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2,791 results on '"Choi, Eun Young"'

3. Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study

Author

Schiff, Nicholas D., Giacino, Joseph T., Butson, Christopher R., Choi, Eun Young, Baker, Jonathan L., O’Sullivan, Kyle P., Janson, Andrew P., Bergin, Michael, Bronte-Stewart, Helen M., Chua, Jason, DeGeorge, Laurel, Dikmen, Sureyya, Fogarty, Adam, Gerber, Linda M., Krel, Mark, Maldonado, Jose, Radovan, Matthew, Shah, Sudhin A., Su, Jason, Temkin, Nancy, Tourdias, Thomas, Victor, Jonathan D., Waters, Abigail, Kolakowsky-Hayner, Stephanie A., Fins, Joseph J., Machado, Andre G., Rutt, Brian K., and Henderson, Jaimie M.

Published
2023
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5. A Prospective Cohort Study of Novel Markers of Hepatitis B Virus Replication in Human Immunodeficiency Virus Coinfection.

Author

Chung, Raymond, King, Wendy, Ghany, Marc, Lisker-Melman, Mauricio, Hinerman, Amanda, Khalili, Mandana, Sulkowski, Mark, Jain, Mamta, Choi, Eun-Young, Nalesnik, Michael, Bhan, Atul, Cloherty, Gavin, Wong, David, and Sterling, Richard

Subjects
HBV, HBV RNA, HBcrAg, HIV, Serum Biomarkers, Adult, Humans, Middle Aged, Antiviral Agents, Biomarkers, Coinfection, DNA, Viral, Hepatitis B Core Antigens, Hepatitis B e Antigens, Hepatitis B Surface Antigens, Hepatitis B virus, Hepatitis B, Chronic, HIV Infections, Prospective Studies, Virus Replication, RNA, Viral
Abstract

BACKGROUND & AIMS: The contribution of the novel biomarkers, hepatitis B virus (HBV) RNA and HBV core-related antigen (HBcrAg), to characterization of HBV-human immunodeficiency virus (HIV) coinfection is unclear. We evaluated the longitudinal dynamics of HBV RNA and HBcrAg and their association with classical HBV serum biomarkers and liver histology and viral staining. METHODS: HBV-HIV co-infected adults from 8 North American centers entered a National Institutes of Health-funded prospective cohort study. Demographic, clinical, serological, and virological data were collected at entry and every 24 to 48 weeks for up to 192 weeks. Participants with HBV RNA and HBcrAg measured ≥2 times (N = 95) were evaluated; 56 had paired liver biopsies obtained at study entry and end of follow-up. RESULTS: Participants had a median age of 50 years; 97% were on combination anti-viral therapy. In hepatitis B e antigen (HBeAg)+ participants, there were significant declines in HBV RNA and HBcrAg over 192 weeks that tracked with declines in HBeAg, hepatitis B surface antigen, HBV DNA, and hepatitis B core antigen (HBcAg) hepatocyte staining grade (all P < .05). In HBeAg- participants, there were not significant declines in HBV RNA (P = .49) and HBcrAg (P = .63), despite modest reductions in hepatitis B surface antigen (P < .01) and HBV DNA (P = .03). HBV serum biomarkers were not significantly related to change in hepatic activity index, Ishak fibrosis score, or hepatocyte HBcAg loss (all P > .05). CONCLUSIONS: In HBV-HIV coinfected adults on suppressive dually active antiviral therapy, the use of novel HBV markers reveals continued improvement in suppression of HBV transcription and translation over time. The lack of further improvement in HBV serum biomarkers among HBeAg- patients suggests limits to the benefit of combination anti-viral therapy and provide rationale for additional agents with distinct mechanisms of action.

Published
2023

6. A high-performance speech neuroprosthesis

Author

Willett, Francis R., Kunz, Erin M., Fan, Chaofei, Avansino, Donald T., Wilson, Guy H., Choi, Eun Young, Kamdar, Foram, Glasser, Matthew F., Hochberg, Leigh R., Druckmann, Shaul, Shenoy, Krishna V., and Henderson, Jaimie M.

Published
2023
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8. Glutamyl-prolyl-tRNA synthetase (EPRS1) drives tubulointerstitial nephritis-induced fibrosis by enhancing T cell proliferation and activity

Author

Kang, Chaelin, Yun, Donghwan, Yoon, Haein, Hong, Minki, Hwang, Juhyeon, Shin, Hyun Mu, Park, Seokwoo, Cheon, Seongmin, Han, Dohyun, Moon, Kyung Chul, Kim, Hye Young, Choi, Eun Young, Lee, Eun-Young, Kim, Myung Hee, Jeong, Chang Wook, Kwak, Cheol, Kim, Dong Ki, Oh, Kook-Hwan, Joo, Kwon Wook, Lee, Dong-Sup, Kim, Yon Su, and Han, Seung Seok

Published
2024
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10. NIPBL: NACC1 Fusion Hepatic Carcinoma

Author

Hissong, Erika, Al Assaad, Majd, Bal, Munita, Reed, Katelyn A., Fornelli, Adele, Levine, Max F., Gundem, Gunes, Semaan, Alissa, Orr, Christine E., Sakhadeo, Uma, Manohar, Jyothi, Sigouros, Michael, Wilkes, David, Sboner, Andrea, Montgomery, Elizabeth A., Graham, Rondell P., Medina-Martínez, Juan S., Robine, Nicolas, Fang, Jiayun M., Choi, Eun-Young K., Westerhoff, Maria, Delgado-de la Mora, Jesús, Caudell, Patricia, Yantiss, Rhonda K., Papaemmanuil, Elli, Elemento, Olivier, Sigel, Carlie, Jessurun, José, and Mosquera, Juan Miguel

Published
2024
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11. NIPBL NACC1 Fusion Hepatic Carcinoma

Author

Hissong, Erika, Al Assaad, Majd, Bal, Munita, Reed, Katelyn A., Fornelli, Adele, Levine, Max F., Gundem, Gunes, Semaan, Alissa, Orr, Christine E., Sakhadeo, Uma, Manohar, Jyothi, Sigouros, Michael, Wilkes, David, Sboner, Andrea, Montgomery, Elizabeth A., Graham, Rondell P., Medina-Martínez, Juan S., Robine, Nicolas, Fang, Jiayun M., Choi, Eun-Young K., Westerhoff, Maria, Delgado-de la Mora, Jesús, Caudell, Patricia, Yantiss, Rhonda K., Papaemmanuil, Elli, Elemento, Olivier, Sigel, Carlie, Jessurun, José, and Mosquera, Juan Miguel

Published
2023
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20. Measuring the Submucosal Depth of Invasion in Endoscopic Mucosal Resections for Barrett-associated Adenocarcinoma: Practical Issues and Relevance for the Decision for Esophagectomy

Author

Taylor, Alexander S., Setia, Namrata, Alpert, Lindsay, Zhao, Lili, Lamps, Laura W., Hart, John, Waxman, Irving, Hissong, Erika, Choi, Eun-Young Karen, Shi, Jiaqi, Owens, Scott, and Westerhoff, Maria

Subjects
Cancer invasiveness -- Diagnosis -- Care and treatment, Excision (Surgery) -- Methods, Adenocarcinoma -- Care and treatment -- Diagnosis, Gastrointestinal system -- Endoscopic surgery, Gastrointestinal cancer -- Care and treatment -- Diagnosis, Barrett's esophagus -- Care and treatment, Health
Abstract

* Context.--Endoscopic mucosal resection (EMR) has made it possible for Barrett esophagus patients with superficial cancers to be treated without esophagectomy. Recent guidelines recommend measuring depth of invasion (DOI) in submucosal cancers based on reports that in low-risk cancers, submucosal invasion 500 [micro]m or less is associated with low nodal metastasis rates. However, pathologists face challenges in reproducibly measuring DOI. Objective.--To determine how often DOI measurements could impact treatment and to evaluate reproducibility in measuring submucosal DOI in EMR specimens. Design.--Consecutive adenocarcinoma EMR cases were identified, including cases of 'low histologic risk' submucosal cancer, as follows: those with negative deep margins, no high-grade histology (G3), and no lymphovascular invasion. Submucosal dOi was measured by 7 pathologists according to guidelines. Results.--Of 213 cancer EMR cases, 46 were submucosa invasive and 6 cases were low histologic risk submucosal cancers for which measurement could impact decision-making. Of these low histologic risk cases, 3 were categorized as superficial, indicating that measurement would be a clinically actionable decision point in only 1.4% of adenocarcinoma EMRs. Interobserver agreement for in-depth categorization between 7 pathologists was moderate ([kappa] = 0.42), and the range of measurements spanned the 500-[micro]m relevant threshold in 40 of 55 measured samples (72.7%). Conclusions.--While therapeutic decisions would rarely have depended on DOI measurements alone in our cohort, interobserver variability raises concerns about their use as a sole factor on which to offer patients conservative therapy. Responsibly reporting and clinically using submucosal DOI measurements will require practical experience troubleshooting common histologic artifacts, as well as multidisciplinary awareness of the impact of variable specimen-handling practices. doi: 10.5858/arpa.2021-0072-OA, Endoscopic mucosal resection (EMR) has made it possible for patients with Barrett esophagus and superficial adenocarcinomas to be treated nonsurgically. This option is attractive given the risks of mortality and [...]

Published
2022
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26. Interobserver study on histologic features of idiopathic non-cirrhotic portal hypertension

Author

Kmeid, Michel, Zuo, Chunlai, Lagana, Stephen M, Choi, Won-Tak, Lin, Jingmei, Yang, Zhaohai, Liu, Xiuli, Westerhoff, Maria, Fiel, M Isabel, Affolter, Kajsa, Choi, Eun-Young K, and Lee, Hwajeong

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Chronic Liver Disease and Cirrhosis, Clinical Research, Digestive Diseases, Liver Disease, Adolescent, Adult, Aged, Female, Humans, Hypertension, Portal, Liver Cirrhosis, Male, Middle Aged, Observer Variation, Pathologists, Young Adult, Portal hypertension, Porto-sinusoidal vascular disease, Interobserver, Pathology, Clinical sciences
Abstract

BackgroundHistologic features of idiopathic non-cirrhotic portal hypertension (INCPH) may overlap with those without INCPH. Recently, these features have been recognized as part of the larger spectrum of porto-sinusoidal vascular disease (PSVD). We assessed interobserver agreement on histologic features that are commonly associated with INCPH and studied whether a provision of relevant clinical history improves interobserver agreement.MethodsThe examined histologic features include lobular (such as anisocytosis, nodular regeneration, sinusoidal dilatation, increased parenchymal draining veins, and incomplete fibrous septa) and portal tract changes (such as paraportal shunting vessel(s), portal tract remnant, increased number of portal vessels, and obliterative portal venopathy). Thirty-four archived liver samples from patients with (group A) and without (group B) INCPH were retrieved. A total of 90 representative images of lobules (L) and portal tracts (P) were distributed among 9 liver pathologists blinded to true clinical history. Each pathologist answered multiple choice questions based on the absence (Q1) or presence (Q2) of clinical history of portal hypertension. Fleiss' kappa coefficient analysis (unweighted) was performed to assess interobserver agreement on normal versus abnormal diagnosis, in L and P, based on Q1 and Q2.ResultsThe kappa values regarding normal versus abnormal diagnosis were 0.24, 0.24, 0.18 and 0.18 for L-Q1, L-Q2, P-Q1, and P-Q2, respectively. With true clinical history provided, the kappa values were L- 0.32, P-0.17 for group A and L-0.12, P-0.14 for group B. Four pathologists changed their assessments based on the provided history. Interobserver agreement on the interpretation of L and P as normal versus abnormal was slight to fair regardless of provision of clinical history.ConclusionsOur findings indicate that the histologic features of INCPH/PSVD are not limited to patients with portal hypertension and are subject to significant interobserver variation.

Published
2020

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