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Aims: In pursuit of enhancing prevention efforts for the notably high endemic Opisthorchis viverrini infection in lower Mekong sub-region countries, particularly Thailand and Laos, this cross-sectional study investigated the transmission potential of O. viverrini and other intestinal helminths along the Thailand-Laos border in seven Thai villages., Methods and Results: Human and pet faecal samples, Bithynia snails and cyprinid fish were analysed for helminth infections. Additionally, a questionnaire survey assessed relevant risk factors among the human population. Two groups of helminth infections were detected in humans: foodborne infections (FBIs) including O. viverrini, minute intestinal flukes (MIFs), and Taenia spp., and soil-transmitted infections (STIs) including hookworm and Strongyloides stercoralis, with prevalence rates of 7.4%, 0.5%, 2.5%, 0.5%, 2.5% and 3%, respectively. Smoking was identified as a risk factor for O. viverrini infection [adjusted odds ratios (ORa) = 3.12, 95% confidence intervals (CI): 1.33-7.30, p = 0.009] and FBIs (ORa = 2.47, 95% CI: 1.14-5.33, p = 0.022), while male was a risk factor for FBIs (ORa = 2.62, 95% CI: 1.16-5.94, p = 0.021). In dogs, hookworm, Toxocara spp., Spirometra mansoni, Trichuris vulpis and Hymenolepis diminuta were identified with prevalence rates of 35.6%, 8.1%, 8.1%, 1.2% and 1.2%, respectively. In cats, hookworm, Toxocara spp., S. mansoni, Strongyloides spp., Platynosomum fastosum, MIFs and H. diminuta were identified with prevalence rates of 50%, 17.9%, 10.7%, 7.1%, 3.6%, 3.6% and 3.6%, respectively. Bithynia snails showed 2% virgulate and 0.7% unknown cercariae infections, while among 19 cyprinid fish species, only unknown metacercariae were found., Conclusions: Our findings underscore the necessity of an integrated approach following the One Health concept to effectively combat these parasitic diseases while addressing human, animal and environmental health., (© 2024 Wiley‐VCH GmbH. Published by John Wiley & Sons Ltd.)

Objective: Aim of the study was to evaluate and compare the prevalence female sexual dysfunction (FSD) in cervical cancer (CC) survivors to a healthy female population., Materials and Methods: This observational prospective trial was conducted at Thammasat University Hospital, Thailand, between April 2023 and February 2024. Participants were CC survival who attended an outpatient cancer clinic. Subject with age between 30 and 60 years old and engaged in sexual intercourse at least once within the last 4 weeks were recruited. The control group was women who attended outpatient gynecologic clinic for routine pelvic examination with no serious medical diseases and no malignancy. The female sexual function index (FSFI) was applied to all the participants during the survey. Other demographic data of the participants were collected., Results: A total of 116 cases were enrolled in the study. Participants were equally divided into the study and control groups. The mean age and BMI of participants were 49.4 years and 24.7 kg/m², respectively without statistical significance. The FSD's prevalence of the CC survival was significantly higher than control group (34.5 and 10.4 percent, respectively). CC survivors reported significantly poorer outcomes in the domains of lubrication, sexual satisfaction, and pain compared to the control group., Conclusion: The prevalence rates of CC survival and control group was 34.5 and 10.4 percent, respectively. Three out of six FSFI domains namely lubrication, satisfaction, and pain showed more problematic for CC survivors compared to control group.

This study aimed to identify the recent risk factors for Opisthorchis viverrini infection and cholangiocarcinoma (CCA) to improve disease prevention. The participants were divided into the following 3 groups based on their health status: healthy control (nonOV and nonCCA), those with O. viverrini infection (OV), and those with CCA. A questionnaire was used to explore their lifestyle and behaviors. Multivariate logistic regression and backward elimination were used to identify the significant risk factors. The results showed that the significant risk factors for both O. viverrini infection and CCA were age>50 years (odd ratio (OR)=8.44, P<0.001, 95% confidence intervals (CI) 2.98-23.90 and OR=43.47, P=0.001, 95% CI 14.71-128.45, respectively) and raw fish consumption (OR=8.48, P< 0.001, 95% CI 3.18-22.63 and OR=3.15, P=0.048, 95% CI 1.01-9.86, respectively). A history of O. viverrini infection was identified as an additional risk factor for CCA (OR=20.93, P=0.011, 95% CI 2.04-215.10). This study provided an update on the risk factors for O. viverrini infection and CCA. Asymptomatic patients with O. viverrini infection, particularly those>50 years old, should be carefully monitored to prevent CCA.