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10. First malaria in pregnancy followed in Philippine real-world setting: proof-of-concept of probabilistic record linkage between disease surveillance and hospital administrative data

Author

Kinoshita, Takuya, Espino, Fe, Bunagan, Raymart, Lim, Dodge, Daga, Chona, Parungao, Sabrina, Balderian, Aileen, Micu, Katherine, Laborera, Rutchel, Basilio, Ramon, Inobaya, Marianette, Baquilod, Mario, Dy, Melecio, Chiba, Hitoshi, Matsumoto, Takehiro, Nakayama, Takeo, Kita, Kiyoshi, and Hirayama, Kenji

Published
2024
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25. Mass spectrometric approaches in discovering lipid biomarkers for COVID‐19 by lipidomics: Future challenges and perspectives.

Author

B. Gowda, Siddabasave Gowda, Shekhar, Chandra, Gowda, Divyavani, Chen, Yifan, Chiba, Hitoshi, and Hui, Shu‐Ping

Subjects
COVID-19, DRUG discovery, LIPID metabolism, LIPID analysis, TARGETED drug delivery
Abstract

Coronavirus disease 2019 (COVID‐19) has emerged as a global health threat and has rapidly spread worldwide. Significant changes in the lipid profile before and after COVID‐19 confirmed the significance of lipid metabolism in regulating the response to viral infection. Therefore, understanding the role of lipid metabolism may facilitate the development of new therapeutics for COVID‐19. Owing to their high sensitivity and accuracy, mass spectrometry (MS)‐based methods are widely used for rapidly identifying and quantifying of thousands of lipid species present in a small amount of sample. To enhance the capabilities of MS for the qualitative and quantitative analysis of lipids, different platforms have been combined to cover a wide range of lipidomes with high sensitivity, specificity, and accuracy. Currently, MS‐based technologies are being established as efficient methods for discovering potential diagnostic biomarkers for COVID‐19 and related diseases. As the lipidome of the host cell is drastically affected by the viral replication process, investigating lipid profile alterations in patients with COVID‐19 and targeting lipid metabolism pathways are considered to be crucial steps in host‐directed drug targeting to develop better therapeutic strategies. This review summarizes various MS‐based strategies that have been developed for lipidomic analyzes and biomarker discoveries to combat COVID‐19 by integrating various other potential approaches using different human samples. Furthermore, this review discusses the challenges in using MS technologies and future perspectives in terms of drug discovery and diagnosis of COVID‐19. [ABSTRACT FROM AUTHOR]

Published
2024
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30. First severe malaria in pregnancy followed in Philippine real-world setting: proof-of-concept of probabilistic record linkage between disease surveillance and hospital administrative data

Author

Kinoshita, Takuya, primary, Espino, Fe Esperanza Caridad, additional, Bunagan, Raymart, additional, Lim, Dodge, additional, Daga, Chona, additional, Parungao, Sabrina, additional, Balderian, Aileen, additional, Micu, Katherine, additional, Laborera, Rutchel, additional, Basilio, Ramon, additional, Inobaya, Marianette, additional, Baquilod, Mario, additional, Dy, Melecio, additional, Chiba, Hitoshi, additional, Matsumoto, Takehiro, additional, Nakayama, Takeo, additional, Kita, Kiyoshi, additional, and Hirayama, Kenji, additional

Published
2023
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36. Kaempferol Improves Cardiolipin and ATP in Hepatic Cells: A Cellular Model Perspective in the Context of Metabolic Dysfunction-Associated Steatotic Liver Disease.

Author

Sakurai, Akiko, Sakurai, Toshihiro, Ho, Hsin-Jung, Chiba, Hitoshi, and Hui, Shu-Ping

Abstract

Targeting mitochondrial function is a promising approach to prevent metabolic dysfunction-associated steatotic liver disease (MASLD). Cardiolipin (CL) is a unique lipid comprising four fatty acyl chains localized in the mitochondrial inner membrane. CL is a crucial phospholipid in mitochondrial function, and MASLD exhibits CL-related anomalies. Kaempferol (KMP), a natural flavonoid, has hepatoprotective and mitochondrial function-improving effects; however, its influence on CL metabolism in fatty liver conditions is unknown. In this study, we investigated the effects of KMP on mitochondrial function, focusing on CL metabolism in a fatty liver cell model (linoleic-acid-loaded C3A cell). KMP promoted mitochondrial respiratory functions such as ATP production, basal respiration, and proton leak. KMP also increased the gene expression levels of CPT1A and PPARGC1A, which are involved in mitochondrial β-oxidation. Comprehensive quantification of CL species and related molecules via liquid chromatography/mass spectrometry showed that KMP increased not only total CL content but also CL72:8, which strongly favors ATP production. Furthermore, KMP improved the monolysocardiolipin (MLCL)/CL ratio, an indicator of mitochondrial function. Our results suggest that KMP promotes energy production in a fatty liver cell model, associated with improvement in mitochondrial CL profile, and can serve as a potential nutrition factor in preventing MASLD. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Sample pretreatment effects on isotopic compositions of oxygen and sulfur in BaSO4 derived from atmospheric sulfate.

Author

Kagawa, Masako, Katsuta, Nagayoshi, Naito, Sayuri, Masuki, Yuma, Yoshimizu, Chikage, Chiba, Hitoshi, and Tayasu, Ichiro

Subjects
METEOROLOGICAL precipitation, ATMOSPHERIC aerosols, DIETHYLENETRIAMINEPENTAACETIC acid, SULFUR, SULFATES
Abstract

Rationale: Preparation of BaSO4 from samples of atmospheric rain, snow, and aerosols has been used for δ18O and δ34S analyses. In the present study, we investigated the effect of various sample pretreatments on δ18O and δ34S values determined from a Na2SO4 reagent solution and samples of atmospheric precipitation to improve assay time and cost efficiency. Methods: BaSO4 was prepared from a Na2SO4 solution by (a) evaporative concentration, (b) evaporation to dryness, (c) evaporation to dryness after adding HCl, and (d) evaporation to concentration after adding HCl, followed by cooling and then precipitation using a BaCl2 solution. To analyze the atmospheric precipitation samples for δ18O, BaSO4 prepared from the samples was treated with diethylenetriaminepentaacetic acid (DTPA) and SO42− and separated chromatographically. The values of δ18O and δ34S were measured using a continuous‐flow elemental analyzer coupled to an isotope‐ratio mass spectrometer. Results: The δ34S values in BaSO4 precipitated from Na2SO4 solution determined by methods (a)–(c) were consistent within precisions of ±0.5‰. The δ18O values of methods (a) and (b) were consistent within ±0.2‰, whereas the δ18O values of methods (c) and (d) increased with increasing HCl concentrations. Similar results were obtained from samples of atmospheric precipitations. The δ18O values from DTPA‐treated BaSO4 were consistent with those obtained by chromatographic separation within ±0.5‰. Conclusions: We found no significant differences in the effects of various pretreatments (acidification, heating, concentration, and drying) on δ18O and δ34S values in sulfate from samples of atmospheric precipitation and aerosols extracted as BaSO4 if HCl was not added to the sample before heating and BaSO4 was treated with DTPA for the δ18O analysis. [ABSTRACT FROM AUTHOR]

Published
2023
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39. Serum 25-hydroxyvitamin D3 Levels and Diabetes in a Japanese Population : The DOSANCO Health Study

Author

Nakamura, Koshi, Hui, Shu-Ping, Ukawa, Shigekazu, Okada, Emiko, Nakagawa, Takafumi, Imae, Akihiro, Okabe, Hiroaki, Chen, Zhen, Miura, Yusuke, Chiba, Hitoshi, and Tamakoshi, Akiko

Subjects
diabetes, 25-hydroxyvitamin D3, insulin resistance, Japanese
Abstract

Background: Both decreased insulin sensitivity and impaired insulin secretion are common in Asian populations with diabetes, in contrast to Western populations. There is limited evidence regarding the association between insulin response in diabetes in Asian populations and serum 25-hydroxyvitamin D3 (25[OH]D3) insufficiency.Methods: The present cross-sectional study compared the prevalence of diabetes, defined as a fasting plasma glucose level >= 126 mg/dL and/or a HbA1c level >= 6.5%, among 480 participants aged 35-79 years not taking anti-diabetes medications, based on serum 25(OH)D3 levels. A logistic regression model was used to calculate the odds ratios for diabetes in each serum 25(OH)D3 group. Furthermore, this study examined the association between serum 25(OH)D3 levels and the index of homeostasis model assessment of insulin resistance (HOMA-IR) using a linear regression model.Results: The prevalence of diabetes was 7.29% in the study population, and was higher in lower serum 25(OH)D3 quartile groups. The odds ratios for diabetes in the first, second, and third serum 25(OH)D3 quartile groups (25[OH]D3: 28.18 ng/mL) serving as the reference group, after adjusting for sociodemographic, lifestyle, physical and environmental factors. Serum 25(OH)D3 levels showed an inverse association with log-transformed HOMA-IR after adjusting for similar factors (standardized beta = -0.08; 95% CI, -0.14 to -0.02).Conclusion: Serum 25(OH)D3 levels were inversely associated with diabetes prevalence in a general Japanese population, with a slight inverse association between serum 25(OH)D3 levels and HOMA-IR.

Published
2023

49. Oxidized Low-Density Lipoproteins Trigger Hepatocellular Oxidative Stress with the Formation of Cholesteryl Ester Hydroperoxide-Enriched Lipid Droplets

Author

Sazaki, Iku, primary, Sakurai, Toshihiro, additional, Yamahata, Arisa, additional, Mogi, Sumire, additional, Inoue, Nao, additional, Ishida, Koutaro, additional, Kikkai, Ami, additional, Takeshita, Hana, additional, Sakurai, Akiko, additional, Takahashi, Yuji, additional, Chiba, Hitoshi, additional, and Hui, Shu-Ping, additional

Published
2023
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