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97 results on '"Cho, Sang Woo"'

4. Trastuzumab Combined With Ramucirumab and Paclitaxel in Patients With Previously Treated Human Epidermal Growth Factor Receptor 2–Positive Advanced Gastric or Gastroesophageal Junction Cancer

Author

Kim, Chang Gon, primary, Jung, Minkyu, additional, Kim, Hyo Song, additional, Lee, Choong-kun, additional, Jeung, Hei-Cheul, additional, Koo, Dong-Hoe, additional, Bae, Woo Kyun, additional, Zang, Dae Young, additional, Kim, Bum Jun, additional, Kim, Hyunki, additional, Yun, Un-Jung, additional, Che, Jingmin, additional, Park, Sejung, additional, Kim, Tae Soo, additional, Kwon, Woo Sun, additional, Park, Juin, additional, Cho, Sang Woo, additional, Nam, Chung Mo, additional, Chung, Hyun Cheol, additional, and Rha, Sun Young, additional

Published
2023
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24. Autophagy inhibits cell death induced by the anti-cancer drug morusin

Author

Cho, Sang Woo, Na, Wooju, Choi, Minji, Kang, Shin Jung, Lee, Seok-Geun, and Choi, Cheol Yong

Subjects
Original Article
Abstract

Autophagy is a cellular process by which damaged organelles and dysfunctional proteins are degraded. Morusin is an anti-cancer drug isolated from the root bark of Morus alba. Morusin induces apoptosis in human prostate cancer cells by reducing STAT3 activity. In this study, we examined whether morusin induces autophagy and also examined the effects of autophagy on the morusin-induced apoptosis. Morusin induces LC3-II accumulation and ULK1 activation in HeLa cells. In addition, we found that induction of ULK1 Ser317 phosphorylation and reduction of ULK1 Ser757 phosphorylation occurred simultaneously during morusin-induced autophagy. Consistently, morusin induces autophagy by activation of AMPK and inhibition of mTOR activity. Next, we investigated the role of autophagy in morusin-induced apoptosis. Inhibition of autophagy by treating cells with the 3-methyladenine (3-MA) autophagic inhibitor induces high levels of morusin-mediated apoptosis, while treatment of cells with morusin alone induces moderate levels of apoptosis. Cell survival was greatly reduced when cells were treated with morusin and 3-MA. Taken together, morusin induces autophagy, which is an impediment for morusin-induced apoptosis, suggesting combined treatment of morusin with an autophagic inhibitor would increase the efficacy of morusin as an anti-cancer drug.

Published
2017

35. Effects of natural antimicrobials with modified atmosphere packaging on the growth kinetics of <italic>Listeria monocytogenes</italic> in ravioli at various temperatures.

Author

Ro, Eun Young, Kim, Geun Su, Kwon, Do Young, Park, Young Min, Cho, Sang Woo, Lee, Sang Yun, Yeo, Ik Hyun, and Yoon, Ki Sun

Subjects
RAVIOLI, ARTICHOKES, FOOD packaging, LISTERIA monocytogenes, BACTERIAL growth, ANTI-infective agents, EFFECT of heat on bacteria, COOKING
Abstract

Abstract: The objective of this study was to investigate the antimicrobial effects of cultured sugar/vinegar (CSV) blend and nisin to control the risk of Listeria monocytogenes in ready to cook (RTC) ravioli. Ravioli dough was prepared with 0.1, 0.3, 0.5, 1% CSV blend and 0.1, 0.2, and 0.3% nisin. Inoculated spinach or artichoke raviolis with 2.0 ± 0.5 log cfu/g of L. monocytogenes were packed aerobically or using modified atmosphere packaging (MAP), and then stored at 4, 10, 17, and 24 °C for 60 days. Growth kinetic parameters of the observed data fit well to the Baranyi equation. Ravioli with spinach filling materials yielded a higher risk than that with artichoke. L. monocytogenes was able to survive in ravioli with artichoke, but did not grow. The addition of 1% CSV blend or 0.3% nisin in spinach ravioli with the combination of MAP effectively controlled the growth of L. monocytogenes at the temperature below 10 °C. The organoleptic quality of spinach ravioli was not also affected by the application of 1% CSV blend. Therefore, the CSV blend can be recommended to improve the microbial safety and quality of natural RTC ravioli at retail market. Practical applications: The risk of ravioli was affected by the filling materials of ravioli at retail market. Addition of 1% cultured sugar/vinegar blend in dough substantially contributes to the extension of shelf‐life of MAP spinach raviolis. classification and regression tree analysis results indicate that refrigeration temperature is the main control factor to affect lag time and growth rate, while packaging method is critical for maximum population density. [ABSTRACT FROM AUTHOR]

Published
2018
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50. cis-[(4 R,5 R)-4,5-Bis­(amino­methyl)-2,2-di­methyl-1,3-dioxolane- N, N′](malonato- O, O′)­platinum(II), an anticancer agent.

Author

Cho, Sang Woo, Cho, Yongkee, Kim, Dae-Kee, and Shin, Whanchul

Abstract

In the title compound, [Pt(C3H2O4)(C7H16N2O2)], the Pt atom is coordinated to two O and two N atoms in a square-planar arrangement. The two independent mol­ecules, which have very similar structures, are approximately related by pseudo-twofold screw-axis symmetry. The six-membered chelate ring in the leaving ligand assumes a conformation intermediate between the half-chair and boat forms. The seven-membered ring in the carrier ligand assumes a twist-chair conformation and the oxolane ring assumes an envelope conformation. The crystal packing consists of extensive hydrogen-bonding networks which form two-dimensional molecular layers, and there are weak van der Waals interactions between these layers. [ABSTRACT FROM AUTHOR]

Published
2000
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