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1. Associations of combined genetic and lifestyle risks with hypertension and home hypertension

Author

Takase, Masato, Hirata, Takumi, Nakaya, Naoki, Nakamura, Tomohiro, Kogure, Mana, Hatanaka, Rieko, Nakaya, Kumi, Chiba, Ippei, Kanno, Ikumi, Nochioka, Kotaro, Tsuchiya, Naho, Narita, Akira, Metoki, Hirohito, Satoh, Michihiro, Obara, Taku, Ishikuro, Mami, Ohseto, Hisashi, Uruno, Akira, Kobayashi, Tomoko, Kodama, Eiichi N., Hamanaka, Yohei, Orui, Masatsugu, Ogishima, Soichi, Nagaie, Satoshi, Fuse, Nobuo, Sugawara, Junichi, Kuriyama, Shinichi, Tamiya, Gen, Hozawa, Atsushi, and Yamamoto, Masayuki

Published
2024
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2. Relationship between traditional risk factors for hypertension and systolic blood pressure in the Tohoku Medical Megabank Community-based Cohort Study

Author

Takase, Masato, Nakaya, Naoki, Tanno, Kozo, Kogure, Mana, Hatanaka, Rieko, Nakaya, Kumi, Chiba, Ippei, Kanno, Ikumi, Nochioka, Kotaro, Tsuchiya, Naho, Nakamura, Tomohiro, Hirata, Takumi, Obara, Taku, Ishikuro, Mami, Kotozaki, Yuka, Uruno, Akira, Kobayashi, Tomoko, Kodama, Eiichi N., Hamanaka, Yohei, Orui, Masatsugu, Ogishima, Soichi, Nagaie, Satoshi, Ohmomo, Hideki, Fuse, Nobuo, Sugawara, Junichi, Shimizu, Atsushi, Izumi, Yoko, Kuriyama, Shinichi, and Hozawa, Atsushi

Published
2024
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3. The association between depressive symptoms and masked hypertension in participants with normotension measured at research center

Author

Tokioka, Sayuri, Nakaya, Naoki, Nakaya, Kumi, Kogure, Mana, Hatanaka, Rieko, Chiba, Ippei, Kanno, Ikumi, Nochioka, Kotaro, Metoki, Hirohito, Murakami, Takahisa, Satoh, Michihiro, Nakamura, Tomohiro, Ishikuro, Mami, Obara, Taku, Hamanaka, Yohei, Orui, Masatsugu, Kobayashi, Tomoko, Uruno, Akira, Kodama, Eiichi N., Nagaie, Satoshi, Ogishima, Soichi, Izumi, Yoko, Fuse, Nobuo, Kuriyama, Shinichi, and Hozawa, Atsushi

Published
2024
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7. Association of olfactory and cognitive function test scores with hippocampal and amygdalar grey matter volume: a cross-sectional study

Author

Sato, Shuichi, Imaeda, Takao, Mugikura, Shunji, Mori, Naoko, Takanashi, Masaki, Hayakawa, Kazumi, Saito, Tomo, Taira, Makiko, Narita, Akira, Kogure, Mana, Chiba, Ippei, Hatanaka, Rieko, Nakaya, Kumi, Kanno, Ikumi, Ishiwata, Ryosuke, Nakamura, Tomohiro, Motoike, Ikuko N., Nakaya, Naoki, Koshiba, Seizo, Kinoshita, Kengo, Kuriyama, Shinichi, Ogishima, Soichi, Nagami, Fuji, Fuse, Nobuo, and Hozawa, Atsushi

Published
2024
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15. Associations between housing and psychological damage by earthquake and modifiable risk factors for dementia in general older adults: Tohoku Medical Megabank community‐based cohort study.

Author

Chiba, Ippei, Nakaya, Naoki, Kogure, Mana, Hatanaka, Rieko, Nakaya, Kumi, Tokioka, Sayuri, Nakamura, Tomohiro, Nagaie, Satoshi, Fuse, Nobuo, Obara, Taku, Kotozaki, Yuka, Tanno, Kozo, Kuriyama, Shinichi, and Hozawa, Atsushi

Subjects
*DEMENTIA risk factors, *RISK assessment, *CROSS-sectional method, *PSYCHOLOGICAL distress, *T-test (Statistics), *RESEARCH funding, *INDEPENDENT living, *DESCRIPTIVE statistics, *CHI-squared test, *LONGITUDINAL method, *ODDS ratio, *PSYCHOLOGICAL stress, *HOUSING, *DATA analysis software, *SOCIODEMOGRAPHIC factors, *CONFIDENCE intervals, *NATURAL disasters, *OLD age
Abstract

Aim: To evaluate the association between housing and psychological damage caused by the Great East Japan Earthquake (GEJE) and modifiable risk factors (MRFs) of dementia for general population of older adults. Methods: This cross‐sectional study enrolled 29 039 community‐dwelling older adults (mean age 69.1 ± 2.9 years, 55.5% women). We evaluated disaster‐related damage (by complete or not complete housing damage) and psychological damage (by post‐traumatic stress reaction [PTSR]) after the GEJE using a self‐report questionnaire. MRFs encompassed the presence of depression, social isolation, physical inactivity, smoking, and diabetes. We examined the association between disaster‐related damage and MRFs using ordinary least squares and modified Poisson regression models adjusted for sociodemographic and health status variables. Results: Complete housing damage and PTSR were identified in 2704 (10.0%) and 855 (3.2%) individuals, respectively. The number of MRFs was significantly larger for the individuals with complete housing damage (β = 0.23; 95% confidence interval [CI]: 0.19–0.27) and PTSR (β = 0.60; 95% CI: 0.53–0.67). Prevalence ratios (PRs) for depression and physical inactivity were higher in individuals with complete housing damage. The PRs for all domains of the MRFs were significantly higher in individuals with PTSR. Conclusions: Housing and psychological damage caused by the GEJE were associated with an increased risk factor of dementia. To attenuate the risk of dementia, especially among older victims who have experienced housing and psychological damage after a disaster, multidimensional support across various aspects of MRFs is required. Geriatr Gerontol Int 2024; 24: 509–516. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Isotemporal Substitution of Sedentary Behavior With Moderate to Vigorous Physical Activity Is Associated With Lower Risk of Disability: A Prospective Longitudinal Cohort Study

Author

Chiba, Ippei, Lee, Sangyoon, Bae, Seongryu, Makino, Keitaro, Shinkai, Yohei, Katayama, Osamu, Harada, Kenji, Yamashiro, Yukari, Takayanagi, Naoto, and Shimada, Hiroyuki

Subjects
Aged -- Health aspects -- Physiological aspects, Sedentary behavior -- Health aspects, Chronic diseases -- Risk factors -- Diagnosis, Physical fitness -- Health aspects, Health
Abstract

Objective. The purpose of the study was to estimate, using an isotemporal substitution model, the effect of replacing sedentary behavior (SB) with physical activity on the incidence of disability in community-dwelling older adults. Methods. This 2-year longitudinal cohort study enrolled 3691 community-dwelling older adults (57.2% women; mean age = 74.0 [SD = 5.0] years). Individuals with dementia, stroke, Parkinson disease, depression, low Mini-Mental State Examination scores, dependence on basic activities of daily living, and missing data were excluded. Physical activity and potential confounding factors were investigated as a baseline survey of disability incidence, defined by Japanese long-term care insurance certification, for 2 years in 2 regions. Physical activity data (SB, light-intensity physical activity, and moderateto vigorous-intensity physical activity [MVPA]) were measured using triaxial accelerometers for 14 days, and daily mean time spent in each physical activity parameter was computed in increments of 10 minutes. The relationship between baseline physical activity and disability incidence adjusted for potential confounders was analyzed using multilevel Cox proportional hazards regression analyses with an isotemporal substitution model. Results. The disability incidence rate was 3.8%, excluding individuals who could not be followed-up. Replacing 10 minutes of SB per day with MVPA was associated with a decreased disability incidence (hazard ratio = 0.870; 95% CI = 0.766-0.988), whereas no evidence was found for replacing SB with light-intensity physical activity (hazard ratio = 0.980; 95% CI = 0.873-1.10). Conclusions. Replacing SB with MVPA was associated with a lower risk of disability. These findings are helpful for establishing disability prevention strategies. Impact. These results suggest that feasible changes in daily behavior, such as replacing 10 minutes of SB with MVPA daily, might have a protective effect on disability incidence. Clarifying these associations is useful for developing disability prevention strategies and may help reduce the incidence of disability in community-dwelling older adults. Keywords: Epidemiology, Geriatrics, Physical Disability, Introduction Physical inactivity is prevalent worldwide and is a significant risk factor for noncommunicable diseases. (1) Physical inactivity is associated with a higher risk of mortality, poor quality of life, [...]

Published
2022
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19. Influence of Diabetes Family History on the Associations of Combined Genetic and Lifestyle Risks with Diabetes in the Tohoku Medical Megabank Community-Based Cohort Study

Author

Takase, Masato, primary, Nakaya, Naoki, additional, Nakamura, Tomohiro, additional, Kogure, Mana, additional, Hatanaka, Rieko, additional, Nakaya, Kumi, additional, Chiba, Ippei, additional, Kanno, Ikumi, additional, Nochioka, Kotaro, additional, Tsuchiya, Naho, additional, Hirata, Takumi, additional, Narita, Akira, additional, Obara, Taku, additional, Ishikuro, Mami, additional, Uruno, Akira, additional, Kobayashi, Tomoko, additional, N Kodama, Eiichi, additional, Hamanaka, Yohei, additional, Orui, Masatsugu, additional, Ogishima, Soichi, additional, Nagaie, Satoshi, additional, Fuse, Nobuo, additional, Sugawara, Junichi, additional, Kuriyama, Shinichi, additional, Tsuji, Ichiro, additional, Tamiya, Gen, additional, Hozawa, Atsushi, additional, and Yamamoto, Masayuki, additional

Published
2023
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22. Prospective Associations of Physical Frailty With Future Falls and Fear of Falling: A 48-Month Cohort Study

Author

Makino, Keitaro, Lee, Sangyoon, Bae, Seongryu, Chiba, Ippei, Harada, Kenji, Katayama, Osamu, Shinkai, Yohei, Makizako, Hyuma, and Shimada, Hiroyuki

Subjects
Falls (Accidents) -- Risk factors -- Statistics, Frail elderly -- Statistics -- Injuries -- Health aspects, Muscle weakness -- Statistics -- Complications and side effects, Health
Abstract

Objective. The present study aimed to examine the prospective associations of physical frailty with future falls and fear of falling (FOF) among community-dwelling older adults. Methods. A prospective cohort study with a 48-month follow-up was conducted in a Japanese community. Participants were 2469 community-dwelling older adults aged 65 years or older who completed baseline and follow-up assessments at intervals of 48 [+ or -] 2 months. Primary outcomes were recent falls (defined as at least one fall within the past year) and FOF (determined by response to 'Are you afraid of falling?') at follow-up survey. Physical frailty, operationalized by the frailty phenotype (slowness, weakness, exhaustion, weight loss, and low activity) based on the criteria of the Japanese version of the Cardiovascular Health Study (J-CHS), was also assessed as a predictor of future falls and FOF. Results. Multivariable logistic regression showed that prefrailty or frailty increase the risk of not only future falls (odds ratio [OR]: 1.57; 95% CI = 1.2 0 -2.05) but also FOF (OR: 1.33; 95%CI = 1.0 5 -1.69). In addition, the relationship between baseline frailty status and future falls remained significant after adjusting for baseline FOF (OR: 1.55; 95% CI = 1.1 9 -2.02), and the relationship between baseline frailty status and future FOF also remained significant after adjusting for baseline falls (OR: 1.32; 95% CI = 1.0 4 -1.68). Conclusions. Frailty status may predict future falls and FOF among community-dwelling older adults. Strategies to prevent frailty may be beneficial to prevent not only future falls but also future FOF in a community setting. Impact. Falls and FOF have a close relationship but a different clinical meaning. Older adults with physical frailty may require monitoring as high risk not only for falls but also for FOF. Keywords: Community-Dwelling Older Adults, Falls, Fear of Falling, Physical Frailty, Introduction With global population aging, frailty in older age has received increased research attention. Frailty is a biological syndrome associated with multisystem decline in physiological reserves and increased vulnerability to [...]

Published
2021
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27. Association between physiological factors and grip and leg extension strength for predicting health outcomes: Tohoku Medical Megabank Community-based cohort study

Author

Noji, Yoshiaki, primary, Hatanaka, Rieko, additional, Nakaya, Naoki, additional, Kogure, Mana, additional, Nakaya, Kumi, additional, Chiba, Ippei, additional, Kanno, Ikumi, additional, Nakamura, Tomohiro, additional, Tsuchiya, Naho, additional, Momma, Haruki, additional, Hamanaka, Yohei, additional, Orui, Masatsugu, additional, Kobayashi, Tomoko, additional, Uruno, Akira, additional, Kodama, Eiichi N, additional, Nagatomi, Ryoichi, additional, Fuse, Nobuo, additional, Kuriyama, Shinichi, additional, and Hozawa, Atsushi, additional

Published
2023
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28. Association Between Olfactory Test Data with Multiple Levels of Odor Intensity and Suspected Cognitive Impairment: A Cross-Sectional Study

Author

Sato, Shuichi, primary, Imaeda, Takao, additional, Mugikura, Shunji, additional, Mori, Naoko, additional, Takanashi, Masaki, additional, Hayakawa, Kazumi, additional, Saito, Tomo, additional, Taira, Makiko, additional, Narita, Akira, additional, Kogure, Mana, additional, Chiba, Ippei, additional, Hatanaka, Rieko, additional, Nakaya, Kumi, additional, Kanno, Ikumi, additional, Ishiwata, Ryosuke, additional, Nakamura, Tomohiro, additional, Motoike, Ikuko N., additional, Nakaya, Naoki, additional, Koshiba, Seizo, additional, Kinoshita, Kengo, additional, Kuriyama, Shinichi, additional, Ogishima, Soichi, additional, Nagami, Fuji, additional, Fuse, Nobuo, additional, and Hozawa, Atsushi, additional

Published
2023
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33. Physical frailty and survival time after the onset of functional disability: Is there a sex difference?

Author

Makino, Keitaro, Raina, Parminder, Griffith, Lauren E., Lee, Sangyoon, Harada, Kenji, Chiba, Ippei, Katayama, Osamu, Tomida, Kouki, Morikawa, Masanori, Makizako, Hyuma, and Shimada, Hiroyuki

Subjects
FRAIL elderly, CONFIDENCE intervals, DISABILITY evaluation, ACTIVITIES of daily living, SEX distribution, FUNCTIONAL assessment, MUSCLE weakness, RESEARCH funding, SURVIVAL analysis (Biometry), QUALITY of life, INDEPENDENT living, WEIGHT loss, DESCRIPTIVE statistics, DEATH, ODDS ratio, LONGITUDINAL method, PHENOTYPES
Abstract

Background: Physical frailty accelerates the timing of both subsequent disability and death; however, evidence regarding the impact of frailty on the period from disability onset to death and sex differences of this impact is lacking. The aim of this study was to examine the relationship among physical frailty, disability, death, and sex differences. Methods: This Japanese cohort study included 10,524 community‐dwelling people aged ≥65 years. Physical frailty was operationalized by key phenotypes as per Fried's criteria (slowness, weakness, exhaustion, weight loss, and low activity) at baseline. We calculated hazard ratios (HRs) with 95% confidence intervals (CIs) for disability onset and post‐disability survival according to the frailty status. Results: During a 5‐year follow‐up, the risk of disability onset for pre‐frailty (HR: 1.74, 95% CI: 1.51–2.00) and frailty (HR: 3.27, 95% CI: 2.77–3.87) were significantly higher than that for robust people. Furthermore, among participants who developed disabilities within 5 years (n = 1481), the risk of post‐disability death for pre‐frailty was not different from that for robust (HR: 1.49, 95% CI: 0.99–2.24), but frailty showed a higher risk of post‐disability death than did robust people. (HR: 1.75, 95% CI: 1.13–2.72). In the sex‐stratified analysis, although the female group showed no association between frailty status and post‐disability death (HR: 1.21, 95% CI: 0.63–2.33 in pre‐frailty; HR: 1.24, 95% CI: 0.60–2.57 in frailty), the male group showed higher risk of post‐disability death in both pre‐frailty (HR: 1.74, 95% CI: 1.03–2.96) and frailty (HR: 2.32, 95% CI: 1.32–4.09). Conclusions: Physical frailty shortens the period from disability onset to death. Additionally, the impact of frailty on post‐disability death is greater for males than for females. Our findings suggest that physical frailty is an important clinical indicator distinct from disability and that interventions to prevent and address frailty in men need further investigation. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Association between lung function and hypertension and home hypertension in a Japanese population: the Tohoku Medical Megabank Community-Based Cohort Study

Author

Takase, Masato, primary, Yamada, Mitsuhiro, additional, Nakamura, Tomohiro, additional, Nakaya, Naoki, additional, Kogure, Mana, additional, Hatanaka, Rieko, additional, Nakaya, Kumi, additional, Chiba, Ippei, additional, Kanno, Ikumi, additional, Nochioka, Kotaro, additional, Tsuchiya, Naho, additional, Hirata, Takumi, additional, Hamanaka, Yohei, additional, Sugawara, Junichi, additional, Kobayashi, Tomoko, additional, Fuse, Nobuo, additional, Uruno, Akira, additional, Kodama, Eiichi N., additional, Kuriyama, Shinichi, additional, Tsuji, Ichiro, additional, and Hozawa, Atsushi, additional

Published
2023
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36. Carotid Intima Media Thickness and Risk Factor for Atherosclerosis: Tohoku Medical Megabank Community-Based Cohort Study

Author

Takase, Masato, primary, Nakaya, Naoki, additional, Nakamura, Tomohiro, additional, Kogure, Mana, additional, Hatanaka, Rieko, additional, Nakaya, Kumi, additional, Chiba, Ippei, additional, Kanno, Ikumi, additional, Nochioka, Kotaro, additional, Tsuchiya, Naho, additional, Hirata, Takumi, additional, Hamanaka, Yohei, additional, Sugawara, Junichi, additional, Kobayashi, Tomoko, additional, Fuse, Nobuo, additional, Uruno, Akira, additional, Kodama, Eiichi N, additional, Kuriyama, Shinichi, additional, Tsuji, Ichiro, additional, and Hozawa, Atsushi, additional

Published
2023
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37. Combined Fat Mass and Fat-free Mass Indices and Lung Function Among Japanese Population: The Tohoku Medical Megabank Community-based Cohort Study

Author

Takase, Masato, primary, Yamada, Mitsuhiro, additional, Nakamura, Tomohiro, additional, Nakaya, Naoki, additional, Kogure, Mana, additional, Hatanaka, Rieko, additional, Nakaya, Kumi, additional, Chiba, Ippei, additional, Kanno, Ikumi, additional, Nochioka, Kotaro, additional, Tsuchiya, Naho, additional, Hirata, Takumi, additional, Hamanaka, Yohei, additional, Sugawara, Junichi, additional, Kobayashi, Tomoko, additional, Fuse, Nobuo, additional, Uruno, Akira, additional, Kodama, Eiichi N., additional, Kuriyama, Shinichi, additional, Tsuji, Ichiro, additional, and Hozawa, Atsushi, additional

Published
2023
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40. Light intensity physical activity is beneficially associated with brain volume in older adults with high cardiovascular risk

Author

Makino, Keitaro, primary, Lee, Sangyoon, additional, Bae, Seongryu, additional, Harada, Kenji, additional, Chiba, Ippei, additional, Katayama, Osamu, additional, Tomida, Kouki, additional, Morikawa, Masanori, additional, Yamashiro, Yukari, additional, Sudo, Motoki, additional, Takayanagi, Naoto, additional, and Shimada, Hiroyuki, additional

Published
2022
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41. Association between COVID-19 emergency declarations and physical activity among community-dwelling older adults enrolled in a physical activity measurement program: Evidence from a retrospective observational study using the regression discontinuity design

Author

Chiba, Ippei, Takahashi, Masayoshi, Lee, Sangyoon, Bae, Seongryu, Makino, Keitaro, Katayama, Osamu, Harada, Kenji, Tomida, Kouki, Morikawa, Masanori, Yamashiro, Yukari, Takayanagi, Naoto, Sudo, Motoki, and Shimada, Hiroyuki

Subjects
*REGRESSION discontinuity design, *COVID-19 pandemic, *PHYSICAL activity, *OLDER people, *PHYSICAL measurements
Abstract

Background: The current study examines the negative impact of the coronavirus disease 2019 (COVID-19) emergency declarations on physical activity among the community-dwelling older adults, the participants of a physical activity measurement program, in Japan. Methods: This retrospective observational study included 1,773 community-dwelling older adults (aged 74.6 ± 6.3 years, 53.9% women) who had participated in the physical activity measurement project from February 2020 to July 2021. We measured physical activity using a tri-axial accelerometer during 547 consecutive days. Three emergency declarations, requesting people to avoid going outside, occurred during the observational period. We multiply-imputed missing values for daily physical activity, such as steps, light physical activity (LPA), and moderate-to-vigorous physical activity (MVPA) for several patterns of datasets according to the maximum missing rates on a person level. We mainly report the results based on less than 50% of the maximum missing rate (n = 1,056). Other results are reported in the supplemental file. Changes in physical activity before and after the start of each emergency declaration were examined by the regression discontinuity design (RDD) within 14-, 28-, and 56-day bandwidths. Results: For all the participants in the multiply-imputed data with the 14-day bandwidth, steps (coefficients [ γ ^ 1 ] , 964.3 steps), LPA ( γ ^ 1 , 5.5 min), and MVPA ( γ ^ 1 , 4.9 min) increased after the first emergency declaration. However, the effects were attenuated as the RDD bandwidths were widened. No consistent negative impact was observed after the second and third declarations. After the second declaration, steps ( γ ^ 1 , -609.7 steps), LPA ( γ ^ 1 , -4.6 min), and MVPA ( γ ^ 1 , -2.8 min) decreased with the 14-day bandwidth. On the other hand, steps ( γ ^ 1 , 143.8 steps) and MVPA ( γ ^ 1 , 1.3 min) increased with the 56-day bandwidth. For the third declaration, LPA consistently decreased with all the bandwidths ( γ ^ 1 , -2.1, -3.0, -0.8 min for the 14, 28, 56-day bandwidth), whereas steps ( γ ^ 1 , -529 steps) and MVPA ( γ ^ 1 , -2.6 min) decreased only with the 28-day bandwidth. Conclusions: For the community-dwelling older adults who regularly self-monitor their physical activity, the current study concludes that there is no evidence of consistently negative impacts of the emergency declarations by the COVID-19 pandemic. [ABSTRACT FROM AUTHOR]

Published
2023
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42. Additional file 1 of The association between social activity and physical frailty among community-dwelling older adults in Japan

Author

Katayama, Osamu, Lee, Sangyoon, Bae, Seongryu, Makino, Keitaro, Chiba, Ippei, Harada, Kenji, Shinkai, Yohei, and Shimada, Hiroyuki

Abstract

Additional file 1: Supplementary Materials. Receiver operating characteristic curve for social participation and social engagement used to detect the cut point for social inactivity. The Youden index resulted in two “No” cut points for social participation and one “No” cut point for social engagement. AUC, Area Under Curve; 95%CI, 95% confidence interval. Social participation (a), Social engagement (b).

Published
2022
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43. Isotemporal Substitution of Sedentary Behavior With Moderate to Vigorous Physical Activity Is Associated With Lower Risk of Disability: A Prospective Longitudinal Cohort Study

Author

Chiba, Ippei, primary, Lee, Sangyoon, additional, Bae, Seongryu, additional, Makino, Keitaro, additional, Shinkai, Yohei, additional, Katayama, Osamu, additional, Harada, Kenji, additional, Yamashiro, Yukari, additional, Takayanagi, Naoto, additional, and Shimada, Hiroyuki, additional

Published
2022
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