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1. Exploratory investigation of virtual lesions in gastrointestinal endoscopy using a novel phase‐shift method for three‐dimensional shape measurement

Author

Sakamoto, Taku, primary, Oda, Ichiro, additional, Okamura, Takuma, additional, Cho, Hourin, additional, Toyoshima, Naoya, additional, Nonaka, Satoru, additional, Suzuki, Haruhisa, additional, Nakamura, Tatsuya, additional, Watanabe, Daichi, additional, Matsuo, Keigo, additional, Hanano, Kazunari, additional, Takeyama, Tetsuhide, additional, Yoshinaga, Shigetaka, additional, and Saito, Yutaka, additional

Published
2024
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3. Identification of barriers to implementation of precision oncology in patients with rare cancers

Author

Takamizawa, Shigemasa, primary, Koyama, Takafumi, additional, Sunami, Kuniko, additional, Sudo, Kazuki, additional, Hirata, Makoto, additional, Kubo, Takashi, additional, Tao, Kayoko, additional, Cho, Hourin, additional, Narita, Yoshitaka, additional, Kato, Ken, additional, Yamazaki, Naoya, additional, Ohe, Yuichiro, additional, Okusaka, Takuji, additional, Matsui, Yoshiyuki, additional, Ogawa, Chitose, additional, Yonemori, Kan, additional, and Yamamoto, Noboru, additional

Published
2024
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5. Long-term outcomes after non-curative endoscopic resection for esophageal squamous cell carcinoma followed by additional chemoradiotherapy.

Author

Cho, Hourin, Abe, Seiichiro, Nonaka, Satoru, Suzuki, Haruhisa, Yoshinaga, Shigetaka, Okuma, Kae, Yamamoto, Shun, Daiko, Hiroyuki, Kato, Ken, Sekine, Shigeki, Boku, Narikazu, and Saito, Yutaka

Subjects
*ENDOSCOPIC surgery, *SQUAMOUS cell carcinoma, *CHEMORADIOTHERAPY, *DISEASE risk factors, *LYMPHATIC metastasis, *OVERALL survival, *ESOPHAGEAL cancer, *RECTAL cancer
Abstract

Endoscopic resection (ER) of esophageal squamous cell carcinoma (ESCC) is evaluated pathologically, and additional treatment is recommended for cases resulting in non-curative resection, defined as pMM with lymphovascular invasion (LVI), pSM, or positive vertical margin. This study aimed to assess long-term outcomes and risk factors for recurrence in patients with ESCC treated with non-curative ER followed by additional chemoradiotherapy (CRT). We retrospectively reviewed the clinical courses of patients who underwent non-curative ER followed by additional CRT for ESCCs between August 2007 and December 2017. Recurrence rates and risk factors for recurrence were analyzed. Among 97 patients with non-curative ER, 73 underwent additional CRT. With a median follow-up period of 71 months, recurrences were observed in 10 (14%) of 73 patients, with a median interval of 24.5 (1–59 months). The 3- and 5-year recurrence-free survival were 89 and 85%, respectively, and the 3- and 5-year overall survival rates were 96 and 91%, respectively. Multivariate analysis showed that lymphatic invasion was an independent risk factor for recurrence in patients with non-curative ESCC receiving additional CRT. Among the 10 patients with recurrence, 4, 3, 2, and 1 underwent surgery, chemotherapy, supportive care, and CRT, respectively. Notably, all four patients who underwent surgery survived, regardless of regional and/or distant lymph node metastasis. Lymphatic invasion is an independent risk factor for the recurrence of non-curative ESCCs. Careful follow-up is required for at least 5 years after ER with additional CRT. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Vonoprazan-based triple therapy is effective for Helicobacter pylori eradication irrespective of clarithromycin susceptibility

Author

Okubo, Hidetaka, Akiyama, Junichi, Kobayakawa, Masao, Kawazoe, Megumi, Mishima, Saori, Takasaki, Yusuke, Nagata, Naoyoshi, Shimada, Takayuki, Yokoi, Chizu, Komori, Shiori, Kimura, Kana, Hisada, Yuya, Iwata, Eri, Watanabe, Kazuhiro, Yanagisawa, Naohiro, Shiroma, Sho, Shimomura, Akira, Okahara, Koki, Cho, Hourin, and Uemura, Naomi

Published
2020
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8. COT-16 NATION-WIDE LANDSCAPE OF GENOMIC ANALYSIS OF ADULT CENTRAL NERVOUS SYSTEM TUMORS IN JAPAN

Author

Takahashi, Masamichi, primary, Watanabe, Yuko, additional, Koyama, Takafumi, additional, Sunami, Kuniko, additional, Kubo, Takashi, additional, Cho, Hourin, additional, Hirata, Makoto, additional, Tao, Kayoko, additional, Sudo, Kazuki, additional, Kohsaka, Shinji, additional, Yanagisawa, Shunsuke, additional, Ohno, Makoto, additional, Miyakita, Yasuji, additional, Yamamoto, Noboru, additional, and Narita, Yoshitaka, additional

Published
2022
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9. PEDT-12 NATIONWIDE LANDSCAPE OF GENOMIC ANALYSIS OF PEDIATRIC CENTRAL NERVOUS SYSTEM TUMORS

Author

Watanabe, Yuko, primary, Takahashi, Masamichi, additional, Koyama, Takafumi, additional, Sunami, Kuniko, additional, Kubo, Takashi, additional, Cho, Hourin, additional, Hirata, Makoto, additional, Tao, Kayoko, additional, Sudo, Kazuki, additional, Kohsaka, Shinji, additional, Yanagisawa, Shunsuke, additional, Ohno, Makoto, additional, Miyakita, Yasuji, additional, Yamamoto, Noboru, additional, and Narita, Yoshitaka, additional

Published
2022
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11. Comparison of postpolypectomy bleeding events between cold snare polypectomy and hot snare polypectomy for small colorectal lesions: a large-scale propensity score–matched analysis

Author

Takamaru, Hiroyuki, primary, Saito, Yutaka, additional, Hammoud, Ghassan M., additional, Mizuguchi, Yasuhiko, additional, Cho, Hourin, additional, Sekiguchi, Masau, additional, Yamada, Masayoshi, additional, Sakamoto, Taku, additional, and Matsuda, Takahisa, additional

Published
2022
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15. Endoscopic features of isolated and traditional serrated adenoma‐associated superficially serrated adenomas of the colorectum

Author

Mizuguchi, Yasuhiko, primary, Tanaka, Yusaku, additional, Cho, Hourin, additional, Sekiguchi, Masau, additional, Takamaru, Hiroyuki, additional, Yamada, Masayoshi, additional, Sakamoto, Taku, additional, Matsuda, Takahisa, additional, Hashimoto, Taiki, additional, Sekine, Shigeki, additional, and Saito, Yutaka, additional

Published
2021
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17. Endoscopic features of isolated and traditional serrated adenoma‐associated superficially serrated adenomas of the colorectum.

Author

Mizuguchi, Yasuhiko, Tanaka, Yusaku, Cho, Hourin, Sekiguchi, Masau, Takamaru, Hiroyuki, Yamada, Masayoshi, Sakamoto, Taku, Matsuda, Takahisa, Hashimoto, Taiki, Sekine, Shigeki, and Saito, Yutaka

Subjects
ADENOMATOUS polyps, SIGMOID colon, ADENOMA, RAS oncogenes, POLYPS, RECTUM
Abstract

Background and Aim: Superficially serrated adenoma (SuSA) is a recently proposed subtype of colorectal serrated lesions. It is characterized by distinct clinicopathological and molecular features, including mixed serrated and adenomatous histology and frequent genetic alterations involving KRAS and RSPO. This study aimed to characterize the endoscopic features of isolated and traditional serrated adenoma (TSA)‐associated SuSAs. Methods: We retrospectively evaluated the endoscopic findings of 25 isolated SuSAs and 21 TSA‐associated SuSAs that were histologically and molecularly characterized. Results: SuSAs appeared as a sessile polyp or slightly elevated lesion located mostly in the sigmoid colon and rectum (88%). The size was between 3 and 20 mm (median, 6 mm). Most of them exhibited KRAS mutations (96%) and RSPO fusions/overexpression (92%). Endoscopically, many lesions had a whitish color (84%), a distinct border (96%), an irregular border (76%), and a lobulated surface (72%). However, diminutive lesions exhibited overlapping features with hyperplastic polyps. On narrow‐band imaging, vessel patterns were invisible or appeared as lacy microvessels in most lesions (80%). Chromoendoscopy invariably showed stellar or elongated/branched stellar pits, indicating a serrated microarchitecture. Most TSA‐associated SuSAs typically presented as polyps with a two‐tier raised appearance, consisting of whitish lower and reddish higher components corresponding to a SuSA and a TSA, respectively. Conclusions: SuSAs exhibit several characteristic endoscopic features on white‐light and image‐enhanced endoscopy. Diminutive lesions exhibit endoscopic features overlapping with hyperplastic polyps. Nonetheless, the endoscopic diagnosis of larger and TSA‐associated SuSAs may be feasible. [ABSTRACT FROM AUTHOR]

Published
2022
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19. Gastric cancer is highly prevalent in Lynch syndrome patients with atrophic gastritis

Author

Cho, Hourin, primary, Yamada, Masayoshi, additional, Sekine, Shigeki, additional, Tanabe, Noriko, additional, Ushiama, Mineko, additional, Hirata, Makoto, additional, Ogawa, Gakuto, additional, Gotoh, Masahiro, additional, Yoshida, Teruhiko, additional, Yoshikawa, Takaki, additional, Saito, Yutaka, additional, Kuchiba, Aya, additional, Oda, Ichiro, additional, and Sugano, Kokichi, additional

Published
2020
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21. Comparison Between Linked Color Imaging and Blue Laser Imaging for Improving the Visibility of Flat Colorectal Polyps: A Multicenter Pilot Study

Author

Yoshida, Naohisa, primary, Hisabe, Takashi, additional, Ikematsu, Hiroaki, additional, Ishihara, Hiroshi, additional, Terasawa, Masaki, additional, Inaba, Atsushi, additional, Sato, Daiki, additional, Cho, Hourin, additional, Ego, Mai, additional, Tanaka, Yusaku, additional, Yasuda, Ritsu, additional, Inoue, Ken, additional, Murakami, Takaaki, additional, Inada, Yutaka, additional, Itoh, Yoshito, additional, and Saito, Yutaka, additional

Published
2019
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24. Comparison Between Linked Color Imaging and Blue Laser Imaging for Improving the Visibility of Flat Colorectal Polyps: A Multicenter Pilot Study.

Author

Yoshida, Naohisa, Hisabe, Takashi, Ikematsu, Hiroaki, Ishihara, Hiroshi, Terasawa, Masaki, Inaba, Atsushi, Sato, Daiki, Cho, Hourin, Ego, Mai, Tanaka, Yusaku, Yasuda, Ritsu, Inoue, Ken, Murakami, Takaaki, Inada, Yutaka, Itoh, Yoshito, and Saito, Yutaka

Subjects
PILOT projects, RESEARCH, COLON polyps, COLONOSCOPY, BIOPSY, INTESTINAL polyps, RESEARCH methodology, ADENOMA, EVALUATION research, MEDICAL cooperation, COLORECTAL cancer, DIAGNOSTIC imaging, COMPARATIVE studies, ADENOMATOUS polyps, RESEARCH funding, VIDEO recording
Abstract

Introduction: Linked color imaging (LCI) and blue laser imaging-bright (BLI-b) improve the visibility of gastrointestinal lesions. In this multicenter study, we compared the effects of LCI and BLI-b on the visibility of flat polyps with visibility scores and color difference (CD) values, including fast-withdrawal and large-monitor observation.Methods: We recorded 120 videos of 40 consecutive flat polyps (2-20 mm), adenoma, and sessile serrated adenoma and polyp (SSA/P), using white light imaging (WLI), BLI-b, and LCI from July 2017 to December 2017. All videos were evaluated by eight endoscopists according to a published polyp visibility score of 4 (excellent) to 1 (poor). Additionally, 1.5 ×faster and 1.7 ×sized videos were evaluated. Moreover, we calculated the CD values for each polyp in three modes.Results: The mean LCI scores (3.1 ± 0.9) were significantly higher than the WLI scores (2.5 ± 1.0, p < 0.001) but not significantly higher than the BLI-b scores (3.0 ± 1.0). The scores of faster videos on LCI (3.0 ± 1.1) were significantly higher than WLI (2.0 ± 1.0, p < 0.001) and BLI-b (2.8 ± 1.1, p = 0.03). The scores of larger-sized videos on LCI were not significantly higher than those of WLI or BLI-b. The CD value of LCI (18.0 ± 7.7) was higher than that of WLI (11.7 ± 7.0, p < 0.001), but was not significantly higher than that of BLI-b (16.6 ± 9.6). The CD value of LCI was significantly higher than that of BLI-b for adenoma, but the CD value of BLI-b was significantly higher than that of LCI for SSA/P.Conclusions: The superiority of LCI to BLI-b was proven for the visibility of adenoma and fast observation. [ABSTRACT FROM AUTHOR]

Published
2020
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26. Tu1298 - Vonoprazan-Based Triple Therapy is Effective for Helicobacter Pylori Eradication Irrespective of Clarithromycin Susceptibility

Author

Okubo, Hidetaka, primary, Akiyama, Junichi, additional, Kobayakawa, Masao, additional, Kawazoe, Megumi, additional, Mishima, Saori, additional, Takasaki, Yusuke, additional, Nagata, Naoyoshi, additional, Shimada, Takayuki, additional, Yokoi, Chizu, additional, Moriyasu, Shiori, additional, Kimura, Kana, additional, Hisada, Yuya, additional, Kihira, Eri, additional, Watanabe, Kazuhiro, additional, Yanagisawa, Naohiro, additional, Shiroma, Shou, additional, Shimomura, Akira, additional, Okahara, Kouki, additional, Cho, Hourin, additional, and Uemura, Naomi, additional

Published
2018
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29. A case of Barrett esophageal cancer : comparison of endoscopic and pathclogical finding

Author

Toshihiko Iizuka, Junichi Akiyama, Toru Igari, Chizu Yokoi, and Cho Hourin

Subjects
medicine.medical_specialty, business.industry, Mechanical Engineering, Internal medicine, medicine, Energy Engineering and Power Technology, Management Science and Operations Research, Esophageal cancer, medicine.disease, business, Gastroenterology
Published
2016

30. Recurrence and prognosis of patients emergently hospitalized for acute esophageal variceal bleeding: A long-term cohort study

Author

Cho, Hourin, primary, Nagata, Naoyoshi, additional, Shimbo, Takuro, additional, Sakurai, Toshiyuki, additional, Sekine, Katsunori, additional, Okubo, Hidetaka, additional, Imbe, Koh, additional, Watanabe, Kazuhiro, additional, Mikami, Shintaro, additional, Yokoi, Chizu, additional, Kobayakawa, Masao, additional, Mizokami, Masashi, additional, Yanase, Mikio, additional, Akiyama, Junichi, additional, and Uemura, Naomi, additional

Published
2016
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31. Utility of multi-gene panel-based germline analysis following genomic profiling and cascade testing in advanced solid tumors: An initial report of the BRANCH study.

Author

Kuwata, Takeshi, Nakamura, Yoshiaki, Nishina, Tomohiro, Takahashi, Naoki, Narimatsu, Hiroto, Cho, Hourin, Inagaki, Chiaki, Kadowaki, Shigenori, Okugawa, Yoshinaga, Matsuzaki, Sawako, Tomita, Naohiro, Yasui, Hisateru, Sunakawa, Yu, Matsukawa, Manami, Kimura, Kaori, Hiraoka, Yumie, Hirata, Makoto, Imoto, Issei, Kosugi, Shinji, and Yoshino, Takayuki

Published
2023
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