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100 results on '"Choe, Won Joo"'

6. Quantitative Computed Tomography Parameters in Coronavirus Disease 2019 Patients and Prediction of Respiratory Outcomes Using a Decision Tree

Author

Kang, Jieun, primary, Kang, Jiyeon, additional, Seo, Woo Jung, additional, Park, So Hee, additional, Kang, Hyung Koo, additional, Park, Hye Kyeong, additional, Song, Je Eun, additional, Kwak, Yee Gyung, additional, Chang, Jeonghyun, additional, Kim, Sollip, additional, Kim, Ki Hwan, additional, Park, Junseok, additional, Choe, Won Joo, additional, Lee, Sung-Soon, additional, and Koo, Hyeon-Kyoung, additional

Published
2022
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14. Selective T-type calcium channel blockade alleviates hyperalgesia in ob/ob mice

Author

Latham, Janelle R., Pathirathna, Sriyani, Jagodic, Miljen M., Choe, Won Joo, Levin, Michaela E., Nelson, Michael T., Lee, Woo Yong, Krishnan, Kathiresan, Covey, Douglas F., Todorovic, Slobodan M., and Jevtovic-Todorovic, Vesna

Subjects
Complications and side effects, Physiological aspects, Research, Risk factors, Calcium channels -- Physiological aspects -- Research, Obesity -- Research -- Risk factors -- Complications and side effects, Diabetes mellitus -- Complications and side effects -- Risk factors -- Research, Diabetic neuropathies -- Risk factors -- Research -- Complications and side effects, Diabetes -- Complications and side effects -- Risk factors -- Research
Abstract

It is predicted that more than 200 million people worldwide will have type 2 diabetes by 2025 (1). A common complication of diabetes is peripheral diabetic neuropathy (PDN), which is [...], OBJECTIVE--Morbid obesity may be accompanied by diabetes and painful diabetic neuropathy, a poorly understood condition that is manifested by mechanical or thermal allodynia and hyperalgesia. Recent studies have highlighted the importance of T-type calcium channels (T-channels) in peripheral nociception; therefore, our goal was to examine the function of these channels in the pathophysiology and development of painful diabetic neuropathy. RESEARCH DESIGN AND METHODS--In vivo testing of mechanical and thermal sensation, morphometric peripheral nerve studies, and electrophysiological and biochemical measurements were used to characterize the role of T-channels and the development of painful diabetic neuropathy in leptin-deficient (ob/ob) mice. RESULTS--We found that ob/ob mice developed significant mechanical and thermal hypersensitivity early in life that coincided with hyperglycemia and was readily reversed with insulin therapy. These disturbances were accompanied by significant biophysical and biochemical modulation of T-channels in dorsal root ganglion neurons as measured by a large increase in the amplitude of T-currents and the expression of mRNA. The most prevalent subtype, α1H ([Ca.sub.v]3.2), was most strongly affected. Moreover, (3β, 5α, 17β)-17-hydroxyestrane-3-carbonitrile (ECN), a novel neuroactive steroid and selective T-channel antagonist, provided dose-dependent alleviation of neuropathic thermal and mechanical hypersensitivity in diabetic ob/ob mice. CONCLUSIONS--Our results indicate that pharmacological antagonism of T-channels is potentially an important novel therapeutic approach for the management of painful diabetic neuropathy.

Published
2009
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48. Two cases of late-onset cardiovascular toxicities after a single injection of local anesthetics during supraclavicular brachial plexus block - A report of two cases.

Author

Kim JY, Park BI, Heo MH, Kim KW, Lee SI, Kim KT, Choe WJ, Park JS, and Kim JH

Abstract

Background: Local anesthetics systemic toxicity (LAST) is a grave complication of regional anesthesia that usually occurs immediately after local anesthetics injection. Here, we report on rare late-onset toxicity cases after supraclavicular brachial plexus blocks., Case: Two patients underwent surgery for radius fractures. We used lidocaine 100 mg and ropivacaine 150 mg for blocking and infused dexmedetomidine for intraoperative sedation. The 63-year-old male patient's blood pressure dropped to 87/60 mmHg after 3 h 15 min after blocking. Ventricular fibrillation occurred 10 min later. After five defibrillations, electrocardiography showed ventricular tachycardia that was normalized through one cardioversion. The 54-year-old female patient's heart rate decreased to 35 beats/min 2 h 30 min after blocking. Her vital signs returned to normal after administering atropine, ephedrine, epinephrine, and lipid emulsion., Conclusions: Physicians should remember that LAST may occur long after local anesthetic injection and be aware of factors that may adversely affect the course of LAST.

Published
2022
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49. Prophylactic use of donut-shaped cushion to reduce sacral pressure injuries during open heart surgery.

Author

Heo MH, Kim JY, Park BI, Lee SI, Kim KT, Park JS, Choe WJ, and Kim JH

Abstract

Background: Pressure injuries are likely to develop in the operating room due to the high temperature and humidity underneath the patients. This study was designed to reduce sacral pressure injuries using donut-shaped cushions on patients undergoing open heart surgery in a supine position for more than three hours., Materials and Methods: Patients undergoing open heart surgery for more than three hours were randomly allocated. Depending on the allocation, either the donut-shaped cushion (donut group) or hydrophilic foam dressing (control group) was applied before draping. Patients were evaluated for the development of pressure injuries, National Pressure Ulcer Advisory Panel (NPUAP) stage, and injury size immediately after surgery, 48 hours, and seven days after surgery., Results: Forty-five patients were enrolled in this study. Twenty-two were assigned to the donut group and 23 were assigned to the control group. Three patients developed pressure injuries of NPUAP stage I or higher. All injuries occurred in the control group, but there was no statistically significant difference ( P = 0.083)., Conclusions: Patients who underwent cardiac surgery for more than three hours and used a donut-shaped cushion did not develop pressure injuries, although no statistical difference was noted. Specific preventative measures in the operating room may play a crucial role in preventing pressure injuries, and further research should be pursued., Competing Interests: There are no conflicts of interest., (Copyright: © 2022 Saudi Journal of Anesthesia.)

Published
2022
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50. Peroneal nerve palsy after compression stockings application.

Author

Kim JH, Kim WI, Kim JY, and Choe WJ

Abstract

Peroneal nerve palsy can be caused by various etiology. We report unilateral peroneal nerve palsy after compression stockings application. A 64-year-old man underwent off-pump coronary bypass graft. Surgeon did not use saphenous vein for the bypass graft. Sedation was stopped after 3 h postoperative. After 16 h, for prophylaxis of deep vein thrombosis, knee-high elastic stocking was applied. After 1 h, he took off right stocking because of numbness but left stocking was kept. After 24 h postoperative, (8 h after stocking application) patient complained suddenly left foot drop. Manual muscle test revealed 0/5 of ankle dorsiflexion, ankle eversion, and toe extension. Sensory was decreased to 70% in lower half of anterolateral aspect of tibia, foot dorsum, and toes. Foot drop and sensory abnormality decreased in 3 weeks. Cardiac surgery patients already have many risk factors for peripheral neuropathy. Clinicians should be careful when applying stockings on those patients.

Published
2016
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