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Fifty-five patients with ischemic stroke, 22 women, 33 men, mean age 61.14 +/- 11.8 years, have been interviewed. A control group included siblings of patients' spouses. In the group of relatives, the frequency of arterial hypertension was higher by 30.8%, diabetes mellitus--by 76%, ischemic heart disease--by 59.4% and stroke--by 41% compared to the controls. In the combined group, the relative risk (RR) of factors studied was substantially higher for relatives by blood. When effect of sex on RR has been determined, the higher RR values for all risk factors in male relatives of patients have been found. In conclusion, the study of familial predisposition to stroke revealed that family members of patients with stroke are a target group for stroke prevention programs.

Immunogenetic structure for erythrocyte antigens was studied in 40 patients with brain stroke in East Kazakhstan. The results of a clinicoimmunogenetic analysis suggest significant positive and negative associations between erythrocyte antigens and stroke. Antigenes M+; Le(epsilon); Kell-, Cw were associated with a higher risk of brain stroke in Kazakh population.

Moderate hyperhomocysteinemia often accompanies cerebral strokes. The aim of this study was to evaluate serum levels of homocysteine in patients with stroke, and its dependence on stroke type, the patient's age and gender, presence or absence of arterial hypertension (AH) background, and cholesterol level. The subjects were 71 patients and 23 healthy adults. The results demonstrate a significant elevation of homocysteine concentration in the stroke patient vs. the healthy subjects, and its dependence on gender, AH background, repeated strokes, and cholesterol level (p < 0.05).

Two hundred and sixty-nine patients with cerebral stroke (CS), including 184 patients with ischemic stroke and 85 with hemorrhagic stroke (HS), were examined. A control group consisted of 56 healthy individuals matched by sex and age. The status of different links of the hemostatic system was assessed in patients with CS, by using "Tekhnologiya-Standart" (Technology Standard) kits (Barnaul). The findings suggest the higher platelet aggregability with the universal aggregation inductor (ADP) and ristomycin, as well as suppressed fibrinolytic activity, elevated levels of soluble fibrin-monomeric complexes, and decreased concentrations of angiotensin III. The lupus anticoagulant causing a poor outcome of the disease was much more frequently detected in patients with HS.