Search

A new photoluminescent disc-like copper (II) metallomesogen of the type [CuL2] {H2L = 2,4-bis((E)-((4-(hexadecyloxy)phenyl)imino)methyl)phenol} have been synthesized. The compounds were characterized by elemental analyses, Fourier transform infrared spectroscopy (FTIR), 1H, 13C nuclear magnetic resonance (NMR), ultraviolet – visible spectroscopy (UV – Vis), thermogravimetric analysis (TGA) and high-resolution mass spectrometry. Mesomorphic behavior of the compounds was probed with the help of polarizing optical microscopy (POM) and differential scanning calorimetry (DSC). The organization of the molecules in the mesophase was investigated by X-ray diffraction techniques. The ligand is non-mesogenic but the copper complex exhibited thermally stable columnar mesophases at about 86°C. The copper complex is a blue-light emitter both in solution and in the solid state. The Density Functional Theory (DFT) study was carried out using 6–31 G (d, p) basis set with unrestricted B3LYP level to obtain a stable, optimized structure, which revealed a distorted square-planar geometry for the copper complexes.

Background Human papilloma virus (HPV) infection is implicated in a proportion of invasive squamous cell carcinoma of the penis (PC). A subset of PC involves dysregulation of the p53 pathway. HPV in situ hybridization (ISH) and p16ink4a positivity are surrogate markers for HPV infection, and p53 immunohistochemistry (IHC) denotes abnormality in the p53 pathway. There remains an ambiguity with regard to the contribution of both the pathways in the prognosis of PC. We sought to analyze the clinicopathologic characteristics of a cohort of Indian PC patients with respect to p16 ink4a and p53 expression. Patients and Methods A cohort of 123 PC patients was studied for p16ink4aand p53IHC and HPVISH. The results of these biomarkers were correlated with various clinicopathologic parameters. Results p16ink4a and HPV ISH were positive in 47% and 53% of the tumors, respectively. The proportion of warty, basaloid, or mixed warty-basaloid tumor subtypes showed significant p16ink4apositivity (P Conclusions There is a strong concordance between p16ink4aIHC and HPV ISH results. p16ink4a status is an independent predictor of survival (OS and CSS) in our cohort of PCs. p53 is a predictor of nodal metastasis irrespective of p16 status. Dual positive tumors have a significantly better outcome in comparison to dual negative tumors

Three new series, each of hemi-discoid oxovanadium(IV) and copper(II) complexes based on halogen-substituted ‘salphen’ type ligands; H2L = [N,N-Bis(4-n-alkoxysalicylidene)-4-fluoro/chloro/bromo-1,2...

This study applies positive matrix factorization (PMF) to 140 groundwater samples collected from four different Public Health Centers in North Brahmaputra basin, Assam, India. The aim of this technique is to identify and quantify the pollution sources (natural and anthropogenic) that affect the water quality. Multivariate statistical analysis, especially factor analysis, is successful in interpreting the water quality data, but it has some limitations: It does not consider analytical uncertainty and factor loadings may be negative which do not give a clear representation of the data. Therefore, we applied PMF to groundwater data and compared the results with those obtained from factor analysis. The major findings from the study are as follows: The first and the second factors show that the natural means are the main source of pollution where Cl, SO4, Ca, Mg, TA and TH were the main contributors from erosion and weathering of rocks. The Pb and NO3 from the third and the fourth factor, respectively, are the major sources of contamination from anthropogenic activities such as the use of fertilizers. The fifth factor results in Fe, As, Mn and Cr, suggesting that both natural and anthropogenic processes are the main pollution contributors. PMF exhibits a more realistic representation of data and helps us to better understand the major sources of contamination and the variation in groundwater quality data. Hence, it can be successfully used for the characterization of groundwater chemistry.

A new liquid crystalline salicylaldimine Schiff base having pendant hydroxymethyl ( CH2OH) groups and a series of lanthanide(III) complexes of the type, [Ln(LH)3(NO3)3] {Ln = La, Pr, Sm, Gd, Tb; LH=(E)-2-((1, 3-dihydroxy-2-(hydroxyl methyl) propan- 2-ylimino)methyl)-5-(hexadecyloxy) phenol} have been synthesised. The compounds were characterised by FT-IR, 1H NMR, 13C NMR, UV–Vis, and FAB-mass spectroscopy. Thermal behaviour of these compounds was studied using polarising optical microscopy (POM) and differential scanning calorimetry. The phase confirmation and molecular organization in the mesophase was ascertained by variable temperature powder X-ray diffraction (XRD) study. The ligand and the complexes both showed highly viscous smecticA and columnar mesophase, respectively. A bilayer self organization of the ligand molecules with interdigitation of the alkyl chains in the mesophase is proposed. Molecular organizations of the complexes in the mesophase involve arrangement of all the aliphatic chain pointing in same direction leading to lamellar columnar phase. The ligand showed an intense blue emission at 452 nm while the gadolinium(III) complex exhibited an intense emission at 458 nm (λex = 310 nm). The samarium(III) complex is a bright orange light emitter over a wide range upon UV irradiation.

Human papilloma virus (HPV) infection is implicated in a proportion of invasive squamous cell carcinoma of the penis (PC). A subset of PC involves dysregulation of the p53 pathway. HPV in situ hybridization (ISH) and p16A cohort of 123 PC patients was studied for p16p16There is a strong concordance between p16

Three new series of photoluminescent nickel(II) metallomesogens, [NiL]; H2L = N,N′-Bis(4-n-alkoxysalicylidene)-4-fluoro/bromo/chloro-1,2-diaminobenzene (n = 12, 14, 16) based on ‘salphen’ ligands h...