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The process of identifying suitable genome-wide association (GWA) studies and formatting the data to calculate multiple polygenic risk scores on a single genome can be laborious. Here, we present a centralized polygenic risk score calculator currently containing over 250,000 genetic variant associations from the NHGRI-EBI GWAS Catalog for users to easily calculate sample-specific polygenic risk scores with comparable results to other available tools. Polygenic risk scores are calculated either online through the Polygenic Risk Score Knowledge Base (PRSKB; https://prs.byu.edu ) or via a command-line interface. We report study-specific polygenic risk scores across the UK Biobank, 1000 Genomes, and the Alzheimer's Disease Neuroimaging Initiative (ADNI), contextualize computed scores, and identify potentially confounding genetic risk factors in ADNI. We introduce a streamlined analysis tool and web interface to calculate and contextualize polygenic risk scores across various studies, which we anticipate will facilitate a wider adaptation of polygenic risk scores in future disease research.

We developed a diamagnetic loop for the estimation of plasma stored energy in the KAIST Magnetic Mirror magnetic mirror device [Oh et al., J. Plasma Phys. 90, 975900202 (2024)]. Diamagnetic loops are used to estimate the plasma stored energy from measurements of the diamagnetic flux in plasma with an applied external magnetic field. However, diamagnetic flux measurements are accompanied by the vacuum flux, which generally exceeds the diamagnetic flux by over 10 000 times. Therefore, it is critical to attain a high signal-to-noise ratio with minimized noise in diamagnetic flux measurements. In this study, we employed a novel method to reduce background noise and improve the signal-to-noise ratio. Using two identical loops with opposite polarities, we successfully removed parasitic capacitive noise from the external insulation while amplifying the inductive signal two times. To eliminate the vacuum flux, we utilized two coaxial loops with different radii positioned at the same axial location. Results obtained from six paired loops confirmed the successful removal of the vacuum flux. The plasma stored energy was also found to agree well with Langmuir probe measurements, which verifies the diamagnetic flux measurements using the developed loop. [ABSTRACT FROM AUTHOR]

A dedicated optical system is designed for the breakdown of the first ITER plasma, when the machine will not be equipped with the equatorial ECRH-launcher. Seven beams from the upper launcher will be transmitted via several in-vessel mirrors through the resonance layer to a beam-dump. The whole system was simulated with the PROFUSION package to obtain the beam parameters, estimate spill-over effects and determine the required polarization in the launcher in order to have X-mode polarization in the resonance.

The ITER Electron Cyclotron Resonance Heating (ECRH) & Current Drive (ECCD) system is planned to be progressively installed and commissioned following the four stage approach of the ITER Research Plan. Starting with an injection of up to 5.8 MW from one Upper Launcher (UL) in the vacuum vessel to assist the plasma breakdown during First Plasma (FP) operation, the system will then be extended to achieve a capability of 20 MW injected power in Pre-Fusion Plasma Operation (PFPO) and Fusion Power Operation (FPO) phases. Development of optical modelling was required to characterize the optical performance of the FP configuration with the so-called First Plasma Protection Components. An optical 3D model using Zemax OpticStudio® has been developed and extended to the UL. Effects of higher order modes, thermal deformations and tolerances on the UL functionality have been characterized and are presented. Finally, in preparation of plasma operation and in the frame of the EC system upgrade layout optimisation, ECRH-ECCD modelling is being undertaken within the ITER Integrated Modelling and Analysis (IMAS) suite.

Traumatic brain injury is a major public health problem in the pediatric population. Previously, management was acute emergency department/primary care evaluation with follow-up by primary care. However, persistent symptoms after traumatic brain injury are common, and many do not have access to a specialized traumatic brain injury clinic to manage chronic issues. The goal of this study was to determine the factors related to outcomes, and identify the interventions provided in this subspecialty clinic. Data were extracted from medical records of 151 retrospective and 403 prospective patients. Relationships between sequelae, injury characteristics, and clinical interventions were analyzed. Most patients returning to clinic were not fully recovered from their injury. Headaches were more common after milder injuries, and seizures were more common after severe. The majority of patients received clinical intervention. The presence of persistent sequelae for traumatic brain injury patients can be evaluated and managed by a specialty concussion/traumatic brain injury clinic ensuring that medical needs are met. [ABSTRACT FROM AUTHOR]