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The growing demand for sustainable building materials, amid escalating costs, has spurred interest in alternative solutions such as wood cement composites. This study explores the feasibility of producing wood cement boards (WCBs) using locally sourced cedar sawdust as a reinforcing agent. Boards with a thickness of 10 mm and a target density of 1200 kg/m3 were manufactured under pressures ranging from 2 to 6 MPa for 24 h. Cedar sawdust, used as raw and untreated material, was incorporated into the mixture as a partial substitute for cement in varying proportions, ranging from 10% to 25% (by weight). The WCBs were cured for 28 days under ambient conditions. Physical properties including density, water absorption (WA), and thickness swelling (TS) were assessed, along with mechanical properties through flexural tests. The results showed that increasing cedar sawdust content decreased both density and mechanical performance while increasing WA and TS. Microstructural analysis (SEM and EDS) revealed significant porosity at higher sawdust contents, while lower contents had better matrix–reinforcement cohesion. Additionally, substantial levels of calcium and silicon were detected on the sawdust surface, indicating stabilized cement hydration products. These findings, supported by thermal (TGA and DSC) and FTIR analyses, clearly demonstrate that cement boards with 10% cedar sawdust exhibit favorable properties for non-structural applications, such as wall and partition cladding. [ABSTRACT FROM AUTHOR]

This study focuses on synthesizing a new series of isoxazolinyl-1,2,3-triazolyl-[1,4]-benzoxazin3-one derivatives 5a–5o. The synthesis method involves a double 1,3-dipolar cycloaddition reaction following a “click chemistry” approach, starting from the respective [1,4]-benzoxazin-3-ones. Additionally, the study aims to evaluate the antidiabetic potential of these newly synthesized compounds through in silico methods. This synthesis approach allows for the combination of three heterocyclic components: [1,4]-benzoxazin-3-one, 1,2,3-triazole, and isoxazoline, known for their diverse biological activities. The synthesis procedure involved a two-step process. Firstly, a 1,3-dipolar cycloaddition reaction was performed involving the propargylic moiety linked to the [1,4]-benzoxazin-3-one and the allylic azide. Secondly, a second cycloaddition reaction was conducted using the product from the first step, containing the allylic part and an oxime. The synthesized compounds were thoroughly characterized using spectroscopic methods, including 1H NMR, 13C NMR, DEPT-135, and IR. This molecular docking method revealed a promising antidiabetic potential of the synthesized compounds, particularly against two key diabetes-related enzymes: pancreatic α-amylase, with the two synthetic molecules 5a and 5o showing the highest affinity values of 9.2 and 9.1 kcal/mol, respectively, and intestinal α-glucosidase, with the two synthetic molecules 5n and 5e showing the highest affinity values of −9.9 and −9.6 kcal/mol, respectively. Indeed, the synthesized compounds have shown significant potential as antidiabetic agents, as indicated by molecular docking studies against the enzymes α-amylase and α-glucosidase. Additionally, ADME analyses have revealed that all the synthetic compounds examined in our study demonstrate high intestinal absorption, meet Lipinski’s criteria, and fall within the required range for oral bioavailability, indicating their potential suitability for oral drug development. [ABSTRACT FROM AUTHOR]

This study investigated the effect of incorporating different amounts of date palm fiber (DPF) on the mechanical, physical, and structural properties of geopolymer composites. These composites were formulated by utilizing mining residue as the geopolymer matrix and PDF as a reinforcing agent. The synthesis procedure involved activating the mining residue with a highly concentrated NaOH solution to form the geopolymer matrix. Subsequently, the resulting matrix was blended with different proportions of DPF, ranging from 1% to 20% (wt/wt), and underwent a 28-day curing period under ambient conditions. Mechanical properties were assessed through compression (CS) and flexural (FS, FM) tests, while water absorption (WA) and thickness swelling (TS) were employed to evaluate physical properties. Additionally, FTIR spectroscopy, X-ray diffraction (XRD), energy dispersive X-ray (EDX) and scanning electron microscopy (SEM) were used to elucidate changes in bonding nature, visualize matrix phases, analyze composition, and examine microstructure, respectively. The results demonstrated that incorporating an optimal amount of DPF fibers, of about 8% (wt/wt), yielded a geopolymer composite with outstanding mechanical properties. Both compressive and flexural strengths were twice as high compared to the geopolymer matrix, highlighting the effectiveness of DPF fiber as a reinforcing agent. However, the increase in fiber loading was associated with a decline in the physical properties of the composite, reaching an acceptable water WA value of 30% and TS value of 0.9% after 168-hours of immersion in water. Structural analysis using FTIR and XRD techniques suggested that mining residue, as an aluminosilicate raw material with a semicrystalline structure, undergoes a geopolymerisation reaction to a relatively lower extent after activation by a highly alkaline solution SEM images revealed a well-established matrix-fiber interface, providing an explanation for the achieved good mechanical and physical properties. EDX results showed an interesting composition of the geopolymer gel derived from mining residue with a significant amount of silicon and a moderate quantity of calcium and aluminum. This confirmed that the geopolymer gel formed primarily undergoes the C-A-S-H process, rather than N-A-S-H process, which is a positive indication of the geopolymer composite's mechanical properties. [ABSTRACT FROM AUTHOR]

The treatment of alkylated nitro derivatives of indazole with stannous chloride in alkanethiol gave after coupling of the obtained amines with 4-methoxybenzenesulfonyl chloride in pyridine the newN-(4-alkylsulfanylindazol-7-yl)-4-methoxybenzene sulfonamides via the nucleophilic substitution of hydrogen in position 4 of indazole, together with the expected 4-methoxy-N-(indazol-7-yl)-benzenesulfonamides. All the newly synthesized compounds have been characterized by elemental analysis and spectroscopic data. [ABSTRACT FROM AUTHOR]

The title compound, C 17 H 12 O 4 , was synthesized from the dye alizarin. The dihedral angle between the mean plane of the anthra-quinone ring system (r.m.s. deviation = 0.039 Å) and the dioxepine ring is 16.29 (8)°. In the crystal, the mol-ecules are linked by C-H⋯O hydrogen bonds, forming sheets lying parallel to the ab plane. The sheets are connected through π-π and C=O⋯π inter-actions to generate a three-dimensional supra-molecular network. Hirshfeld surface analysis was used to investigate inter-molecular inter-actions in the solid-state: the most important contributions are from H⋯H (43.0%), H⋯O/O⋯H (27%), H⋯C/C⋯H (13.8%) and C⋯C (12.4%) contacts., (© Zazouli et al. 2020.)

In the title compound, C14H13NOS2, the atoms of the allyl group are disordered over two sets of sites, with an occupancy ratio of 0.559 (10):0.441 (10). The rhodanine ring makes a dihedral angle of 5.51 (12)° with the mean plane through the p-tolyl group. There are no specific inter-molecular inter-actions in the crystal packing.