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977 results on '"Chiesa S."'

1. OCCURRENCE OF ALLOCHTHONOUS FRESHWATER CRAYFISHES IN LATIUM (CENTRAL ITALY)

Author

CHIESA S., SCALICI M., and GIBERTIN G.

Subjects
allochthonous freshwater crayfishes, Procambarus clarkii, Orconectes limosus, Astacus leptodactylus, central Italy, Aquaculture. Fisheries. Angling, SH1-691
Abstract

The introduction of animal species, transfaunation and habitat destruction are among the greatest threats for biodiversity. In fact, in the water systems of Latium the occurrence of allochthonous crayfishes Procambarus clarkii, Orconectes limosus and Astacus leptodactylus has been observed. The distribution of these species in Latium highlighted some differences between them: Orconectes limosus and Astacus leptodactylus are present in restricted areas, while Procambarus clarkii has a wide distribution throughout the region. The present study confirmed their ecological plasticity, strong capability of invasion and adaptation to new environments of all three species, due to their rapid growth, utilisation of different trophic resources and the frequency and length of their reproduction periods. These aspects can cause irreversible ecologic and economic damage. The eradication of Procambarus clarkii would be a difficult task, because of its wide distribution and the many records of the species, especially in the Province of Latina, where complex field irrigation systems are found. All the agencies for environmental protection should increase control activities, with a serious field effort. As regards the other two species, eradication would be easier due to their limited distribution. It is important to avoid the spreading of these species; this can be done through public opinion awareness-raising campaigns and a continuous control on the region, increasing research and supporting it with new laws concerning the introduction and treatment of alien species.

Published
2006
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2. REGOMA-OSS: a large, Italian, multicenter, prospective, observational study evaluating the efficacy and safety of regorafenib in patients with recurrent glioblastoma

Author

Caccese, M., Desideri, I., Villani, V., Simonelli, M., Buglione, M., Chiesa, S., Franceschi, E., Gaviani, P., Stasi, I., Caserta, C., Brugnara, S., Lolli, I., Bennicelli, E., Bini, P., Cuccu, A.S., Scoccianti, S., Padovan, M., Gori, S., Bonetti, A., Giordano, P., Pellerino, A., Gregucci, F., Riva, N., Cinieri, S., Internò, V., Santoni, M., Pernice, G., Dealis, C., Stievano, L., Paiar, F., Magni, G., De Salvo, G.L., Zagonel, V., and Lombardi, G.

Published
2024
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4. A multicenter LArge retrospectIve daTabase on the personalization of stereotactic ABlative radiotherapy use in lung metastases from colon-rectal cancer: The LaIT-SABR study

Author

Nicosia, L., Franceschini, D., Perrone-Congedi, F., Casamassima, F., Gerardi, M.A., Rigo, M., Mazzola, R., Perna, M., Scotti, V., Fodor, A., Iurato, A., Pasqualetti, F., Gadducci, G., Chiesa, S., Niespolo, R.M., Bruni, A., Alicino, G., Frassinelli, L., Borghetti, P., Di Marzo, A., Ravasio, A., De Bari, B., Sepulcri, M., Aiello, D., Mortellaro, G., Sangalli, C., Franceschini, M., Montesi, G., Aquilanti, F.M., Lunardi, G., Valdagni, R., Fazio, I., Scarzello, Giovanni, Corti, L., Vavassori, V., Maranzano, E., Magrini, S.M., Arcangeli, S., Gambacorta, Maria Antonietta, Valentini, V., Paiar, F., Ramella, S., Di Muzio, N.G., Livi, L., Jereczek-Fossa, B.A., Osti, M.F., Scorsetti, M., and Alongi, F.

Published
2022
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5. Optimized Confinement of Fermions in Two Dimensions

Author

Cone, J. D., Chiesa, S., Rousseau, V. R., Batrouni, G. G., and Scalettar, R. T.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

One of the challenging features of studying model Hamiltonians with cold atoms in optical lattices is the presence of spatial inhomogeneities induced by the confining potential, which results in the coexistence of different phases. This paper presents Quantum Monte Carlo results comparing meth- ods for confining fermions in two dimensions, including conventional diagonal confinement (DC), a recently proposed 'off-diagonal confinement' (ODC), as well as a trap which produces uniform den- sity in the lattice. At constant entropy and for currently accessible temperatures, we show that the current DC method results in the strongest magnetic signature, primarily because of its judicious use of entropy sinks at the lattice edge. For d-wave pairing, we show that a constant density trap has the more robust signal and that ODC can implement a constant density profile. This feature is important to any prospective search for superconductivity in optical lattices.

Published
2012
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6. Superconductivity and charge order of confined Fermi systems

Author

Assmann, E., Chiesa, S., Batrouni, G. G., Evertz, H. G., and Scalettar, R. T.

Subjects
Condensed Matter - Quantum Gases
Abstract

The low-temperature properties of the two-dimensional attractive Hubbard model are strongly influenced by the fermion density. Away from half-filling, there is a finite-temperature transition to a phase with s-wave pairing order. However, the critical temperature is suppressed to zero at half-filling, where long-range charge-density-wave order also appears, degenerate with superconductivity. This paper presents Determinant Quantum Monte Carlo simulations of the attractive Hubbard model in the presence of a confining potential V which makes the fermion density \rho{} inhomogeneous across the lattice. Pair correlations are shown to be large at low temperatures in regions of the trapped system with incommensurate filling, and to exhibit a minimum as the local density \rho(i) passes through one fermion per site. In this ring of \rho=1, charge order is enhanced. A comparison is made between treating V within the local-density approximation (LDA) and in an ab initio manner. It is argued that certain sharp features of the LDA result at integer filling do not survive the proximity of doped sites. The critical temperature of confined systems of fixed characteristic density is estimated., Comment: 7 pages, 5 figures; minor changes from v1

Published
2011
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7. Kondo screening and Magnetism at Interfaces

Author

Euverte, A., Hébert, F., Chiesa, S., Scalettar, R. T., and Batrouni, G. G.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

The nature of magnetic order and transport properties near surfaces is a topic of great current interest. Here we model metal-insulator interfaces with a multi-layer system governed by a tight-binding Hamiltonian in which the interaction is non-zero on one set of adjacent planes and zero on another. As the interface hybridization is tuned, magnetic and metallic properties undergo an evolution that reflects the competition between anti-ferromagnetism and (Kondo) singlet formation in a scenario similar to that occurring in heavy-fermion materials. For a few-layer system at intermediate hybridization, a Kondo insulating phase results where magnetic order and conductivity are suppressed in all layers. As more insulating layers are added, magnetic order is restored in all correlated layers except that at the interface. Residual signs of Kondo physics are however evident in the bulk as a substantial reduction of the order parameter in the 2-3 layers immediately adjacent to the interfacial one. We find no signature of long range magnetic order in the metallic

Published
2011
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8. Fundamental Role of Pentose Phosphate Pathway within the Endoplasmic Reticulum in Glutamine Addiction of Triple-Negative Breast Cancer Cells

Author

Marini, C, Cossu, V, Carta, S, Greotti, E, Gaglio, D, Bertola, N, Chiesa, S, Bruno, S, Vitale, F, Bonanomi, M, Porro, D, Riondato, M, Orengo, A, Bauckneht, M, Morbelli, S, Ravera, S, Sambuceti, G, Marini C., Cossu V., Carta S., Greotti E., Gaglio D., Bertola N., Chiesa S., Bruno S., Vitale F., Bonanomi M., Porro D., Riondato M., Orengo A. M., Bauckneht M., Morbelli S., Ravera S., Sambuceti G., Marini, C, Cossu, V, Carta, S, Greotti, E, Gaglio, D, Bertola, N, Chiesa, S, Bruno, S, Vitale, F, Bonanomi, M, Porro, D, Riondato, M, Orengo, A, Bauckneht, M, Morbelli, S, Ravera, S, Sambuceti, G, Marini C., Cossu V., Carta S., Greotti E., Gaglio D., Bertola N., Chiesa S., Bruno S., Vitale F., Bonanomi M., Porro D., Riondato M., Orengo A. M., Bauckneht M., Morbelli S., Ravera S., and Sambuceti G.

Abstract

Cancer utilization of large glutamine equivalents contributes to diverging glucose-6-P flux toward the pentose phosphate shunt (PPP) to feed the building blocks and the antioxidant responses of rapidly proliferating cells. In addition to the well-acknowledged cytosolic pathway, cancer cells also run a largely independent PPP, triggered by hexose-6P-dehydrogenase within the endoplasmic reticulum (ER), whose activity is mandatory for the integrity of ER–mitochondria networking. To verify whether this reticular metabolism is dependent on glutamine levels, we complemented the metabolomic characterization of intermediates of the glucose metabolism and tricarboxylic acid cycle with the estimation of proliferating activity, energy metabolism, redox damage, and mitochondrial function in two breast cancer cell lines. ER-PPP activity and its determinants were estimated by the ER accumulation of glucose analogs. Glutamine shortage decreased the proliferation rate despite increased ATP and NADH levels. It depleted NADPH reductive power and increased malondialdehyde content despite a marked increase in glucose-6P-dehydrogenase. This paradox was explained by the deceleration of ER-PPP favored by the decrease in hexose-6P-dehydrogenase expression coupled with the opposite response of its competitor enzyme glucose-6P-phosphatase. The decreased ER-PPP activity eventually hampered mitochondrial function and calcium exchanges. These data configure the ER-PPP as a powerful, unrecognized regulator of cancer cell metabolism and proliferation.

Published
2023

9. Quantum Monte Carlo study of the two-dimensional fermion Hubbard Model

Author

Varney, C. N., Lee, C. -R., Bai, Z. J., Chiesa, S., Jarrell, M., and Scalettar, R. T.

Subjects
Condensed Matter - Strongly Correlated Electrons, Physics - Atomic Physics
Abstract

We report large scale determinant Quantum Monte Carlo calculations of the effective bandwidth, momentum distribution, and magnetic correlations of the square lattice fermion Hubbard Hamiltonian at half-filling. The sharp Fermi surface of the non-interacting limit is significantly broadened by the electronic correlations, but retains signatures of the approach to the edges of the first Brillouin zone as the density increases. Finite size scaling of simulations on large lattices allows us to extract the interaction dependence of the antiferromagnetic order parameter, exhibiting its evolution from weak coupling to the strong coupling Heisenberg limit. Our lattices provide improved resolution of the Green's function in momentum space, allowing a more quantitative comparison with time-of-flight optical lattice experiments., Comment: 8 pages, 11 figures. Published by Phys. Rev. B. on 18 August 2009.

Published
2009
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11. PD-0733 RADAR Project: pediatric patients AI-profiling, focus on clinical and psychological outcomes

Author

Marconi, E., primary, Meldolesi, E., additional, Beghella Bartoli, F., additional, Kraja, F.P., additional, Mariani, S., additional, Panza, G., additional, Mastronuzzi, A., additional, Ruggiero, A., additional, Gambacorta, M.A., additional, Valentini, V., additional, Balducci, M., additional, Chieffo, D.P.R., additional, and Chiesa, S., additional

Published
2023
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12. Art and digital technologies to support resilience during the oncological journey: The Art4ART project

Author

Tagliaferri, L, Dinapoli, L, Casa, C, Colloca, G, Marazzi, F, Cornacchione, P, Mazzarella, C, Masiello, V, Chiesa, S, Beghella Bartoli, F, Marconi, E, D'Oria, M, Cesario, A, Chieffo, D, Valentini, V, Gambacorta, M, Tagliaferri L., Dinapoli L., Casa C., Colloca G. F., Marazzi F., Cornacchione P., Mazzarella C., Masiello V., Chiesa S., Beghella Bartoli F., Marconi E., D'Oria M., Cesario A., Chieffo D. P. R., Valentini V., Gambacorta M. A., Tagliaferri, L, Dinapoli, L, Casa, C, Colloca, G, Marazzi, F, Cornacchione, P, Mazzarella, C, Masiello, V, Chiesa, S, Beghella Bartoli, F, Marconi, E, D'Oria, M, Cesario, A, Chieffo, D, Valentini, V, Gambacorta, M, Tagliaferri L., Dinapoli L., Casa C., Colloca G. F., Marazzi F., Cornacchione P., Mazzarella C., Masiello V., Chiesa S., Beghella Bartoli F., Marconi E., D'Oria M., Cesario A., Chieffo D. P. R., Valentini V., and Gambacorta M. A.

Abstract

Introduction: New digital technologies can become a tool for welcoming the patient through the artistic dimension. Cancer patients, in particular, need support that accompanies and supports them throughout their treatment. Materials and methods: The Art4ART project consist in the structural proposal to cancer patients of a web-based digital platform containing several forms of art as video-entertainments; a multimedia immersive room; an art-based welcoming of the patients with several original paintings; an environment with a peacefulness vertical garden; a reconceptualization of the chemotherapy-infusion seats. Data regarding patients’ preference and choices will be stored and analysed also using artificial intelligence (AI) algorithm to measure and predict impact indicators regarding clinical outcomes (survival and toxicity), psychological indicators. Moreover, the same digital platform will contribute to a better organization of the activities. Discussion: Through the systematic acquisition of patient preferences and through integration with other clinical parameters, it will be possible to measure the clinical, psychological, organisational, and social impact of the newly implemented Art4ART project. The use of digital technology leads us to apply the reversal of viewpoint from therapeutic acts to patient-centred care.

Published
2022

13. A multicenter LArge retrospectIve daTabase on the personalization of stereotactic ABlative radiotherapy use in lung metastases from colon-rectal cancer: The LaIT-SABR study

Author

Nicosia, L, Franceschini, D, Perrone-Congedi, F, Casamassima, F, Gerardi, M, Rigo, M, Mazzola, R, Perna, M, Scotti, V, Fodor, A, Iurato, A, Pasqualetti, F, Gadducci, G, Chiesa, S, Niespolo, R, Bruni, A, Alicino, G, Frassinelli, L, Borghetti, P, Di Marzo, A, Ravasio, A, De Bari, B, Sepulcri, M, Aiello, D, Mortellaro, G, Sangalli, C, Franceschini, M, Montesi, G, Aquilanti, F, Lunardi, G, Valdagni, R, Fazio, I, Scarzello, G, Corti, L, Vavassori, V, Maranzano, E, Magrini, S, Arcangeli, S, Gambacorta, M, Valentini, V, Paiar, F, Ramella, S, Di Muzio, N, Livi, L, Jereczek-Fossa, B, Osti, M, Scorsetti, M, Alongi, F, Nicosia L., Franceschini D., Perrone-Congedi F., Casamassima F., Gerardi M. A., Rigo M., Mazzola R., Perna M., Scotti V., Fodor A., Iurato A., Pasqualetti F., Gadducci G., Chiesa S., Niespolo R. M., Bruni A., Alicino G., Frassinelli L., Borghetti P., Di Marzo A., Ravasio A., De Bari B., Sepulcri M., Aiello D., Mortellaro G., Sangalli C., Franceschini M., Montesi G., Aquilanti F. M., Lunardi G., Valdagni R., Fazio I., Scarzello G., Corti L., Vavassori V., Maranzano E., Magrini S. M., Arcangeli S., Gambacorta M. A., Valentini V., Paiar F., Ramella S., Di Muzio N. G., Livi L., Jereczek-Fossa B. A., Osti M. F., Scorsetti M., Alongi F., Nicosia, L, Franceschini, D, Perrone-Congedi, F, Casamassima, F, Gerardi, M, Rigo, M, Mazzola, R, Perna, M, Scotti, V, Fodor, A, Iurato, A, Pasqualetti, F, Gadducci, G, Chiesa, S, Niespolo, R, Bruni, A, Alicino, G, Frassinelli, L, Borghetti, P, Di Marzo, A, Ravasio, A, De Bari, B, Sepulcri, M, Aiello, D, Mortellaro, G, Sangalli, C, Franceschini, M, Montesi, G, Aquilanti, F, Lunardi, G, Valdagni, R, Fazio, I, Scarzello, G, Corti, L, Vavassori, V, Maranzano, E, Magrini, S, Arcangeli, S, Gambacorta, M, Valentini, V, Paiar, F, Ramella, S, Di Muzio, N, Livi, L, Jereczek-Fossa, B, Osti, M, Scorsetti, M, Alongi, F, Nicosia L., Franceschini D., Perrone-Congedi F., Casamassima F., Gerardi M. A., Rigo M., Mazzola R., Perna M., Scotti V., Fodor A., Iurato A., Pasqualetti F., Gadducci G., Chiesa S., Niespolo R. M., Bruni A., Alicino G., Frassinelli L., Borghetti P., Di Marzo A., Ravasio A., De Bari B., Sepulcri M., Aiello D., Mortellaro G., Sangalli C., Franceschini M., Montesi G., Aquilanti F. M., Lunardi G., Valdagni R., Fazio I., Scarzello G., Corti L., Vavassori V., Maranzano E., Magrini S. M., Arcangeli S., Gambacorta M. A., Valentini V., Paiar F., Ramella S., Di Muzio N. G., Livi L., Jereczek-Fossa B. A., Osti M. F., Scorsetti M., and Alongi F.

Abstract

Introduction: Stereotactic ablative radiotherapy (SABR) has been shown to increase survival in oligometastatic disease, but local control of colorectal metastases remains poor. We aimed to identify potential predictive factors of SBRT response through a multicenter large retrospective database and to investigate the progression to the polymetastatic disease (PMD). Material and methods: The study involved 23 centers, and was approved by the Ethical Committee (Prot. Negrar 2019-ZT). 1033 lung metastases were reported. Clinical and biological parameters were evaluated as predictive for freedom from local progression-free survival (FLP). Secondary end-point was the time to the polymetastatic conversion (tPMC). Results: Two-year FLP was 75.4%. Two-year FLP for lesions treated with a BED < 00 Gy, 100–124 Gy, and ≥125 Gy was 76.1%, 70.6%, and 94% (p = 0.000). Two-year FLP for lesion measuring ≤10 mm, 10–20 mm, and >20 mm was 79.7%, 77.1%, and 66.6% (p = 0.027). At the multivariate analysis a BED ≥125 Gy significantly reduced the risk of local progression (HR 0.24, 95%CI 0.11–0.51; p = 0.000). Median tPMC was 26.8 months. Lesions treated with BED ≥125 Gy reported a significantly longer tPMC as compared to lower BED. The median tPMC for patients treated to 1, 2–3 or 4–5 simultaneous oligometastases was 28.5, 25.4, and 9.8 months (p = 0.035). Conclusion: The present is the largest series of lung colorectal metastases treated with SABR. The results support the use of SBRT in lung oligometastatic colorectal cancer patients as it might delay the transition to PMD or offer relatively long disease-free period in selected cases. Predictive factors were identified for treatment personalization.

Published
2022

17. MRI-derived radiomics to guide post-operative management of glioblastoma: Implication for personalized radiation treatment volume delineation

Author

Chiesa, Silvia, Russo, Rosellina, Beghella Bartoli, Francesco, Palumbo, I, Sabatino, Giovanni, Cannatà, M C, Gigli, Riccardo, Longo, Silvia, Tran, H E, Boldrini, Luca, Dinapoli, Nicola, Votta, C, Cusumano, Davide, Pignotti, Fabrizio, Lupattelli, M, Camilli, F, Della Pepa, Giuseppe Maria, D'Alessandris, G Q, Olivi, Alessandro, Balducci, Mario, Colosimo, Cesare, Gambacorta, Maria Antonietta, Valentini, Vincenzo, Aristei, Cynthia, Gaudino, Simona, Chiesa, S (ORCID:0000-0003-0168-3459), Russo, R, Beghella Bartoli, F, Sabatino, G (ORCID:0000-0002-4227-0434), Gigli, R, Longo, S, Boldrini, L, Dinapoli, N, Cusumano, D, Pignotti, F, Della Pepa, G M (ORCID:0000-0001-8698-3359), Olivi, A (ORCID:0000-0002-4489-7564), Balducci, M (ORCID:0000-0003-0398-9726), Colosimo, C (ORCID:0000-0003-3800-3648), Gambacorta, M A (ORCID:0000-0001-5455-8737), Valentini, V (ORCID:0000-0003-4637-6487), Aristei, C, Gaudino, S (ORCID:0000-0003-1681-4343), Chiesa, Silvia, Russo, Rosellina, Beghella Bartoli, Francesco, Palumbo, I, Sabatino, Giovanni, Cannatà, M C, Gigli, Riccardo, Longo, Silvia, Tran, H E, Boldrini, Luca, Dinapoli, Nicola, Votta, C, Cusumano, Davide, Pignotti, Fabrizio, Lupattelli, M, Camilli, F, Della Pepa, Giuseppe Maria, D'Alessandris, G Q, Olivi, Alessandro, Balducci, Mario, Colosimo, Cesare, Gambacorta, Maria Antonietta, Valentini, Vincenzo, Aristei, Cynthia, Gaudino, Simona, Chiesa, S (ORCID:0000-0003-0168-3459), Russo, R, Beghella Bartoli, F, Sabatino, G (ORCID:0000-0002-4227-0434), Gigli, R, Longo, S, Boldrini, L, Dinapoli, N, Cusumano, D, Pignotti, F, Della Pepa, G M (ORCID:0000-0001-8698-3359), Olivi, A (ORCID:0000-0002-4489-7564), Balducci, M (ORCID:0000-0003-0398-9726), Colosimo, C (ORCID:0000-0003-3800-3648), Gambacorta, M A (ORCID:0000-0001-5455-8737), Valentini, V (ORCID:0000-0003-4637-6487), Aristei, C, and Gaudino, S (ORCID:0000-0003-1681-4343)

Abstract

BackgroundThe glioblastoma's bad prognosis is primarily due to intra-tumor heterogeneity, demonstrated from several studies that collected molecular biology, cytogenetic data and more recently radiomic features for a better prognostic stratification. The GLIFA project (GLIoblastoma Feature Analysis) is a multicentric project planned to investigate the role of radiomic analysis in GB management, to verify if radiomic features in the tissue around the resection cavity may guide the radiation target volume delineation. Materials and methodsWe retrospectively analyze from three centers radiomic features extracted from 90 patients with total or near total resection, who completed the standard adjuvant treatment and for whom we had post-operative images available for features extraction. The Manual segmentation was performed on post gadolinium T1w MRI sequence by 2 radiation oncologists and reviewed by a neuroradiologist, both with at least 10 years of experience. The Regions of interest (ROI) considered for the analysis were: the surgical cavity +/- post-surgical residual mass (CTV_cavity); the CTV a margin of 1.5 cm added to CTV_cavity and the volume resulting from subtracting the CTV_cavity from the CTV was defined as CTV_Ring. Radiomic analysis and modeling were conducted in RStudio. Z-score normalization was applied to each radiomic feature. A radiomic model was generated using features extracted from the Ring to perform a binary classification and predict the PFS at 6 months. A 3-fold cross-validation repeated five times was implemented for internal validation of the model. ResultsTwo-hundred and seventy ROIs were contoured. The proposed radiomic model was given by the best fitting logistic regression model, and included the following 3 features: F_cm_merged.contrast, F_cm_merged.info.corr.2, F_rlm_merged.rlnu. A good agreement between model predicted probabilities and observed outcome probabilities was obtained (p-value of 0.49 by Hosmer and Lemeshow statistical te

Published
2023

18. MRI-derived radiomics to guide post-operative management of glioblastoma: Implication for personalized radiation treatment volume delineation

Author

Chiesa, S., primary, Russo, R., additional, Beghella Bartoli, F., additional, Palumbo, I., additional, Sabatino, G., additional, Cannatà, M. C., additional, Gigli, R., additional, Longo, S., additional, Tran, H. E., additional, Boldrini, L., additional, Dinapoli, N., additional, Votta, C., additional, Cusumano, D., additional, Pignotti, F., additional, Lupattelli, M., additional, Camilli, F., additional, Della Pepa, G. M., additional, D’Alessandris, G. Q., additional, Olivi, A., additional, Balducci, M., additional, Colosimo, C., additional, Gambacorta, M. A., additional, Valentini, V., additional, Aristei, C., additional, and Gaudino, S., additional

Published
2023
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22. Environmental Security

Author

WENNING, R.J, APITZ, S.E., BELLUCK, D.A., CHIESA, S., FIGUEIRA, J., FILIP, Z., IGNATAVI IUS, G., KIKER, M.A., LAHDELMA, R., MACDONELL, M., MANNINI, A., RAISSOUNI, B., SINKA, D., XENIDIS, Y., Linkov, Igor, editor, Kiker, Gregory A., editor, and Wenning, Richard J., editor

Published
2007
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24. Machine Learning–Based Prediction of 6-Month Postoperative Karnofsky Performance Status in Patients with Glioblastoma: Capturing the Real-Life Interaction of Multiple Clinical and Oncologic Factors

Author

Della Pepa, G. M., Caccavella, V. M., Menna, G., Ius, T., Auricchio, A. M., Chiesa, S., Gaudino, S., Marchese, E., Olivi, A., Della Pepa G. M. (ORCID:0000-0001-8698-3359), Menna G., Auricchio A. M., Chiesa S. (ORCID:0000-0003-0168-3459), Gaudino S. (ORCID:0000-0003-1681-4343), Marchese E. (ORCID:0000-0001-8551-0357), Olivi A. (ORCID:0000-0002-4489-7564), Della Pepa, G. M., Caccavella, V. M., Menna, G., Ius, T., Auricchio, A. M., Chiesa, S., Gaudino, S., Marchese, E., Olivi, A., Della Pepa G. M. (ORCID:0000-0001-8698-3359), Menna G., Auricchio A. M., Chiesa S. (ORCID:0000-0003-0168-3459), Gaudino S. (ORCID:0000-0003-1681-4343), Marchese E. (ORCID:0000-0001-8551-0357), and Olivi A. (ORCID:0000-0002-4489-7564)

Abstract

Objective: Ability to thrive after invasive and intensive treatment is an important parameter to assess in patients with glioblastoma multiforme (GBM). Karnofsky Performance Status (KPS) is used to identify those patients suitable for postoperative radiochemotherapy. The aim of the present study is to investigate whether machine learning (ML)-based models can reliably predict patients' KPS 6 months after surgery. Methods: A cohort of 416 patients undergoing surgery for a histopathologically confirmed GBM were collected from a multicentric database and split into a training and hold-out test set in an 80:20 ratio. Worsening of KPS at 6 months after surgery (compared with preoperative KPS) occurred in 138 patients (33.2%). Relevant preoperative, intraoperative, and immediately postoperative variables were selected by a recursive features selection algorithm (Boruta) and used to build 2 ML-based predictive models. Results: A random forest classifier and a random forest regressor were trained to predict 6 months postoperative KPS as a categorical (worsening vs. stable/improving) and continuous variables; they achieved, respectively, an area under the curve of 0.81 (95% confidence interval, 0.76–0.84) and a mean absolute error of 4.4 (95% confidence interval, 4.0–4.7). Leveraging the predictive value resulting from the combination of independent variables, the random forest classifier outperformed conventional statistics (area under the curve improvement of +21%). Conclusions: Two robust ML-based prediction models were successfully trained and internally validated. Considerable effort remains to improve the interpretation of the results when these predictions are used in a patient-centered care context.

Published
2021

25. A Multicenter Large Retrospective Database on the Personalization of Stereotactic Ablative Radiotherapy for Lung Metastases From Colon-Rectal Cancer: The LaIT-SABR Study

Author

Nicosia, L, Franceschini, D, Perrone, F, Casamassima, F, Gerardi, M, Perna, M, Scotti, V, Fodor, A, Mazzola, R, Rigo, M, Iurato, A, Pasqualetti, F, Chiesa, S, Niespolo, R, Bruni, A, Frassinelli, L, Borghetti, P, Marzo, A, Ravasio, A, De Bari, B, Sepulcri, M, Aiello, D, Mortellaro, G, Sangalli, C, Franceschini, M, Montesi, G, Aquilanti, F, Valdagni, R, Fazio, I, Corti, L, Vavassori, L, Maranzano, E, Magrini, S, Lohr, F, Arcangeli, S, Valentini, V, Paiar, F, Ramella, S, Di Muzio, N, Livi, L, Jereczek-Fossa, B, Osti, M, Scorsetti, M, Alongi, F, Nicosia L., Franceschini D., Perrone F., Casamassima F., Gerardi M. A., Perna M., Scotti V., Fodor A., Mazzola R., Rigo M., Iurato A., Pasqualetti F., Chiesa S., Niespolo R. M., Bruni A., Frassinelli L., Borghetti P., Marzo A. D., Ravasio A., De Bari B., Sepulcri M., Aiello D., Mortellaro G., Sangalli C., Franceschini M., Montesi G., Aquilanti F. M., Valdagni R., Fazio I., Corti L., Vavassori L., Maranzano E., Magrini S., Lohr F., Arcangeli S., Valentini V., Paiar F., Ramella S., Di Muzio N. G., Livi L., Jereczek-Fossa B. A., Osti M. F., Scorsetti M., Alongi F., Nicosia, L, Franceschini, D, Perrone, F, Casamassima, F, Gerardi, M, Perna, M, Scotti, V, Fodor, A, Mazzola, R, Rigo, M, Iurato, A, Pasqualetti, F, Chiesa, S, Niespolo, R, Bruni, A, Frassinelli, L, Borghetti, P, Marzo, A, Ravasio, A, De Bari, B, Sepulcri, M, Aiello, D, Mortellaro, G, Sangalli, C, Franceschini, M, Montesi, G, Aquilanti, F, Valdagni, R, Fazio, I, Corti, L, Vavassori, L, Maranzano, E, Magrini, S, Lohr, F, Arcangeli, S, Valentini, V, Paiar, F, Ramella, S, Di Muzio, N, Livi, L, Jereczek-Fossa, B, Osti, M, Scorsetti, M, Alongi, F, Nicosia L., Franceschini D., Perrone F., Casamassima F., Gerardi M. A., Perna M., Scotti V., Fodor A., Mazzola R., Rigo M., Iurato A., Pasqualetti F., Chiesa S., Niespolo R. M., Bruni A., Frassinelli L., Borghetti P., Marzo A. D., Ravasio A., De Bari B., Sepulcri M., Aiello D., Mortellaro G., Sangalli C., Franceschini M., Montesi G., Aquilanti F. M., Valdagni R., Fazio I., Corti L., Vavassori L., Maranzano E., Magrini S., Lohr F., Arcangeli S., Valentini V., Paiar F., Ramella S., Di Muzio N. G., Livi L., Jereczek-Fossa B. A., Osti M. F., Scorsetti M., and Alongi F.

Abstract

PURPOSE/OBJECTIVE(S): stereotactic ablative radiotherapy (SABR) has been shown to increase survival rates in oligometastatic disease (OMD), but local control of colorectal metastases still remains poor. We aimed to identify potential predictive factors of SBRT response through a multicenter large retrospective database and to investigate how lung SBRT can impact on the progression to the polymetastatic disease (PMD). MATERIALS/METHODS: the study involved 22 centers, and was approved by the Ethical Committee (Prot. Negrar 2019-ZT). 1023 lung metastases treated with SBRT in 622 patients were reported. The median BED was 105 Gy10. Lesion diameter GTV, PTV volume, dose, fractionations, and site of primary tumor were evaluated as potential predictive marker for SBRT response for the primary end-point local progression-free survival (LPFS). EGFR, KRAS, NRAS, BRAF, and MSI were also evaluated. Secondary end-point was the time to the polymetastatic conversion (ttPMC). RESULTS: the median follow-up was 26 months (range 3-117 months). The median lesion diameter was 13 mm (range 4-58 mm). The 2- and 3-year LPFS were 75.6% and 71%, respectively. At the univariate analysis, BED ≥125Gy10 was associated with improved LPFS (2-year: 94.1% versus 72.6%; P = < 0.0001), single fraction SBRT correlated with better LPFS in the overall population (2-year: 80.6% versus 73.7%; P = 0.03), but no significant difference was observed when considering the population treated with BED > 100 Gy10. Lesion diameter ≤19 mm correlated with improved LPFS (2-year 80% versus 60%; P = < 0.0001). The median ttPMC was 26 months, and the 2-year ttPMC was 54.5%. The median PFS was 11.3 months. After SABR, 36% patients had polymetastatic relapse, 39.5% patients had an oligometastatic relapse, and 24.5% patients had no further relapse. CONCLUSION: the present is the largest series of lung colorectal metastases treated with SABR. The results support the use of SBRT in lung oligometastatic colorectal canc

Published
2021

26. P02.11.B An hypothesis generating study of MRI-Derived Radiomics on tumor and microenvironment tissue heterogeneity to guide post-operative management of glioblastoma: toward personalized radiation treatment volume delineation

Author

Cannatà, M, primary, Russo, R, additional, Beghella Bartoli, F, additional, Palumbo, I, additional, Tran, H, additional, Votta, C, additional, Lupattelli, M, additional, Boldrini, L, additional, Dinapoli, N, additional, Camilli, F, additional, Balducci, M, additional, Gambacorta, M, additional, Valentini, V, additional, Aristei, C, additional, Sabatino, G, additional, Pignotti, F, additional, Gaudino, S, additional, and Chiesa, S, additional

Published
2022
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30. 191P Radiotherapy (RT) in oligoprogressive metastatic breast cancer (mBC): A retrospective analysis

Author

Marazzi, F., primary, Orlandi, A., additional, Masiello, V., additional, Zinicola, T., additional, Moschella, F., additional, Palazzo, A., additional, Chiesa, S., additional, Garufi, G., additional, Frascino, V., additional, Tagliaferri, L., additional, Franceschini, G., additional, Fabi, A., additional, Gambacorta, M.A., additional, Bria, E., additional, Masetti, R., additional, Tortora, G., additional, and Valentini, V., additional

Published
2022
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31. OC-0929 How to manage consolidative radiotherapy after HD methotrexate in PCNSL patients: a phase II study

Author

Chiesa, S., primary, Beghella Bartoli, F., additional, Mazzarella, C., additional, Hohaus, S., additional, Cannatà, M.C., additional, Catucci, F., additional, D'Alò, F., additional, Bracci, S., additional, Nardangeli, A., additional, Martino, A., additional, Dinapoli, N., additional, Marazzi, F., additional, Manfrida, S., additional, Gambacorta, M.A., additional, Aristei, C., additional, Valentini, V., additional, and Balducci, M., additional

Published
2022
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32. OC-0602 A pREDictive model of polymetastatic disease on oligometastatic colorectal cancer: the RED LaIT-SABR

Author

Nicosia, L., primary, Franceschini, D., additional, Perrone Congedi, F., additional, Casamassima, F., additional, Gerardi, M.A., additional, Rigo, M., additional, Mazzola, R., additional, Perna, M., additional, Scotti, V., additional, Fodor, A., additional, Iurato, A., additional, Pasqualetti, F., additional, Gadducci, G., additional, Chiesa, S., additional, Niespolo, R.M., additional, Bruni, A., additional, Alicino, G., additional, Frassinelli, L., additional, Borghetti, P., additional, Di Marzo, A., additional, Ravasio, A., additional, De Bari, B., additional, Sepulcri, M., additional, Aiello, D., additional, Mortellaro, G., additional, Sangalli, C., additional, Franceschini, M., additional, Montesi, G., additional, Aquilanti, F.M., additional, Lunardi, G., additional, Valdagni, R., additional, Fazio, I., additional, Corti, L., additional, Vavassori, V., additional, Maranzano, E., additional, Magrini, S.M., additional, Arcangeli, S., additional, Valentini, V., additional, Paiar, F., additional, Ramella, S., additional, Di Muzio, N.G., additional, Livi, L., additional, Jereczek- Fossa, B.A., additional, Osti, M.F., additional, Scorsetti, M., additional, and Alongi, F., additional

Published
2022
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33. PO-1135 The challenge of glioblastoma recurrence treatment: a real-life experience with regorafenib.

Author

Mazzarella, C., primary, Chiesa, S., additional, Martino, A., additional, Bracci, S., additional, Beghella Bartoli, F., additional, Cannatà, M.C., additional, Nardangeli, A., additional, Masiello, V., additional, D'Alessandris, G., additional, Gaudino, S., additional, Lepre, E., additional, Frascino, V., additional, Meldolesi, E., additional, Olivi, A., additional, Gambacorta, M.A., additional, Valentini, V., additional, and Balducci, M., additional

Published
2022
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35. PO-1123 Unconventional treatment in GBM with pseudoprogression: low-dose radiotherapy could be an option?

Author

Beghella Bartoli, F., primary, Nardangeli, A., additional, Chiesa, S., additional, Mazzarella, C., additional, Topa, F.M., additional, Lepre, E., additional, Martino, A., additional, Bracci, S., additional, Cannatà, M.C., additional, Della Pepa, G.M., additional, Dinapoli, L., additional, Colloca, G.F., additional, Longo, S., additional, Massaccesi, M., additional, Olivi, A., additional, Gambacorta, M.A., additional, Valentini, V., additional, and Balducci, M., additional

Published
2022
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36. Global maps of soil temperature

Author

Lembrechts, J. J. (Jonas J.), van den Hoogen, J. (Johan), Aalto, J. (Juha), Ashcroft, M. B. (Michael B.), De Frenne, P. (Pieter), Kemppinen, J. (Julia), Kopecky, M. (Martin), Luoto, M. (Miska), Maclean, I. M. (Ilya M. D.), Crowther, T. W. (Thomas W.), Bailey, J. J. (Joseph J.), Haesen, S. (Stef), Klinges, D. H. (David H.), Niittynen, P. (Pekka), Scheffers, B. R. (Brett R.), Van Meerbeek, K. (Koenraad), Aartsma, P. (Peter), Abdalaze, O. (Otar), Abedi, M. (Mehdi), Aerts, R. (Rien), Ahmadian, N. (Negar), Ahrends, A. (Antje), Alatalo, J. M. (Juha M.), Alexander, J. M. (Jake M.), Allonsius, C. N. (Camille Nina), Altman, J. (Jan), Ammann, C. (Christof), Andres, C. (Christian), Andrews, C. (Christopher), Ardo, J. (Jonas), Arriga, N. (Nicola), Arzac, A. (Alberto), Aschero, V. (Valeria), Assis, R. L. (Rafael L.), Assmann, J. J. (Jakob Johann), Bader, M. Y. (Maaike Y.), Bahalkeh, K. (Khadijeh), Barancok, P. (Peter), Barrio, I. C. (Isabel C.), Barros, A. (Agustina), Barthel, M. (Matti), Basham, E. W. (Edmund W.), Bauters, M. (Marijn), Bazzichetto, M. (Manuele), Marchesini, L. B. (Luca Belelli), Bell, M. C. (Michael C.), Benavides, J. C. (Juan C.), Benito Alonso, J. L. (Jose Luis), Berauer, B. J. (Bernd J.), Bjerke, J. W. (Jarle W.), Bjork, R. G. (Robert G.), Bjorkman, M. P. (Mats P.), Bjornsdottir, K. (Katrin), Blonder, B. (Benjamin), Boeckx, P. (Pascal), Boike, J. (Julia), Bokhorst, S. (Stef), Brum, B. N. (Barbara N. S.), Bruna, J. (Josef), Buchmann, N. (Nina), Buysse, P. (Pauline), Camargo, J. L. (Jose Luis), Campoe, O. C. (Otavio C.), Candan, O. (Onur), Canessa, R. (Rafaella), Cannone, N. (Nicoletta), Carbognani, M. (Michele), Carnicer, J. (Jofre), Casanova-Katny, A. (Angelica), Cesarz, S. (Simone), Chojnicki, B. (Bogdan), Choler, P. (Philippe), Chown, S. L. (Steven L.), Cifuentes, E. F. (Edgar F.), Ciliak, M. (Marek), Contador, T. (Tamara), Convey, P. (Peter), Cooper, E. J. (Elisabeth J.), Cremonese, E. (Edoardo), Curasi, S. R. (Salvatore R.), Curtis, R. (Robin), Cutini, M. (Maurizio), Dahlberg, C. J. (C. Johan), Daskalova, G. N. (Gergana N.), Angel de Pablo, M. (Miguel), Della Chiesa, S. (Stefano), Dengler, J. (Juergen), Deronde, B. (Bart), Descombes, P. (Patrice), Di Cecco, V. (Valter), Di Musciano, M. (Michele), Dick, J. (Jan), Dimarco, R. D. (Romina D.), Dolezal, J. (Jiri), Dorrepaal, E. (Ellen), Dusek, J. (Jiri), Eisenhauer, N. (Nico), Eklundh, L. (Lars), Erickson, T. E. (Todd E.), Erschbamer, B. (Brigitta), Eugster, W. (Werner), Ewers, R. M. (Robert M.), Exton, D. A. (Dan A.), Fanin, N. (Nicolas), Fazlioglu, F. (Fatih), Feigenwinter, I. (Iris), Fenu, G. (Giuseppe), Ferlian, O. (Olga), Fernandez Calzado, M. R. (M. Rosa), Fernandez-Pascual, E. (Eduardo), Finckh, M. (Manfred), Higgens, R. F. (Rebecca Finger), Forte, T. G. (T'ai G. W.), Freeman, E. C. (Erika C.), Frei, E. R. (Esther R.), Fuentes-Lillo, E. (Eduardo), Garcia, R. A. (Rafael A.), Garcia, M. B. (Maria B.), Geron, C. (Charly), Gharun, M. (Mana), Ghosn, D. (Dany), Gigauri, K. (Khatuna), Gobin, A. (Anne), Goded, I. (Ignacio), Goeckede, M. (Mathias), Gottschall, F. (Felix), Goulding, K. (Keith), Govaert, S. (Sanne), Graae, B. J. (Bente Jessen), Greenwood, S. (Sarah), Greiser, C. (Caroline), Grelle, A. (Achim), Guenard, B. (Benoit), Guglielmin, M. (Mauro), Guillemot, J. (Joannes), Haase, P. (Peter), Haider, S. (Sylvia), Halbritter, A. H. (Aud H.), Hamid, M. (Maroof), Hammerle, A. (Albin), Hampe, A. (Arndt), Haugum, S. V. (Siri, V), Hederova, L. (Lucia), Heinesch, B. (Bernard), Helfter, C. (Carole), Hepenstrick, D. (Daniel), Herberich, M. (Maximiliane), Herbst, M. (Mathias), Hermanutz, L. (Luise), Hik, D. S. (David S.), Hoffren, R. (Raul), Homeier, J. (Juergen), Hörtnagl, L. (Lukas), Hoye, T. T. (Toke T.), Hrbacek, F. (Filip), Hylander, K. (Kristoffer), Iwata, H. (Hiroki), Jackowicz-Korczynski, M. A. (Marcin Antoni), Jactel, H. (Herve), Jarveoja, J. (Jarvi), Jastrzebowski, S. (Szymon), Jentsch, A. (Anke), Jimenez, J. J. (Juan J.), Jonsdottir, I. S. (Ingibjorg S.), Jucker, T. (Tommaso), Jump, A. S. (Alistair S.), Juszczak, R. (Radoslaw), Kanka, R. (Robert), Kaspar, V. (Vit), Kazakis, G. (George), Kelly, J. (Julia), Khuroo, A. A. (Anzar A.), Klemedtsson, L. (Leif), Klisz, M. (Marcin), Kljun, N. (Natascha), Knohl, A. (Alexander), Kobler, J. (Johannes), Kollar, J. (Jozef), Kotowska, M. M. (Martyna M.), Kovacs, B. (Bence), Kreyling, J. (Juergen), Lamprecht, A. (Andrea), Lang, S. I. (Simone, I), Larson, C. (Christian), Larson, K. (Keith), Laska, K. (Kamil), Maire, G. I. (Guerric Ie), Leihy, R. I. (Rachel, I), Lens, L. (Luc), Liljebladh, B. (Bengt), Lohila, A. (Annalea), Lorite, J. (Juan), Loubet, B. (Benjamin), Lynn, J. (Joshua), Macek, M. (Martin), Mackenzie, R. (Roy), Magliulo, E. (Enzo), Maier, R. (Regine), Malfasi, F. (Francesco), Malis, F. (Frantisek), Man, M. (Matej), Manca, G. (Giovanni), Manco, A. (Antonio), Manise, T. (Tanguy), Manolaki, P. (Paraskevi), Marciniak, F. (Felipe), Matula, R. (Radim), Clara Mazzolari, A. (Ana), Medinets, S. (Sergiy), Medinets, V. (Volodymyr), Meeussen, C. (Camille), Merinero, S. (Sonia), Guimaraes Mesquita, R. d. (Rita de Cassia), Meusburger, K. (Katrin), Meysman, F. J. (Filip J. R.), Michaletz, S. T. (Sean T.), Milbau, A. (Ann), Moiseev, D. (Dmitry), Moiseev, P. (Pavel), Mondoni, A. (Andrea), Monfries, R. (Ruth), Montagnani, L. (Leonardo), Moriana-Armendariz, M. (Mikel), di Cella, U. M. (Umberto Morra), Moersdorf, M. (Martin), Mosedale, J. R. (Jonathan R.), Muffler, L. (Lena), Munoz-Rojas, M. (Miriam), Myers, J. A. (Jonathan A.), Myers-Smith, I. H. (Isla H.), Nagy, L. (Laszlo), Nardino, M. (Marianna), Naujokaitis-Lewis, I. (Ilona), Newling, E. (Emily), Nicklas, L. (Lena), Niedrist, G. (Georg), Niessner, A. (Armin), Nilsson, M. B. (Mats B.), Normand, S. (Signe), Nosetto, M. D. (Marcelo D.), Nouvellon, Y. (Yann), Nunez, M. A. (Martin A.), Ogaya, R. (Roma), Ogee, J. (Jerome), Okello, J. (Joseph), Olejnik, J. (Janusz), Olesen, J. E. (Jorgen Eivind), Opedal, O. H. (Oystein H.), Orsenigo, S. (Simone), Palaj, A. (Andrej), Pampuch, T. (Timo), Panov, A. V. (Alexey V.), Pärtel, M. (Meelis), Pastor, A. (Ada), Pauchard, A. (Aníbal), Pauli, H. (Harald), Pavelka, M. (Marian), Pearse, W. D. (William D.), Peichl, M. (Matthias), Pellissier, L. (Loïc), Penczykowski, R. M. (Rachel M.), Penuelas, J. (Josep), Petit Bon, M. (Matteo), Petraglia, A. (Alessandro), Phartyal, S. S. (Shyam S.), Phoenix, G. K. (Gareth K.), Pio, C. (Casimiro), Pitacco, A. (Andrea), Pitteloud, C. (Camille), Plichta, R. (Roman), Porro, F. (Francesco), Portillo-Estrada, M. (Miguel), Poulenard, J. (Jérôme), Poyatos, R. (Rafael), Prokushkin, A. S. (Anatoly S.), Puchalka, R. (Radoslaw), Pușcaș, M. (Mihai), Radujković, D. (Dajana), Randall, K. (Krystal), Ratier Backes, A. (Amanda), Remmele, S. (Sabine), Remmers, W. (Wolfram), Renault, D. (David), Risch, A. C. (Anita C.), Rixen, C. (Christian), Robinson, S. A. (Sharon A.), Robroek, B. J. (Bjorn J. M.), Rocha, A. V. (Adrian V.), Rossi, C. (Christian), Rossi, G. (Graziano), Roupsard, O. (Olivier), Rubtsov, A. V. (Alexey V.), Saccone, P. (Patrick), Sagot, C. (Clotilde), Sallo Bravo, J. (Jhonatan), Santos, C. C. (Cinthya C.), Sarneel, J. M. (Judith M.), Scharnweber, T. (Tobias), Schmeddes, J. (Jonas), Schmidt, M. (Marius), Scholten, T. (Thomas), Schuchardt, M. (Max), Schwartz, N. (Naomi), Scott, T. (Tony), Seeber, J. (Julia), Segalin De Andrade, A. C. (Ana Cristina), Seipel, T. (Tim), Semenchuk, P. (Philipp), Senior, R. A. (Rebecca A.), Serra-Diaz, J. M. (Josep M.), Sewerniak, P. (Piotr), Shekhar, A. (Ankit), Sidenko, N. V. (Nikita V.), Siebicke, L. (Lukas), Siegwart Collier, L. (Laura), Simpson, E. (Elizabeth), Siqueira, D. P. (David P.), Sitková, Z. (Zuzana), Six, J. (Johan), Smiljanic, M. (Marko), Smith, S. W. (Stuart W.), Smith-Tripp, S. (Sarah), Somers, B. (Ben), Sørensen, M. V. (Mia Vedel), Souza, J. J. (José João L. L.), Souza, B. I. (Bartolomeu Israel), Dias, A. S. (Arildo Souza), Spasojevic, M. J. (Marko J.), Speed, J. D. (James D. M.), Spicher, F. (Fabien), Stanisci, A. (Angela), Steinbauer, K. (Klaus), Steinbrecher, R. (Rainer), Steinwandter, M. (Michael), Stemkovski, M. (Michael), Stephan, J. G. (Jörg G.), Stiegler, C. (Christian), Stoll, S. (Stefan), Svátek, M. (Martin), Svoboda, M. (Miroslav), Tagesson, T. (Torbern), Tanentzap, A. J. (Andrew J.), Tanneberger, F. (Franziska), Theurillat, J.-P. (Jean-Paul), Thomas, H. J. (Haydn J. D.), Thomas, A. D. (Andrew D.), Tielbörger, K. (Katja), Tomaselli, M. (Marcello), Treier, U. A. (Urs Albert), Trouillier, M. (Mario), Turtureanu, P. D. (Pavel Dan), Tutton, R. (Rosamond), Tyystjärvi, V. A. (Vilna A.), Ueyama, M. (Masahito), Ujházy, K. (Karol), Ujházyová, M. (Mariana), Uogintas, D. (Domas), Urban, A. V. (Anastasiya V.), Urban, J. (Josef), Urbaniak, M. (Marek), Ursu, T.-M. (Tudor-Mihai), Vaccari, F. P. (Francesco Primo), Van De Vondel, S. (Stijn), Van Den Brink, L. (Liesbeth), Van Geel, M. (Maarten), Vandvik, V. (Vigdis), Vangansbeke, P. (Pieter), Varlagin, A. (Andrej), Veen, G. F. (G. F.), Veenendaal, E. (Elmar), Venn, S. E. (Susanna E.), Verbeeck, H. (Hans), Verbrugggen, E. (Erik), Verheijen, F. G. (Frank G. A.), Villar, L. (Luis), Vitale, L. (Luca), Vittoz, P. (Pascal), Vives-Ingla, M. (Maria), Von Oppen, J. (Jonathan), Walz, J. (Josefine), Wang, R. (Runxi), Wang, Y. (Yifeng), Way, R. G. (Robert G.), Wedegärtner, R. E. (Ronja E. M.), Weigel, R. (Robert), Wild, J. (Jan), Wilkinson, M. (Matthew), Wilmking, M. (Martin), Wingate, L. (Lisa), Winkler, M. (Manuela), Wipf, S. (Sonja), Wohlfahrt, G. (Georg), Xenakis, G. (Georgios), Yang, Y. (Yan), Yu, Z. (Zicheng), Yu, K. (Kailiang), Zellweger, F. (Florian), Zhang, J. (Jian), Zhang, Z. (Zhaochen), Zhao, P. (Peng), Ziemblińska, K. (Klaudia), Zimmermann, R. (Reiner), Zong, S. (Shengwei), Zyryanov, V. I. (Viacheslav I.), Nijs, I. (Ivan), Lenoir, J. (Jonathan), Lembrechts, J. J. (Jonas J.), van den Hoogen, J. (Johan), Aalto, J. (Juha), Ashcroft, M. B. (Michael B.), De Frenne, P. (Pieter), Kemppinen, J. (Julia), Kopecky, M. (Martin), Luoto, M. (Miska), Maclean, I. M. (Ilya M. D.), Crowther, T. W. (Thomas W.), Bailey, J. J. (Joseph J.), Haesen, S. (Stef), Klinges, D. H. (David H.), Niittynen, P. (Pekka), Scheffers, B. R. (Brett R.), Van Meerbeek, K. (Koenraad), Aartsma, P. (Peter), Abdalaze, O. (Otar), Abedi, M. (Mehdi), Aerts, R. (Rien), Ahmadian, N. (Negar), Ahrends, A. (Antje), Alatalo, J. M. (Juha M.), Alexander, J. M. (Jake M.), Allonsius, C. N. (Camille Nina), Altman, J. (Jan), Ammann, C. (Christof), Andres, C. (Christian), Andrews, C. (Christopher), Ardo, J. (Jonas), Arriga, N. (Nicola), Arzac, A. (Alberto), Aschero, V. (Valeria), Assis, R. L. (Rafael L.), Assmann, J. J. (Jakob Johann), Bader, M. Y. (Maaike Y.), Bahalkeh, K. (Khadijeh), Barancok, P. (Peter), Barrio, I. C. (Isabel C.), Barros, A. (Agustina), Barthel, M. (Matti), Basham, E. W. (Edmund W.), Bauters, M. (Marijn), Bazzichetto, M. (Manuele), Marchesini, L. B. (Luca Belelli), Bell, M. C. (Michael C.), Benavides, J. C. (Juan C.), Benito Alonso, J. L. (Jose Luis), Berauer, B. J. (Bernd J.), Bjerke, J. W. (Jarle W.), Bjork, R. G. (Robert G.), Bjorkman, M. P. (Mats P.), Bjornsdottir, K. (Katrin), Blonder, B. (Benjamin), Boeckx, P. (Pascal), Boike, J. (Julia), Bokhorst, S. (Stef), Brum, B. N. (Barbara N. S.), Bruna, J. (Josef), Buchmann, N. (Nina), Buysse, P. (Pauline), Camargo, J. L. (Jose Luis), Campoe, O. C. (Otavio C.), Candan, O. (Onur), Canessa, R. (Rafaella), Cannone, N. (Nicoletta), Carbognani, M. (Michele), Carnicer, J. (Jofre), Casanova-Katny, A. (Angelica), Cesarz, S. (Simone), Chojnicki, B. (Bogdan), Choler, P. (Philippe), Chown, S. L. (Steven L.), Cifuentes, E. F. (Edgar F.), Ciliak, M. (Marek), Contador, T. (Tamara), Convey, P. (Peter), Cooper, E. J. (Elisabeth J.), Cremonese, E. (Edoardo), Curasi, S. R. (Salvatore R.), Curtis, R. (Robin), Cutini, M. (Maurizio), Dahlberg, C. J. (C. Johan), Daskalova, G. N. (Gergana N.), Angel de Pablo, M. (Miguel), Della Chiesa, S. (Stefano), Dengler, J. (Juergen), Deronde, B. (Bart), Descombes, P. (Patrice), Di Cecco, V. (Valter), Di Musciano, M. (Michele), Dick, J. (Jan), Dimarco, R. D. (Romina D.), Dolezal, J. (Jiri), Dorrepaal, E. (Ellen), Dusek, J. (Jiri), Eisenhauer, N. (Nico), Eklundh, L. (Lars), Erickson, T. E. (Todd E.), Erschbamer, B. (Brigitta), Eugster, W. (Werner), Ewers, R. M. (Robert M.), Exton, D. A. (Dan A.), Fanin, N. (Nicolas), Fazlioglu, F. (Fatih), Feigenwinter, I. (Iris), Fenu, G. (Giuseppe), Ferlian, O. (Olga), Fernandez Calzado, M. R. (M. Rosa), Fernandez-Pascual, E. (Eduardo), Finckh, M. (Manfred), Higgens, R. F. (Rebecca Finger), Forte, T. G. (T'ai G. W.), Freeman, E. C. (Erika C.), Frei, E. R. (Esther R.), Fuentes-Lillo, E. (Eduardo), Garcia, R. A. (Rafael A.), Garcia, M. B. (Maria B.), Geron, C. (Charly), Gharun, M. (Mana), Ghosn, D. (Dany), Gigauri, K. (Khatuna), Gobin, A. (Anne), Goded, I. (Ignacio), Goeckede, M. (Mathias), Gottschall, F. (Felix), Goulding, K. (Keith), Govaert, S. (Sanne), Graae, B. J. (Bente Jessen), Greenwood, S. (Sarah), Greiser, C. (Caroline), Grelle, A. (Achim), Guenard, B. (Benoit), Guglielmin, M. (Mauro), Guillemot, J. (Joannes), Haase, P. (Peter), Haider, S. (Sylvia), Halbritter, A. H. (Aud H.), Hamid, M. (Maroof), Hammerle, A. (Albin), Hampe, A. (Arndt), Haugum, S. V. (Siri, V), Hederova, L. (Lucia), Heinesch, B. (Bernard), Helfter, C. (Carole), Hepenstrick, D. (Daniel), Herberich, M. (Maximiliane), Herbst, M. (Mathias), Hermanutz, L. (Luise), Hik, D. S. (David S.), Hoffren, R. (Raul), Homeier, J. (Juergen), Hörtnagl, L. (Lukas), Hoye, T. T. (Toke T.), Hrbacek, F. (Filip), Hylander, K. (Kristoffer), Iwata, H. (Hiroki), Jackowicz-Korczynski, M. A. (Marcin Antoni), Jactel, H. (Herve), Jarveoja, J. (Jarvi), Jastrzebowski, S. (Szymon), Jentsch, A. (Anke), Jimenez, J. J. (Juan J.), Jonsdottir, I. S. (Ingibjorg S.), Jucker, T. (Tommaso), Jump, A. S. (Alistair S.), Juszczak, R. (Radoslaw), Kanka, R. (Robert), Kaspar, V. (Vit), Kazakis, G. (George), Kelly, J. (Julia), Khuroo, A. A. (Anzar A.), Klemedtsson, L. (Leif), Klisz, M. (Marcin), Kljun, N. (Natascha), Knohl, A. (Alexander), Kobler, J. (Johannes), Kollar, J. (Jozef), Kotowska, M. M. (Martyna M.), Kovacs, B. (Bence), Kreyling, J. (Juergen), Lamprecht, A. (Andrea), Lang, S. I. (Simone, I), Larson, C. (Christian), Larson, K. (Keith), Laska, K. (Kamil), Maire, G. I. (Guerric Ie), Leihy, R. I. (Rachel, I), Lens, L. (Luc), Liljebladh, B. (Bengt), Lohila, A. (Annalea), Lorite, J. (Juan), Loubet, B. (Benjamin), Lynn, J. (Joshua), Macek, M. (Martin), Mackenzie, R. (Roy), Magliulo, E. (Enzo), Maier, R. (Regine), Malfasi, F. (Francesco), Malis, F. (Frantisek), Man, M. (Matej), Manca, G. (Giovanni), Manco, A. (Antonio), Manise, T. (Tanguy), Manolaki, P. (Paraskevi), Marciniak, F. (Felipe), Matula, R. (Radim), Clara Mazzolari, A. (Ana), Medinets, S. (Sergiy), Medinets, V. (Volodymyr), Meeussen, C. (Camille), Merinero, S. (Sonia), Guimaraes Mesquita, R. d. (Rita de Cassia), Meusburger, K. (Katrin), Meysman, F. J. (Filip J. R.), Michaletz, S. T. (Sean T.), Milbau, A. (Ann), Moiseev, D. (Dmitry), Moiseev, P. (Pavel), Mondoni, A. (Andrea), Monfries, R. (Ruth), Montagnani, L. (Leonardo), Moriana-Armendariz, M. (Mikel), di Cella, U. M. (Umberto Morra), Moersdorf, M. (Martin), Mosedale, J. R. (Jonathan R.), Muffler, L. (Lena), Munoz-Rojas, M. (Miriam), Myers, J. A. (Jonathan A.), Myers-Smith, I. H. (Isla H.), Nagy, L. (Laszlo), Nardino, M. (Marianna), Naujokaitis-Lewis, I. (Ilona), Newling, E. (Emily), Nicklas, L. (Lena), Niedrist, G. (Georg), Niessner, A. (Armin), Nilsson, M. B. (Mats B.), Normand, S. (Signe), Nosetto, M. D. (Marcelo D.), Nouvellon, Y. (Yann), Nunez, M. A. (Martin A.), Ogaya, R. (Roma), Ogee, J. (Jerome), Okello, J. (Joseph), Olejnik, J. (Janusz), Olesen, J. E. (Jorgen Eivind), Opedal, O. H. (Oystein H.), Orsenigo, S. (Simone), Palaj, A. (Andrej), Pampuch, T. (Timo), Panov, A. V. (Alexey V.), Pärtel, M. (Meelis), Pastor, A. (Ada), Pauchard, A. (Aníbal), Pauli, H. (Harald), Pavelka, M. (Marian), Pearse, W. D. (William D.), Peichl, M. (Matthias), Pellissier, L. (Loïc), Penczykowski, R. M. (Rachel M.), Penuelas, J. (Josep), Petit Bon, M. (Matteo), Petraglia, A. (Alessandro), Phartyal, S. S. (Shyam S.), Phoenix, G. K. (Gareth K.), Pio, C. (Casimiro), Pitacco, A. (Andrea), Pitteloud, C. (Camille), Plichta, R. (Roman), Porro, F. (Francesco), Portillo-Estrada, M. (Miguel), Poulenard, J. (Jérôme), Poyatos, R. (Rafael), Prokushkin, A. S. (Anatoly S.), Puchalka, R. (Radoslaw), Pușcaș, M. (Mihai), Radujković, D. (Dajana), Randall, K. (Krystal), Ratier Backes, A. (Amanda), Remmele, S. (Sabine), Remmers, W. (Wolfram), Renault, D. (David), Risch, A. C. (Anita C.), Rixen, C. (Christian), Robinson, S. A. (Sharon A.), Robroek, B. J. (Bjorn J. M.), Rocha, A. V. (Adrian V.), Rossi, C. (Christian), Rossi, G. (Graziano), Roupsard, O. (Olivier), Rubtsov, A. V. (Alexey V.), Saccone, P. (Patrick), Sagot, C. (Clotilde), Sallo Bravo, J. (Jhonatan), Santos, C. C. (Cinthya C.), Sarneel, J. M. (Judith M.), Scharnweber, T. (Tobias), Schmeddes, J. (Jonas), Schmidt, M. (Marius), Scholten, T. (Thomas), Schuchardt, M. (Max), Schwartz, N. (Naomi), Scott, T. (Tony), Seeber, J. (Julia), Segalin De Andrade, A. C. (Ana Cristina), Seipel, T. (Tim), Semenchuk, P. (Philipp), Senior, R. A. (Rebecca A.), Serra-Diaz, J. M. (Josep M.), Sewerniak, P. (Piotr), Shekhar, A. (Ankit), Sidenko, N. V. (Nikita V.), Siebicke, L. (Lukas), Siegwart Collier, L. (Laura), Simpson, E. (Elizabeth), Siqueira, D. P. (David P.), Sitková, Z. (Zuzana), Six, J. (Johan), Smiljanic, M. (Marko), Smith, S. W. (Stuart W.), Smith-Tripp, S. (Sarah), Somers, B. (Ben), Sørensen, M. V. (Mia Vedel), Souza, J. J. (José João L. L.), Souza, B. I. (Bartolomeu Israel), Dias, A. S. (Arildo Souza), Spasojevic, M. J. (Marko J.), Speed, J. D. (James D. M.), Spicher, F. (Fabien), Stanisci, A. (Angela), Steinbauer, K. (Klaus), Steinbrecher, R. (Rainer), Steinwandter, M. (Michael), Stemkovski, M. (Michael), Stephan, J. G. (Jörg G.), Stiegler, C. (Christian), Stoll, S. (Stefan), Svátek, M. (Martin), Svoboda, M. (Miroslav), Tagesson, T. (Torbern), Tanentzap, A. J. (Andrew J.), Tanneberger, F. (Franziska), Theurillat, J.-P. (Jean-Paul), Thomas, H. J. (Haydn J. D.), Thomas, A. D. (Andrew D.), Tielbörger, K. (Katja), Tomaselli, M. (Marcello), Treier, U. A. (Urs Albert), Trouillier, M. (Mario), Turtureanu, P. D. (Pavel Dan), Tutton, R. (Rosamond), Tyystjärvi, V. A. (Vilna A.), Ueyama, M. (Masahito), Ujházy, K. (Karol), Ujházyová, M. (Mariana), Uogintas, D. (Domas), Urban, A. V. (Anastasiya V.), Urban, J. (Josef), Urbaniak, M. (Marek), Ursu, T.-M. (Tudor-Mihai), Vaccari, F. P. (Francesco Primo), Van De Vondel, S. (Stijn), Van Den Brink, L. (Liesbeth), Van Geel, M. (Maarten), Vandvik, V. (Vigdis), Vangansbeke, P. (Pieter), Varlagin, A. (Andrej), Veen, G. F. (G. F.), Veenendaal, E. (Elmar), Venn, S. E. (Susanna E.), Verbeeck, H. (Hans), Verbrugggen, E. (Erik), Verheijen, F. G. (Frank G. A.), Villar, L. (Luis), Vitale, L. (Luca), Vittoz, P. (Pascal), Vives-Ingla, M. (Maria), Von Oppen, J. (Jonathan), Walz, J. (Josefine), Wang, R. (Runxi), Wang, Y. (Yifeng), Way, R. G. (Robert G.), Wedegärtner, R. E. (Ronja E. M.), Weigel, R. (Robert), Wild, J. (Jan), Wilkinson, M. (Matthew), Wilmking, M. (Martin), Wingate, L. (Lisa), Winkler, M. (Manuela), Wipf, S. (Sonja), Wohlfahrt, G. (Georg), Xenakis, G. (Georgios), Yang, Y. (Yan), Yu, Z. (Zicheng), Yu, K. (Kailiang), Zellweger, F. (Florian), Zhang, J. (Jian), Zhang, Z. (Zhaochen), Zhao, P. (Peng), Ziemblińska, K. (Klaudia), Zimmermann, R. (Reiner), Zong, S. (Shengwei), Zyryanov, V. I. (Viacheslav I.), Nijs, I. (Ivan), and Lenoir, J. (Jonathan)

Abstract

Research in global change ecology relies heavily on global climatic grids derived from estimates of air temperature in open areas at around 2 m above the ground. These climatic grids do not reflect conditions below vegetation canopies and near the ground surface, where critical ecosystem functions occur and most terrestrial species reside. Here, we provide global maps of soil temperature and bioclimatic variables at a 1-km² resolution for 0‐5 and 5‐15 cm soil depth. These maps were created by calculating the difference (i.e. offset) between in situ soil temperature measurements, based on time series from over 1200 1‐km² pixels (summarized from 8519 unique temperature sensors) across all the world’s major terrestrial biomes, and coarse-grained air temperature estimates from ERA5-Land (an atmospheric reanalysis by the European Centre for Medium-Range Weather Forecasts). We show that mean annual soil temperature differs markedly from the corresponding gridded air temperature, by up to 10° degrees C (mean = 3.0 +/‐ 2.1° degrees C), with substantial variation across biomes and seasons. Over the year, soils in cold and/or dry biomes are substantially warmer (+3.6 +/‐2.3° degrees C) than gridded air temperature, whereas soils in warm and humid environments are on average slightly cooler (‐0.7 +/‐ 2.3° degrees C). The observed substantial and biome-specific offsets emphasize that the projected impacts of climate and climate change on near-surface biodiversity and ecosystem functioning are inaccurately assessed when air rather than soil temperature is used, especially in cold environments. The global soil-related bioclimatic variables provided here are an important step forward for any application in ecology and related disciplines. Nevertheless, we highlight the need to fill remaining geographic gaps by collecting more in situ measurements of microclimate conditions to further enhance the spatiotemporal resolution of global soil temperature products for ecological

Published
2022

37. Glycoprotein acetyls:a novel inflammatory biomarker of early cardiovascular risk in the young

Author

Chiesa, S. T. (Scott T.), Charakida, M. (Marietta), Georgiopoulos, G. (Georgios), Roberts, J. D. (Justin D.), Stafford, S. J. (Simon J.), Park, C. (Chloe), Mykkänen, J. (Juha), Kähönen, M. (Mika), Lehtimäki, T. (Terho), Ala‐Korpela, M. (Mika), Raitakari, O. (Olli), Pietiäinen, M. (Milla), Pussinen, P. (Pirkko), Muthurangu, V. (Vivek), Hughes, A. D. (Alun D.), Sattar, N. (Naveed), Timpson, N. J. (Nicholas J.), Deanfield, J. E. (John E.), Chiesa, S. T. (Scott T.), Charakida, M. (Marietta), Georgiopoulos, G. (Georgios), Roberts, J. D. (Justin D.), Stafford, S. J. (Simon J.), Park, C. (Chloe), Mykkänen, J. (Juha), Kähönen, M. (Mika), Lehtimäki, T. (Terho), Ala‐Korpela, M. (Mika), Raitakari, O. (Olli), Pietiäinen, M. (Milla), Pussinen, P. (Pirkko), Muthurangu, V. (Vivek), Hughes, A. D. (Alun D.), Sattar, N. (Naveed), Timpson, N. J. (Nicholas J.), and Deanfield, J. E. (John E.)

Abstract

Background: Low‐grade inflammation in the young may contribute to the early development of cardiovascular disease. We assessed whether circulating levels of glycoprotein acetyls (GlycA) were better able to predict the development of adverse cardiovascular disease risk profiles compared with the more commonly used biomarker high‐sensitivity CRP (C‐reactive protein). Methods: A total of 3306 adolescents and young adults from the Avon Longitudinal Study of Parents and Children (mean age, 15.4±0.3; n=1750) and Cardiovascular Risk in Young Finns Study (mean age, 32.1±5.0; n=1556) were included. Baseline associations between inflammatory biomarkers, body composition, cardiovascular risk factors, and subclinical measures of vascular dysfunction were assessed cross‐sectionally in both cohorts. Prospective risk of developing hypertension and metabolic syndrome during 9‐to‐10‐year follow‐up were also assessed as surrogate markers for future cardiovascular risk. GlycA showed greater within‐subject correlation over 9‐to‐10‐year follow‐up in both cohorts compared with CRP, particularly in the younger adolescent group (r=0.36 versus 0.07). In multivariable analyses, GlycA was found to associate with multiple lifestyle‐related cardiovascular disease risk factors, cardiometabolic risk factor burden, and vascular dysfunction (eg, mean difference in flow‐mediated dilation=−1.2 [−1.8, −0.7]% per z‐score increase). In contrast, CRP levels appeared predominantly driven by body mass index and showed little relationship to any measured cardiovascular risk factors or phenotypes. In both cohorts, only GlycA predicted future risk of both hypertension (risk ratio [RR], ≈1.1 per z‐score increase for both cohorts) and metabolic syndrome (RR, ≈1.2–1.3 per z‐score increase for both cohorts) in 9‐to‐10‐year follow‐up. Conclusions: Low‐grade inflammation captured by the novel biomarker GlycA is associated with adverse cardiovascular risk profiles from as early as adolescence and predicts f

Published
2022

38. Targeted therapy for pediatric diffuse intrinsic pontine glioma: a single-center experience

Author

Del Baldo, G., Carai, A., Abbas, R., Cacchione, A., Vinci, M., Di Ruscio, V., Colafati, G. S., Rossi, S., Diomedi Camassei, F., Maestro, N., Temelso, S., Pericoli, G., De Billy, E., Giovannoni, I., Carboni, A., Rinelli, M., Agolini, E., Mackay, A., Jones, C., Chiesa, S., Balducci, Mario, Locatelli, Franco, Mastronuzzi, A., Balducci M. (ORCID:0000-0003-0398-9726), Locatelli F. (ORCID:0000-0002-7976-3654), Del Baldo, G., Carai, A., Abbas, R., Cacchione, A., Vinci, M., Di Ruscio, V., Colafati, G. S., Rossi, S., Diomedi Camassei, F., Maestro, N., Temelso, S., Pericoli, G., De Billy, E., Giovannoni, I., Carboni, A., Rinelli, M., Agolini, E., Mackay, A., Jones, C., Chiesa, S., Balducci, Mario, Locatelli, Franco, Mastronuzzi, A., Balducci M. (ORCID:0000-0003-0398-9726), and Locatelli F. (ORCID:0000-0002-7976-3654)

Abstract

Background: Diffuse intrinsic pontine glioma (DIPG) is a fatal disease with a median overall survival (OS) of less than 12 months after diagnosis. Radiotherapy (RT) still remains the mainstay treatment. Several other therapeutic strategies have been attempted in the last years without a significant effect on OS. Although radiological imaging is the gold standard for DIPG diagnosis, the urgent need to improve the survival has led to the reconsideration of biopsy with the aim to better understand the molecular profile of DIPG and support personalized treatment. Methods: In this study, we present a single-center experience in treating DIPG patients at disease progression combining targeted therapies with standard of care. Biopsy was proposed to all patients at diagnosis or disease progression. First-line treatment included RT and nimotuzumab/vinorelbine or temozolomide. Immunohistochemistry-targeted research included study of mTOR/p-mTOR pathway and BRAFv600E. Molecular analyses included polymerase chain reaction, followed by Sanger sequences and/or next-generation sequencing. Results: Based on the molecular profile, targeted therapy was administered in 9 out of 25 patients, while the remaining 16 patients were treated with standard of care. Personalized treatment included inhibition of the PI3K/AKT/mTOR pathway (5/9), PI3K/AKT/mTOR pathway and BRAFv600E (1/9), ACVR1 (2/9) and PDGFRA (1/9); no severe side effects were reported during treatment. Response to treatment was evaluated according to Response Assessment in Pediatric Neuro-Oncology criteria, and the overall response rate within the cohort was 66%. Patients treated with targeted therapies were compared with the control cohort of 16 patients. Clinical and pathological characteristics of the two cohorts were homogeneous. Median OS in the personalized treatment and control cohort was 20.26 and 14.18 months, respectively (p = 0.032). In our experience, the treatment associated with the best OS was everolimus. Conclu

Published
2022

39. Art and digital technologies to support resilience during the oncological journey: The Art4ART project

Author

Tagliaferri, Luca, Dinapoli, Loredana, Casa, Cristina, Colloca, Giuseppe Ferdinando, Marazzi, Fabio, Cornacchione, Patrizia, Mazzarella, Maria Cristina, Masiello, Valeria, Chiesa, Silvia, Beghella Bartoli, Francesco, Marconi, Elisa, D'Oria, Marika, Cesario, Alfredo, Chieffo, Daniela Pia Rosaria, Valentini, Vincenzo, Gambacorta, Maria Antonietta, Tagliaferri L. (ORCID:0000-0003-2308-0982), Dinapoli L., Casa C., Colloca G. F., Marazzi F., Cornacchione P., Mazzarella C., Masiello V., Chiesa S. (ORCID:0000-0003-0168-3459), Beghella Bartoli F., Marconi E. (ORCID:0000-0001-6722-8390), D'Oria M., Cesario A. (ORCID:0000-0003-4687-0709), Chieffo D. P. R., Valentini V. (ORCID:0000-0003-4637-6487), Gambacorta M. A. (ORCID:0000-0001-5455-8737), Tagliaferri, Luca, Dinapoli, Loredana, Casa, Cristina, Colloca, Giuseppe Ferdinando, Marazzi, Fabio, Cornacchione, Patrizia, Mazzarella, Maria Cristina, Masiello, Valeria, Chiesa, Silvia, Beghella Bartoli, Francesco, Marconi, Elisa, D'Oria, Marika, Cesario, Alfredo, Chieffo, Daniela Pia Rosaria, Valentini, Vincenzo, Gambacorta, Maria Antonietta, Tagliaferri L. (ORCID:0000-0003-2308-0982), Dinapoli L., Casa C., Colloca G. F., Marazzi F., Cornacchione P., Mazzarella C., Masiello V., Chiesa S. (ORCID:0000-0003-0168-3459), Beghella Bartoli F., Marconi E. (ORCID:0000-0001-6722-8390), D'Oria M., Cesario A. (ORCID:0000-0003-4687-0709), Chieffo D. P. R., Valentini V. (ORCID:0000-0003-4637-6487), and Gambacorta M. A. (ORCID:0000-0001-5455-8737)

Abstract

Introduction: New digital technologies can become a tool for welcoming the patient through the artistic dimension. Cancer patients, in particular, need support that accompanies and supports them throughout their treatment. Materials and methods: The Art4ART project consist in the structural proposal to cancer patients of a web-based digital platform containing several forms of art as video-entertainments; a multimedia immersive room; an art-based welcoming of the patients with several original paintings; an environment with a peacefulness vertical garden; a reconceptualization of the chemotherapy-infusion seats. Data regarding patients’ preference and choices will be stored and analysed also using artificial intelligence (AI) algorithm to measure and predict impact indicators regarding clinical outcomes (survival and toxicity), psychological indicators. Moreover, the same digital platform will contribute to a better organization of the activities. Discussion: Through the systematic acquisition of patient preferences and through integration with other clinical parameters, it will be possible to measure the clinical, psychological, organisational, and social impact of the newly implemented Art4ART project. The use of digital technology leads us to apply the reversal of viewpoint from therapeutic acts to patient-centred care.

Published
2022

40. Clinical and NGS predictors of response to regorafenib in recurrent glioblastoma

Author

Chiesa, Silvia, Mangraviti, A., Martini, Maurizio, Cenci, Tonia, Mazzarella, Maria Cristina, Gaudino, Simona, Bracci, S., Martino, Antonella, Della Pepa, Giuseppe Maria, Offi, Martina, Gessi, Marco, Russo, Rosellina, Martucci, Matia, Beghella Bartoli, F., Larocca, Luigi Maria, Lauretti, Liverana, Olivi, Alessandro, Pallini, Roberto, Balducci, Mario, D'Alessandris, Quintino Giorgio, Chiesa S. (ORCID:0000-0003-0168-3459), Martini M. (ORCID:0000-0002-6260-6310), Cenci T., Mazzarella C., Gaudino S. (ORCID:0000-0003-1681-4343), Martino A., Della Pepa G. M. (ORCID:0000-0001-8698-3359), Offi M., Gessi M., Russo R., Martucci M., Larocca L. M. (ORCID:0000-0003-1739-4758), Lauretti L. (ORCID:0000-0002-6463-055X), Olivi A. (ORCID:0000-0002-4489-7564), Pallini R. (ORCID:0000-0002-4611-8827), Balducci M. (ORCID:0000-0003-0398-9726), D'Alessandris Q. G. (ORCID:0000-0002-2953-9291), Chiesa, Silvia, Mangraviti, A., Martini, Maurizio, Cenci, Tonia, Mazzarella, Maria Cristina, Gaudino, Simona, Bracci, S., Martino, Antonella, Della Pepa, Giuseppe Maria, Offi, Martina, Gessi, Marco, Russo, Rosellina, Martucci, Matia, Beghella Bartoli, F., Larocca, Luigi Maria, Lauretti, Liverana, Olivi, Alessandro, Pallini, Roberto, Balducci, Mario, D'Alessandris, Quintino Giorgio, Chiesa S. (ORCID:0000-0003-0168-3459), Martini M. (ORCID:0000-0002-6260-6310), Cenci T., Mazzarella C., Gaudino S. (ORCID:0000-0003-1681-4343), Martino A., Della Pepa G. M. (ORCID:0000-0001-8698-3359), Offi M., Gessi M., Russo R., Martucci M., Larocca L. M. (ORCID:0000-0003-1739-4758), Lauretti L. (ORCID:0000-0002-6463-055X), Olivi A. (ORCID:0000-0002-4489-7564), Pallini R. (ORCID:0000-0002-4611-8827), Balducci M. (ORCID:0000-0003-0398-9726), and D'Alessandris Q. G. (ORCID:0000-0002-2953-9291)

Abstract

Predictive factors for response to regorafenib in recurrent glioblastoma, IDH-wildtype, are scarcely recognized. The objective of this study was to identify molecular predictive factors for response to regorafenib using a clinically available platform. We analyzed a prospective cohort of 30 patients harboring recurrent glioblastoma, IDH-wildtype, and treated with regorafenib. Next-generation sequencing (NGS) analysis was performed on DNA extracted from paraffin-embedded tissues using a clinically available platform. Moreover, MGMT methylation and EGFRvIII expression analyses were performed. Six-month progression-free survival (PFS) was 30% and median overall survival (OS) was 7.5 months, in line with literature data. NGS analysis revealed a mutation in the EGFR pathway in 18% of cases and a mutation in the mitogen-activated protein-kinase (MAPK) pathway in 18% of cases. In the remaining cases, no mutations were detected. Patients carrying MAPK pathway mutation had a poor response to regorafenib treatment, with a significantly shorter PFS and a nonsignificantly shorter OS compared to EGFR-mutated patients (for PFS, 2.5 vs 4.5 months, p = 0.0061; for OS, 7 vs 9 months, p = 0.1076). Multivariate analysis confirmed that MAPK pathway mutations independently predicted a shorter PFS after regorafenib treatment (p = 0.0188). The negative prognostic role of MAPK pathway alteration was reinforced when we combined EGFR-mutated with EGFRvIII-positive cases. Recurrent glioblastoma tumors with an alteration in MAPK pathway could belong to the mesenchymal subtype and respond poorly to regorafenib treatment, while EGFR-altered cases have a better response to regorafenib. We thus provide a molecular selection criterion easy to implement in the clinical practice.

Published
2022

41. Neurosurgical Defeats: Critically Ill Patients and the Role of Palliative Care Service

Author

D'Alessandris, Quintino Giorgio, Ricciotti, Maria Adelaide, Palombi, Davide, Agostini, Ludovico, Mattogno, Pier Paolo, Della Pepa, Giuseppe Maria, Albanese, Alessio, Chiesa, Silvia, Dispenza, S., Meloni, E., Tummolo, A. M., Pallini, Roberto, Barillaro, Christian, Olivi, Alessandro, Lauretti, Liverana, D'Alessandris Q. G. (ORCID:0000-0002-2953-9291), Ricciotti M. A., Palombi D., Agostini L., Mattogno P. P., Della Pepa G. M. (ORCID:0000-0001-8698-3359), Albanese A. (ORCID:0000-0001-8783-2974), Chiesa S. (ORCID:0000-0003-0168-3459), Pallini R. (ORCID:0000-0002-4611-8827), Barillaro C., Olivi A. (ORCID:0000-0002-4489-7564), Lauretti L. (ORCID:0000-0002-6463-055X), D'Alessandris, Quintino Giorgio, Ricciotti, Maria Adelaide, Palombi, Davide, Agostini, Ludovico, Mattogno, Pier Paolo, Della Pepa, Giuseppe Maria, Albanese, Alessio, Chiesa, Silvia, Dispenza, S., Meloni, E., Tummolo, A. M., Pallini, Roberto, Barillaro, Christian, Olivi, Alessandro, Lauretti, Liverana, D'Alessandris Q. G. (ORCID:0000-0002-2953-9291), Ricciotti M. A., Palombi D., Agostini L., Mattogno P. P., Della Pepa G. M. (ORCID:0000-0001-8698-3359), Albanese A. (ORCID:0000-0001-8783-2974), Chiesa S. (ORCID:0000-0003-0168-3459), Pallini R. (ORCID:0000-0002-4611-8827), Barillaro C., Olivi A. (ORCID:0000-0002-4489-7564), and Lauretti L. (ORCID:0000-0002-6463-055X)

Abstract

The onco-functional balance in neuro-oncology requires maximizing tumor removal while rigorously preserving patients’ neurological status. When postoperative worsening prevents the implementation of oncologic treatments, palliative care service offers an individualized path for symptom and psychosocial distress relief. Here, we report on a series of 25 patients operated on for malignant brain tumor who did not undergo adjuvant treatments after neurosurgery; they represented 3.9% of the whole institutional surgical series. These patients were significantly older and had a lower preoperative Karnofsky performance status than the whole cohort. Importantly, in 22 out of 25 (88%) cases, a surgical complication occurred, leading to clinical worsening in 21 patients. For the end of life, the majority of patients chose a hospice care facility (72%). While a careful selection of brain tumor patients candidate to neurosurgery is required, palliative care service provided invaluable help in coping with patients’ and caregivers’ needs.

Published
2022

46. List of Contributors

Author

Androulakis, E., primary, Briasoulis, A., additional, Chandrasekhar, J., additional, Charakida, M., additional, Chiesa, S., additional, Christophides, T., additional, Dumitru, R.M., additional, Farmaki, E., additional, Glennon, P., additional, Hatzis, G., additional, Hayat, S.A., additional, Karatolios, K., additional, Lim, P.B., additional, McAloon, C.J., additional, Mehran, R., additional, Michail, M., additional, Norrington, K., additional, Oikonomou, E., additional, Osman, F., additional, Papageorgiou, N., additional, Siasos, G., additional, Swerdlow, D.I., additional, Tousoulis, D., additional, Zacharia, E., additional, Zacharias, K., additional, and Zaromitidou, M., additional

Published
2016
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48. A Multicenter Large Retrospective Database on the Personalization of Stereotactic Ablative Radiotherapy for Lung Metastases From Colon-Rectal Cancer: The LaIT-SABR Study

Author

Nicosia, L., primary, Franceschini, D., additional, Perrone, F., additional, Casamassima, F., additional, Gerardi, M.A., additional, Perna, M., additional, Scotti, V., additional, Fodor, A., additional, Mazzola, R., additional, Rigo, M., additional, Iurato, A., additional, Pasqualetti, F., additional, Chiesa, S., additional, Niespolo, R.M., additional, Bruni, A., additional, Frassinelli, L., additional, Borghetti, P., additional, Marzo, A. Di, additional, Ravasio, A., additional, De Bari, B., additional, Sepulcri, M., additional, Aiello, D., additional, Mortellaro, G., additional, Sangalli, C., additional, Franceschini, M., additional, Montesi, G., additional, Aquilanti, F.M., additional, Valdagni, R., additional, Fazio, I., additional, Corti, L., additional, Vavassori, L., additional, Maranzano, E., additional, Magrini, S., additional, Lohr, F., additional, Arcangeli, S., additional, Valentini, V., additional, Paiar, F., additional, Ramella, S., additional, Di Muzio, N.G., additional, Livi, L., additional, Jereczek-Fossa, B.A., additional, Osti, M.F., additional, Scorsetti, M., additional, and Alongi, F., additional

Published
2021
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