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14 results on '"Chirumarry, Sridhar"'

3. Asymmetric Formal Synthesis of (+)-Lactacystin

Author

Laghuvarapu Radhika, B.V.D. Vijaykumar, Srivari Chandrasekhar, Chirumarry Sridhar, and Dong-Soo Shin

Subjects
Organic Chemistry, Enantioselective synthesis, Epoxide, chemistry.chemical_element, Combinatorial chemistry, Chiral resolution, chemistry.chemical_compound, chemistry, Nucleophile, Ethyl acrylate, Organic chemistry, Azide, Physical and Theoretical Chemistry, Isobutyraldehyde, Palladium
Abstract

A formal synthesis of (+)-lactacystin was achieved from commercially available isobutyraldehyde and ethyl acrylate. A Baylis–Hillman reaction, an intermolecular nucleophilic displacement under Mitsunobu conditions, a Sharpless asymmetric epoxidation, a palladium(0)-catalyzed syn-selective ring opening of an epoxide by treatment with an azide, a one-pot azide reductive lactamization, and a ruthenium-catayzed oxidation were employed as the key steps.

Published
2014
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4. Synthesis and Catalytic Applications of Ruthenium(0) Nanoparticles in Click Chemistry

Author

Chirumarry Sridhar, Min-Wook Baek, Avvaru Praveen Kumar, Yong-Ill Lee, and Begari Prem Kumar

Subjects
chemistry, Drug discovery, Click chemistry, Chemical biology, Nanoparticle, chemistry.chemical_element, Nanomedicine, Nanotechnology, General Chemistry, Combinatorial chemistry, Nanomaterial-based catalyst, Catalysis, Ruthenium
Abstract

nanocatalysts. Click chemistry has recentlyemerged to become one of the most powerful tools in drug discovery, chemical biology, proteomics, medicalsciences and nanotechnology/nanomedicine. In addition, preliminary tests of recycling showed good resultswith neither loss of activity or significant precipitation. Key Words : Ru

Published
2014
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5. Synthesis and Self-Assembly of Bolaamphiphiles Based onβ-Amino Acids or an Alcohol

Author

Prathama S. Mainkar, Srivari Chandrasekhar, Ambadi Sudhakar, and Chirumarry Sridhar

Subjects
chemistry.chemical_classification, Precipitation (chemistry), Stereochemistry, Organic Chemistry, Glycoside, Alcohol, Biochemistry, Catalysis, Amino acid, Inorganic Chemistry, chemistry.chemical_compound, chemistry, Drug Discovery, Organic chemistry, Sugar amino acid, Self-assembly, Physical and Theoretical Chemistry, Norbornene
Abstract

The synthesis of bolaamphiphiles from unusual β-amino acids or an alcohol and C12 or C20 spacers is described. Unusual β-amino acids such as a sugar amino acid, an AZT-derived amino acid, a norbornene amino acid, and an AZT-derived amino alcohol were coupled with spacers under standard conditions to get the novel bolaamphiphiles 5–8 (Scheme 1), 12 and 13 (Scheme 2), and 17 and 20 (Scheme 3). Some of these compounds, on precipitation from MeOH/H2O, self-assembled into organized molecular structures.

Published
2013
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6. A carbohydrate approach for the formal total synthesis of the prostacyclin analogue (16S)-iloprost

Author

Chirumarry Sridhar, Srivari Chandrasekhar, and Pabbaraja Srihari

Subjects
Julia olefination, Chemistry, Stereochemistry, Organic Chemistry, Convergent synthesis, Total synthesis, Prostacyclin, Carbohydrate, Catalysis, Inorganic Chemistry, Aldol reaction, cardiovascular system, medicine, Organic chemistry, lipids (amino acids, peptides, and proteins), Physical and Theoretical Chemistry, Iloprost, medicine.drug
Abstract

The formal total synthesis of the synthetic and stable analogue of prostacyclin, (16 S ) - iloprost is described via a convergent synthesis starting from readily available d -glucose. Julia olefination and the aldol reaction are the key steps involved in the synthesis.

Published
2012
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8. ChemInform Abstract: Synthesis and Catalytic Applications of Ruthenium(0) Nanoparticles in Click Chemistry

Author

Yong-Ill Lee, Avvaru Praveen Kumar, Begari Prem Kumar, Chirumarry Sridhar, and Min-Wook Baek

Subjects
chemistry, Triazole derivatives, Click chemistry, chemistry.chemical_element, Nanoparticle, General Medicine, Combinatorial chemistry, Cycloaddition, Ruthenium, Catalysis
Abstract

The Ru(0)-nanoparticles are used as smooth catalyst for the azide-alkyne cycloaddition reactions.

Published
2014
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13. Practical Synthesis of (9 S,10 R)-9,10-epoxy-(3 Z,6 Z)-henicosadiene: The Major Pheromone of the Saltmarsh Caterpillar moth Estigmene acrea.

Author

Kumar, Deepak, Chirumarry, Sridhar, Vijaykumar, B. V. D., Harshavardhan, S. J., Shin, Dong-Soo, Jang, Kiwan, and Lee, Dong-Ha

Subjects
*PHEROMONES, *CATERPILLARS, *DIOLEFINS synthesis, *OLEFINATION reactions, *WITTIG reaction, *ASYMMETRIC synthesis, *CHIRALITY, *HYDROXYLATION
Abstract

An efficient synthesis of (3 Z,6 Z)- cis-9,10-epoxy-3,6-henicosadiene ( 1), the major component of sex pheromone of saltmarsh caterpillar moth Estigmene acrea (Drury), was accomplished from commercially available pentadec-3-yn-1-ol and bromoundecane. Chirality was introduced by employing Sharpless asymmetric dihydroxylation on cis-olefin intermediate in the synthesis of 1, for the first time. The other key reactions include metal-dissolving coupling, Lindlar's catalyst-assisted partial hydrogenation, one-pot, three-step epoxidation from vicinal diol, and Wittig olefination. The overall yield of 1 was 24.7% in eight steps. The efficiency and simplicity of this synthesis allow the potential use of pheromone 1 in pest management programs. [ABSTRACT FROM AUTHOR]

Published
2015
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14. Design, Synthesis In Vitro Anticancer Activity and Docking Studies of (-)-Catechin Derivatives.

Author

Kumar, Deepak, Harshavardhan, S. J., Chirumarry, Sridhar, Dong-Soo Shin, Poornachandra, Y., Kumar, C. Ganesh, Kiwan Jang, Yong-Jin Yoon, Bao-Xiang Zhao, and Jun-Ying Miao

Subjects
CATECHIN, ANTINEOPLASTIC agents, CELL-mediated cytotoxicity, DOXORUBICIN, CANCER cells, MYOBLAST transfer therapy, ADENOCARCINOMA
Abstract

Novel series of (-)-catechin derivatives 1a-l were synthesized, characterized and assayed for their cytotoxicity against four selected human cancer cell lines by standard MTT assay method. Most of the compounds significantly active among which 1d exhibited promising activity with IC50 values of 2.5,4.8 and 5.4 μM specifically against hepatocellular liver carcinoma (HepG2), lung adenocarcinoma (A549) and prostate (DU-145) cell lines, while compound 1j showed promising cytotoxicity against human breast adenocarcinoma MDA-MB-231 (IC50 value of 6.6 μM). Compounds 1a, 1d, 1e, 1f and 1j exhibited broad spectrum cytotoxicity against all the cell lines screened. Molecular docking studies of compound 1d established the good binding affinity and are in favor of the observed biological activity. These data collectively suggest that compound 1d could serve as a new template for further optimization as anticancer agent. [ABSTRACT FROM AUTHOR]

Published
2015
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