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40 results on '"Choeyklin, Rattaket"'

4. Lanostane triterpenoids from artificially cultivated fruiting bodies of Ganoderma cf. mastoporum.

Author

Yangchum, Arunrat, Rachtawee, Pranee, Srichomthong, Kitlada, Choeyklin, Rattaket, Boonpratuang, Thitiya, Thongpanchang, Chawanee, and Isaka, Masahiko

Subjects
FRUITING bodies (Fungi), GANODERMA, TRITERPENOIDS, COUMARINS, MASS spectrometry, BIOACTIVE compounds
Abstract

In the quest for bioactive compounds from Ganoderma, artificially cultivated fruiting bodies of Ganoderma cf. mastoporum, strain TBRC-BCC 47851 were chemically investigated. The study led to the isolation of three undescribed lanostane triterpenoids (1–3) together with twelve known compounds. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data. The new compounds were inactive in the antimalarial and antitubercular activity assays. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Acetylenic sesquiterpenoids from cultures of the basidiomycete Stereum cf. hirsutum BCC 26597.

Author

Isaka, Masahiko, Yangchum, Arunrat, Choeyklin, Rattaket, and Anaphon, Sakaokan

Subjects
SESQUITERPENES, ANALYTICAL chemistry, STATISTICAL correlation
Abstract

A new acetylenic sesquiterpenoid, stereyne A (1), and its acetonide derivative, stereyne B (2), were isolated from cultures of the basidiomycete Stereum cf. hirsutum BCC 26597. The structures were elucidated by spectroscopic analysis and a chemical correlation. Their absolute configurations were determined by application of the modified Mosher's method. They represent new structural type of sesquiterpenoids from Stereum. [ABSTRACT FROM AUTHOR]

Published
2021
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29. Highly Modified Lanostane Triterpenes from the Wood-Rot Basidiomycete Ganoderma colossus: Comparative Chemical Investigations of Natural and Artificially Cultivated Fruiting Bodies and Mycelial Cultures

Author

Isaka, Masahiko, Chinthanom, Panida, Choeyklin, Rattaket, Thummarukcharoen, Tuksaporn, Rachtawee, Pranee, Sappan, Malipan, Srichomthong, Kitlada, Fujii, Ryoma, Kawashima, Kyohei, and Mori, Seiji

Abstract

The wood-rot basidiomycete Ganoderma colossushas been chemically investigated. Comparative analyses of the natural fruiting body, artificially cultivated fruiting bodies, and mycelial cultures resulted in the isolation, in total, of 13 new highly modified lanostanes, ganocolossusins A–H (1–8) and ganodermalactones T–X (9–13), together with 23 known compounds (14–36). There were significant overlaps of the same compounds among the three different states of the fungal materials. Ganocolossusin D (4) displayed the most potent antimalarial activity against Plasmodium falciparumK1 (multi-drug-resistant strain) with an IC50value of 2.4 μM, while it was noncytotoxic to Vero cells at 50 μg/mL.

Published
2020
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34. Lanostane triterpenoids from cultivated fruiting bodies of the basidiomycete <italic>Ganoderma australe</italic>.

Author

Isaka, Masahiko, Chinthanom, Panida, Mayteeworakoon, Sermsiri, Laoteng, Kobkul, Choowong, Wilunda, and Choeyklin, Rattaket

Abstract

A new lanostane triterpene (1), together with three known compounds (2-4), were isolated from cultivated fruiting bodies of the basidiomycete Ganoderma australe. The structure was elucidated on the basis of NMR spectroscopic and mass spectrometry data. The olefinic geometry of methyl australate (2) was revised from 20(22)Z to 20(22)E. These compounds (1-4) were different from the lanostanes isolated from mycelial cultures of the same strain source. [ABSTRACT FROM AUTHOR]

Published
2018
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36. Seco-Tremulanes from Cultures of the Basidiomycete Flavodon flavus BCC 17421.

Author

Isaka, Masahiko, Palasarn, Somporn, Supothina, Sumalee, Srichomthong, Kitlada, and Choeyklin, Rattaket

Abstract

A new seco-tremulane, 11,12-epoxy-5,6-secotremula-1,6(13)-dien-5,12-olide ( 1), was isolated together with the known compounds, conocenolides A ( 2) and B ( 3), tremulenediol A ( 4), tremulenolide A ( 5), and two lanostane triterpenoids, trametenolic acid B ( 6), and pinicolic acid A ( 7), from cultures of the basidiomycete Flavodon flavus BCC 17421. Interconversion of conocenolides A/B was demonstrated. Compound 1 exhibited weak cytotoxic activities, whereas tremulenediol A showed antiplasmodial activity ( IC50 8.6 μg/ml). Pinicolic acid A exhibited activity against herpes simplex virus type-1 ( IC50 15 μg/ml) as well as cytotoxic activities. [ABSTRACT FROM AUTHOR]

Published
2016
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38. Antitubercular Lanostane Triterpenes from Cultures of the Basidiomycete Ganodermasp. BCC 16642

Author

Isaka, Masahiko, Chinthanom, Panida, Sappan, Malipan, Danwisetkanjana, Kannawat, Boonpratuang, Thitiya, and Choeyklin, Rattaket

Abstract

Sixteen new lanostane triterpenoids (1–16), together with 26 known compounds (17–42), were isolated from cultures of the basidiomycete Ganodermasp. BCC 16642. Antitubercular activities of these Ganodermalanostanoids against Mycobacterium tuberculosisH37Ra were evaluated, and structure–activity relationships are proposed.

Published
2016
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39. Lanostane triterpenoids from cultivated fruiting bodies of the basidiomycete Ganoderma australe.

Author

Isaka M, Chinthanom P, Mayteeworakoon S, Laoteng K, Choowong W, and Choeyklin R

Subjects
Anti-Bacterial Agents chemistry, Drug Evaluation, Preclinical methods, Magnetic Resonance Spectroscopy, Microbial Sensitivity Tests, Molecular Structure, Spectrometry, Mass, Electrospray Ionization, Triterpenes pharmacology, Anti-Bacterial Agents pharmacology, Fruiting Bodies, Fungal chemistry, Ganoderma chemistry, Triterpenes chemistry
Abstract

A new lanostane triterpene (1), together with three known compounds (2-4), were isolated from cultivated fruiting bodies of the basidiomycete Ganoderma australe. The structure was elucidated on the basis of NMR spectroscopic and mass spectrometry data. The olefinic geometry of methyl australate (2) was revised from 20(22)Z to 20(22)E. These compounds (1-4) were different from the lanostanes isolated from mycelial cultures of the same strain source.

Published
2018
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40. Antitubercular Lanostane Triterpenes from Cultures of the Basidiomycete Ganoderma sp. BCC 16642.

Author

Isaka M, Chinthanom P, Sappan M, Danwisetkanjana K, Boonpratuang T, and Choeyklin R

Subjects
Antitubercular Agents chemistry, Fruiting Bodies, Fungal chemistry, Lanosterol chemistry, Lanosterol isolation & purification, Lanosterol pharmacology, Molecular Structure, Mycobacterium tuberculosis drug effects, Nuclear Magnetic Resonance, Biomolecular, Structure-Activity Relationship, Thailand, Triterpenes chemistry, Antitubercular Agents isolation & purification, Antitubercular Agents pharmacology, Ganoderma chemistry, Lanosterol analogs & derivatives, Triterpenes isolation & purification, Triterpenes pharmacology
Abstract

Sixteen new lanostane triterpenoids (1-16), together with 26 known compounds (17-42), were isolated from cultures of the basidiomycete Ganoderma sp. BCC 16642. Antitubercular activities of these Ganoderma lanostanoids against Mycobacterium tuberculosis H37Ra were evaluated, and structure-activity relationships are proposed.

Published
2016
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