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1. Radiation dose from medical imaging in end stage renal disease patients: a Nationwide Italian Survey

Author: Postorino, M, Lizio, D, De Mauri, A, Marino, C, Tripepi, G, Zoccali, C, Brambilla, M, Balestra, E, Bellino, D, Benevento, R, Bregant, C, Bregant, P, Cannillo, B, Casto, G, Chiarinotti, D, Cimolai, S, Colussi, G, De Agostini, A, Declich, F, Facchini, M, Galione, M, Gavotti, C, Gerini, U, Isoardi, P, Izzo, C, Levrero, F, Lorenzon, E, Maffei, S, Maggi, S, Mari, A, Mattana, F, Menegotto, A, Meniconi, O, Paruccini, N, Pierotti, L, Pieruzzi, F, Pontoriero, G, Postorino, A, Quaglia, M, Rampado, O, Ranghino, A, Reccanello, S, Sabatino, S, Sangalli, G, Sottocornola, C, Sutto, M, Tata, S, Torresin, A, Traino, A, Trianni, A, Zeni, L, Postorino M., Lizio D., De Mauri A., Marino C., Tripepi G. L., Zoccali C., Brambilla M., Balestra E., Bellino D., Benevento R., Bregant C., Bregant P., Cannillo B., Casto G., Chiarinotti D., Cimolai S., Colussi G., De Agostini A., Declich F., Facchini M. G., Galione M. A., Gavotti C., Gerini U., Isoardi P., Izzo C., Levrero F., Lorenzon E., Maffei S., Maggi S., Mari A., Mattana F., Menegotto A., Meniconi O., Paruccini N., Pierotti L., Pieruzzi F., Pontoriero G., Postorino A., Quaglia M., Rampado O., Ranghino A., Reccanello S., Sabatino S., Sangalli G., Sottocornola C., Sutto M., Tata S., Torresin A., Traino A., Trianni A., Zeni L., Postorino, M, Lizio, D, De Mauri, A, Marino, C, Tripepi, G, Zoccali, C, Brambilla, M, Balestra, E, Bellino, D, Benevento, R, Bregant, C, Bregant, P, Cannillo, B, Casto, G, Chiarinotti, D, Cimolai, S, Colussi, G, De Agostini, A, Declich, F, Facchini, M, Galione, M, Gavotti, C, Gerini, U, Isoardi, P, Izzo, C, Levrero, F, Lorenzon, E, Maffei, S, Maggi, S, Mari, A, Mattana, F, Menegotto, A, Meniconi, O, Paruccini, N, Pierotti, L, Pieruzzi, F, Pontoriero, G, Postorino, A, Quaglia, M, Rampado, O, Ranghino, A, Reccanello, S, Sabatino, S, Sangalli, G, Sottocornola, C, Sutto, M, Tata, S, Torresin, A, Traino, A, Trianni, A, Zeni, L, Postorino M., Lizio D., De Mauri A., Marino C., Tripepi G. L., Zoccali C., Brambilla M., Balestra E., Bellino D., Benevento R., Bregant C., Bregant P., Cannillo B., Casto G., Chiarinotti D., Cimolai S., Colussi G., De Agostini A., Declich F., Facchini M. G., Galione M. A., Gavotti C., Gerini U., Isoardi P., Izzo C., Levrero F., Lorenzon E., Maffei S., Maggi S., Mari A., Mattana F., Menegotto A., Meniconi O., Paruccini N., Pierotti L., Pieruzzi F., Pontoriero G., Postorino A., Quaglia M., Rampado O., Ranghino A., Reccanello S., Sabatino S., Sangalli G., Sottocornola C., Sutto M., Tata S., Torresin A., Traino A., Trianni A., and Zeni L.
Abstract: Background and objectives: End stage renal disease (ESRD) patients are exposed to the risk of ionizing radiation during repeated imaging studies. The variability in diagnostic imaging policies and the accompanying radiation doses across various renal units is still unknown. We studied this variability at the centre level and quantified the associated radiation doses at the patient level. Methods: Fourteen Italian nephrology departments enrolled 739 patients on haemodialysis and 486 kidney transplant patients. The details of the radiological procedures performed over one year were recorded. The effective doses and organ doses of radiation were estimated for each patient using standardized methods to convert exposure parameters into effective and organ doses Results: Computed tomography (CT) was the major contributor (> 77%) to ionizing radiation exposure. Among the haemodialysis and kidney transplant patients, 15% and 6% were in the high (≥ 20 mSv per year) radiation dose groups, respectively. In haemodialysis patients, the most exposed organs were the liver (16 mSv), the kidney (15 mSv) and the stomach (14 mSv), while the uterus (6.2 mSv), the lung (5.7 mSv) and the liver (5.5 mSv) were the most exposed in kidney transplant patients. The average cumulative effective dose (CED) of ionizing radiation among centres in this study was highly variable both in haemodialysis (from 6.4 to 18.8 mSv per patient-year; p = 0.018) and even more so in kidney transplant (from 0.6 to 13.7 mSv per patient-year; p = 0.002) patients. Conclusions: Radiation exposure attributable to medical imaging is high in distinct subgroups of haemodialysis and transplant patients. Furthermore, there is high inter-centre variability in radiation exposure, suggesting that nephrology units have substantially different clinical policies for the application of diagnostic imaging studies.
Published: 2021

2. Radiation dose from medical imaging in end stage renal disease patients: a Nationwide Italian Survey

Author: Postorino M., Lizio D., De Mauri A., Marino C., Tripepi G. L., Zoccali C., Brambilla M., Balestra E., Bellino D., Benevento R., Bregant C., Bregant P., Cannillo B., Casto G., Chiarinotti D., Cimolai S., Colussi G., De Agostini A., Declich F., Facchini M. G., Galione M. A., Gavotti C., Gerini U., Isoardi P., Izzo C., Levrero F., Lorenzon E., Maffei S., Maggi S., Mari A., Mattana F., Menegotto A., Meniconi O., Paruccini N., Pierotti L., Pieruzzi F., Pontoriero G., Postorino A., Quaglia M., Rampado O., Ranghino A., Reccanello S., Sabatino S., Sangalli G., Sottocornola C., Sutto M., Tata S., Torresin A., Traino A., Trianni A., Zeni L., Postorino, M, Lizio, D, De Mauri, A, Marino, C, Tripepi, G, Zoccali, C, Brambilla, M, Balestra, E, Bellino, D, Benevento, R, Bregant, C, Bregant, P, Cannillo, B, Casto, G, Chiarinotti, D, Cimolai, S, Colussi, G, De Agostini, A, Declich, F, Facchini, M, Galione, M, Gavotti, C, Gerini, U, Isoardi, P, Izzo, C, Levrero, F, Lorenzon, E, Maffei, S, Maggi, S, Mari, A, Mattana, F, Menegotto, A, Meniconi, O, Paruccini, N, Pierotti, L, Pieruzzi, F, Pontoriero, G, Postorino, A, Quaglia, M, Rampado, O, Ranghino, A, Reccanello, S, Sabatino, S, Sangalli, G, Sottocornola, C, Sutto, M, Tata, S, Torresin, A, Traino, A, Trianni, A, and Zeni, L
Subjects: Nephrology, medicine.medical_specialty, 030232 urology & nephrology, 030204 cardiovascular system & hematology, Radiation Dosage, Effective dose (radiation), End stage renal disease, Ionizing radiation, Haemodialysi, Kidney transplantation, 03 medical and health sciences, 0302 clinical medicine, Radiation dosimetry, Renal Dialysis, Internal medicine, Medical imaging, medicine, Humans, Cancer, Kidney, business.industry, Stomach, medicine.disease, medicine.anatomical_structure, Italy, Kidney Failure, Chronic, Female, Radiology, business, Tomography, X-Ray Computed
Abstract: Background and objectives: End stage renal disease (ESRD) patients are exposed to the risk of ionizing radiation during repeated imaging studies. The variability in diagnostic imaging policies and the accompanying radiation doses across various renal units is still unknown. We studied this variability at the centre level and quantified the associated radiation doses at the patient level. Methods: Fourteen Italian nephrology departments enrolled 739 patients on haemodialysis and 486 kidney transplant patients. The details of the radiological procedures performed over one year were recorded. The effective doses and organ doses of radiation were estimated for each patient using standardized methods to convert exposure parameters into effective and organ doses Results: Computed tomography (CT) was the major contributor (> 77%) to ionizing radiation exposure. Among the haemodialysis and kidney transplant patients, 15% and 6% were in the high (≥ 20mSv per year) radiation dose groups, respectively. In haemodialysis patients, the most exposed organs were the liver (16mSv), the kidney (15mSv) and the stomach (14mSv), while the uterus (6.2mSv), the lung (5.7mSv) and the liver (5.5mSv) were the most exposed in kidney transplant patients. The average cumulative effective dose (CED) of ionizing radiation among centres in this study was highly variable both in haemodialysis (from 6.4 to 18.8mSv per patient-year; p = 0.018) and even more so in kidney transplant (from 0.6 to 13.7mSv per patient-year; p = 0.002) patients. Conclusions: Radiation exposure attributable to medical imaging is high in distinct subgroups of haemodialysis and transplant patients. Furthermore, there is high inter-centre variability in radiation exposure, suggesting that nephrology units have substantially different clinical policies for the application of diagnostic imaging studies.
Published: 2020

3. First considerations on the SARS-CoV-2 epidemic in the Dialysis Units of Piedmont and Aosta Valley, Northern Italy

Author: Manganaro, M., Baldovino, S., Besso, L., Biancone, L., Boero, R., Borzumati, M., Calabrese, G., Cantaluppi, V., Chiappero, F., Chiarinotti, D., Cusinato, S., Filiberti, O., Formica, M., Gianoglio, B., Maffei, S., Manes, M., Roccatello, D., Sacco, C., Salomone, M., Savoldi, S., Tognarelli, G., Viglino, G., Vitale, C., Amoroso, A., and Vanzino, S.
Subjects: Adult, Male, 2019-20 coronavirus outbreak, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Health Personnel, Pneumonia, Viral, Ambulatory Care Facilities, Health personnel, Betacoronavirus, Pandemic, 80 and over, Prevalence, Medicine, Humans, Aged, Aged, 80 and over, Coronavirus Infections, Epidemics, Female, Hospitalization, Italy, Kidney Transplantation, Middle Aged, Pandemics, Peritoneal Dialysis, Preliminary Data, Renal Insufficiency, Chronic, Viral, Renal Insufficiency, Chronic, business.industry, SARS-CoV-2, COVID-19, Pneumonia, Archaeology, Northern italy, Nephrology, Dialysis unit, Dialisis peritoneal, business
Published: 2020

4. NATIVE VASCULAR ACCESS FOR HEMODIALYSIS IN DIABETIC PATIENTS: A SINGLE CENTRE EXPERIENCE

Author: David, P., Navino, C., Capurro, F., Chiarinotti, D., Ruva, C., De Maria, M., Conte, M., De Mauri, A., Brustia, M., and De Leo, M.
Published: 2009

5. MIDDLE ARM ARTERIOVENOUS FISTULA: A RELIABLE AND SAFE HEMODIALYSIS ACCESS TO PRESERVE VASCULAR VESSELS

Author: Capurro, F., Navino, C., David, P., Brustia, M., De Maria, M., De Mauri, A., Conte, M., Chiarinotti, D., Ruva, C. E., and De Leo, M.
Published: 2009

6. REPORT SUI DATI RACCOLTI DURANTE LA GIORNATA MONDIALE DEL RENE IN ITALIA NEGLI ANNI 2015-2016- Report for the World Kidney Days in Italy 2015-2016

Author: Esposito, P, Battaglia, Yuri, Caramella, E, Russo, D, Balducci, A., Aucella, F, Avino, D, Borzumati, M, Botti, P, Brizzi, F, Castellino, S, Cuomo, V, Dagostino, F, De Simone, W, Di Loreto, P, Fiorini, F, Garibotto, G, Iulianiello, G, La Peccerella, L, Mancini, C, Mereu, Mc, Passaghe, M, Prati, E, Re, A, Rondanini, V, Pergamo, O, Simeoni, Ma, Storari, A, Carlini, A, Tedesco, A, Amato, M, Costantino, E, D'Alessandro, V, Montagna, E, Sozzo, E, Lomonte, C, Lisi, P, Parsi, R, Saffiotti, S, Santoro, D, Tira, P, Tosini, R, Gianni, S, Sessa, C, Scafarto, A, Chiarinotti, D, Boero, R, Buonfantino, A, D'Amaro, E, Lus, G, D'Alessandro, A, Cossu, M, Ballestri, M, Gasparro, V, and Vernaglione, L.
Subjects: World Kidney Day, Prevention, Hypertension, Urinalysis
Published: 2017

7. Clinical policies on the management of chronic kidney disease patients in Italy

Author: SIR SIN STUDY INVESTIGATORS ACCIARRI P, MENEGATO MA, ANCARANI E, ANDREUCCI V, ANTONELLI A, AURICCHIO MR, BALDUCCI A, BASSI A, BATTAGLIA G, BELLINGHERI G, BELTRAME A, BIAGINI M, BONFANTE L, BONOFIGLIO R, BONOMINI M, BORGHI M, BRIGANTE M, BUCCIANTI G, BUONGIORNO E, CABIBBE M, CANCARINI G, CAPISTRANO M, CAPPELLI G, CAPUANO M, CASCONE C, CATIZONE L, CATUCCI AE, CAVATORTA F, CHIARINOTTI D, CICCHETTI T, CONCAS G, CONCETTI M, CONTE F, CONTI M, CORATELLI P, CORTI MM, COSTANZO R, DAL CANTON A, D'APICE L, DAVID S, DE CRISTOFARO V, DEFERRARI G, DELLA GROTTA F, DE NICOLA, Luca, DE SANTO NG, DE SIMONE W, DI DANIELE N, DI GIULIO S, DI LANDRO D, DI LUZIO V, DI MAGGIO A, FAGUGLI R, FARINA M, FERIANI M, GALLIENI M, GAMBARO G, GIORDANO R, GRECO S, GRILLO C, HUBER W, LIUZZO G, LOCATELLI F, LOMBARDI L, LOPEZ T, MALBERTI F, MANCINI W, MANENTI F, MANISCO G, MARROCCO A, MATOCCI G, MERICO G, MESSA P, MINUTOLO, Roberto, MONARDO P, MORICONI L, MURRONE P, NARDO A, NASO A, NOBILE R, PANARELLO G, PAONE A, PARRAVANO M, PEDRINI L, PIAZZA V, PISTIS R, PROCIDA M, QUARELLO F, RAPISARDA F, RICCIARDI B, RINDI P, RONCO C, ROTOLO U, RUSSO G, SARANITI A, SASDELLI M, SAVICA V, SCANZIANI R, SIDOTI A, SPOTTI D, STALTERI A, STEFONI S, STELLA A, STRIPPOLI P, TEATINI U, TEODORO C, TOZZO C, TRIOLO G, ZOCCALI C., Locatelli F, Zoccali C, Acciarri P, Menegato MA, Ancarani E, Andreucci V, Antonelli A, Auricchio MR, Balducci A, Bassi A, Battaglia G, Bellingheri G, Beltrame A, Biagini M, Bonfante L, Bonofiglio R, Bonomini M, Borghi M, Brigante M, Buccianti G, Buongiorno E, Cabibbe M, Cancarini G, Capistrano M, Cappelli G, Capuano M, Cascone C, Catizone L, Catucci AE, Cavatorta F, Chiarinotti D, Cicchetti T, Concas G, Concetti M, Conte F, Conti M, Coratelli P, Corti MM, Costanzo R, Dal Canton A, D'Apice L, David S, De Cristofaro V, Deferrari G, Della Grotta F, De Nicola L, De Santo NG, De Simone W, Di Daniele N, Di Giulio S, Di Landro D, Di Luzio V, Di Maggio A, Fagugli R, Farina M, Feriani M, Gallieni M, Gambaro G, Giordano R, Greco S, Grillo C, Huber W, Liuzzo G, Lombardi L, Lopez T, Malberti F, Mancini W, Manenti F, Manisco G, Marrocco A, Matocci G, Merico G, Messa P, Minutolo R, Monardo P, Moriconi L, Murrone P, Nardo A, Naso A, Nobile R, Panarello G, Paone A, Parravano M, Pedrini L, Piazza V, Pistis R, Procida M, Quarello F, Rapisarda F, Ricciardi B, Rindi P, Ronco C, Rotolo U, Russo G, Saraniti A, Sasdelli M, Savica V, Scanziani R, Sidoti A, Spotti D, Stalteri A, Stefoni S, Stella A, Strippoli P, Teatini U, Teodoro C, Tozzo C, Triolo G., SIR SIN STUDY INVESTIGATORS ACCIARRI, P, Menegato, Ma, Ancarani, E, Andreucci, V, Antonelli, A, Auricchio, Mr, Balducci, A, Bassi, A, Battaglia, G, Bellingheri, G, Beltrame, A, Biagini, M, Bonfante, L, Bonofiglio, R, Bonomini, M, Borghi, M, Brigante, M, Buccianti, G, Buongiorno, E, Cabibbe, M, Cancarini, G, Capistrano, M, Cappelli, G, Capuano, M, Cascone, C, Catizone, L, Catucci, Ae, Cavatorta, F, Chiarinotti, D, Cicchetti, T, Concas, G, Concetti, M, Conte, F, Conti, M, Coratelli, P, Corti, Mm, Costanzo, R, DAL CANTON, A, D'Apice, L, David, S, DE CRISTOFARO, V, Deferrari, G, DELLA GROTTA, F, DE NICOLA, Luca, DE SANTO, Ng, DE SIMONE, W, DI DANIELE, N, DI GIULIO, S, DI LANDRO, D, DI LUZIO, V, DI MAGGIO, A, Fagugli, R, Farina, M, Feriani, M, Gallieni, M, Gambaro, G, Giordano, R, Greco, S, Grillo, C, Huber, W, Liuzzo, G, Locatelli, F, Lombardi, L, Lopez, T, Malberti, F, Mancini, W, Manenti, F, Manisco, G, Marrocco, A, Matocci, G, Merico, G, Messa, P, Minutolo, Roberto, Monardo, P, Moriconi, L, Murrone, P, Nardo, A, Naso, A, Nobile, R, Panarello, G, Paone, A, Parravano, M, Pedrini, L, Piazza, V, Pistis, R, Procida, M, Quarello, F, Rapisarda, F, Ricciardi, B, Rindi, P, Ronco, C, Rotolo, U, Russo, G, Saraniti, A, Sasdelli, M, Savica, V, Scanziani, R, Sidoti, A, Spotti, D, Stalteri, A, Stefoni, S, Stella, A, Strippoli, P, Teatini, U, Teodoro, C, Tozzo, C, Triolo, G, and Zoccali, C.
Subjects: Nephrology, medicine.medical_specialty, Referral, Anemia, medicine.medical_treatment, Context (language use), Metabolic Diseases, Internal medicine, Surveys and Questionnaires, Italian Society of Nephrology, chronic kidney disease, questionnaire, medicine, Humans, Intensive care medicine, Dialysis, Settore MED/14 - Nefrologia, Transplantation, business.industry, Guideline, medicine.disease, Italy, Chronic Disease, Kidney Diseases, Hemodialysis, Guideline Adherence, business, Kidney disease
Abstract: BACKGROUND: Recent studies have indicated that the implementation of international guidelines for the management of renal patients is suboptimal in Italy. The Italian Society of Nephrology (SIN) decided to undertake a multicentre study to obtain a clear picture of clinical policies on chronic kidney disease (CKD) in Italy. METHODS: A 76-item structured questionnaire, designed to evaluate the organization of clinical care, was administered to the director of each participating centre, within the context of a large observational trial in 100 Italian nephrology centres, collecting information on newly diagnosed CKD patients (K/DOQI stage 3-5) on conservative treatment. This paper reports the questionnaire results related to management of anaemia and bone metabolism disorders; assessment of renal function; creation of a vascular access for dialysis and referral of patients to a nephrologist. RESULTS: Clinical policies at the centre level deviated from guideline recommendations in 70% (timing of vascular access creation) to 25% (assessment of iron deficiency) of centres. Assessment of renal function differed from the recommended approach in 30% of centres; clinical policies related to anaemia and bone disease did not coincide with guideline standards in 50 and 40% of centres, respectively. Directors of renal unit estimates indicate that the creation of a vascular access occurs very late in 38% of patients and that referral to a nephrologist is late in approximately 40% of cases. CONCLUSION: This survey in Italy highlights important deviations of clinical policies at the centre level from guideline recommendations.
Published: 2008

8. Epidemiology and Course of Hereditary Nephritis: Personal Experience

Author: A. Baroni, Cavagnino A, Ragazzoni E, C. Cusaro, Verzetti G, and Chiarinotti D
Subjects: medicine.medical_specialty, business.industry, Family medicine, Epidemiology, medicine, business, medicine.disease, Nephritis
Published: 2015
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9. Prognostic role of LDL cholesterol in non-dialysis chronic kidney disease: Multicenter prospective study in Italy

Author: De Nicola, Luca, Provenzano, Michele, Chiodini, Paolo, D'Arrigo, Graziella, Tripepi, Giovanni, Del Vecchio, Lucia, Conte, Giuseppe, Locatelli, Francesco, Zoccali, Carmine, Minutolo, RobertoAcciarri P, Adorati, M, Ancarani, E, Andreucci, V, Antonelli, A, Auricchio, Mr, Balducci, A, Bassi, A, Battaglia, G, Bellingheri, G, Beltrame, A, Biagini, M, Bonfante, L, Bonofiglio, R, Bonomini, M, Borghi, M, Brigante, M, Buccianti, G, Buongiorno, E, Cabibbe, M, Cancarini, Giovanni, Capistrano, M, Cappelli, G, Capuano, M, Cascone, C, Catizone, L, Catucci, Ae, Cavatorta, F, Chiarinotti, D, Cicchetti, T, Concas, G, Concetti, M, Conte, F, Conte, G, Conti, M, Coratelli, P, Corti, Mm, Costanzo, R, Dal Canton, A, D'Apice, L, David, S, De Cristofaro, V, Deferrari, G, Della Grotta, F, De Santo NG, De Simone, W, Di Daniele, N, Di Giulio, S, Di Landro, D, Di Luzio, V, Di Maggio, A, Fagugli, R, Farina, M, Feriani, M, Gallieni, M, Gambaro, G, Giordano, R, Greco, S, Grillo, C, Huber, W, Liuzzo, G, Locatelli, F, Lombardi, L, Lopez, T, Malberti, F, Mancini, W, Manenti, F, Manisco, G, Marrocco, A, Matocci, G, Merico, G, Messa, P, Minutolo, R, Monardo, P, Moriconi, L, Murrone, P, Nardo, A, Naso, A, Nobile, R, Panarello, G, Paone, A, Parravano, M, Pedrini, L, Piazza, V, Pistis, R, Procida, M, Quarello, F, Rapisarda, F, Ricciardi, B, Rindi, P, Ronco, C, Rotolo, U, Russo, G, Santoro, D, Saraniti, A, Sasdelli, M, Savica, V, Scanziani, R, Sidoti, A, Spotti, D, Stalteri, A, Stefoni, S, Stella, A, Strippoli, P, Teatini, U, Teodoro, C, Tozzo, C, Triolo, G, Zoccali, C., De Nicola, L, Provenzano, M, Chiodini, P, D'Arrigo, G, Tripepi, G, Del Vecchio, L, Conte, G, Locatelli, F, Zoccali, C, and Minutolo, R
Subjects: Male, Nephrology, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Medicine (miscellaneous), Kidney Function Tests, Severity of Illness Index, chemistry.chemical_compound, Endocrinology, Risk Factors, Chronic kidney disease, 80 and over, Prospective Studies, Renal Insufficiency, Chronic, Prospective cohort study, Cardiovascular risk, Cholesterol, ESRD, LDL, Renal clinic, Nutrition and Dietetics, Cardiology and Cardiovascular Medicine, Aged, 80 and over, Medicine (all), Middle Aged, Prognosis, Diabetes and Metabolism, Italy, Cardiovascular Diseases, Female, Glomerular Filtration Rate, medicine.medical_specialty, Renal function, Median follow-up, Internal medicine, Diabetes mellitus, medicine, Humans, Renal replacement therapy, Renal Insufficiency, Chronic, Aged, business.industry, Cholesterol, LDL, medicine.disease, chemistry, business, Kidney disease
Abstract: Background and aims The prognostic role of LDL in non-dialysis chronic kidney disease (CKD) is still undefined. We addressed this question in a multicenter prospective study including patients referred to nephrologist for management. Methods and results 1306 patients with CKD stage III–V were studied at basal visit in 79 Italian nephrology clinics in 2004–2006, and then followed for survival analyses. Study endpoints were incident cardiovascular -CV events (fatal and major non-fatal) and renal events (start of renal replacement therapy or eGFR halving). Mean age was 67.6 ± 11.8 years, male 65%, diabetes 25%, CV disease 27%, and eGFR 35.8 ± 12.5 mL/min/1.73 m 2 . LDL was 119 ± 40 mg/dL, with high levels in 50.1% and 82.8% defined on the basis of the individual CV risk profile estimated according to ATPIII 2001 and ESC 2012 guidelines (LDL 100 to 160, and >70 or >100 mg/dL, respectively). Over a median follow up of 2.87 years, 178 CV and 181 renal events occurred. At multivariable Cox analyses, CV risk linearly increased with higher LDL (hazard ratio-HR per 40 mg/dL higher LDL: 1.20, 95% confidence intervals-CI 1.03–1.39); risk doubled when considering high LDL defined according to ESC 2012 (HR 2.37, 95%CI 1.39–4.03) while this association was not significant when considering the higher threshold levels of ATPIII 2001 (HR 1.10, 95%CI 0.82–1.49). No association emerged between LDL and renal risk. Conclusion In non-dialysis CKD patients, CV risk increases linearly with higher LDL and is more than doubled when considering the lower threshold values currently indicated for defining optimal LDL level.
Published: 2015

10. Studio degli indicatori di risultato multipli nella popolazione affetta da irc in terapia conservativa (SIR-SIN). Risultati del questionario KDQOL-SF (Kidney Disease Quality of Life Short Form) sulla qualità della vita

Author: Locatelli F, Zoccali C, Catucci AE, Minutolo R, De Nicola L, Grillo C, Beltrame A, Fagugli R, Catizone L, Mancini W, Di Luzio V, Brigante M, Battaglia G, Adorati Menegato M, Bonfante L, Parravano M, Ronco C, Farina M, Spotti D, De Santo NG, Moriconi L, Bellinghieri G, Ricciardi B, Costanzo R, Conti M, Piazza V, Dal Canton A, Corti MM, Della Grotta F, Bonofiglio R, Paone A, Chiarinotti D, Messa PG, Teodoro C, Pedrini L, Feriani M, Greco S, Merico G, Gallieni M., STEFONI, SERGIO, Locatelli F, Zoccali C, Catucci AE, Minutolo R, De Nicola L, Grillo C, Beltrame A, Fagugli R, Catizone L, Mancini W, Di Luzio V, Brigante M, Battaglia G, Adorati Menegato M, Bonfante L, Stefoni S, Parravano M, Ronco C, Farina M, Spotti D, De Santo NG, Moriconi L, Bellinghieri G, Ricciardi B, Costanzo R, Conti M, Piazza V, Dal Canton A, Corti MM, Della Grotta F, Bonofiglio R, Paone A, Chiarinotti D, Messa PG, Teodoro C, Pedrini L, Feriani M, Greco S, Merico G, and Gallieni M
Published: 2007

11. Diagnosi e trattamento dell'anemia nell'IRC in terapia conservativa. Dati preliminari dello studio SIN-SIR (Studio italiano Indicatori di Risultato multipli - Epidemiologia dell'IRC in Italia) della Società Italiana di Nefrologia

Author: Locatelli F, Zoccali C, Catucci AE, Savica V, Liuzzo G, Nardo A, Minutolo R, De Nicola L, Ricciardi B, Mancini W, Balducci A, Costanzo R, Di Luca M, Ariano R, Di Luzio V, Brigante M, Battaglia G, Di Landro D, Adorati Menegato M, Altieri P, Lodeserto C, D'Angelo A, Imbasciati E, Spotti D, Rapisarda F, Piazza V, Ronco C, De Santo NG, Stella A, Moriconi L, Dal Canton A, Auricchio MR, Corti MM, Della Grotta F, Grillo C, Cabibbe M, Bonofiglio R, Capistrano M, Paone A, Buongiorno E, Feliciani AL, Chiarinotti D, Gallieni M, Brambilla N, Piacentini A, Merico G, Del Santo A, Bottalico D., STEFONI, SERGIO, Locatelli F, Zoccali C, Catucci AE, Savica V, Liuzzo G, Nardo A, Minutolo R, De Nicola L, Ricciardi B, Mancini W, Balducci A, Costanzo R, Di Luca M, Ariano R, Di Luzio V, Brigante M, Battaglia G, Di Landro D, Adorati Menegato M, Altieri P, Lodeserto C, D'Angelo A, Imbasciati E, Spotti D, Rapisarda F, Piazza V, Ronco C, De Santo NG, Stella A, Moriconi L, Dal Canton A, Stefoni S, Auricchio MR, Corti MM, Della Grotta F, Grillo C, Cabibbe M, Bonofiglio R, Capistrano M, Paone A, Buongiorno E, Feliciani AL, Chiarinotti D, Gallieni M, Brambilla N, Piacentini A, Merico G, Del Santo A, and Bottalico D.
Subjects: ANEMIA, TERAPIA CONSERVATIVA, INSUFFICIENZA RENALE CRONICA
Published: 2006

12. Studio SIR-SIN (Studio italiano Indicatori di Risultato multipli - Epidemiologia dell'IRC in Italia) della Societa Italiana di Nefrologia nella popolazione affetta da IRC in terapia conservativa. Dati preliminari

Author: Locatelli F, Zoccali C, Catucci AE, Savica V, Liuzzo G, Nardo A, Minutolo R, De Nicola L, Ricciardi B, Mancini W, Balducci A, Costanzo R, Di Luca M, Ariano R, Di Luzio V, Brigante M, Battaglia G, Di Landro D, Adorati Menegato M, Altieri P, Lodeserto C, D'Angelo A, Imbasciati E, Spotti D, Rapisarda F, Piazza V, Ronco C, De Santo NG, Stella A, Moriconi L, Dal Canton A, Auricchio MR, Corti MM, Della Grotta F, Grillo C, Cabibbe M, Bonofiglio R, Capistrano M, Paone A, Buongiorno E, Feliciani AL, Chiarinotti D, Gallieni M, Brambilla N, Piacentini A, Merico G, Del Santo A, Bottalico D., STEFONI, SERGIO, Locatelli F, Zoccali C, Catucci AE, Savica V, Liuzzo G, Nardo A, Minutolo R, De Nicola L, Ricciardi B, Mancini W, Balducci A, Costanzo R, Di Luca M, Ariano R, Di Luzio V, Brigante M, Battaglia G, Di Landro D, Adorati Menegato M, Altieri P, Lodeserto C, D'Angelo A, Imbasciati E, Spotti D, Rapisarda F, Piazza V, Ronco C, De Santo NG, Stella A, Moriconi L, Dal Canton A, Stefoni S, Auricchio MR, Corti MM, Della Grotta F, Grillo C, Cabibbe M, Bonofiglio R, Capistrano M, Paone A, Buongiorno E, Feliciani AL, Chiarinotti D, Gallieni M, Brambilla N, Piacentini A, Merico G, Del Santo A, and Bottalico D.
Subjects: INSUFFICIENZA RENAEL CRONICA, TERAPIA CONSERVATIVA
Published: 2006

13. Timing di creazione dell'accesso vascolare per emodialisi. Dati preliminari dello studio SIN-SIR (Studio italiano Indicatori di Risultato multipli - Epidemiologia dell'IRC in Italia) della Società Italiana di Nefrologia nella popolazione affetta da IRC in terapia conservativa

Author: Locatelli F, Zoccali C, Catucci AE, Savica V, Liuzzo G, Nardo A, Minutolo R, De Nicola L, Ricciardi B, Mancini W, Balducci A, Costanzo R, Di Luca M, Ariano R, Di Luzio V, Brigante M, Battaglia G, Di Landro D, Adorati Menegato M, Altieri P, Lodeserto C, D'Angelo A, Imbasciati E, Spotti D, Rapisarda F, Piazza V, Ronco C, De Santo NG, Stella A, Moriconi L, Dal Canton A, Auricchio MR, Corti MM, Della Grotta F, Grillo C, Cabibbe M, Bonofiglio R, Capistrano M, Paone A, Buongiorno E, Feliciani AL, Chiarinotti D, Gallieni M, Brambilla N, Piacentini A, Merico G, Del Santo A, Bottalico D., STEFONI, SERGIO, Locatelli F, Zoccali C, Catucci AE, Savica V, Liuzzo G, Nardo A, Minutolo R, De Nicola L, Ricciardi B, Mancini W, Balducci A, Costanzo R, Di Luca M, Ariano R, Di Luzio V, Brigante M, Battaglia G, Di Landro D, Adorati Menegato M, Altieri P, Lodeserto C, D'Angelo A, Imbasciati E, Spotti D, Rapisarda F, Piazza V, Ronco C, De Santo NG, Stella A, Moriconi L, Dal Canton A, Stefoni S, Auricchio MR, Corti MM, Della Grotta F, Grillo C, Cabibbe M, Bonofiglio R, Capistrano M, Paone A, Buongiorno E, Feliciani AL, Chiarinotti D, Gallieni M, Brambilla N, Piacentini A, Merico G, Del Santo A, and Bottalico D.
Subjects: ACCESSO VASCOLARE, EMODIALISI, TERAPIA CONSERVATIVA, INSUFFICIENZA RENALE CRONICA
Published: 2006

14. Chronic kidney disease (CKD) in Italy: A multicenter study. Results of a questionnaire on the clinical management of CKD stage 3-5 patients

Author: Locatelli, F., Zoccali, C., Catucci, Ae, Savica, V., Liuzzo, G., Nardo, A., Minutolo, R., Nicola, L., Ricciardi, B., Mancini, W., Balducci, A., Costanzo, R., Di Luca, M., Ariano, R., Di Luzio, V., Brigante, M., Battaglia, G., Menegato, Ma, Di Landro, D., Altieri, P., Auricchio, Mr, Lodeserto, C., Stefoni, S., D Angelo, A., Imbasciati, E., Spotti, D., Cristofaro, V., Rapisarda, F., Piazza, V., Claudio Ronco, De Santo NG, Stella, A., Dani, L., Dal Canton, A., Corti, Mm, Teodoro, C., Della Grotta, F., Grillo, C., Catizone, L., Cabibbe, M., Bonofiglio, R., Capistrano, M., Paone, A., Buongiorno, E., Feliciani, Al, Chiarinotti, D., Rotolo, U., Feriani, M., Garibotto, G., Gallieni, M., Merico, G., Del Santo, A., Bottalico, D., Locatelli F, Zoccali C, Catucci AE, Savica V, Liuzzo G, Nardo A, Minutolo R, De Nicola L, Ricciardi B, Mancini W, Balducci A, Costanzo R, Di Luca M, Ariano R, Di Luzio V, Brigante M, Battaglia G, Adorati Menegato M, Di Landro D, Altieri P, Auricchio MR, Lodeserto C, Stefoni S, D'Angelo A, Imbasciati E, Spotti D, De Cristofaro V, Rapisarda F, Piazza V, Ronco C, De Santo NG, Stella A, Dani L, Dal Canton A, Corti MM, Teodoro C, Della Grotta F, Grillo C, Catizone L, Cabibbe M, Bonofiglio R, Capistrano M, Paone A, Buongiorno E, Feliciani AL, Chiarinotti D, Rotolo U, Feriani M, Garibotto G, Gallieni M, Merico G, Del Santo A, and Bottalico D
Published: 2006

15. Modalità di stima del filtrato glomerulare (FG) e inizio della dialisi. Dati preliminari dello studio SIR-SIN (Studio italiano Indicatori di Risultato multipli - Epidemiologia dell'IRC in Italia) della Societa Italiana di Nefrologia nella popolazione affetta da IRC in terapia conservativa

Author: Locatelli F, Zoccali C, Catucci AE, Savica V, Liuzzo G, Nardo A, Minutolo R, De Nicola L, Ricciardi B, Mancini W, Balducci A, Costanzo R, Di Luca M, Ariano R, Di Luzio V, Brigante M, Battaglia G, Di Landro D, Adorati Menegato M, Altieri P, Lodeserto C, D'Angelo A, Imbasciati E, Spotti D, Rapisarda F, Piazza V, Ronco C, De Santo NG, Stella A, Moriconi L, Dal Canton A, Auricchio MR, Corti MM, Della Grotta F, Grillo C, Cabibbe M, Bonofiglio R, Capistrano M, Paone A, Buongiorno E, Feliciani AL, Chiarinotti D, Gallieni M, Brambilla N, Piacentini A, Merico G, Del Santo A, Bottalico D., STEFONI, SERGIO, Locatelli F, Zoccali C, Catucci AE, Savica V, Liuzzo G, Nardo A, Minutolo R, De Nicola L, Ricciardi B, Mancini W, Balducci A, Costanzo R, Di Luca M, Ariano R, Di Luzio V, Brigante M, Battaglia G, Di Landro D, Adorati Menegato M, Altieri P, Lodeserto C, D'Angelo A, Imbasciati E, Spotti D, Rapisarda F, Piazza V, Ronco C, De Santo NG, Stella A, Moriconi L, Dal Canton A, Stefoni S, Auricchio MR, Corti MM, Della Grotta F, Grillo C, Cabibbe M, Bonofiglio R, Capistrano M, Paone A, Buongiorno E, Feliciani AL, Chiarinotti D, Gallieni M, Brambilla N, Piacentini A, Merico G, Del Santo A, and Bottalico D
Subjects: FILTRATO GLOMERULARE, DIALISI, INSUFFICIENZA RENALE CRONICA
Published: 2006

16. [Renal biopsy practice in Piedmont and Valle d'Aosta] INDAGINE SULLE MODALITÀ DI ESECUZIONE DELLA BIOPSIA RENALE IN PIEMONTE E VALLE D’AOSTA

Author: Manganaro, M, Nebiolo, Pe, Rollino, C, Giacchino, F, Savoldi, S, Besso, L, Colla, L, Amore, A, Ferro, M, Marazzi, F, Chiarinotti, D, Guarnieri, A, Quaglia, M, Manes, M, Vaccaro, V, Marcuccio, C, Licata, C, Patti, R, Mariano, F, Bongi, Am, Biamino, E, Boschetti, Ma, Della Volpe, M, Malcangi, U, Baroni, A, Vagelli, G, Costantini, L, Salomone, M, Formica, M, Caramello, E, Campo, A, Pignone, E, Messuerotti, A, Roccatello, D, Stratta, P, Segoloni, G, and Coppo, R
Subjects: kidney, renal biopsy, needle biopsy
Published: 2012

17. Clinical policies on the management of chronic kidney disease patients in Italy

Author: Locatelli, F, Zoccali, C, SIR SIN STUDY INVESTIGATORS, COLLABORATORS ACCIARRI, P, Menegato, Ma, Ancarani, E, Andreucci, V, Antonelli, A, Auricchio, Mr, Balducci, A, Bassi, A, Battaglia, G, Bellingheri, G, Beltrame, A, Biagini, M, Bonfante, L, Bonofiglio, R, Bonomini, M, Borghi, M, Brigante, M, Buccianti, G, Buongiorno, E, Cabibbe, M, Cancarini, Giovanni, Capistrano, M, Cappelli, G, Capuano, M, Cascone, C, Catizone, L, Catucci, Ae, Cavatorta, F, Chiarinotti, D, Cicchetti, T, Concas, G, Concetti, M, Conte, F, Conti, M, Coratelli, P, Corti, Mm, Costanzo, R, Dal, Canton, A, D'Apice, L, David, S, DE CRISTOFARO, V, Deferrari, G, DELLA GROTTA, F, Nicola, L, DE SANTO NG, DE SIMONE, W, DI DANIELE, N, DI GIULIO, S, DI LANDRO, D, Luzio, V, DI MAGGIO, A, Fagugli, R, Farina, M, Feriani, M, Gallieni, M, Gambaro, G, Giordano, R, Greco, S, Grillo, C, Huber, W, Liuzzo, G, Lombardi, L, Lopez, T, Malberti, F, Mancini, W, Manenti, F, Manisco, G, Marrocco, A, Matocci, G, Merico, G, Messa, P, Minutolo, R, Monardo, P, Moriconi, L, Murrone, P, Nardo, A, Naso, A, Nobile, R, Panarello, G, Paone, A, Parravano, M, Pedrini, L, Piazza, V, Pistis, R, Procida, M, Quarello, F, Rapisarda, F, Ricciardi, B, Rindi, P, Ronco, C, Rotolo, U, Russo, G, Saraniti, A, Sasdelli, M, Savica, V, Scanziani, R, Sidoti, A, Spotti, D, Stalteri, A, Stefoni, S, Stella, A, Strippoli, P, Teatini, U, Teodoro, C, Tozzo, C, Triolo, G, and Zoccali, C.
Subjects: Chrinic kidney disease, anemia
Published: 2008

18. TIMING DI CREAZIONE DELL’ACCESSO VASCOLARE PER EMODIALISI. DATI PRELIMINARI DELLO STUDIO SIR-SIN (STUDIO ITALIANO INDICATORI DI RISULTATI MULTIPLI-EPIDEMIOLOGIA DELL’IRC IN ITALIA) DELLA SOCIETA’ ITALIANA DI NEFROLOGIA NELLA POPOLAZIONE AFFETTA DA IRC IN TERAPIA CONSERVATIVA

Author: Locatelli, F, Zoccali, C, Catucci, Ae, Savica, V, Liuzzo, G, Nardo, A, Minutolo, R, DE NICOLA, L, Ricciardi, B, Mancini, W, Balducci, A, Costanzo, R, DI LUCA, M, Ariano, R, DI LUZIO, V, Brigante, M, Battaglia, G, DI LANDRO, D, ADORATI MENEGATO, M, Altieri, P, Lodeserto, C, Dangelo, A, Imbasciati, E, Spotti, D, Rapisarda, Francesco, Piazza, V, Ronco, C, DE SANTO NG, Stella, A, Moriconi, L, DAL CANTON, A, Stefoni, S, Auricchio, Mr, Corti, Mm, DELLA GROTTA, F, Grillo, C, Cabibbe, M, Bonofiglio, R, Capistrano, M, Paone, A, Buongiorno, E, Feliciani, Al, Chiarinotti, D, Gallieni, M, Brambilla, N, Piacentini, A, Merico, G, DEL SANTO, A, and Bottalico, D.
Published: 2006

19. MODALITA’ DI STIMA DEL FILTRATO GLOMERULARE(FG) E INIZIO DELLA DIALISI. DATI PRELIMINARI DELLO STUDIO SIR-SIN (STUDIO ITALIANO INDICATORI DI RISULTATI MULTIPLI-EPIDEMIOLOGIA DELL’IRC IN ITALIA) DELLA SOCIETA’ ITALIANA DI NEFROLOGIA NELLA POPOLAZIONE AFFETTA DA IRC IN TERAPIA CONSERVATIVA

Author: Locatelli, F, Zoccali, C, Catucci, Ae, Savica, V, Liuzzo, G, Nardo, A, Minutolo, R, DE NICOLA, L, Ricciardi, B, Mancini, W, Balducci, A, Costanzo, R, DI LUCA, M, Ariano, R, DI LUZIO, V, Brigante, M, Battaglia, G, DI LANDRO, D, ADORATI MENEGATO, M, Altieri, P, Lodeserto, C, Dangelo, A, Imbasciati, E, Spotti, D, Rapisarda, Francesco, Piazza, V, Ronco, C, DE SANTO NG, Stella, A, Moriconi, L, DAL CANTON, A, Stefoni, S, Auricchio, Mr, Corti, Mm, DELLA GROTTA, F, Grillo, C, Cabibbe, M, Bonofiglio, R, Capistrano, M, Paone, A, Buongiorno, E, Feliciani, Al, Chiarinotti, D, Gallieni, M, Brambilla, N, Piacentini, A, Merico, G, DEL SANTO, A, and Bottalico, D.
Published: 2006

20. CHRONIC KIDNEY DISEASE IN ITALY: A MULTICENTER STUDY. RESULTS OF A QUESTIONNAIRE ON THE CLINICAL MANAGEMENT OF CKD STAGE 3-5 PATIENTS

Author: Locatelli, F, Zoccali, C, Catucci, Ae, Savica, V, Liuzzo, G, Nardo, A, Minutolo, R, DE NICOLA, L, Ricciardi, B, Mancini, W, Balducci, A, Costanzo, R, DI LUCA, M, Ariano, R, DI LUZIO, V, Brigante, M, Battaglia, G, ADORATI MENEGATO, M, DI LANDRO, D, Altieri, P, Auricchio, M. R., Lodeserto, C, Stefoni, S, Dangelo, A, Imbasciati, E, Spotti, D, DE CRISTOFORO, V, Rapisarda, Francesco, Piazza, V, Ronco, C, DE SANTO NG, Stella, A, Dani, L, DAL CANTON, A, Corti, M. M., Teodoro, C, DELLA GROTTA, F, Grillo, C, Catizone, L, Cabibbe, M, Bonofiglio, R, Capistrano, M, Paone, A, Buongiorno, E, Feliciani, A. L., Chiarinotti, D, Rotolo, U, Feriani, M, Garibotto, G, Gallieni, M, Merico, G, and DEL SANTO, A. AND BOTTALICO D.
Published: 2006

21. Epidemiology and Course of Hereditary Nephritis: Personal Experience

Author: Cusaro, C., primary, Baroni, A., additional, Chiarinotti, D., additional, Ragazzoni, E., additional, Cavagnino, A., additional, and Verzetti, G., additional
Full Text: View/download PDF

22. DIALYSIS. PATHOPHYSIOLOGY AND CLINICAL STUDIES

Author: Humalda, J. K., primary, Assa, S., additional, Navis, G. J., additional, Franssen, C. F. M., additional, De Borst, M. H., additional, Ogawa, H., additional, Ota, Y., additional, Watanabe, T., additional, Watanabe, Y., additional, Nishii, H., additional, Sato, A., additional, Waniewski, J., additional, Debowska, M., additional, Wojcik-Zaluska, A., additional, Ksiazek, A., additional, Zaluska, W., additional, Guastoni, C. M., additional, Turri, C., additional, Toma, L., additional, Rombola, G., additional, Frattini, G., additional, Romei Longhena, G., additional, Teatini, U., additional, Siriopol, D.-C., additional, Stuard, S., additional, Ciolan, A., additional, Mircescu, G., additional, Raluca, D., additional, Nistor, I., additional, Covic, A., additional, De Roij Van Zuijdewijn, C. L., additional, Chapdelaine, I., additional, Nube, M. J., additional, Blankestijn, P. J., additional, Bots, M. L., additional, Konings, S. J., additional, Van Den Dorpel, M. A., additional, Van Der Weerd, N. C., additional, Ter Wee, P. M., additional, Grooteman, M. P., additional, Djuric, P. S., additional, Jankovic, A., additional, Tosic, J., additional, Bajcetic, S., additional, Damjanovic, T., additional, Popovic, J., additional, Dimkovic, N., additional, Marinkovic, J., additional, Djuric, Z., additional, Knezevic, V., additional, Lazarevic, T., additional, Ljubenovic, S., additional, Markovic, R., additional, Rabrenovic, V., additional, Djukanovic, L., additional, Radovic Maslarevic, V., additional, Mathrani, V., additional, Drew, P., additional, Chess, J. I., additional, Williams, A. I., additional, Robertson, S., additional, Jibani, M., additional, Aithal, V. I., additional, Kumwenda, M., additional, Roberts, G., additional, Mikhail, A. I., additional, Grzegorzewska, A. E., additional, Ostromecki, G., additional, Mostowska, A., additional, Sowi ska, A., additional, Jagodzi ski, P. P., additional, Wu, H.-Y., additional, Chen, H.-Y., additional, Hsu, S.-P., additional, Pai, M.-F., additional, Yang, J.-Y., additional, Peng, Y.-S., additional, Hirose, M., additional, Hasegawa, T., additional, Kaneshima, N., additional, Sasai, F., additional, Komukai, D., additional, Takahashi, K., additional, Koiwa, F., additional, Shishido, K., additional, Yoshimura, A., additional, Selim, G., additional, Stojceva-Taneva, O., additional, Tozija, L., additional, Dzekova-Vidimliski, P., additional, Trajceska, L., additional, Petronievic, Z., additional, Gelev, S., additional, Amitov, V., additional, Sikole, A., additional, Moon, S. J., additional, Yoon, S. Y., additional, Shin, D. H., additional, Lee, J. E., additional, Kim, H.-J., additional, Park, H.-C., additional, Hadjiyannakos, D., additional, Filiopoulos, V., additional, Loukas, G., additional, Pagonis, S., additional, Andriopoulos, C., additional, Drakou, A., additional, Vlassopoulos, D., additional, Catarino, C., additional, Cunha, P., additional, Ribeiro, S., additional, Rocha-Pereira, P., additional, Reis, F., additional, Sameiro-Faria, M., additional, Miranda, V., additional, Bronze-Rocha, E., additional, Belo, L., additional, Costa, E., additional, Santos-Silva, A., additional, De Mauri, A., additional, Brambilla, M., additional, Chiarinotti, D., additional, Lizio, D., additional, Matheoud, R., additional, Conti, N., additional, Conte, M. M., additional, Carriero, A., additional, De Leo, M., additional, Karpetas, A. V., additional, Sarafidis, P. A., additional, Georgianos, P. I., additional, Koutroumpas, G., additional, Divanis, D., additional, Vakianis, P., additional, Tzanis, G., additional, Raptopoulou, K., additional, Protogerou, A., additional, Stamatiadis, D., additional, Syrganis, C., additional, Liakopoulos, V., additional, Efstratiadis, G., additional, Lasaridis, A. N., additional, Tersi, M., additional, Stamatiadis, D. N., additional, Kuczera, P., additional, Adamczak, M., additional, Wiecek, A., additional, Bove, S., additional, Giacon, B., additional, Corradini, R., additional, Prati, E., additional, Brognoli, M., additional, Tommasi, A., additional, Sereni, L., additional, Palladino, G., additional, Moriya, H., additional, Mochida, Y., additional, Ishioka, K., additional, Oka, M., additional, Maesato, K., additional, Hidaka, S., additional, Ohtake, T., additional, Kobayashi, S., additional, Moura, A., additional, Madureira, J., additional, Alija, P., additional, Fernandes, J. C., additional, Oliveira, J. G., additional, Lopez, M., additional, Filgueiras, M., additional, Amado, L., additional, Vieira, M., additional, Seok, J.-H., additional, Choi, H. Y., additional, Ha, S. K., additional, Park, H. C., additional, Bossola, M., additional, Laudisio, A., additional, Antocicco, M., additional, Tazza, L., additional, Colloca, G., additional, Tosato, M., additional, Zuccala, G., additional, Ettema, E. M., additional, Kuipers, J., additional, Groen, H., additional, Gansevoort, R. T., additional, Stade, K., additional, Bakker, S. J. L., additional, Gaillard, C. A. J. M., additional, Westerhuis, R., additional, Bacchetta, J., additional, Couchoud, K., additional, Semlali, S., additional, Sellier-Leclerc, A.-L., additional, Bertholet-Thomas, A., additional, Cartier, R., additional, Cochat, P., additional, Ranchin, B., additional, Kim, J. C., additional, Park, K., additional, Van Ende, C., additional, Wilmes, D., additional, Lecouvet, F. E., additional, Labriola, L., additional, Cuvelier, R., additional, Van Ingelgem, G., additional, Jadoul, M., additional, Doriana, C., additional, David, P., additional, Capurro, F., additional, Brustia, M., additional, Ruva, C. E., additional, Giungi, S., additional, Di Stasio, E., additional, Lemesch, S., additional, Leber, B., additional, Horvath, A., additional, Ribitsch, W., additional, Schilcher, G., additional, Zettel, G., additional, Tawdrous, M., additional, Rosenkranz, A. R., additional, Stadlbauer-Kollner, V., additional, Matsushima, H., additional, Oyama, A., additional, Bosch Benitez-Parodi, E., additional, Baamonde Laborda, E., additional, Batista Garcia, F., additional, Perez Suarez, G., additional, Anton Perez, G., additional, Garcia Canton, C., additional, Toledo Gonzalez, A., additional, Lago Alonso, M. M., additional, Checa Andres, M. D., additional, Cobo, G., additional, Di Gioia, C., additional, Camacho, R., additional, Garcia Lacalle, C., additional, Ortega, O., additional, Rodriguez, I., additional, Herrero, J., additional, Oliet, A., additional, Ortiz, M., additional, Mon, C., additional, Vigil, A., additional, Gallar, P., additional, Pellu, V., additional, Nebiolo, P. E., additional, Sasaki, K., additional, Yamguchi, S., additional, Hesaka, A., additional, Iwahashi, E., additional, Sakai, S., additional, Fujimoto, T., additional, Minami, S., additional, Fujita, Y., additional, Yokoyama, K., additional, Shutov, E., additional, Ryabinskya, G., additional, Lashutin, S., additional, Gorelova, E., additional, Volodicheva, E., additional, Podesta, M. A., additional, Cancarini, G., additional, Cucchiari, D., additional, Montanelli, A., additional, Badalamenti, S., additional, Graziani, G., additional, Distasio, E., additional, Pchelin, I., additional, Shishkin, A., additional, Fedorova, Y., additional, Kao, C.-C., additional, Chu, T.-S., additional, Tsai, T.-J., additional, Wu, K.-D., additional, Wu, M.-S., additional, Raikou, V., additional, Kaisidis, P., additional, Tsamparlis, E., additional, Kanellopoulos, P., additional, Boletis, J., additional, Ueda, A., additional, Hirayama, A., additional, Owada, S., additional, Nagai, K., additional, Saito, C., additional, and Yamagata, K., additional
Published: 2014
Full Text: View/download PDF

23. Vascular access

Author: McCullough, K. P., primary, Lok, C. E., additional, Fluck, R. J., additional, Spergel, L. M., additional, Andreucci, V. E., additional, Fort, J., additional, Krishnan, M., additional, Fissell, R. B., additional, Kawanishi, H., additional, Saran, R., additional, Port, F. K., additional, Robinson, B. M., additional, Pisoni, R. L., additional, Shinzato, T., additional, Shionoya, Y., additional, Fukui, H., additional, Sasaki, M., additional, Miwa, M., additional, Toma, S., additional, Lin, C.-C., additional, Yang, W.-C., additional, Simone, S., additional, Loverre, A., additional, Cariello, M., additional, Divella, C., additional, Castellano, G., additional, Gesualdo, L., additional, Grandaliano, G., additional, Pertosa, G., additional, Mattei, S., additional, Pignatelli, G., additional, Corradini, M., additional, Stefani, A., additional, Bovino, A., additional, Iannuzzella, F., additional, Vaglio, A., additional, Manari, A., additional, Pasquali, S., additional, Chan, J.-S., additional, Wu, T.-C., additional, Roy-Chaudhury, P., additional, Shih, C.-C., additional, Chen, J.-W., additional, Ponce, P., additional, Scholz, C., additional, Goncalves, P., additional, Grassmann, A., additional, Canaud, B., additional, Marcelli, D., additional, Suzuki, S., additional, Shibata, K., additional, Kuji, T., additional, Kawata, S., additional, Koguchi, N., additional, Nishihara, M., additional, Satta, H., additional, Toya, Y., additional, Umemura, S., additional, Corbett, R., additional, Demicheli, N., additional, Iori, F., additional, Grechy, L., additional, Khiroya, R., additional, Ellis, D., additional, Crane, J., additional, Hamady, M., additional, Gedroyc, W., additional, Duncan, N., additional, Vincent, P., additional, Caro, C., additional, Sarween, N., additional, Price, A., additional, Powers, S., additional, Allen, C., additional, Holland, M., additional, Gupta, I., additional, Baharani, J., additional, Parisotto, M. T., additional, Schoder, V., additional, Kaufmann, P., additional, Miriunis, C., additional, Moura, A., additional, Madureira, J., additional, Alija, P., additional, Fernandes, J., additional, Oliveira, J. G., additional, Lopez, M., additional, Felgueiras, M., additional, Amado, L., additional, Sameiro-Faria, M., additional, Miranda, V., additional, Vieira, M., additional, Santos-Silva, A., additional, Costa, E., additional, David, P., additional, Capurro, F., additional, Brustia, M., additional, De Mauri, A., additional, Ruva, C., additional, Chiarinotti, D., additional, Gravellone, L., additional, De Leo, M., additional, Turkvatan, A., additional, Kirkpantur, A., additional, Mandiroglu, S., additional, Afsar, B., additional, Seloglu, B., additional, Alkis, M., additional, Erkula, S., additional, GURBUZ, H. G., additional, Serin, M., additional, CALIK, Y., additional, Mandiroglu, F., additional, Balci, M., additional, Rikker, C., additional, Juhasz, E., additional, Tornoci, L., additional, Tovarosi, S., additional, Greguschik, J., additional, Rosivall, L., additional, Ibeas, J., additional, Valeriano, J., additional, Vallespin, J., additional, Fortuno, J., additional, Rodriguez-Jornet, A., additional, Cabre, C., additional, Merino, J., additional, Vinuesa, X., additional, Bolos, M., additional, Branera, J., additional, Mateos, A., additional, Jimeno, V., additional, Grau, C., additional, Criado, E., additional, Moya, C., additional, Ramirez, J., additional, Gimenez, A., additional, Garcia, M., additional, Kirmizis, D., additional, Kougioumtzidou, O., additional, Vakianis, P., additional, Bandera, A., additional, Veniero, P., additional, Brunori, G., additional, Dimitrijevic, Z., additional, Cvetkovic, T., additional, Paunovic, K., additional, Stojanovic, M., additional, Ljubenovic, S., additional, Mitic, B., additional, Djordjevic, V., additional, Aicha Henriette, S., additional, Farideh, A., additional, Daniela, B., additional, Zafer, T., additional, Francois, C., additional, Donati, G., additional, Scrivo, A., additional, Cianciolo, G., additional, La Manna, G., additional, Panicali, L., additional, Rucci, P., additional, Marchetti, A., additional, Giampalma, E., additional, Galaverni, M., additional, Golfieri, R., additional, Stefoni, S., additional, Skornyakov, I., additional, Kiselev, N., additional, Rozhdestvenskaya, A., additional, Stolyar, A., additional, Ancarani, P. P. A., additional, Devoto, E., additional, Dardano, G. G. D., additional, Coskun yavuz, Y., additional, Selcuk, N. Y., additional, Guney, I., additional, Altintepe, L., additional, Gerasimovska, V., additional, Gerasimovska-Kitanovska, B., additional, Persic, V., additional, Buturovic-Ponikvar, J., additional, Arnol, M., additional, Ponikvar, R., additional, Conti, N., additional, Scrivano, J., additional, Pettorini, L., additional, Giuliani, A., additional, Punzo, G., additional, Mene, P., additional, Pirozzi, N., additional, Kocyigit, I., additional, Unal, A., additional, Guney, A., additional, Mavili, E., additional, Deniz, K., additional, Sipahioglu, M., additional, Eroglu, E., additional, Tokgoz, B., additional, Oymak, O., additional, Gunal, A., additional, Boubaker, K., additional, Kaaroud, H., additional, Kheder, A., additional, Vidal, M., additional, Amengual, M. J., additional, Orellana, R., additional, Sanfeliu, I., additional, Marquina, D., additional, Xirinachs, M., additional, Sanchez, E., additional, Rey, M., additional, Strozecki, P., additional, Flisinski, M., additional, Kapala, A., additional, Manitius, J., additional, Gerasimovska-Kitanovska, B. D., additional, Sikole, A., additional, Weber, E., additional, Adrych, D., additional, Wolyniec, W., additional, Liberek, T., additional, Rutkowski, B., additional, Oguchi, K., additional, Nakahara, T., additional, Okamoto, M., additional, Iwabuchi, H., additional, Asano, M., additional, Rap, O., additional, Ruiz-Valverde, M., additional, Rodriguez-Murillo, J. A., additional, Mallafre-Anduig, J. M., additional, Zeid, M. M., additional, Deghady, A. A., additional, Elshair, H. S., additional, Elkholy, N. A., additional, Panagoutsos, S., additional, Devetzis, V., additional, Roumeliotis, A., additional, Kantartzi, K., additional, Mourvati, E., additional, Vargemezis, V., additional, Passadakis, P., additional, Kang, S. H., additional, Jung, S. Y., additional, Lee, S. H., additional, Cho, K. H., additional, Park, J. W., additional, Yoon, K. W., additional, and Do, J. Y., additional
Published: 2013
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24. Cardiovascular disease in CKD

Author: van den Broek, J. S., primary, Hoekstra, T., additional, Drechsler, C., additional, Brandenburg, V. M., additional, Dekker, F. W., additional, Vervloet, M. G., additional, Albrizio, P., additional, Sepe, V., additional, Gnecchi, M., additional, Cervio, E., additional, Mangione, F., additional, Fiorini, F., additional, Rampino, T., additional, Libetta, C., additional, Dal Canton, A., additional, Di Marco, G., additional, Reuter, S., additional, Kentrup, D., additional, Tiemann, K., additional, Fobker, M., additional, Engelbertz, C., additional, Breithardt, G., additional, Reinecke, H., additional, Brand, E., additional, Pavenstadt, H., additional, Brand, M., additional, De Mauri, A., additional, Conti, N., additional, Chiarinotti, D., additional, David, P., additional, Capurro, F., additional, De Leo, M., additional, Delanaye, P., additional, Krzesinski, J.-M., additional, Warling, X., additional, Smelten, N., additional, Cavalier, E., additional, Hayashi, M., additional, Kanno, Y., additional, Iwai, M., additional, Yoshida, T., additional, and Abe, T., additional
Published: 2013
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25. Cumulative radiation dose from medical imaging in kidney transplant patients

Author: De Mauri, A., primary, Brambilla, M., additional, Izzo, C., additional, Matheoud, R., additional, Chiarinotti, D., additional, Carriero, A., additional, Stratta, P., additional, and De Leo, M., additional
Published: 2012
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26. Cardiovascular complications in CKD 5D

Author: Fusaro, M., primary, Fusaro, M., additional, Noale, M., additional, Tripepi, G., additional, D'angelo, A., additional, Miozzo, D., additional, Gallieni, M., additional, Study Group, P.-V., additional, Tsamelesvili, M., additional, Dimitriadis, C., additional, Papagianni, A., additional, Raidis, C., additional, Efstratiadis, G., additional, Memmos, D., additional, Mutluay, R., additional, Konca Degertekin, C., additional, Derici, U., additional, Deger, S. M., additional, Akkiyal, F., additional, Gultekin, S., additional, Gonen, S., additional, Tacoy, G., additional, Arinsoy, T., additional, Sindel, S., additional, Sanchez-Perales, C., additional, Vazquez, E., additional, Merino, E., additional, Perez Del Barrio, P., additional, Borrego, F. J., additional, Borrego, M. J., additional, Liebana, A., additional, Krzanowski, M., additional, Janda, K., additional, Dumnicka, P., additional, Krasniak, A., additional, Sulowicz, W., additional, Kim, Y.-O., additional, Yoon, S.-A., additional, Yun, Y.-S., additional, Song, H.-C., additional, Kim, B.-S., additional, Cheong, M. A., additional, Pasch, A., additional, Farese, S., additional, Floege, J., additional, Jahnen-Dechent, W., additional, Ohtake, T., additional, Furuya, R., additional, Iwagami, M., additional, Tsutsumi, D., additional, Mochida, Y., additional, Ishioka, K., additional, Oka, M., additional, Maesato, K., additional, Moriya, H., additional, Hidaka, S., additional, Kobayashi, S., additional, Guedes, A., additional, Malho Guedes, A., additional, Pinho, A., additional, Fragoso, A., additional, Cruz, A., additional, Mendes, P., additional, Morgado, E., additional, Bexiga, I., additional, Silva, A. P., additional, Neves, P., additional, Oyake, N., additional, Suzuki, K., additional, Itoh, S., additional, Yano, S., additional, Turkmen, K., additional, Kayikcioglu, H., additional, Ozbek, O., additional, Saglam, M., additional, Toker, A., additional, Tonbul, H. Z., additional, Gelev, S., additional, Trajceska, L., additional, Srbinovska, E., additional, Pavleska, S., additional, Amitov, V., additional, Selim, G., additional, Dzekova, P., additional, Sikole, A., additional, Bouarich, H., additional, Lopez, S., additional, Alvarez, C., additional, Arribas, I., additional, DE Sequera, P., additional, Rodriguez, D., additional, Tanaka, S., additional, Kanemitsu, T., additional, Sugahara, M., additional, Kobayashi, M., additional, Uchida, L., additional, Ishimoto, Y., additional, Kotera, N., additional, Tanimoto, S., additional, Tanabe, K., additional, Hara, K., additional, Sugimoto, T., additional, Mise, N., additional, Goldstein, B., additional, Turakhia, M., additional, Arce, C., additional, Winkelmayer, W., additional, Zayed, B. E.-D., additional, Said, K., additional, Nishimura, M., additional, Okamoto, Y., additional, Tokoro, T., additional, Nishida, M., additional, Hashimoto, T., additional, Iwamoto, N., additional, Takahashi, H., additional, Ono, T., additional, Sato, N., additional, Raimann, J., additional, Usvyat, L. A., additional, Sands, J., additional, Levin, N. W., additional, Kotanko, P., additional, Iwasaki, M., additional, Joki, N., additional, Tanaka, Y., additional, Ikeda, N., additional, Hayashi, T., additional, Kubo, S., additional, Imamura, T.-A., additional, Takahashi, Y., additional, Hirahata, K., additional, Imamura, Y., additional, Hase, H., additional, Claes, K., additional, Meijers, B., additional, Bammens, B., additional, Kuypers, D., additional, Naesens, M., additional, Vanrenterghem, Y., additional, Evenepoel, P., additional, Boscutti, G., additional, Calabresi, L., additional, Bosco, M., additional, Simonelli, S., additional, Boer, E., additional, Vitali, C., additional, Martone, M., additional, Mattei, P. L., additional, Franceschini, G., additional, Baligh, E., additional, El-Shafey, E., additional, Ezaat, A., additional, Zawada, A., additional, Rogacev, K., additional, Hummel, B., additional, Grun, O., additional, Friedrich, A., additional, Rotter, B., additional, Winter, P., additional, Geisel, J., additional, Fliser, D., additional, Heine, G. H., additional, Makino, J.-I., additional, Makino, K.-S., additional, Ito, T., additional, Genovesi, S., additional, Santoro, A., additional, Fabbrini, P., additional, Rossi, E., additional, Pogliani, D., additional, Stella, A., additional, Bonforte, G., additional, Remuzzi, G., additional, Bertoli, S., additional, Pozzi, C., additional, Pasquali, S., additional, Cagnoli, L., additional, Conte, F., additional, Buzadzic, I., additional, Tosic, J., additional, Dimkovic, N., additional, Djuric, Z., additional, Popovic, J., additional, Pejin Grubisa, I., additional, Barjaktarevic, N., additional, DI Napoli, A., additional, DI Lallo, D., additional, Salvatori, M. F., additional, Franco, F., additional, Chicca, S., additional, Guasticchi, G., additional, Onofriescu, M., additional, Hogas, S., additional, Luminita, V., additional, Mugurel, A., additional, Gabriel, V., additional, Laura, F., additional, Irina, M., additional, Adrian, C., additional, Bosch, E., additional, Baamonde, E., additional, Culebras, C., additional, Perez, G., additional, El Hayek, B., additional, Ramirez, J. I., additional, Ramirez, A., additional, Garcia, C., additional, Lago, M., additional, Toledo, A., additional, Checa, M. D., additional, Taira, T., additional, Hirano, T., additional, Nohtomi, K., additional, Hyodo, T., additional, Chiba, T., additional, Saito, A., additional, Kim, Y. K., additional, Choi, E. J., additional, Yang, C. W., additional, Kim, Y.-S., additional, Lim, P. S., additional, Ming Ying, W., additional, Ya-Chung, J., additional, Zaripova, I., additional, Kayukov, I., additional, Essaian, A., additional, Nimgirova, A., additional, Young, H., additional, Dungey, M., additional, Watson, E. L., additional, Baines, R., additional, Burton, J. O., additional, Smith, A. C., additional, Yamazaki, K., additional, Bossola, M., additional, Colacicco, L., additional, Scribano, D., additional, Vulpio, C., additional, Tazza, L., additional, Okada, T., additional, Okada, N., additional, Michibata, I., additional, Yura, T., additional, Montero, N., additional, Soler, M., additional, Pascual, M., additional, Barrios, C., additional, Marquez, E., additional, Rodriguez, E., additional, Orfila, M. A., additional, Cao, H., additional, Arcos, E., additional, Comas, J., additional, Pascual, J., additional, Ferrario, M., additional, Garzotto, F., additional, Sironi, T., additional, Monacizzo, S., additional, Basso, F., additional, Cruz, D. N., additional, Moissl, U., additional, Tetta, C., additional, Signorini, M. G., additional, Cerutti, S., additional, Ronco, C., additional, Mostovaya, I., additional, Grooteman, M., additional, Van den Dorpel, M., additional, Penne, L., additional, Van der Weerd, N., additional, Mazairac, A., additional, Den Hoedt, C., additional, Levesque, R., additional, Nube, M., additional, Ter Wee, P., additional, Bots, M., additional, Blankestijn, P., additional, Liu, J., additional, MA, K. L., additional, Zhang, X., additional, Liu, B. C., additional, Vladu, I.-D., additional, Mustafa, R., additional, Cana-Ruiu, D., additional, Vaduva, C., additional, Grauntanu, C., additional, Mota, E., additional, Singh, R., additional, Abbasian, N., additional, Stover, C., additional, Brunskill, N., additional, Burton, J., additional, Herbert, K., additional, Bevington, A., additional, Wu, M., additional, Tang, R.-N., additional, Gao, M., additional, Liu, H., additional, Chen, L., additional, LV, L.-L., additional, Liu, B.-C., additional, Nikodimopoulou, M., additional, Liakos, S., additional, Kapoulas, S., additional, Karvounis, C., additional, Fedak, D., additional, Kuzniewski, M., additional, Paulina, D., additional, Kusnierz-Cabala, B., additional, Kapusta, M., additional, Solnica, B., additional, Junque, A., additional, Vicent, E. S., additional, Moreno, L., additional, Fulquet, M., additional, Duarte, V., additional, Saurina, A., additional, Pou, M., additional, Macias, J., additional, Lavado, M., additional, Ramirez de Arellano, M., additional, Ryuzaki, M., additional, Nakamoto, H., additional, Kinoshita, S., additional, Kobayashi, E., additional, Takimoto, C., additional, Shishido, T., additional, Enia, G., additional, Torino, C., additional, Tripepi, R., additional, Panuccio, V., additional, Postorino, M., additional, Clementi, A., additional, Garozzo, M., additional, Bonanno, G., additional, Boito, R., additional, Natale, G., additional, Cicchetti, T., additional, Chippari, A., additional, Logozzo, D., additional, Alati, G., additional, Cassani, S., additional, Sellaro, A., additional, Zoccali, C., additional, Quiroga, B., additional, Verde, E., additional, Abad, S., additional, Vega, A., additional, Goicoechea, M., additional, Reque, J., additional, Lopez-Gomez, J. M., additional, Luno, J., additional, Cabre Menendez, C., additional, Moles, V., additional, Vives, J. P., additional, Villa, D., additional, Vinas, J., additional, Compte, T., additional, Arruche, M., additional, Diaz, C., additional, Soler, J., additional, Aguilera, J., additional, Martinez Vea, A., additional, De Mauri, A., additional, David, P., additional, Conte, M. M., additional, Chiarinotti, D., additional, Ruva, C. E., additional, De Leo, M., additional, Bargnoux, A.-S., additional, Morena, M., additional, Jaussent, I., additional, Chalabi, L., additional, Bories, P., additional, Dion, J.-J., additional, Henri, P., additional, Delage, M., additional, Dupuy, A.-M., additional, Badiou, S., additional, Canaud, B., additional, Cristol, J.-P., additional, Sironi, E., additional, Pieruzzi, F., additional, Galbiati, E., additional, Vigano, M. R., additional, Anpalakhan, S., additional, Rocha, S., additional, Chitalia, N., additional, Sharma, R., additional, Kaski, J. C., additional, Chambers, J., additional, Goldsmith, D., additional, Banerjee, D., additional, Cernaro, V., additional, Lacquaniti, A., additional, Lupica, R., additional, Lucisano, S., additional, Fazio, M. R., additional, Donato, V., additional, Buemi, M., additional, Segalen, I., additional, Vinsonneau, U., additional, Tanquerel, T., additional, Quiniou, G., additional, Le Meur, Y., additional, Seibert, E., additional, Girndt, M., additional, Zohles, K., additional, Ulrich, C., additional, Kluttig, A., additional, Nuding, S., additional, Swenne, C., additional, Kors, J., additional, Werdan, K., additional, Fiedler, R., additional, Van der Weerd, N. C., additional, Grooteman, M. P., additional, Van den Dorpel, M. A., additional, Nube, M. J., additional, Wetzels, J., additional, Swinkels, D. W., additional, Ter Wee, P. M., additional, Khandekar, A., additional, Khandge, J., additional, Lee, J. E., additional, Moon, S. J., additional, Choi, K. H., additional, Lee, H. Y., additional, Kim, B. S., additional, Tuaillon, E., additional, Rodriguez, A., additional, Chenine, L., additional, Vendrell, J.-P., additional, Sue, Y.-M., additional, Tang, C.-H., additional, Chen, Y.-C., additional, Segura, P., additional, Garcia Cortes, M. J., additional, Gil, J. M., additional, Biechy, M. M., additional, Poulikakos, D., additional, Shah, A., additional, Persson, M., additional, Dattolo, P., additional, Amidone, M., additional, Michelassi, S., additional, Moriconi, L., additional, Betti, G., additional, Conti, P., additional, Rosati, A., additional, Mannarino, A., additional, Panichi, V., additional, Pizzarelli, F., additional, Klejna, K., additional, Naumnik, B., additional, Koc-Zorawska, E., additional, Mysliwiec, M., additional, Dimitrie, S., additional, Simona, H., additional, Mihaela, O., additional, Gabriela, O., additional, Radu, S., additional, Octavian, P., additional, Akdam, H., additional, Akar, H., additional, Yenicerioglu, Y., additional, Kucuk, O., additional, Kurt Omurlu, I., additional, Thambiah, S., additional, Roplekar, R., additional, Manghat, P., additional, Fogelman, I., additional, Fraser, W., additional, Hampson, G., additional, Likaj, E., additional, Caco, G., additional, Seferi, S., additional, Rroji, M., additional, Barbullushi, M., additional, Thereska, N., additional, Serban, A., additional, Carmen, V., additional, Cristian, S., additional, Silvia, L., additional, and Covic, A., additional
Published: 2012
Full Text: View/download PDF

27. Transplantation: clinical studies

Author: Crespo, M., primary, Collado, S., additional, Mir, M., additional, Hurtado, S., additional, Cao, H., additional, Barbosa, F., additional, Serra, C., additional, Hidalgo, C., additional, Faura, A., additional, Garcia de Lomas, J., additional, Montero, M., additional, Horcajada, J. P., additional, Puig, J. M., additional, Pascual, J., additional, Ulusal Okyay, G., additional, Uludag, K., additional, Sozen, H., additional, Arman, D., additional, Dalgic, A., additional, Guz, G., additional, Fraile, P., additional, Garcia-Cosmes, P., additional, Rosado, C., additional, Gonzalez, C., additional, Tabernero, J. M., additional, Costa, C., additional, Saldan, A., additional, Astegiano, S., additional, Terlizzi, M. E., additional, Messina, M., additional, Bergallo, M., additional, Segoloni, G., additional, Cavallo, R., additional, Schwarz, A., additional, Grosshennig, A., additional, Heim, A., additional, Broecker, V., additional, Haller, H., additional, Linnenweber, S., additional, Liborio, A. B., additional, Mendoza, T. R., additional, Esmeraldo, R. M., additional, Oliveira, M. L. M. B., additional, Nogueira Paes, F. J. V., additional, Silva Junior, G. B., additional, Daher, E. F., additional, Hodgson, K., additional, Baharani, J., additional, Fenton, A., additional, Mjoen, G., additional, Hartmann, A., additional, Reisaeter, A., additional, Midtvedt, K., additional, Dahle, D. O., additional, Holdaas, H., additional, Shabir, S., additional, Lukacik, P., additional, Bevins, A., additional, Basnayake, K., additional, Bental, A., additional, Hughes, R. G., additional, Cockwell, P., additional, Burrows, R., additional, Hutchison, C. A., additional, Varma, P., additional, Kumar, A., additional, Hooda, A., additional, Badwal, S., additional, Barrios, C., additional, Crespo, M., additional, Fumado, L., additional, Frances, A., additional, Arango, O., additional, Pawlik, A., additional, Chudek, J., additional, Kolonko, A., additional, Wilk, J., additional, Jalowiecki, P., additional, Wiecek, A., additional, Teplan, V., additional, Kralova-Lesna, I., additional, Mahrova, A., additional, Racek, J., additional, tollova, M., additional, Maggisano, V., additional, Caracciolo, V., additional, Solazzo, A., additional, Montanari, M., additional, Della Grotta, F., additional, Nakazawa, D., additional, Nishio, S., additional, Nakagaki, T., additional, Ishikawa, Y., additional, Ito, M., additional, Shibazaki, S., additional, Shimoda, N., additional, Miura, M., additional, Morita, K., additional, Nonomura, K., additional, Koike, T., additional, Locsey, L., additional, Seres, I., additional, Sztanek, F., additional, Harangi, M., additional, Padra, J., additional, Asztalos, L., additional, Paragh, G., additional, Rodriguez-Reimundes, E., additional, Soler-Pujol, G., additional, Diaz, C. H., additional, Davalos-Michel, M., additional, Vilches, A. R., additional, Laham, G., additional, Stavem, K., additional, Norby, G., additional, Tutal, E., additional, Canver, B., additional, Can, S., additional, Sezer, S., additional, Colak, T., additional, Paschoalin, R., additional, Barros, X., additional, Duran, C., additional, Torregrosa, J. V., additional, Tellez, E., additional, Marin, M., additional, Smalcelj, R., additional, Smalcelj, A., additional, Claes, K., additional, Petit, T., additional, Bammens, B., additional, Kuypers, D., additional, Naesens, M., additional, Vanrenterghem, Y., additional, Evenepoel, P., additional, Gerhart, M. K., additional, Colbus, S., additional, Seiler, S., additional, Grun, O., additional, Fliser, D., additional, Heine, G. H., additional, Vincenti, F., additional, Grinyo, J., additional, Larsen, C., additional, Medina Pestana, J., additional, Dong, Y., additional, Thomas, D., additional, Charpentier, B., additional, Luna, E., additional, Martinez, R., additional, Cerezo, I., additional, Ferreira, F., additional, Cubero, J., additional, Villa, J., additional, Martinez, C., additional, Garcia, C., additional, Rodrigo, E., additional, Santos, L., additional, Pinera, C., additional, Quintela, E., additional, Ruiz, J. C., additional, Fernandez-Fresnedo, G., additional, Palomar, R., additional, Gomez-Alamillo, C., additional, Martin de Francisco, A. L., additional, Arias, M., additional, Nainan, G., additional, del Carmen Rial, M., additional, Steinberg, S., additional, Kamar, N., additional, Durrbach, A., additional, Becker, T., additional, Florman, S., additional, Lang, P., additional, Schnitzler, M., additional, Duan, T., additional, Block, A., additional, Sawosz, M., additional, Cieciura, T., additional, Durlik, M., additional, Perkowska, A., additional, Sikora, P., additional, Beck, B., additional, De Mauri, A., additional, Brambilla, M., additional, Stratta, P., additional, Chiarinotti, D., additional, De Leo, M., additional, Attou, S., additional, Arzour, H., additional, Boudrifa, N., additional, Mekhlouf, N., additional, Gaouar, A., additional, Merazga, S., additional, Kalem, K., additional, and Haddoum, F., additional
Published: 2011
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28. [Renal biopsy practice in Piedmont and Valle d'Aosta].,Indagine sulle modalità di esecuzione delle biopsia renale in Piemonte e Valle d'Aosta

Author: Manganaro, M., Nebiolo, P. E., Rollino, C., Giacchino, F., Savoldi, S., Besso, L., Colla, L., Amore, A., Ferro, M., Marazzi, F., Chiarinotti, D., Guarnieri, A., Quaglia, M., Manes, M., Vaccaro, V., Marcuccio, C., Licata, C., Patti, R., Mariano, F., Bongi, A. M., Biamino, E., Boschetti, M. A., Della Volpe, M., Malcangi, U., Baroni, A., Vagelli, G., Costantini, L., Salomone, M., Marco Formica, Caramello, E., Campo, A., Pignone, E., Messuerotti, A., Roccatello, D., Stratta, P., Segoloni, G., and Coppo, R.

29. [Renal biopsy practice in Piedmont and Valle d'Aosta]

Author: Manganaro, M., Nebiolo, Pe, Rollino, C., Giacchino, F., Savoldi, S., Besso, L., Colla, L., Amore, A., Ferro, M., Marazzi, F., Chiarinotti, D., Guarnieri, A., Marco QUAGLIA, Manes, M., Vaccaro, V., Marcuccio, C., Licata, C., Patti, R., Mariano, F., Bongi, Am, Biamino, E., Boschetti, Ma, Della Volpe, M., Malcangi, U., Baroni, A., Vagelli, G., Costantini, L., Salomone, M., Formica, M., Caramello, E., Campo, A., Pignone, E., Messuerotti, A., Roccatello, D., Stratta, P., Segoloni, G., and Coppo, R.
Subjects: Italy, Biopsy, Needle, Humans, Practice Patterns, Physicians', Kidney
Abstract: In 2010 a questionnaire was administered to the renal units of Piedmont and Valle d'Aosta to analyze their procedures for renal biopsy (RB). Seventy-eight percent of units performed RBs, 57% for more than 20 years, but only 43% performed at least 20 BRs per year. 20/21 units performed RB in an inpatient setting and 1/21 in day hospital with the patient remaining under observation the night after. Thirty-two percent did not consider a single kidney as a contraindication to RB, 59% considered it a relative contraindication and 9% considered it an absolute contraindication. In 90.5% of units there was a specific protocol for patient preparation for RB and 86% used a specific informed consent form. Ninety-five percent of units performed ultrasound-guided RB, 60% of them using needle guides attached to the probe. In 81% of units the left side was preferred; 71% put a pillow under the patient's abdomen. All units used disposable, automated or semi-automated needles. Needle size was 16G in 29%, 18G in 58%, and both 16G and 18G in 14% of units; 1 to 3 samples were drawn. One third of units had a microscope available for immediate evaluation of specimen adequacy. After RB, 86% of units kept patients in the prone position for 2-6 hours and all prescribed a period of bed rest (at least 24 hours in 90.5%). 90.5% of units followed a specific postbiopsy observation protocol consisting of blood pressure, heart rate and red blood cell measurements at different times, and urine monitoring and ultrasound control within 12-24 hours (only half of them also employing color Doppler). One third of all units discharged patients after 1 day and two thirds after 2-3 days; all prescribed abstention from effort and from antiplatelet drugs for 7-15 days. In 9 units both RB and tissue processing and examination were done in the same hospital, while 12 units sent the samples elsewhere. 76% obtained results in 2-4 days, 19% in 6-7 days, and 5% in 10-15 days. Less than 20% of the interviewed operators were fully familiar with the clauses of hospital insurance securing their activity. Use of RB is widespread in Piedmont and Valle d'Aosta but its practice shows variation between centers.

30. Effects of Rheopheresis in dialysis patients with peripheral artery disease and diabetic foot ulcers: A multicentric Italian study.

Author: Altobelli C, Fabiani FC, Anastasio P, Pluvio C, de Pascale E, Vernaglione L, Gernone G, Di Luca M, Bertuzzi V, Brescia P, Toffoletto P, D'Arezzo M, Brustia M, Andreana De Mauri, Chiarinotti D, Loschiavo C, Grecò M, D'Elia F, Gallo MA, Tarroni G, Di Liberato L, Perna AF, Capasso G, and Capolongo G
Subjects: Humans, Male, Aged, Female, Middle Aged, Italy, Blood Component Removal methods, Treatment Outcome, Wound Healing, Aged, 80 and over, Peripheral Arterial Disease therapy, Renal Dialysis adverse effects, Diabetic Foot therapy
Abstract: Background: Peripheral artery disease (PAD) in hemodialysis (HD) patients has a significant social impact due to its prevalence, poor response to standard therapy and dismal prognosis. Rheopheresis is indicated by guidelines for PAD treatment., Materials and Methods: Twenty-five HD patients affected by PAD stage IV Lerichè-Fontaine and ischemic ulcer 1C or 2C according to the University of Texas Wound Classification System (UTWCS), without amelioration after traditional medical therapy and/or revascularization, were selected and underwent 12 Rheopheresis sessions in 10 weeks. Improvements in pain symptoms using Numerical Rating Scale (NRS), healing ulcers and laboratory hemorheological parameters have been evaluated., Results: A clinically and statistically significant mean value reduction and of relative percentage differences between estimated marginal means (Δ), calculated at each visits, of NRS was observed, with a maximum value (-48.5%) between the first and last visit. At the end of the treatment period 14.3% of ulcers were completely healed, 46.4% downgraded, 53.6% were stable. Overall, no ulcers upgraded. A statistically significant reduction of the Δ, between the first and last visit, for fibrinogen (-16%) was also observed., Conclusion: Rheopheresis reduced overall painful symptoms; data suggest that it could heal or improve ulcers and hemorheological laboratory parameters in HD patients with PAD and ischemic ulcers resistant to standard therapies., (© 2024 The Author(s). Journal of Clinical Apheresis published by Wiley Periodicals LLC.)
Published: 2024
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31. Increase of continuous treatments and regional citrate anticoagulation during renal replacement therapy in the ICUs of the North-West of Italy from 2007 to 2015.

Author: Mariano F, Inguaggiato P, Pozzato M, Turello E, David P, Berutti S, Manes M, Leonardi G, Gai M, Mella A, Canepari G, Forneris G, Storace G, Brustia M, Pellù V, Consiglio V, Tognarelli G, Bonaudo R, Gianoglio B, Campo A, Viglino G, Marino A, Maffei S, Roscini E, Calabrese G, Gherzi M, Formica M, Stramignoni E, Salomone M, Martina G, Serra A, Deagostini C, Savoldi S, Marciello A, Todini V, Chiappero F, Vio P, Borzumati M, Costantini L, Filiberti O, Cesano G, Boero R, Vitale C, Chiarinotti D, Manganaro M, Besso L, Cusinato S, Roccatello D, and Biancone L
Subjects: Humans, Renal Replacement Therapy methods, Intensive Care Units, Italy, Citrates, Anticoagulants, Renal Dialysis, Citric Acid
Abstract: Background: Few reports have addressed the change in renal replacement therapy (RRT) management in the Intensive care Units (ICUs) over the years in western countries. This study aims to assess the trend of dialytic practice in a 4.5-million population-based study of the northwest of Italy., Methods: A nine-year survey covering all the RRT provided in the ICUs. Consultant nephrologists of the 26 Nephrology and Dialysis centers reported their activities in the years 2007, 2009, 2012, and 2015., Results: From 2007 to 2015 the patients treated increased from 1042 to 1139, and the incidence of RRT from 254 to 263 cases/10^6 inhabitants. The workload for dialysis center was higher in the larger hub hospitals. RRT for acute kidney injury (AKI), continuation of treatment in chronically dialyzed patients, or extrarenal indications accounted for about the stable rate of 70, 25 and 5% of all RRT sessions, respectively. Continuous modality days increased from 2731 days (39.5%) in 2007 to 5076 (70.6%) in 2015, when the continuous+prolonged treatment days were 6880/7196 (95.6% of total days). As to RRT timing, in 2015 only the classical clinical criteria, and no K-DIGO stage were adopted by most Centers. As to RRT interruption, in 2015 urine volume was the first criterion. Implementation of citrate anticoagulation (RCA) for RRT patients significantly increased from 2.8% in 2007 to 30.9% in 2015, when it was applied in all 26 Centers., Conclusions: From 2007 to 2015, current practice has changed towards shared protocols, with increasing continuous modality and RCA implementation.
Published: 2023
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32. Ionizing radiation exposure from dialysis tunneled catheters procedures: European directive and legal implications.

Author: De Mauri A, Matheoud R, Guzzardi G, Vaccarone V, David P, Brambilla M, and Chiarinotti D
Subjects: Humans, Radiation, Ionizing, Renal Dialysis, Catheterization, Central Venous adverse effects, Catheterization, Central Venous methods, Central Venous Catheters, Radiation Exposure adverse effects, Radiation Exposure prevention & control, Radiation Protection
Abstract: Background: Advances in medical imaging and interventional procedures have been associated with increased exposure to ionizing radiation. Thus, the International Commission on Radiological Protection (ICRP) established uniform safety standards to protect the general public against the dangers arising from ionizing radiations. In Europe, the ICRP standards are listed in the European Directive 2013/59/EURATOM, which should be transposed into national legislation by member states. They require that the administered dose must be part of the radiological report and identify the practitioners' responsibilities in justifying and optimizing the dose and correctly informing the patient.Despite these indications, the literature lacks information about the dose from fluoroscopically inserted dialysis tunneled central venous catheters (td-CVC). This study aimed to quantify the effective dose and organ dose to relevant organs in td-CVC to comply with the EU statements., Methods: We revised fluoroscopically-guided procedures of td-CVC insertion, considering dose per area product, fluoroscopic time, effective dose, organ dose, and anatomical district. We also compared these parameters with those of fluoroscopically inserted oncological central venous devices (Port-a-cath)., Results: The dose-area product, fluoroscopic time, and organ dose for td-CVC were 13 ± 22.2 Gy*cm 2 , 81 ± 129 s, and 1.9 ± 3.3 mSv. The radiological parameters for the left internal jugular, subclavian and femoral veins were similar but higher than for the right internal jugular vein. The radiological parameters were significantly higher for td-CVC than for Port-a-cath., Conclusions: Fluoroscopically inserted td-CVC are associated with a relatively low dose of ionizing radiation, with considerable variability due to the anatomical puncture site and previous accesses' history. In light of the European Directive, it is a concern for nephrologists to be aware of the administered ionizing dose to comply with their legal responsibilities.
Published: 2022
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33. Does Mediterranean Adequacy Index Correlate with Cardiovascular Events in Patients with Advanced Chronic Kidney Disease? An Exploratory Study.

Author: De Mauri A, Carrera D, Vidali M, Bagnati M, Rolla R, Riso S, Chiarinotti D, and Torreggiani M
Subjects: Adult, Female, Humans, Indican, Male, Quality of Life, Sulfates, Cardiovascular Diseases etiology, Diet, Mediterranean, Renal Insufficiency, Chronic, Toxins, Biological
Abstract: The Mediterranean Diet (MD) is a healthy dietary pattern, demonstrated to reduce the risk of cancer, diabetes, cardiovascular and neurodegenerative diseases, and early death. The Mediterranean Adequacy Index (MAI) is used to measure adherence to the MD in perspective studies in the general population and correlates with cardiovascular events. The aim of this study was to calculate the MAI among patients with advanced chronic kidney disease (CKD) and correlate it with traditional uremic, microbiota-derived, and proatherogenic toxins as well as nutritional status, quality of life, and cardiovascular events. A total of 60 adult patients with advanced CKD were enrolled and their MAI was calculated. According to the median value, patients were divided into lower (l-MAI, <1.80) and higher (h-MAI, ≥1.80) MAI groups. Biochemical parameters, microbiota-derived and proatherogenic toxins (p-Cresyl sulphate, Indoxyl-sulphate, and Lipoprotein-associated phospholipase A2), nutritional status, quality of life, and cardiovascular events that occurred in the previous three years were recorded. The mean value of the MAI was 2.78 ± 2.86. The MAI was significantly higher in foreigners (median (IQR) 6.38 (8.98) vs. 1.74 (1.67), p < 0.001) and diabetic patients. The l-MAI and h-MAI groups had similar routinary blood, p-Cresyl-sulphate, Indoxyl-sulphate, and Lp-PLA2 as well as nutritional status and quality of life parameters. The MAI was not associated with previous cardiovascular events and did not correlate with cardiovascular events in CKD patients. New and nephro-tailored indexes are warranted to evaluate nutritional therapy in CKD patients.
Published: 2022
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34. Probiotics-Supplemented Low-Protein Diet for Microbiota Modulation in Patients with Advanced Chronic Kidney Disease (ProLowCKD): Results from a Placebo-Controlled Randomized Trial.

Author: De Mauri A, Carrera D, Bagnati M, Rolla R, Vidali M, Chiarinotti D, Pane M, Amoruso A, and Del Piano M
Subjects: Cholesterol, LDL, Diet, Protein-Restricted, Double-Blind Method, Female, Humans, Male, Gastrointestinal Microbiome, Microbiota, Probiotics therapeutic use, Renal Insufficiency, Chronic microbiology, Renal Insufficiency, Chronic therapy, Toxins, Biological pharmacology
Abstract: The probiotics-supplemented low-protein diet in chronic kidney disease (ProLowCKD) was a single-centre, double-blind, placebo-controlled, randomised trial that was conducted to investigate whether the association between a low protein diet (LPD) and a new formulation of probiotics ( Bifidobacterium longum and Lactobacillus reuteri ) was effective at reducing traditional uremic, microbiota-derived, and proatherogenic toxins in sixty patients affected by advanced CKD. After 2 months of a LPD-a reduction in blood urea nitrogen (52 ± 17 vs. 46 ± 15 mg/dL, p = 0.003), total cholesterol (185 ± 41 vs. 171 ± 34 mg/dL, p = 0.001), and triglycerides (194 ± 148 vs. 161 ± 70 mg/dL, p = 0.03) was observed; 57 subjects were then randomized to receive probiotics or a placebo for the subsequent 3 months. A total of 27 patients in the placebo group showed increased serum values of total cholesterol (169 ± 36 vs. 185 ± 40 mg/dL, p = 0.01), LDL cholesterol (169 ± 36 vs. 185 ± 40 mg/dL, p = 0.02), lipoprotein-associated phospholipase A 2 (155.4 ± 39.3 vs. 167.5 ± 51.4 nmol/mL/min, p = 0.006), and indoxyl-sulphate (30.1 ± 17.6 vs. 34.5 ± 20.2 μM, p = 0.026), while the 24 subjects in the probiotics group showed a trend in the reduction of microbiota toxins. A reduction of antihypertensive and diuretic medications was possible in the probiotics group. This study shows that associating probiotics to LPD may have an additional beneficial effect on the control and modulation of microbiota-derived and proatherogenic toxins in CKD patients.
Published: 2022
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35. Compliance, Adherence and Concordance Differently Predict the Improvement of Uremic and Microbial Toxins in Chronic Kidney Disease on Low Protein Diet.

Author: De Mauri A, Carrera D, Vidali M, Bagnati M, Rolla R, Riso S, Torreggiani M, and Chiarinotti D
Subjects: Adult, Blood Urea Nitrogen, Diet, Protein-Restricted, Humans, Patient Compliance, Renal Insufficiency, Chronic, Toxins, Biological
Abstract: Background: In medicine, "compliance" indicates that the patient complies with the prescriber's recommendations, "adherence" means that "the patient matches the recommendations" and "concordance" means "therapeutic alliance" between patient and clinician. While a low protein diet (LPD) is a cornerstone treatment of chronic kidney disease (CKD), monitoring the actual performance of LPD is a challenge., Patients: Fifty-seven advanced CKD adult patients were enrolled and LPD prescribed. Compliance was evaluated through the normalized protein catabolic rate (nPCR), adherence by the dietitian by means of a 24-h dietary recall and concordance by the nephrologist during consultations. Traditional parameters as well as total p-Cresyl Sulphate (t-PCS), total Indoxyl Sulphate (t-IS) and Lipoprotein-associated phspholipase A 2 (Lp-PLA 2 ) were compared between adherent/not adherent and concordant/not concordant subjects at enrolment and after two months., Results: nPCR, blood urea nitrogen, cholesterol and triglycerides significantly decreased in all patients. t-PCS and t-IS decreased among adherent subjects. Lp-PLA 2 , t-PCS, free-PCS and t-IS decreased among concordant subjects, while these increased in non-concordant ones., Conclusion: This study demonstrates that LPD may improve the control of traditional uremic toxins and atherogenic toxins in "adherent" and "concordant" patients. A comprehensive and multidisciplinary approach is needed to evaluate the compliance/adherence/concordance to LPD for optimizing nutritional interventions.
Published: 2022
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36. Lipoprotein-associated phospholipase A2 predicts lower limb ischemia in hemodialysis subjects.

Author: De Mauri A, Vidali M, Chiarinotti D, Dianzani U, and Rolla R
Subjects: Aged, Female, Humans, Ischemia blood, Ischemia enzymology, Leg blood supply, Male, Middle Aged, Peripheral Arterial Disease enzymology, Prevalence, Risk Assessment, 1-Alkyl-2-acetylglycerophosphocholine Esterase blood, Peripheral Arterial Disease blood, Peripheral Arterial Disease epidemiology, Renal Dialysis
Abstract: Hemodialyzed patients (HD) have high prevalence of peripheral arterial disease. In the general population, lipoprotein-associated phospholipase A2 (Lp-PLA 2 ) is associated with peripheral arterial disease but no data are available for renal subjects. The aim of this study was to evaluate the relationship between Lp-PLA 2 and lower limb ischemia among dialyzed patients. One hundred and two dialyzed subjects, with median (IQR) age of 71 (59-78) years, enrolled in June 2013 and followed until June 2018, were investigated for Lp-PLA 2 activity and the occurrence of peripheral arterial disease and lower limb ischemia. The median (IQR) levels of Lp-PLA 2 were 184 nmol/min/mL (156.5-214.5). The 43 HD patients with abnormal Lp-PLA 2 activity (>194 nmol/min/mL) had higher levels of total and LDL-cholesterol, ApoB/A1 ratio, and higher occurrence of lower limb ischemia during the follow up (44% vs 17%, P = .003). In multivariate analysis, Lp-PLA 2 activity (P = .018) and diabetes (P < .001) were independently associated with time to lower limb ischemia, and when the presence of previous PAD was added to the multivariate model, only presence of previous PAD (P < .001) and Lp-PLA 2 (P = .003) remained associated. Lp-PLA 2 is an independent predictor of lower limb ischemia in dialyzed patients., (© 2019 International Society for Apheresis, Japanese Society for Apheresis, and Japanese Society for Dialysis Therapy.)
Published: 2020
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37. Lipoprotein-associated phospholipase A2 predicts cardiovascular events in dialyzed patients.

Author: De Mauri A, Vidali M, Chiarinotti D, Bellomo G, and Rolla R
Subjects: Aged, Biomarkers blood, Cardiovascular Diseases diagnosis, Cardiovascular Diseases mortality, Female, Humans, Kidney Diseases blood, Kidney Diseases diagnosis, Kidney Diseases mortality, Male, Middle Aged, Prognosis, Renal Dialysis mortality, Retrospective Studies, Risk Assessment, Risk Factors, Time Factors, Up-Regulation, 1-Alkyl-2-acetylglycerophosphocholine Esterase blood, Cardiovascular Diseases blood, Kidney Diseases therapy, Renal Dialysis adverse effects
Abstract: Background: Lipoprotein-associated phospholipase A 2 (Lp-PLA 2 ) is a serine lipase that enhances the instability of the atherosclerotic plaques. While in the general and cardiac population Lp-PLA 2 is recognized as an important determinant of cardiovascular (CV) accidents, no data are available for the renal population. The aim of this study was to evaluate the relationship between Lp-PLA2 and acute CV events in hemodialyzed patients., Methods: We enrolled 102 dialyzed patients, 63% male, age 71 years (59-78), 35% with diabetes, 54% hypertension, 40% coronary artery disease and 31% peripheral vascular disease. They were investigated for Lp-PLA2 (cut-off < 194 nmol/min/ml), lipoprotein profile and the occurrence of acute CV events and death in the subsequent 3 years of follow-up., Results: The median (interquartile ranges) levels of Lp-PLA2, total-, HDL-, LDL-cholesterol and ApoB/ApoA lipoprotein ratio were 184.5 (156.5-214.5) nmol/min/ml, 158 (127-191) mg/dl, 41 (33-51) mg/dl, 79 (63-102) mg/dl and 0.72 (0.58-0.89), respectively. In 42% of patients, Lp-PLA2 was > 194 nmol/min/ml and total- and LDL-cholesterol were higher, as well as CV morbidity and mortality. During follow-up, 51% of patients developed at least one CV event; the median survival time was 36 months, with a total and CV mortality of 42 and 29%, respectively. At multivariate Cox regression, Lp-PLA2 > 194 nmol/min/ml (HR = 2.98, p = 0.005), age (HR = 1.03, p = 0.029), diabetes (HR = 2.86, p = 0.002) and hypertension (HR = 2.93, p = 0.002) were independently associated with time to CV events., Conclusions: Lp-PLA2 activity is elevated among dialyzed patients and is an independent risk factor for acute CV events in a mean follow-up of 3 years.
Published: 2019
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38. [Efficacy of SUPRA HFR in the treatment of acute renal damage during multiple myeloma].

Author: Daidola G, Guarena C, Brustia M, Leonardi G, Vigotti FN, Marciello A, Bianco S, Chiarinotti D, Saltarelli M, Besso L, and Biancone L
Subjects: Acute Kidney Injury etiology, Aged, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Combined Modality Therapy, Female, Humans, Immunoglobulin Light Chains metabolism, Male, Middle Aged, Multiple Myeloma drug therapy, Myeloma Proteins metabolism, Plasmapheresis, Treatment Outcome, Acute Kidney Injury therapy, Hemodiafiltration methods, Multiple Myeloma complications
Abstract: Acute Kidney Injury (AKI) is a frequent complication of multiple myeloma (MM) with unfavorable prognostic significance. Light chains removal, combined with hematological therapy (CT) seems to offer significant benefits to renal function recovery (RFR). The SUPRA HFR, through the combination of high cut-off membrane without albumin loss and adsorbent cartridge, represents one of the "emerging" light chain removal methods. We report our multicentric retrospective experience with SUPRA HFR in 7 MM patients. At the end of the treatment with SUPRA HFR a significant reduction in serum free light chains compared to baseline was observed (min 24%; max 90%; median 74%). Despite a not always early start of the treatment, all patients recovered renal function with withdrawal from dialysis in 6/7 cases. Our preliminary experience of a combination of SUPRA HFR treatment with CT in 7 MM patients with AKI showed a significative renale functional recovery, with favourable cost/benefit ratio and a simple treatment schedule. These encouraging data suggest to further extend such treatment option, waiting for larger studies in this field., (Copyright by Società Italiana di Nefrologia SIN, Rome, Italy.)
Published: 2018

39. Vitamin K Antagonist Therapy Is a Risk Factor for Ulcer Development and Death Among Dialyzed Patients.

Author: De Mauri A, Torreggiani M, Brambilla M, and Chiarinotti D
Subjects: Aged, Amputation, Surgical statistics & numerical data, Comorbidity, Female, Humans, Lower Extremity, Male, Renal Dialysis, Retrospective Studies, Risk Factors, Uremia epidemiology, Anticoagulants adverse effects, Diabetes Mellitus, Type 2 epidemiology, Foot Ulcer epidemiology, Peripheral Arterial Disease epidemiology, Vitamin K antagonists & inhibitors
Abstract: Peripheral artery disease is a common complication among dialyzed patients. Since Vitamin K antagonists promote metastatic calcifications and these are the main determinants of vascular damage, we investigated their role in the development of lower limb ulcers in dialyzed patients. We retrospectively enrolled 316 dialyzed patients, aged 68 ± 15 years, 65% male, 32% diabetic, 43% with ischemic heart disease and followed them for 36 ± 25 months. 60 patients assumed Vitamin K antagonists: they were older, with a higher prevalence of heart disease, at greater risk of death and they developed more ulcers and underwent more lower limb amputations compared to the rest of our cohort. Peripheral artery disease, Vitamin K antagonists and diabetes were independent risk factors for foot lesions. In addition, Vitamin K antagonists were also an independent risk factor for death. Vitamin K antagonists are a potent independent risk factor for the development of the uremic foot syndrome and death., (© 2017 International Society for Apheresis, Japanese Society for Apheresis, and Japanese Society for Dialysis Therapy.)
Published: 2017
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40. Radiation exposure from medical imaging in dialyzed patients undergoing renal pre-transplant evaluation.

Author: De Mauri A, Matheoud R, Carriero A, Lizio D, Chiarinotti D, and Brambilla M
Subjects: Adult, Aged, Female, Humans, Male, Middle Aged, Radiation Dosage, Retrospective Studies, Diagnostic Imaging, Kidney Transplantation, Renal Dialysis
Abstract: Background and Aim: Ionizing radiation exposure from medical procedures is rising sharply-the per-capita annual effective dose in the US is 3.0 millisieverts (mSv). Hemodialyzed and kidney transplanted patients receive still higher doses of ionizing radiation due to the presence of multiple comorbidities. The aim of this study was to assess the cumulative effective dose (CED) among dialyzed patients undergoing renal pre-transplant evaluation., Patients and Methods: We evaluated 70 hemodialysis patients between June 2009 and December 2014, aged 46.4 ± 12.0 years. The number and type of radiologic procedures were collected through the Radiology Information System. CED was expressed as total mSv/patient and annual CED (mSv/patient/year)., Results: A total of 744 radiologic procedures were performed, accounting for 3869 mSv of ionizing radiation: conventional radiology, computed tomography and nuclear medicine accounted for 78, 14 and 8 % of the procedures, but they represented, respectively, 8, 83 and 9 % of the total CED. The mean (median) annual CED was 35 (7) mSv/patient/year, while total CED was 72 (32) mSv/patient. Thirty-seven patients were active waitlisted and received 47 (10) mSv during the pre-transplant evaluation and 36 (5) mSv during the waiting phase to maintain active status. Concerning cancer risk, 4 (7 %) patients were classified at low risk (<3 mSv/year), 19 (35 %) at moderate risk (3 to <20 mSv/year), 8 (15 %) at high risk (20 to <50 mSv/year), and 23 (43 %) at very high risk (≥50 mSv/year)., Conclusions: Our study demonstrated that during renal pre-transplant evaluation, dialyzed patients receive a high dose of ionizing radiation. Considering that transplanted individuals have a high incidence of cancer due to multifactorial etiology, it is mandatory to reduce the ionizing radiation imaging.
Published: 2017
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41. Polymorphisms Associated with Increased Cardiovascular Risk in the General Population do not Predict Acute Events in Hemodialysis Patients.

Author: Rolla R, De Mauri A, Vidali M, Valsesia A, Chiarinotti D, and Bellomo G
Subjects: Aged, Factor V genetics, Factor XIII genetics, Female, Humans, Integrin beta3 genetics, Male, Middle Aged, Prothrombin genetics, Cardiovascular Diseases etiology, Polymorphism, Genetic, Renal Dialysis
Abstract: Background: Cardiovascular diseases are the leading cause of morbidity and mortality in hemodialysis patients (HP). The aim of the study was to analyze a series of polymorphisms (known to be associated with increased cardiovascular risk in the general population) in HP, in order to better understand the mechanisms of cardiovascular disease and to find new prevention strategies., Methods: 102 hemodialysis patients were investigated for polymorphisms associated with increased cardiovascular risk in unselected population (FV Leiden R506Q; FV H1299R; FII G20210A; PAI-1 var 4G/5G; GpIIIA T1565C; FXIII var G/T; β-FIBRINOGENO var G/A; ACE I/D; AGT var M/T; ATR-1A1166C; APOE T112C; APOE T158C; MTHFR C677T; MTHFR A1298C; CBS 844ins68)., Results: No difference was observed in the prevalence of the analysed polymorphisms between HP and Caucasian unselected population, with the exception of FV H1299R, PAI-1 (4G/5G), and Factor XIII V34L, which were significantly higher in HP. However none of the genetic factors analysed was associated in HP with the cardiovascular events (non-fatal and fatal) recorded at the time of recruitment or during the eighteen months -follow up., Conclusions: In HP, the traditional genetic risk factors for cardiovascular disease are not able to predict acute cardiac events, peripheral vascular events, and cerebral vascular events recorded during a follow up period of eighteen months.
Published: 2016
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42. Lipoprotein profile, lipoprotein-associated phospholipase A2 and cardiovascular risk in hemodialysis patients.

Author: Rolla R, De Mauri A, Valsesia A, Vidali M, Chiarinotti D, and Bellomo G
Subjects: Adult, Aged, Aged, 80 and over, Apolipoprotein A-I blood, Apolipoproteins B blood, Atherosclerosis blood, C-Reactive Protein metabolism, Case-Control Studies, Ceruloplasmin metabolism, Cholesterol blood, Female, Follow-Up Studies, Humans, Lipoproteins, HDL blood, Lipoproteins, LDL blood, Male, Middle Aged, Prospective Studies, Renal Dialysis, Renal Insufficiency, Chronic complications, Renal Insufficiency, Chronic therapy, Risk, Serum Amyloid A Protein metabolism, Triglycerides blood, 1-Alkyl-2-acetylglycerophosphocholine Esterase blood, Cardiovascular Diseases blood, Cardiovascular Diseases etiology, Renal Insufficiency, Chronic blood
Abstract: Background: Cardiovascular disease is the leading cause of morbidity and mortality in hemodialysis patients; the increased risk of cardiovascular disease is due to accelerated atherosclerosis, inflammation and impaired lipoprotein metabolism. We aimed to evaluate lipoprotein-associated phospholipase A2 (Lp-PLA2) and some pro-inflammatory aspects of the lipoprotein profile in dialyzed patients in order to evaluate the relationship with the accelerated atherosclerosis and vascular accidents., Methods: In 102 dialysis patients and 40 non-uremic controls, we investigated the lipoprotein plasma profile, high sensitivity C-reactive protein (CRP), ceruloplasmin and serum amyloid A protein (SAA), and followed patients for 1 year to analyze the risk of acute cardiovascular events., Results: Total cholesterol, low-density lipoprotein and high-density lipoprotein plasma levels were significantly lower in uremic patients than controls, whereas CRP, SAA, ceruloplasmin, Lp-PLA2 and their ratio with apolipoprotein A1 were significantly higher. Patients with Lp-PLA2 levels >194 nmol/min/ml had more acute cardiovascular events than patients with lower values., Conclusion: Our results show that in dialysis subjects: (1) low-density lipoproteins show a more atherogenic phenotype than in the general population; (2) high-density lipoproteins are less anti-inflammatory; (3) Lp-PLA2 could potentially be used to evaluate cardiovascular risk.
Published: 2015
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43. Stenotrophomonas maltophilia: an emerging pathogen in dialysis units.

Author: De Mauri A, Torreggiani M, Chiarinotti D, Andreoni S, Molinari G, and De Leo M
Subjects: Algorithms, Catheter-Related Infections epidemiology, Humans, Catheter-Related Infections microbiology, Communicable Diseases, Emerging, Gram-Negative Bacterial Infections epidemiology, Gram-Negative Bacterial Infections microbiology, Renal Dialysis, Stenotrophomonas maltophilia isolation & purification
Abstract: Infection is an important cause of morbidity and mortality among patients with end stage renal disease. Stenotrophomonas maltophilia is an unusual yet emerging pathogen in dialysis units. We performed a systematic PubMed/Medline and Scopus review of peer-reviewed English papers on S. maltophilia infections among patients undergoing chronic dialysis, with regard to vascular accesses, systemic infections and environment contaminations. Moreover, we suggest a treatment algorithm to preserve the patient and the permanent dialysis catheters., (© 2014 The Authors.)
Published: 2014
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44. [Acute pielonephritis and renal abscesses in Piedmont and Aosta Valley].

Author: Giacchino F, Piccoli G, Colla L, Fenoglio R, Marazzi F, Amore A, Rollino C, Stratta P, Vella Maria C, Deluca A, Boero R, Chiarinotti D, Licata C, Cravero R, Bainotti S, Manes M, Marcuccio C, Brezzi B, Filippo M, Pignone E, Reinero R, Radin E, and Tamagnone M
Subjects: Acute Disease, Anti-Bacterial Agents therapeutic use, Female, Humans, Italy, Kidney Diseases diagnosis, Kidney Diseases drug therapy, Male, Middle Aged, Abdominal Abscess diagnosis, Abdominal Abscess drug therapy, Bacterial Infections diagnosis, Bacterial Infections drug therapy, Kidney Diseases microbiology, Pyelonephritis diagnosis, Pyelonephritis drug therapy, Pyelonephritis microbiology, Urinary Tract Infections diagnosis, Urinary Tract Infections drug therapy
Abstract: The Piedmont Group of Clinical Nephrology compared the activity of 18 nephrology centers in Piedmont and Aosta Valley as regards acute pielonephritis (APN). Data from more than 500 cases per year of APN were examined. The microbial spectrum of APN consists mainly of Escherichia coli and Klebsiella pneumoniae. Diagnosis was based on both clinical and radiological criteria in most of the centers (computed tomography-CT o Magnetic Resonance Imaging-MRI). In four centers diagnosis was made with the radiological criteria and in one center only with the clinical features. CT and MRI were performed in about 47% and 44% of cases respectively. Urine culture was positive in 22 up to 100% of cases. The most commonly used antibiotics were fluoroquinolones (ciprofloxacin or levofloxacin) and ceftriaxone (50% of centers) or amoxicillin/clavulanic acid (25% of centers). In 75% of the centers, patients received a combination of two antibiotics (aminoglycoside in 22% of them ). In 72% of the centers, almost 50% of the patients were re-examined, while 38.8% of centers re-examined all the patients. Renal ultrasound was inappropriate to identify abscesses. The mean of patients in whom renal abscesses were detected by CT or MRI was 18.2%. The analysis shows a high variability in the way of diagnosing and treating APN in Piedmont and Aosta Valley regions. This suggests that even if APN is a frequent pathological condition, practical recommendations are required.
Published: 2014

45. Leclercia adecarboxylata and catheter-related bacteraemia: review of the literature and outcome with regard to catheters and patients.

Author: De Mauri A, Chiarinotti D, Andreoni S, Molinari GL, Conti N, and De Leo M
Subjects: Administration, Intravenous, Aged, 80 and over, Anti-Bacterial Agents administration & dosage, Catheter-Related Infections drug therapy, Catheter-Related Infections epidemiology, Catheter-Related Infections microbiology, Catheterization, Central Venous adverse effects, Communicable Diseases, Emerging diagnosis, Communicable Diseases, Emerging drug therapy, Communicable Diseases, Emerging epidemiology, Communicable Diseases, Emerging microbiology, Enterobacteriaceae Infections drug therapy, Enterobacteriaceae Infections epidemiology, Enterobacteriaceae Infections microbiology, Humans, Male, Treatment Outcome, Catheter-Related Infections diagnosis, Enterobacteriaceae isolation & purification, Enterobacteriaceae Infections diagnosis
Abstract: Infection is a common complication in patients carrying a central venous catheter (CVC) and is associated with increased morbidity and mortality. Leclercia adecarboxylata is an unusual but emerging pathogen in healthy and immunocompromised patients. We report a case of L. adecarboxylata bacteraemia in a patient with a haemodialysis tunnelled CVC. In accordance with the susceptibility to the tested antimicrobials, a long-course treatment with intravenous gentamicin plus amoxicillin-clavulanic acid and gentamicin-lock therapy was adopted. The patient had a full recovery and the catheter was not removed. We also performed a systematic PubMed/Medline and Scopus review of peer-reviewed English papers on L. adecarboxylata infections, focusing on bacteraemia in patients with different types of CVCs. Moreover, we suggest a treatment algorithm to preserve the patient and maintain the CVC.
Published: 2013
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46. Report of a transient increase in tunneled catheter infections following dialysis facility transfer to a prefabricated structure.

Author: De Mauri A, Chiarinotti D, and De Leo M
Subjects: Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents therapeutic use, Catheter-Related Infections drug therapy, Catheter-Related Infections microbiology, Chi-Square Distribution, Female, Humans, Incidence, Italy epidemiology, Male, Middle Aged, Prospective Studies, Risk Factors, Time Factors, Ambulatory Care Facilities, Catheter-Related Infections epidemiology, Catheterization, Central Venous adverse effects, Catheterization, Central Venous instrumentation, Catheters, Indwelling adverse effects, Central Venous Catheters adverse effects, Facility Design and Construction, Renal Dialysis
Abstract: Purpose: Despite the efforts to promote the native artero-venous fistula as dialysis access, the use of tunneled central venous catheters (tCVC) is increasing. Main complications remain infections of the access, and the environment plays an important role in determining them; however, no studies are available that report dialysis provided in prefabricated temporary buildings. The aim of our study was to assess the incidence of tCVC infections in a container building., Methods: Since May 2009 our Dialysis Center has been located in a container building. The occurrence of local and systemic infections of tCVC when dialysis was provided in the container was compared with the previous two years, when dialysis was provided at the "Home" center. Each year was also divided into semesters to maintain the temporary relationship between the new location and the infections., Results: tCVCs represented approximately 13% of all vascular accesses. In the first six months in the temporary building, 50% of patients presented infections, compared to 13% to 20% during the other periods (P=0.02). In the first six months in the container the incidence of infections was 1.44 per 1000 catheters-days, higher than in any other semester (P=0.02). More infections requiring systemic antibacterial agents occurred over this period., Conclusions: Our study demonstrates that, when a dialysis center is moved to a prefabricated temporary building, the likelihood of tCVC infections increases within the initial months and returns back to the previous levels after a period of adaptation.
Published: 2013
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47. [Renal biopsy practice in Piedmont and Valle d'Aosta].

Author: Manganaro M, Nebiolo PE, Rollino C, Giacchino F, Savoldi S, Besso L, Colla L, Amore A, Ferro M, Marazzi F, Chiarinotti D, Guarnieri A, Quaglia M, Manes M, Vaccaro V, Marcuccio C, Licata C, Patti R, Mariano F, Bongi AM, Biamino E, Boschetti MA, Della Volpe M, Malcangi U, Baroni A, Vagelli G, Costantini L, Salomone M, Formica M, Caramello E, Campo A, Pignone E, Messuerotti A, Roccatello D, Stratta P, Segoloni G, and Coppo R
Subjects: Biopsy, Needle, Humans, Italy, Practice Patterns, Physicians', Kidney pathology
Abstract: In 2010 a questionnaire was administered to the renal units of Piedmont and Valle d'Aosta to analyze their procedures for renal biopsy (RB). Seventy-eight percent of units performed RBs, 57% for more than 20 years, but only 43% performed at least 20 BRs per year. 20/21 units performed RB in an inpatient setting and 1/21 in day hospital with the patient remaining under observation the night after. Thirty-two percent did not consider a single kidney as a contraindication to RB, 59% considered it a relative contraindication and 9% considered it an absolute contraindication. In 90.5% of units there was a specific protocol for patient preparation for RB and 86% used a specific informed consent form. Ninety-five percent of units performed ultrasound-guided RB, 60% of them using needle guides attached to the probe. In 81% of units the left side was preferred; 71% put a pillow under the patient's abdomen. All units used disposable, automated or semi-automated needles. Needle size was 16G in 29%, 18G in 58%, and both 16G and 18G in 14% of units; 1 to 3 samples were drawn. One third of units had a microscope available for immediate evaluation of specimen adequacy. After RB, 86% of units kept patients in the prone position for 2-6 hours and all prescribed a period of bed rest (at least 24 hours in 90.5%). 90.5% of units followed a specific postbiopsy observation protocol consisting of blood pressure, heart rate and red blood cell measurements at different times, and urine monitoring and ultrasound control within 12-24 hours (only half of them also employing color Doppler). One third of all units discharged patients after 1 day and two thirds after 2-3 days; all prescribed abstention from effort and from antiplatelet drugs for 7-15 days. In 9 units both RB and tissue processing and examination were done in the same hospital, while 12 units sent the samples elsewhere. 76% obtained results in 2-4 days, 19% in 6-7 days, and 5% in 10-15 days. Less than 20% of the interviewed operators were fully familiar with the clauses of hospital insurance securing their activity. Use of RB is widespread in Piedmont and Valle d'Aosta but its practice shows variation between centers.
Published: 2012

48. The middle arm arteriovenous fistula is an additional option to expand autogenous hemodialysis access.

Author: Capurro F, De Mauri A, Navino C, David P, Chiarinotti D, and De Leo M
Subjects: Age Factors, Aged, Arteriovenous Shunt, Surgical adverse effects, Chi-Square Distribution, Diabetes Complications etiology, Female, Humans, Italy, Kaplan-Meier Estimate, Male, Middle Aged, Retrospective Studies, Risk Assessment, Risk Factors, Time Factors, Treatment Outcome, Vascular Patency, Arteriovenous Shunt, Surgical methods, Renal Dialysis, Upper Extremity blood supply
Abstract: Purpose: The native arteriovenous fistula is the gold standard for hemodialysis access. Unfortunately, the wrist fistula is often not practical and the upper arm fistula is hindered by several complications. The aim of this study is to assess the safety of the middle-arm fistula as additional native access., Methods: We reviewed and compared the patency rates at 12, 48, and 60 months of distal, middle, and upper arm fistula performed from January 2003 to December 2008. For diabetic and old patients we compared distal and middle-arm fistulas., Results: Of 273 native access, 149 (54.6%) were distal, 92 (33.7%) middle-arm, and 32 (11.7%) upper fistula. Patency rates were 81%, 58%, and 52% for distal, 85%, 69%, and 69% for middle-arm, and 82%, 46%, and 29% for upper arm fistula (P NS). Patency rates were 92%, 70%, and 54% in middle-arm fistula as first access and 80%, 71%, and 71% in middle-arm fistula as a rescue access (P NS). Among patients > 75 years patency rates were 78%, 62%, and 62% for distal and 87%, 67%, and 67% for middle-arm fistula. Among diabetic subjects patency rates were 81%, 58%, and 58% for middle-arm and 65%, 57%, and 57% for distal fistula at 12, 48, and 60 months (P NS) respectively., Conclusions: A middle-arm fistula is as safe as a distal fistula among dialyzed patients, even diabetic and elderly. This could be considered a reliable option to expand native accesses.
Published: 2012
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49. [Human papillomavirus infection and cervical intraepithelial neoplasia in dialyzed patients].

Author: David P, Tarrano E, De Mauri A, Navino C, Brustia M, Chiarinotti D, Gherzi R, and De Leo M
Subjects: Adolescent, Adult, Aged, Female, Humans, Middle Aged, Prevalence, Young Adult, Papillomavirus Infections epidemiology, Renal Dialysis, Uterine Cervical Neoplasms epidemiology, Uterine Cervical Neoplasms virology, Uterine Cervical Dysplasia epidemiology, Uterine Cervical Dysplasia virology
Abstract: Human papillomavirus (HPV) infection is a risk factor for the development of cervical intraepithelial neoplasia (CIN). The incidence of certain cancers such as HPV-associated CIN is higher among dialysis patients than in the general population. In the literature there are few studies on the prevalence of HPV infection among dialyzed women and almost all of these studies concerned women with positive Pap smears. We enrolled 73 hemodialyzed women attending our center from January 2009 to December 2010; 29 denied informed consent and 44 underwent Pap tests and cervical curettage for HPV (mean age 62 ± 15 years). We found HPV positivity in 6 women (prevalence 13.6%). The prevalence of CIN in our sample was also 13.6% (6/44), 83.3% of which HPV related. Since cervical curettage for HPV is a cheap and easy to perform test with high specificity and sensitivity, we believe it is worthwhile including it in the pre-transplant workup of such women to lower the incidence of CIN in dialyzed patients and transplant recipients.
Published: 2012

50. Plasma B-type natriuretic peptide in dialyzed patients: marker of cardiovascular disease or link to plasma refilling.

Author: De Mauri A, Bellomo G, Navino C, David P, Chiarinotti D, Capurro F, Brustia M, De Maria M, Ruva CE, Ciardi L, and De Leo M
Subjects: Aged, Aged, 80 and over, Aldosterone blood, Biomarkers blood, C-Reactive Protein metabolism, Cardiovascular Diseases complications, Cardiovascular Diseases mortality, Diabetes Mellitus blood, Extracellular Fluid physiology, Female, Fluid Shifts physiology, Humans, Kidney Failure, Chronic complications, Kidney Failure, Chronic physiopathology, Male, Middle Aged, Natriuretic Peptide, Brain physiology, Renin blood, Troponin I blood, Weight Loss physiology, Blood Volume physiology, Cardiovascular Diseases blood, Hemodiafiltration, Kidney Failure, Chronic blood, Natriuretic Peptide, Brain blood
Abstract: Background: B-type natriuretic peptide (BNP) is released in response to extracellular volume and blood pressure (BP) overload and is a risk factor for cardiovascular diseases (CVD). BNP is increased in dialyzed patients (HDpts). The aim of this study was to evaluate the relationships between BNP and renin, aldosterone and blood volume reduction rate (BV/WL), with the presence of CVD and mortality., Methods: Fifty-one HDpts aged 70 ± 14 years were enrolled. BP, BV/WL, BNP, aldosterone, renin, C-reactive protein (CRP), troponin I and routine biochemistry were measured. According to the predialytic plasma BNP levels, the patients were divided into group A with higher BNP and group B with lower BNP than the median value of 330 pg/mL. Follow-up was 1 year., Results: After HD, plasma BNP (449.6 ± 582.2 pg/mL vs. 264.1 ± 269.8 pg/mL, p=0.0008) and aldosterone (421.8 ± 573.4 pg/mL vs. 265.1 ± 566.2 pg/mL, p=0.0003) decreased, but not rennin. BNP decreased more after hemodiafiltration than after standard HD (-55.1% ± 28.5% vs. -26.5% ± 19.5%, p=0.002). Patients in group A exhibited more diabetes (58% vs. 28%, p=0.03), ischemic heart disease (42% vs. 16%, p=0.04), left ventricular hypertrophy (88.8% vs. 33.3%, p<0.001), elevated levels of troponin I, CRP (50% vs. 24%, p=0.05), and low BV/BWL in a lower percentage (8% vs. 32%, p=0.03). After 11.2 ± 3.5 months, 8 patients (33.3%) had died in group A and 2 (8%) in group B (p=0.02)., Conclusion: This study demonstrates that BNP is high in HDpts and decreases after HD. It is correlated with a good capacity for plasma refilling, with diabetes, CVD and short-term mortality risk.
Published: 2011
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