and Antonio Aversa
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hypogonadotropic hypogonadism ,infertility ,cerebellar ataxia ,amenorrhea ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Adult-onset cases of idiopathic hypogonadotropic hypogonadism (IHH) are characterized by partial or normal puberty development until adolescence and by the impairment of the hypothalamic–pituitary–gonadal (HPG) axis in adulthood. WDR11 and DCC genes are known to be involved in axonal development, particularly of hypothalamic GnRH neurons, and ciliogenesis. We report a female case of adult-onset hypogonadism and cerebellar ataxia, in which we identified two gene mutations. A panel of 48 genes was set up to search for variants in the causative genes of CHH. The variants found were analyzed following the American College of Medical Genetics and Genomics (ACMG) criteria to define their pathogenicity. We identified a missense heterozygous variant in the WDR11 gene NM_018117.12:c.2306T>G (p.Met769Arg) and a mutation in a second gene DCC resulting in amino acid substitutions NM_005215.4:c.3533C>T (p.Ser1178Phe). These variants were classified as being of uncertain clinical significance. We assume that there is a link between the variants found and the impairment of the gonadotrophic and neurological phenotype of the patient. Therefore, we propose the genetic test to identify the best therapeutic approach to identify infertility in female patients with IHH; we believe it is necessary to test WDR11 and DCC genes in larger populations with the same condition to introduce it in future protocols of assessment.
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- 2024
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35. De La Chapelle Syndrome: Clinical and Physical Performance Implications
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Paola Chiarello, Giuseppe Seminara, Sabrina Bossio, Luciana Sicilia, Francesca Greco, Paola Malatesta, Emanuela Alessandra Greco, and Antonio Aversa
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gynecomastia ,hypogonadism ,rare disease ,DSD ,short stature ,physical performance ,Psychology ,BF1-990 ,Special aspects of education ,LC8-6691 ,Medicine (General) ,R5-920 - Abstract
Gynecomastia in adolescence is a benign condition that mostly disappears spontaneously within approximately two years from onset. When it is associated with hypogonadism, it may suggest a disorder of sexual differentiation. We report the case of a young man (18 years old) with gynecomastia associated with azoospermia, small testes, hyperestrogenism and hypergonadotropic hypogonadism. A karyotype 46,XX was found, and searching for SRY (sex-determining region Y) by fluorescence in situ hybridization (FISH) highlighted the presence of the gene on the terminal region of the short arm, with breakpoints likely in Xp22.3 and Yp11.3. Implications of testosterone replacement therapy with respect to sex differentiation disorder and to physical performance are discussed.
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- 2024
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36. The Tracking performance for the IDEA drift chamber
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Elmetenawee, Walaa, chiarello, gianluigi, Corvaglia, Alessandro, Cuna, Federica, De Filippis, Nicola, Gorini, Edoardo, Grancagnolo, Francesco, Maggi, Marcello, Miccoli, Alessandro, Panareo, Marco, Primavera, Margherita, Tassielli, Giovanni Francesco, and Ventura, Andrea
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Physics - Instrumentation and Detectors - Abstract
The IDEA detector concept for a future e$^{+}$e$^{-}$ collider adopts an ultra-low mass drift chamber as a central tracking system. The He-based ultra-low mass drift chamber is designed to provide efficient tracking, a high-precision momentum measurement, and excellent particle identification by exploiting the cluster counting technique. This paper describes the expected tracking performance, obtained with full and fast simulation, for track reconstruction on detailed simulated physics events. Moreover, the details of the construction parameters of the drift chamber, including the inspection of new material for the wires, new techniques for soldering the wires, the development of an improved schema for the drift cell, and the choice of a gas mixture, will be described.
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- 2022
37. THz optical beat-note detection with a fast Hot Electron Bolometer operating up to 31 GHz
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Torrioli, G., Forrer, A., Beck, M., Carelli, P., Chiarello, F., Faist, J., Gaggero, A., Giovine, E., Martini, F., Senica, U., Leoni, R., Scalari, G., and Cibella, S.
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Physics - Optics ,Physics - Instrumentation and Detectors - Abstract
We study the performance of an hot-electron bolometer (HEB) operating at THz frequencies based on superconducting niobium nitride films. We report on the voltage response of the detector over a large optical bandwidth carried out with different THz sources. We show that the impulse response of the fully packaged HEB at 7.5 K has a 3 dB cut-off around 2 GHz. Remarkably, detection capability is still observed above 30 GHz in an heterodyne beating experiment using a THz quantum cascade laser frequency comb. Additionally, the HEB sensitivity has been evaluated and an optical noise equivalent power NEP of 0.8 pW/sqrt(Hz) has been measured at 1 MHz.
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- 2022
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38. Particle identification with the cluster counting technique for the IDEA drift chamber
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Caputo, Claudio, Chiarello, Gianluigi, Corvaglia, Alessandro, Cuna, Federica, D'Anzi, Brunella, De Filippis, Nicola, Elmetenawee, Walaa, Gorini, Edoardo, Grancagnolo, Francesco, Greco, Matteo, Gribanov, Sergei, Johnson, Kurtis, Miccoli, Alessandro, Panareo, Marco, Popov, Alexander, Primavera, Margherita, Taliercio, Angela, Tassielli, Giovanni Francesco, Ventura, Andrea, and Xin, Shuiting
- Subjects
High Energy Physics - Experiment ,Physics - Instrumentation and Detectors - Abstract
IDEA (Innovative Detector for an Electron-positron Accelerator) is a general-purpose detector concept, designed to study electron-positron collisions in a wide energy range from a very large circular leptonic collider. Its drift chamber is designed to provide an efficient tracking, a high precision momentum measurement and an excellent particle identification by exploiting the application of the cluster counting technique. To investigate the potential of the cluster counting techniques on physics events, a simulation of the ionization clusters generation is needed, therefore we developed an algorithm which can use the energy deposit information provided by Geant4 toolkit to reproduce, in a fast and convenient way, the clusters number distribution and the cluster size distribution. The results obtained confirm that the cluster counting technique allows to reach a resolution 2 times better than the traditional dE/dx method. A beam test has been performed during November 2021 at CERN on the H8 to validate the simulations results, to define the limiting effects for a fully efficient cluster counting and to count the number of electron clusters released by an ionizing track at a fixed $\beta\gamma$ as a function of the track angle. The simulation and the beam test results will be described briefly in this issue., Comment: 2 pages, 4 figures, Proceedings of: PM2021
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- 2022
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39. An Interactive Digital Experience to Enhance the Cultural Heritage of the Town of Gallipoli: The Gallipoli MAB Project.
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Carola Gatto, Sofia Chiarello, Laura Corchia, Federica Faggiano, and Lucio Tommaso De Paolis
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- 2024
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40. Extended Reality in Performing Arts: Enhancing the Experience of Archaeological Heritage.
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Carola Gatto, Sofia Chiarello, Federica Faggiano, Giovanna Ilenia Paladini, Giada Sumerano, and Lucio Tommaso De Paolis
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- 2024
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41. Teaching and Recognition of Skills in the Digital Era Through OER-Based Personalized and Gamified Learning: The ENCORE Project.
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Antonio Bucchiarone, Filippo Chiarello, Juliana Elisa Raffaghelli, Vito Giordano, Andrea Vázquez-Ingelmo, Gianluca Schiavo, Alessandra Antonaci, Valentina Grion, and Alessandro Guadagni
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- 2024
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42. Oxidative Stress in Preeclampsia and Preterm Newborn
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Abad, C., Chiarello, D. I., Rojas, D., Beretta, V., Perrone, S., Marín, R., Andreescu, Silvana, editor, Henkel, Ralf, editor, and Khelfi, Abderrezak, editor
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- 2024
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43. Stability Estimates for Nonlocal Balance Laws Arising in Traffic Modelling
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Chiarello, Felisia A., Contreras, Harold D., Castro, Carlos, Editor-in-Chief, Formaggia, Luca, Editor-in-Chief, Groppi, Maria, Series Editor, Larson, Mats G., Series Editor, Lopez Fernandez, Maria, Series Editor, Morales de Luna, Tomás, Series Editor, Pareschi, Lorenzo, Series Editor, Vázquez-Cendón, Elena, Series Editor, Zunino, Paolo, Series Editor, Parés, Carlos, editor, Castro, Manuel J., editor, and Muñoz-Ruiz, María Luz, editor
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- 2024
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44. Trafficking in Persons Vis-à-Vis the Recent Jurisprudence of the Inter-American Court of Human Rights: Lessons for Brazil
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Atchabahian, Ana Cláudia Ruy Cardia, de Souza Pinto, Felipe Chiarello, Rodrigues, Anabela Miranda, editor, and Guia, Maria João, editor
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- 2024
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45. Linearly multiplexed Photon Number Resolving single-photon detectors array
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Limongi, Leonardo, Martini, Francesco, Dao, Thu Ha, Gaggero, Alessandro, Hasnaoui, Hamza, Lopez-Gonzalez, Igor, Chiarello, Fabio, De Matteis, Fabio, Quaranta, Alberto, Salamon, Andrea, Mattioli, Francesco, Bernard, Martino, and Lobino, Mirko
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- 2025
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46. SÍNDROME HEREDITÁRIA HIPERFERRITINEMIA-CATARATA - UM RELATO DE CASO NO INTERIOR DO RIO GRANDE DO SUL
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AA Hofmann, TD Mora, A Pagnussat, MH Muller, G Wichnovski, and JG Chiarello
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
Objetivo: Relatar caso de síndrome de hiperferritinemia-catarata congênita. Introdução: A síndrome hiperferritinemia-catarata (SHC) é uma condição genética autossômica dominante rara, caracterizada pelo elevado nível sérico de ferritina. A regulação da concentração intracelular de ferro é mediada pela região 5’UTR do gene da cadeia leve da ferritina (FTL), situado no cromossomo 19q13 e por proteínas reguladoras de ferro. Dessa forma, quando há mutações específicas nessa região, o ferro é incapaz de se ligar à sua proteína reguladora. Com isso, os níveis de ferritina aumentam consideravelmente devido à síntese constante de FTL, sem sobrecarga de ferro. Essa síndrome apresenta-se precocemente através da catarata bilateral devido ao acúmulo de ferritina no cristalino, no entanto, por ser uma condição rara, muitos pacientes são diagnosticados erroneamente. Relato de caso: Paciente do sexo feminino, caucasiana, 10 anos, assintomática, foi encaminhada ao serviço de hematologia em por apresentar aumento nos níveis séricos de ferritina (1.129 ng/mL), perfil ferro dentro da normalidade, sem diagnóstico estabelecido. Os exames laboratoriais foram repetidos e ampliados para investigação de condições inflamatórias associadas. Resultados dos exames demonstraram permanência da hiperferritinemia sem sinais de sobrecarga de ferro. Provas autoimunes e reumatológicas negativas, assim como as sorologias e função renal e hepática. Prosseguindo a investigação de doenças familiares, a mãe da paciente referiu ter sido diagnosticada com catarata aos 15 anos. Devido à suspeição de síndrome de hiperferritinemia-catarata hereditária, fizemos anamnese direcionada e questionamos a paciente sobre alteração visual, a mesma afirmou turvamento visual e visão embaçada, dessa forma, foi encaminhada para avaliação com o oftalmologista, confirmando catarata e encaminhada para correção cirúrgica. Discussão: A SHC é uma doença autossômica dominante rara, causada por mutações na região 5’UTR do gene FTL. No Brasil, a prevalência dessa doença é desconhecida e muitos casos tendem a ser subestimados já que esse distúrbio é frequentemente diagnosticado erroneamente como hemocromatose hereditária, uma patologia que também cursa com hiperferritinemia, porém há sobrecarga de ferro associada. Os achados patognomônicos da SHC incluem catarata congênita com níveis elevados de ferritina em exames laboratoriais, enquanto os níveis ferro sérico e saturação de transferrina são normais. A hipótese mais aceita para o desenvolvimento da catarata bilateral é o acúmulo de de ferritina depositada na forma de cristais precipitados no córtex do cristalino. Ainda, a morfologia das cataratas na SHC difere dos outros tipos de catarata, o que pode ser útil para o diagnóstico da patologia. De acordo com outros relatos de SHC publicados, o diagnóstico é frequentemente confirmado por pesquisa de mutações na região 5’UTR do gene FTL, o que contribui para diagnóstico preciso e tratamento adequado. Todavia, não dispomos de exames genéticos e diante das características clínicas, laboratoriais e histórico familiar, o distúrbio pode ser manejado como SHC. Conclusão: Em pacientes com SHC, a única anormalidade clínica é a presença de catarata congênita. Portanto, é essencial que médicos oftalmologistas testem os níveis de ferritina durante a investigação de cataratas, principalmente em crianças. Da mesma forma, toda a hiperferritinemia inexplicada deve ser encaminhada para avaliação oftalmológica pois, mesmo que assintomática, o diagnóstico correto favorece intervenções específicas em tempo adequado. Ademais, relatos como este são necessários, visto que essa condição é extremamente rara e há escassa literatura sobre o tema.
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- 2024
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47. The Athena X-ray Integral Field Unit: a consolidated design for the system requirement review of the preliminary definition phase
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Barret, Didier, Albouys, Vincent, Herder, Jan-Willem den, Piro, Luigi, Cappi, Massimo, Huovelin, Juhani, Kelley, Richard, Mas-Hesse, J. Miguel, Paltani, Stéphane, Rauw, Gregor, Rozanska, Agata, Svoboda, Jiri, Wilms, Joern, Yamasaki, Noriko, Audard, Marc, Bandler, Simon, Barbera, Marco, Barcons, Xavier, Bozzo, Enrico, Ceballos, Maria Teresa, Charles, Ivan, Costantini, Elisa, Dauser, Thomas, Decourchelle, Anne, Duband, Lionel, Duval, Jean-Marc, Fiore, Fabrizio, Gatti, Flavio, Goldwurm, Andrea, Hartog, Roland den, Jackson, Brian, Jonker, Peter, Kilbourne, Caroline, Korpela, Seppo, Macculi, Claudio, Mendez, Mariano, Mitsuda, Kazuhisa, Molendi, Silvano, Pajot, François, Pointecouteau, Etienne, Porter, Frederick, Pratt, Gabriel W., Prêle, Damien, Ravera, Laurent, Sato, Kosuke, Schaye, Joop, Shinozaki, Keisuke, Skup, Konrad, Soucek, Jan, Thibert, Tanguy, Vink, Jacco, Webb, Natalie, Chaoul, Laurence, Raulin, Desi, Simionescu, Aurora, Torrejon, Jose Miguel, Acero, Fabio, Branduardi-Raymont, Graziella, Ettori, Stefano, Finoguenov, Alexis, Grosso, Nicolas, Kaastra, Jelle, Mazzotta, Pasquale, Miller, Jon, Miniutti, Giovanni, Nicastro, Fabrizio, Sciortino, Salvatore, Yamaguchi, Hiroya, Beaumont, Sophie, Cucchetti, Edoardo, D'Andrea, Matteo, Eckart, Megan, Ferrando, Philippe, Kammoun, Elias, Lotti, Simone, Mesnager, Jean-Michel, Natalucci, Lorenzo, Peille, Philippe, de Plaa, Jelle, Ardellier, Florence, Argan, Andrea, Bellouard, Elise, Carron, Jérôme, Cavazzuti, Elisabetta, Fiorini, Mauro, Khosropanah, Pourya, Martin, Sylvain, Perry, James, Pinsard, Frederic, Pradines, Alice, Rigano, Manuela, Roelfsema, Peter, Schwander, Denis, Torrioli, Guido, Ullom, Joel, Vera, Isabel, Villegas, Eduardo Medinaceli, Zuchniak, Monika, Brachet, Frank, Cicero, Ugo Lo, Doriese, William, Durkin, Malcom, Fioretti, Valentina, Geoffray, Hervé, Jacques, Lionel, Kirsch, Christian, Smith, Stephen, Adams, Joseph, Gloaguen, Emilie, Hoogeveen, Ruud, van der Hulst, Paul, Kiviranta, Mikko, van der Kuur, Jan, Ledot, Aurélien, van Leeuwen, Bert-Joost, van Loon, Dennis, Lyautey, Bertrand, Parot, Yann, Sakai, Kazuhiro, van Weers, Henk, Abdoelkariem, Shariefa, Adam, Thomas, Adami, Christophe, Aicardi, Corinne, Akamatsu, Hiroki, Alonso, Pablo Eleazar Merino, Amato, Roberta, André, Jérôme, Angelinelli, Matteo, Anon-Cancela, Manuel, Anvar, Shebli, Atienza, Ricardo, Attard, Anthony, Auricchio, Natalia, Balado, Ana, Bancel, Florian, Barusso, Lorenzo Ferrari, Bernard, Vivian, Berrocal, Alicia, Blin, Sylvie, Bonino, Donata, Bonnet, François, Bonny, Patrick, Boorman, Peter, Boreux, Charles, Bounab, Ayoub, Boutelier, Martin, Boyce, Kevin, Brienza, Daniele, Bruijn, Marcel, Bulgarelli, Andrea, Calarco, Simona, Callanan, Paul, Camus, Thierry, Canourgues, Florent, Capobianco, Vito, Cardiel, Nicolas, Castellani, Florent, Cheatom, Oscar, Chervenak, James, Chiarello, Fabio, Clerc, Nicolas, Clerc, Laurent, Cobo, Beatriz, Coeur-Joly, Odile, Coleiro, Alexis, Colonges, Stéphane, Corcione, Leonardo, Coriat, Mickael, Coynel, Alexandre, Cuttaia, Francesco, D'Ai, Antonino, D'anca, Fabio, Dadina, Mauro, Daniel, Christophe, DeNigris, Natalie, Dercksen, Johannes, DiPirro, Michael, Doumayrou, Eric, Dubbeldam, Luc, Dupieux, Michel, Dupourqué, Simon, Durand, Jean Louis, Eckert, Dominique, Eiriz, Valvanera, Ercolani, Eric, Etcheverry, Christophe, Finkbeiner, Fred, Fiocchi, Mariateresa, Fossecave, Hervé, Franssen, Philippe, Frericks, Martin, Gabici, Stefano, Gant, Florent, Gao, Jian-Rong, Gastaldello, Fabio, Genolet, Ludovic, Ghizzardi, Simona, Gil, M Angeles Alcacera, Giovannini, Elisa, Godet, Olivier, Gomez-Elvira, Javier, Gonzalez, Manuel, Gonzalez, Raoul, Gottardi, Luciano, Granat, Dolorès, Gros, Michel, Guignard, Nicolas, Hieltjes, Paul, Hurtado, Adolfo Jesus, Irwin, Kent, Jacquey, Christian, Janiuk, Agnieszka, Jaubert, Jean, Jiménez, Maria, Jolly, Antoine, Jourdan, Thierry, Julien, Sabine, Kedziora, Bartosz, Korb, Andrew, Kreykenbohm, Ingo, König, Ole, Langer, Mathieu, Laudet, Philippe, Laurent, Philippe, Laurenza, Monica, Lesrel, Jean, Ligori, Sebastiano, Lorenz, Maximilian, Luminari, Alfredo, Maffei, Bruno, Maisonnave, Océane, Marelli, Lorenzo, Massonet, Didier, Maussang, Irwin, Melchor, Alejandro Gonzalo, Mer, Isabelle Le, Michalski, Lea, Millerioux, Jean-Pierre, Mineo, Teresa, Minervini, Gabriele, Molin, Alexeï, Monestes, David, Montinaro, Nicola, Mot, Baptiste, Murat, David, Nagayoshi, Kenichiro, Nazé, Yaël, Noguès, Loïc, Pailot, Damien, Panessa, Francesca, Parodi, Luigi, Petit, Pascal, Piconcelli, Enrico, Pinto, Ciro, Plaza, Jose Miguel Encinas, Poyatos, David, Prouvé, Thomas, Ptak, Andy, Puccetti, Simonetta, Puccio, Elena, Ramon, Pascale, Reina, Manuel, Rioland, Guillaume, Rodriguez, Louis, Roig, Anton, Rollet, Bertrand, Roncarelli, Mauro, Roudil, Gilles, Rudnicki, Tomasz, Sanisidro, Julien, Sciortino, Luisa, Silva, Vitor, Sordet, Michael, Soto-Aguilar, Javier, Spizzi, Pierre, Surace, Christian, Sánchez, Miguel Fernández, Taralli, Emanuele, Terrasa, Guilhem, Terrier, Régis, Todaro, Michela, Ubertini, Pietro, Uslenghi, Michela, de Vaate, Jan Geralt Bij, Vaccaro, Davide, Varisco, Salvatore, Varnière, Peggy, Vibert, Laurent, Vidriales, María, Villa, Fabrizio, Vodopivec, Boris Martin, Volpe, Angela, de Vries, Cor, Wakeham, Nicholas, Walmsley, Gavin, Wise, Michael, de Wit, Martin, and Woźniak, Grzegorz
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics - Abstract
The Athena X-ray Integral Unit (X-IFU) is the high resolution X-ray spectrometer, studied since 2015 for flying in the mid-30s on the Athena space X-ray Observatory, a versatile observatory designed to address the Hot and Energetic Universe science theme, selected in November 2013 by the Survey Science Committee. Based on a large format array of Transition Edge Sensors (TES), it aims to provide spatially resolved X-ray spectroscopy, with a spectral resolution of 2.5 eV (up to 7 keV) over an hexagonal field of view of 5 arc minutes (equivalent diameter). The X-IFU entered its System Requirement Review (SRR) in June 2022, at about the same time when ESA called for an overall X-IFU redesign (including the X-IFU cryostat and the cooling chain), due to an unanticipated cost overrun of Athena. In this paper, after illustrating the breakthrough capabilities of the X-IFU, we describe the instrument as presented at its SRR, browsing through all the subsystems and associated requirements. We then show the instrument budgets, with a particular emphasis on the anticipated budgets of some of its key performance parameters. Finally we briefly discuss on the ongoing key technology demonstration activities, the calibration and the activities foreseen in the X-IFU Instrument Science Center, and touch on communication and outreach activities, the consortium organisation, and finally on the life cycle assessment of X-IFU aiming at minimising the environmental footprint, associated with the development of the instrument. Thanks to the studies conducted so far on X-IFU, it is expected that along the design-to-cost exercise requested by ESA, the X-IFU will maintain flagship capabilities in spatially resolved high resolution X-ray spectroscopy, enabling most of the original X-IFU related scientific objectives of the Athena mission to be retained. (abridged)., Comment: 48 pages, 29 figures, Accepted for publication in Experimental Astronomy with minor editing
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- 2022
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48. The measuring systems of the wire tension for the MEG II Drift Chamber by means of the resonant frequency technique
- Author
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Baldini, A. M., Benmansour, H., Cavoto, G., Cei, F., Chiappini, M., Chiarello, G., Chiri, C., Cocciolo, G., Corvaglia, A., Cuna, F., Francesconi, M., Galli, L., Grancagnolo, F., Grassi, M., Meucci, M., Miccoli, A., Nicolo', D., Panareo, M., Papa, A., Pinto, C., Raffaelli, F., Renga, F., Signorelli, G., Tassielli, G. F., Venturini, A., Vitali, B., and Voena, C.
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Physics - Instrumentation and Detectors - Abstract
The ultra-low mass cylindrical drift chamber designed for the MEG II experiment is a challenging apparatus made of 1728 phi = 20 micron gold plated tungsten sense wires, 7680 phi = 40 micron and 2496 phi = 50 micron silver plated aluminum field wires. Because of electrostatic stability requirements all the wires have to be stretched at mechanical tensions of about 25, 19 and 29 g respectively which must be controlled at a level better than 0.5 g. This chamber is presently in acquisition, but during its construction about 100 field wires broke, because of chemical corrosion induced by the atmospheric humidity. On the basis of the experience gained with this chamber we decided to build a new one, equipped with a different type of wires less sensitive to corrosion. The choice of the new wire required a deep inspection of its characteristics and one of the main tools for doing this is a system for measuring the wire tension by means of the resonant frequency technique, which is described in this paper. The system forces the wires to oscillate by applying a sinusoidal signal at a known frequency, and then measures the variation of the capacitance between a wire and a common ground plane as a function of the external signal frequency. We present the details of the measuring system and the results obtained by scanning the mechanical tensions of two samples of MEG II cylindrical drift chamber wires and discuss the possible improvements of the experimental apparatus and of the measuring technique., Comment: Nineteen pages, thirteen figures, published on Nuclear Instruments and Methods A
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- 2022
49. ATHENA X-IFU Demonstration Model: First joint operation of the main TES Array and its Cryogenic AntiCoincidence Detector (CryoAC)
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D'Andrea, M., Ravensberg, K., Argan, A., Brienza, D., Lotti, S., Macculi, C., Minervini, G., Piro, L., Torrioli, G., Chiarello, F., Barusso, L. Ferrari, Biasotti, M., Gallucci, G., Gatti, F., Rigano, M., Akamatsu, H., Dercksen, J., Gottardi, L., de Groote, F., Hartog, R. den, Herder, J. -W. den, Hoogeveen, R., Jackson, B., McCalden, A., Rosman, S., Taralli, E., Vaccaro, D., de Wit, M., Chervenak, J., Smith, S., and Wakeham, N.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Physics - Instrumentation and Detectors - Abstract
The X-IFU is the cryogenic spectrometer onboard the future ATHENA X-ray observatory. It is based on a large array of TES microcalorimeters, which works in combination with a Cryogenic AntiCoincidence detector (CryoAC). This is necessary to reduce the particle background level thus enabling part of the mission science goals. Here we present the first joint test of X-IFU TES array and CryoAC Demonstration Models, performed in a FDM setup. We show that it is possible to operate properly both detectors, and we provide a preliminary demonstration of the anti-coincidence capability of the system achieved by the simultaneous detection of cosmic muons., Comment: Accepted for publication in the Journal of Low Temperature Physics for LTD-19 special issue
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- 2022
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50. Macroscopic limits of non-local kinetic descriptions of vehicular traffic
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Chiarello, Felisia Angela and Tosin, Andrea
- Subjects
Condensed Matter - Statistical Mechanics ,Mathematical Physics ,Physics - Physics and Society ,35Q20, 35Q70, 90B20 - Abstract
We study the derivation of macroscopic traffic models out of optimal speed and follow-the-leader particle dynamics as hydrodynamic limits of non-local Povzner-type kinetic equations. As a first step, we show that optimal speed vehicle dynamics produce a first order macroscopic model with non-local flux. Next, we show that non-local follow-the-leader vehicle dynamics have a universal macroscopic counterpart in the second order Aw-Rascle-Zhang traffic model, at least when the non-locality of the interactions is sufficiently small. Finally, we show that the same qualitative result holds also for a general class of follow-the-leader dynamics based on the headway of the vehicles rather than on their speed. We also investigate the correspondence between the solutions to particle models and their macroscopic limits by means of numerical simulations., Comment: 24 pages, 11 figures
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- 2022
- Full Text
- View/download PDF
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