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7. Production of the lantibiotic salivaricin A and its variants by oral streptococci and use of a specific induction assay to detect their presence in human saliva

Author

Wescombe, Philip A., Upton, Mathew, Dierksen, Karen P., Ragland, Nancy L., Sivabalan, Senthuran, Wirawan, Ruth E., Inglis, Megan A., Moore, Chris J., Walker, Glenn V., Chilcott, Chris N., Jenkinson, Howard F., and Tagg, John R.

Subjects
Saliva -- Research, Streptococcus -- Research, Salivary glands -- secretions, Salivary glands -- Research, Biological sciences
Abstract

A highly specific Salivaricin A (SalA) induction system is used to directly detect the presence of SalA in the saliva of humans who either harbor populations of SalA-producing Streptococcus Salivarius or who have been colonized with the SalA2-producing probiotic S. Salivarius K12. Four additional variants SalA2 to Sal A5 are identified.

Published
2006

8. Effects of ciprofloxacin, norfloxacin, and ofloxacin on in vitro adhesion and survival of Pseudomonas aeruginosa AK1 on urinary catheters

Author

Wescombe, Philip A., Burton, Jeremy P., Cadieux, Peter A., Klesse, Nikolai A., Hyink, Otto, Heng, Nicholas C.K., Chilcott, Chris N., Reid, Gregor, and Tagg, John R.

Subjects
stomatognathic diseases, Bacteriocins, bacteria, Megaplasmid, Lantibiotics, Streptococcus salivarius
Abstract

Streptococcus salivarius strains commonly produce bacteriocins as putative anticompetitor or signalling molecules. Here we report that bacteriocin production by the oral probiotic strain S. salivarius K12 is encoded by a large (ca. 190 kb) plasmid. Oral cavity transmission of the plasmid from strain K12 to a plasmid-negative variant of this bacterium was demonstrated in two subjects. Tests of additional S. salivarius strains showed large (up to ca. 220 kb) plasmids present in bacteriocin-producing isolates. Various combinations (up to 3 per plasmid) of loci encoding the known streptococcal lantibiotics salivaricin A, salivaricin B, streptin and SA-FF22 were localised to these plasmids. Since all bacteriocin-producing strains of S. salivarius tested to date appear to harbour plasmids, it appears that they may function as mobile repositories for bacteriocin loci, especially those of the lantibiotic class. © Springer Science+Business Media B.V. 2006.

Published
2006

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