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3. Updates in Immunotherapy for Pancreatic Cancer.

Author

Chick, Robert Connor and Pawlik, Timothy M.

Subjects
*IMMUNE checkpoint inhibitors, *PANCREATIC duct, *CANCER vaccines, *TUMOR microenvironment, *PANCREATIC cancer
Abstract

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with limited effective therapeutic options. Due to a variety of cancer cell-intrinsic factors, including KRAS mutations, chemokine production, and other mechanisms that elicit a dysregulated host immune response, PDAC is often characterized by poor immune infiltration and an immune-privileged fibrotic stroma. As understanding of the tumor microenvironment (TME) evolves, novel therapies are being developed to target immunosuppressive mechanisms. Immune checkpoint inhibitors have limited efficacy when used alone or with radiation. Combinations of immune therapies, along with chemotherapy or chemoradiation, have demonstrated promise in preclinical and early clinical trials. Despite dismal response rates for immunotherapy for metastatic PDAC, response rates with neoadjuvant immunotherapy are somewhat encouraging, suggesting that incorporation of immunotherapy in the treatment of PDAC should be earlier in the disease course. Precision therapy for PDAC may be informed by advances in transcriptomic sequencing that can identify immunophenotypes, allowing for more appropriate treatment selection for each individual patient. Personalized and antigen-specific therapies are an increasing topic of interest, including adjuvant immunotherapy using personalized mRNA vaccines to prevent recurrence. Further development of personalized immune therapies will need to balance precision with generalizability and cost. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Prospective, randomized, double-blind phase 2B trial of the TLPO and TLPLDC vaccines to prevent recurrence of resected stage III/IV melanoma: a prespecified 36-month analysis

Author

Carpenter, Elizabeth Lee, primary, Van Decar, Spencer, additional, Adams, Alexandra M, additional, O’Shea, Anne E, additional, McCarthy, Patrick, additional, Chick, Robert Connor, additional, Clifton, Guy Travis, additional, Vreeland, Timothy, additional, Valdera, Franklin A, additional, Tiwari, Ankur, additional, Hale, Diane, additional, Kemp Bohan, Phillip, additional, Hickerson, Annelies, additional, Smolinsky, Todd, additional, Thomas, Katryna, additional, Cindass, Jessica, additional, Hyngstrom, John, additional, Berger, Adam C, additional, Jakub, James, additional, Sussman, Jeffrey J, additional, Shaheen, Montaser F, additional, Yu, Xianzhong, additional, Wagner, Thomas E, additional, Faries, Mark, additional, and Peoples, George E, additional

Published
2023
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7. The influence of harvest method on dendritic cell function and clinical outcomes in a randomized trial of a dendritic cell vaccine to prevent recurrences in high-risk melanoma.

Author

Adams, Alexandra, primary, Clifton, G. Travis, additional, Vreeland, Timothy J., additional, O'Shea, Anne E., additional, McCarthy, Patrick M., additional, Chick, Robert Connor, additional, Kemp Bohan, Phillip M., additional, Hickerson, Annelies, additional, Hale, Diane F., additional, Hyngstrom, John Robert, additional, Berger, Adam C., additional, Jakub, James W., additional, Sussman, Jeffrey J., additional, Shaheen, Montaser F., additional, Wagner, Thomas, additional, Faries, Mark B, additional, and Peoples, George Earl, additional

Published
2021
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8. Abstract 6536: Safety and efficacy of autologous tumor lysate particle loaded dendritic cell (TLPLDC) vaccination in combination with systemic therapies in patients with metastatic melanoma

Author

Chick, Robert Connor, primary, Hickerson, Annelies T., additional, Clifton, Guy Travis, additional, Bohan, Phillip M. Kemp, additional, Brown, Tommy A., additional, Cindass, Jessica L., additional, Myers, John W., additional, Vreeland, Timothy J., additional, Jackson, Doreen O., additional, Hale, Diane F., additional, Peace, Kaitlin M., additional, Herbert, Garth S., additional, Yu, Xianzhong, additional, Wagner, Thomas, additional, and Peoples, George E., additional

Published
2020
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9. Abstract 6537: Impact of disease-free interval on recurrence in high-risk melanoma patients in a phase IIb trial of the tumor lysate particle loaded dendritic cell (TLPLDC) vaccine

Author

Chick, Robert Connor, primary, Bohan, Phillip M. Kemp, additional, Vreeland, Timothy J., additional, Hickerson, Annelies T., additional, Cindass, Jessica L., additional, Hale, Diane F., additional, Clifton, Guy Travis, additional, and Peoples, George E., additional

Published
2020
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11. Multi-institutional, prospective, randomized, double-blind, placebo-controlled phase IIb trial of the tumor lysate, particle-loaded, dendritic cell (TLPLDC) vaccine to prevent recurrence in high-risk melanoma patients: A subgroup analysis.

Author

Chick, Robert Connor, primary, Faries, Mark B., additional, Hale, Diane F., additional, Kemp Bohan, Phillip M., additional, Hickerson, Annelies, additional, Vreeland, Timothy J., additional, Myers, John William, additional, Cindass, Jessica L., additional, Brown, Tommy A., additional, Hyngstrom, John Robert, additional, Jakub, James W., additional, Sussman, Jeffrey J., additional, Berger, Adam C., additional, Shaheen, Montaser F., additional, Clifton, G. Travis, additional, Wagner, Thomas, additional, and Peoples, George Earl, additional

Published
2020
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