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26 results on '"Chitrit, Yvon"'

2. DST variants are responsible for neurogenic arthrogryposis multiplex congenita enlarging the spectrum of type VI hereditary sensory autonomic neuropathy.

Author

Capri, Yline, Bourmance, Lucas, Dupont, Céline, Saint‐Frison, Marie‐Hélène, Guimiot, Fabien, Grotto, Sarah, Chitrit, Yvon, Laquerrière, Annie, and Melki, Judith

Subjects
ARTHROGRYPOSIS, SCIATIC nerve, FETAL movement, PERIPHERAL nervous system, TRANSMISSION electron microscopy, NEUROPATHY, FETUS
Abstract

Arthrogryposis multiplex congenita (AMC) is a developmental condition characterized by multiple joint contractures resulting from reduced or absent fetal movements. Through whole‐exome sequencing combined with arrayCGH from DNA of a fetus presenting with early onset AMC, we identified biallelic loss of function variants in Dystonin (DST): a stop gain variant (NM_001144769.5:c.12208G > T:p.(Glu4070Ter)) on the neuronal isoform and a 175 kb microdeletion including exons 25–96 of this isoform on the other allele [NC_000006.11:g.(56212278_56323554)_(56499398_56507586)del]. Transmission electron microscopy of the sciatic nerve revealed abnormal morphology of the peripheral nerve with severe hypomyelination associated with dramatic reduction of fiber density which highlights the critical role of DST in peripheral nerve axonogenesis during development in human. Variants in the neuronal isoforms of DST cause hereditary sensory and autonomic neuropathy which has been reported in several unrelated families with highly variable age of onset from fetal to adult onset. Our data enlarge the disease mechanisms of neurogenic AMC. [ABSTRACT FROM AUTHOR]

Published
2023
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13. Antibiotics for amniotic-fluid colonization by Ureaplasma and/or Mycoplasma spp. to prevent preterm birth: A randomized trial

Author

Kayem, Gilles, primary, Doloy, Alexandra, additional, Schmitz, Thomas, additional, Chitrit, Yvon, additional, Bouhanna, Philippe, additional, Carbonne, Bruno, additional, Jouannic, Jean Marie, additional, Mandelbrot, Laurent, additional, Benachi, Alexandra, additional, Azria, Elie, additional, Maillard, Francoise, additional, Fenollar, Florence, additional, Poyart, Claire, additional, Bebear, Cécile, additional, and Goffinet, François, additional

Published
2018
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14. Prenatal therapy with pyrimethamine + sulfadiazine vs spiramycin to reduce placental transmission of toxoplasmosis: a multicenter, randomized trial

Author

Mandelbrot, Laurent, primary, Kieffer, François, additional, Sitta, Rémi, additional, Laurichesse-Delmas, Hélène, additional, Winer, Norbert, additional, Mesnard, Louis, additional, Berrebi, Alain, additional, Le Bouar, Gwenaëlle, additional, Bory, Jean-Paul, additional, Cordier, Anne-Gaëlle, additional, Ville, Yves, additional, Perrotin, Franck, additional, Jouannic, Jean-Marie, additional, Biquard, Florence, additional, d’Ercole, Claude, additional, Houfflin-Debarge, Véronique, additional, Villena, Isabelle, additional, Thiébaut, Rodolphe, additional, Pons, Denis, additional, Nourrisson, C., additional, Lavergne, Rose-Anne, additional, Fillaux, Judith, additional, Assouline, Corinne, additional, Robert-Gangneux, Florence, additional, L’Ollivier, Coralie, additional, Bretelle, Florence, additional, Guidicelli, Béatrice, additional, Garcia, Patricia, additional, Cordier, Anne-Gaelle, additional, Benachi, Alexandra, additional, Vauloup-Fellous, Christelle, additional, Letamendia, Emmanuelle, additional, Bougnoux, Marie-Elisabeth, additional, Van Langendonck, Nathalie, additional, Potin, Jérôme, additional, Marty, Pierre, additional, Pomarès, Christelle, additional, Trastour, Cynthia, additional, Deleplancque, Anne Sophie, additional, Costa, Jean-Marc, additional, Chève, Marie-Thérèse, additional, Col, Jean-Yves, additional, Cimon, Bernard, additional, Sterkers, Y., additional, Lachaud, Laurence, additional, Burlet, Gilles, additional, Maréchaud, Martine, additional, Perraud, Estelle, additional, Grébille, Anne-Gaelle, additional, Valentin, Morgane, additional, Houzé, Sandrine, additional, Omnès, Sophie, additional, Chitrit, Yvon, additional, Boissinot, Christine, additional, Yéra, Hélène, additional, Anselem, Olivia, additional, Tsatsaris, Vassilis, additional, Sénat, Marie-Victoire, additional, Fuchs, Florent, additional, Angoulvant, Adela, additional, Muszynski, Charles, additional, Totet, Anne, additional, Noël, Catherine, additional, Bidat, Laurent, additional, Barjat, Tiphaine, additional, Flori, Pierre, additional, Pelloux, Hervé, additional, Brenier-Pinchart, Marie-Pierre, additional, Thong-Vanh, Catherine, additional, Mandelbrot, Laurent, additional, Floch, Corinne, additional, Carbillon, Lionel, additional, Lachassine, Eric, additional, Ricbourg, Aude, additional, Paris, Luc, additional, Dommergues, Marc, additional, Rousseau, Thierry, additional, Dalle, Frederic, additional, Dardé, Marie Laure, additional, Aubard, Véronique, additional, Olivier, Camille, additional, Verspyk, Eric, additional, and Favennec, Loic, additional

Published
2018
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15. Posterior urethral valves and vesicoureteral reflux: can prenatal ultrasonography distinguish between these two conditions in male fetuses?

Author

Chitrit, Yvon, primary, Bourdon, Mathilde, additional, Korb, Diane, additional, Grapin-Dagorno, Christine, additional, Joinau-Zoulovits, Félicia, additional, Vuillard, Edith, additional, Paye-Jaouen, Annabel, additional, Peycelon, Matthieu, additional, Belarbi, Nadia, additional, Delezoide, Anne-Lyse, additional, Schmitz, Thomas, additional, El Ghoneimi, Alaa, additional, Sibony, Olivier, additional, and Oury, Jean-François, additional

Published
2016
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16. LB1: Prevention of maternal and perinatal complications by enoxaparin in women with previous severe preeclampsia (hepepe): an open-label, multicenter, prospective, randomized, controlled trial

Author

Haddad, Bassam, primary, Winer, Norbert, additional, Chitrit, Yvon, additional, Houfflin-Debarge, Véronique, additional, Chauleur, Céline, additional, Bages, Karine, additional, Tsatsaris, Vassilis, additional, Gris, Jean Christophe, additional, and Bastuji-Garin, Sylvie, additional

Published
2016
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24. POSTERIOR URETHRAL VALVES VERSUS VESICO-URETERAL REFLUX IN LIVE BIRTHS: IS PRENATAL DIAGNOSIS BY ULTRASONOGRAPHY FEASIBLE?

Author

Chitrit, Yvon, Bourdon, Mathilde, Peycelon, Matthieu, Grapin-Dagorno, Christine, Korb, Diane, Vuillard, Edith, Paye-Jaouen, Annabel, Schmitz, Thomas, El Ghoneimi, Alaa, Sibony, Olivier, and Oury, Jean-Francois

Subjects
*CONFERENCES & conventions, *FETAL ultrasonic imaging, *EVALUATION of medical care, *PREGNANCY, *VESICO-ureteral reflux, URETHRAL obstruction
Abstract

Objectives: To evaluate prenatal sonographic signs that distinguish male children born alive with posterior urethral valves (PUV) from those with vesicoureteral reflux (VUR). Methods: Antenatal data were retrospectively retrieved for all pregnant women who delivered consecutively between 2003 and 2012 a boy born alive with a postnatal diagnosis of PUV or VUR. Prenatal parameters included fetal bladder characteristics, identification of a dilated posterior urethra, fluctuating activity in the fetal renal pelvis or ureter and amniotic fluid volume. Results: 123 women gave birth to male infants born alive for whom there was a postnatal diagnosis of PUV in 36 cases and VUR in 87. A thickened bladder wall was highly associated with the diagnosis of PUV (30 fetuses [83.3%] versus 4 fetuses [4.6%] with VUR, p<0.000, OR 100 [95% CI 27.0-333]). An enlarged bladder was observed in 20 fetuses (55.6%) with a postnatal diagnosis of PUV and in 29 fetuses (33.3%) with VUR (p=0.027, OR 2.50 [95% CI 1.13-5.53]). A posterior urethral dilatation was visualized in 18 fetuses (50.0%) with PUV and was not present in any cases of fetuses with VUR (p<0.000, OR 173 [95% CI 9.97-3001]). In addition, oligoanhydramnios appeared to be strongly associated with the postnatal diagnosis of PUV compared with that of VUR (13 [36.1%] versus 7 [8.05%], p=0.000). Fluctuating activity in the fetal renal pelvis or ureter was observed in15 (17.2%) of 87 children with reflux, versus 1 (2.78%) of 36 newborns with valves (p=0.037). Conclusions: This study demonstrates that prenatal ultrasound can differentiate with reasonable accuracy male neonates born alive with a postnatal diagnosis of PUV from those with VUR. Dilated posterior urethra, thickened bladder wall and oligoanhydramnios were significantly associated with PUV. The best indicator of VUR was a fluctuating activity in ureters. These results may help in perinatal management and prenatal counselling. [ABSTRACT FROM AUTHOR]

Published
2017
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25. Cloaca in discordant monoamniotic twins: prenatal diagnosis and consequence for fetal lung development.

Author

Chitrit Y, Vuillard E, Khung S, Belarbi N, Guimiot F, Muller F, Ghoneimi AE, and Oury JF

Abstract

Objective Describe a case of cloaca prenatally diagnosed in one of a set of monoamniotic twins. Study Design Retrospective review of a case. Results Cloaca is one of the most complex and severe degrees of anorectal malformations in girls. We present a discordant cloaca in monoamniotic twins. Fetal ultrasound showed a female fetus with a pelvic midline cystic mass, a phallus-like structure, a probable anorectal atresia with absence of anal dimple and a flat perineum, and renal anomalies. The diagnosis was confirmed by fetal magnetic resonance imaging postnatally. Conclusions The rarity of the malformation in a monoamniotic pregnancy, the difficulties of prenatal diagnosis, the pathogenic assumptions, and the consequences of adequate amniotic fluid for fetal lung development are discussed.

Published
2014
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26. Feto-maternal alloimmune thrombocytopenia due to HPA-5b incompatibility: a case report.

Author

Herrero RJ, Chitrit Y, Caubel P, and Lusina D

Subjects
Adult, Algeria ethnology, Cesarean Section, Female, Fetal Diseases diagnosis, France, Gestational Age, Humans, Immunoglobulins, Intravenous therapeutic use, Pregnancy, Prenatal Diagnosis, Thrombocytopenia diagnosis, Thrombocytopenia drug therapy, Antigens, Human Platelet immunology, Fetal Diseases immunology, Isoantibodies immunology, Thrombocytopenia immunology
Abstract

Feto-maternal alloimmune thrombocytopenia (FMAIT) results from the maternal production of antibodies against fetal platelets with incompatible antigens inherited from the father. We present a case where this condition was diagnosed prenatally without previously affected siblings. The severe fetal thrombocytopenia was due to anti-HLA-5b maternal alloantibodies. This was treated successfully by intravenous immunoglobulins. Our case reflects that FMAIT due to anti-HPA-5b may be severe and may be corrected successfully with intravenous immunoglogulins.

Published
2003
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