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243 results on '"Choi, Harry"'

6. Association of aortic vascular uptake of 18FDG by PET/CT and aortic wall thickness by MRI in psoriasis: a prospective observational study

Author

Groenendyk, Jacob W., Shukla, Parag, Dey, Amit K., Elnabawi, Youssef A., Aksentijevich, Milena, Choi, Harry, Genovese, Leonard D., Harrington, Charlotte L., Natarajan, Balaji, Goyal, Aditya, Reddy, Aarthi S., Rodante, Justin, Kabbany, Mohammad Tarek, Sadek, Ahmed, Al Najafi, Mina, Playford, Martin P., Joshi, Aditya A., Ahlman, Mark A., Gelfand, Joel M., Bluemke, David A., and Mehta, Nehal N.

Published
2019
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8. Preclinical evaluation of HL001, a novel lysophosphatidic acid 1 (LPA1) receptor antagonist, for idiopathic pulmonary fibrosis utilizing physiologically relevant stem cell-derived lung organoids

Author

Yamamoto, Yuki, primary, Nagamoto, Tetsuharu, additional, Choi, Harry, additional, Ito, Shunsuke, additional, Kishihata, Masako, additional, Iwase, Noriaki, additional, Arai, Kenichi, additional, Kojima, Masahiro, additional, Nishikawa, Kenji, additional, Okanari, Eiji, additional, and Shinohara, Yuuko, additional

Published
2023
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16. Treatment of Psoriasis With Biologic Therapy Is Associated With Improvement of Coronary Artery Plaque Lipid-Rich Necrotic Core: Results From a Prospective, Observational Study

Author

Choi, Harry, Uceda, Domingo E., Dey, Amit K., Abdelrahman, Khaled M., Aksentijevich, Milena, Rodante, Justin A., Elnabawi, Youssef A., Reddy, Aarthi, Keel, Andrew, Erb-Alvarez, Julie, Teague, Heather, Playford, Martin P., Zhou, Wunan, Chen, Marcus Y., Gelfand, Joel M., Bluemke, David A., Buckler, Andrew, and Mehta, Nehal N.

Published
2020
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20. Prognostic Power of Quantitative Assessment of Functional Mitral Regurgitation and Myocardial Scar Quantification by Cardiac Magnetic Resonance.

Author

Kai Ming Wang, Tom, Kocyigit, Duygu, Choi, Harry, Anthony, Chris M., Chan, Nicholas, Bullen, Jennifer, Popović, Zoran B., Kapadia, Samir R., Krishnaswamy, Amar, Griffin, Brian P., Flamm, Scott D., Tang, W. H. Wilson, and Kwon, Deborah H.

Abstract

BACKGROUND: The severity classification of functional mitral regurgitation (FMR) remains controversial despite adverse prognosis and rapidly evolving interventions. Furthermore, it is unclear if quantitative assessment with cardiac magnetic resonance can provide incremental risk stratification for patients with ischemic cardiomyopathy (ICM) or non-ICM (NICM) in terms of FMR and late gadolinium enhancement (LGE). We evaluated the impact of quantitative cardiac magnetic resonance parameters on event-free survival separately for ICM and NICM, to assess prognostic FMR thresholds and interactions with LGE quantification. METHODS: Patients (n=1414) undergoing cardiac magnetic resonance for cardiomyopathy (ejection fraction<50%) assessment from April 1, 2001 to December 31, 2017 were evaluated. The primary end point was all-cause death, heart transplant, or left ventricular assist device implantation during follow-up. Multivariable Cox analyses were conducted to determine the impact of FMR, LGE, and their interactions with event-free survival. RESULTS: There were 510 primary end points, 395/782 (50.5%) in ICM and 114/632 (18.0%) in NICM. Mitral regurgitationfraction per 5% increase was independently associated with the primary end point, hazards ratios (95% CIs) of 1.04 (1.01-1.07; P=0.034) in ICM and 1.09 (1.02-1.16; P=0.011) in NICM. Optimal mitral regurgitation-fraction threshold for moderate and severe FMR were =20% and =35%, respectively, in both ICM and NICM, based on the prediction of the primary outcome. Similarly, optimal LGE thresholds were =5% in ICM and =2% in NICM. Mitral regurgitation-fraction×LGE emerged as a significant interaction for the primary end point in ICM (P=0.006), but not in NICM (P=0.971). CONCLUSIONS: Mitral regurgitation-fraction and LGE are key quantitative cardiac magnetic resonance biomarkers with differential associations with adverse outcomes in ICM and NICM. Optimal prognostic thresholds may provide important clinical risk prognostication and may further facilitate the ability to derive selection criteria to guide therapeutic decision-making. [ABSTRACT FROM AUTHOR]

Published
2023
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22. sj-pdf-1-vmj-10.1177_1358863X231171948 – Supplemental material for Machine learning demonstrates top predictors of lipid-rich necrotic core modulation over 1 year in psoriasis

Author

Hong, Christin G, Li, Haiou, Parel, Philip M, Berg, Alexander R, Patel, Nidhi, Choi, Harry, Teague, Heather L, Munger, Eric, Buckler, Andrew J, Sorokin, Alexander V, and Mehta, Nehal N

Subjects
FOS: Clinical medicine, Cardiology, 110323 Surgery
Abstract

Supplemental material, sj-pdf-1-vmj-10.1177_1358863X231171948 for Machine learning demonstrates top predictors of lipid-rich necrotic core modulation over 1 year in psoriasis by Christin G Hong, Haiou Li, Philip M Parel, Alexander R Berg, Nidhi Patel, Harry Choi, Heather L Teague, Eric Munger, Andrew J Buckler, Alexander V Sorokin and Nehal N Mehta in Vascular Medicine

Published
2023
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23. sj-pdf-2-vmj-10.1177_1358863X231171948 – Supplemental material for Machine learning demonstrates top predictors of lipid-rich necrotic core modulation over 1 year in psoriasis

Author

Hong, Christin G, Li, Haiou, Parel, Philip M, Berg, Alexander R, Patel, Nidhi, Choi, Harry, Teague, Heather L, Munger, Eric, Buckler, Andrew J, Sorokin, Alexander V, and Mehta, Nehal N

Subjects
FOS: Clinical medicine, Cardiology, 110323 Surgery
Abstract

Supplemental material, sj-pdf-2-vmj-10.1177_1358863X231171948 for Machine learning demonstrates top predictors of lipid-rich necrotic core modulation over 1 year in psoriasis by Christin G Hong, Haiou Li, Philip M Parel, Alexander R Berg, Nidhi Patel, Harry Choi, Heather L Teague, Eric Munger, Andrew J Buckler, Alexander V Sorokin and Nehal N Mehta in Vascular Medicine

Published
2023
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25. Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors

Author

Zhang, Gao, Frederick, Dennie T., Wu, Lawrence, Wei, Zhi, Krepler, Clemens, Srinivasan, Satish, Chae, Young Chan, Xu, Xiaowei, Choi, Harry, Dimwamwa, Elaida, Ope, Omotayo, Shannan, Batool, Basu, Devraj, Zhang, Dongmei, Guha, Manti, Xiao, Min, Randell, Sergio, Sproesser, Katrin, Xu, Wei, Liu, Jephrey, Karakousis, Giorgos C., Schuchter, Lynn M., Gangadhar, Tara C., Amaravadi, Ravi K., Gu, Mengnan, Xu, Caiyue, Ghosh, Abheek, Xu, Weiting, Tian, Tian, Zha, Shijie, Liu, Qin, Brafford, Patricia, Weeraratna, Ashani, Davies, Michael A., Wargo, Jennifer A., Avadhani, Narayan G., Lu, Yiling, Mills, Gordon B., Altieri, Dario C., Flaherty, Keith T., and Herlyn, Meenhard

Subjects
Mitochondrial biogenesis -- Research, Drug resistance -- Development and progression -- Analysis, Extracellular signal-regulated kinases -- Analysis, Health care industry
Abstract

Targeting multiple components of the MAPK pathway can prolong the survival of patients with BRAFV600E melanoma. This approach is not curative, as some BRAF-mutated melanoma cells are intrinsically resistant to MAPK inhibitors (MAPKi). At the systemic level, our knowledge of how signaling pathways underlie drug resistance needs to be further expanded. Here, we have shown that intrinsically resistant BRAF-mutated melanoma cells with a low basal level of mitochondrial biogenesis depend on this process to survive MAPKi. Intrinsically resistant cells exploited an integrated stress response, exhibited an increase in mitochondrial DNA content, and required oxidative phosphorylation to meet their bioenergetic needs. We determined that intrinsically resistant cells rely on the genes encoding TFAM, which controls mitochondrial genome replication and transcription, and TRAP1, which regulates mitochondrial protein folding. Therefore, we targeted mitochondrial biogenesis with a mitochondrium-targeted, small-molecule HSP90 inhibitor (Gamitrinib), which eradicated intrinsically resistant cells and augmented the efficacy of MAPKi by inducing mitochondrial dysfunction and inhibiting tumor bioenergetics. A subset of tumor biopsies from patients with disease progression despite MAPKi treatment showed increased mitochondrial biogenesis and tumor bioenergetics. A subset of acquired drug-resistant melanoma cell lines was sensitive to Gamitrinib. Our study establishes mitochondrial biogenesis, coupled with aberrant tumor bioenergetics, as a potential therapy escape mechanism and paves the way for a rationale-based combinatorial strategy to improve the efficacy of MAPKi., Introduction Cutaneous melanoma is a devastating disease, with a 10-year survival rate of less than 10% in patients diagnosed with stage IV melanoma (1). Approximately 50% of melanoma patients' tumors [...]

Published
2016
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30. Age-related Dysregulation of Autophagy Contributes to Microglial Dysfunction and Chronic Neurobehavioral Deficits After Traumatic Brain Injury

Author

Ritzel, Rodney, primary, Li, Yun, additional, Lei, Zhuofan, additional, Carter, Jordan, additional, He, Junyun, additional, Choi, Harry, additional, Khan, Niaz, additional, Li, Hui, additional, Allen, Samantha, additional, Lipinski, Marta M, additional, Faden, Alan I, additional, and Wu, Junfang, additional

Published
2021
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31. Lee Seung Taek: NATIONAL MUSEUM OF MODERN AND CONTEMPORARY ART

Author

Choi, Harry C.H.

Subjects
Sculpture -- Exhibitions -- South Korea, Performance art -- Exhibitions, Arts, visual and performing
Abstract

Lee Seung Taek NATIONAL MUSEUM OF MODERN AND CONTEMPORARY ART Less is not always more, as the art of Lee Seung Taek shows. 'Lee Seung Taek's Non-Art: The Inversive Act,' [...]

Published
2021

32. Koki Tanaka: ART SONJE CENTER

Author

Choi, Harry C.H.

Subjects
Video art -- Exhibitions, Arts, visual and performing
Abstract

SEOUL Koki Tanaka ART SONJE CENTER Trade disputes in 2019 between South Korea and its former colonial ruler accomplished the seemingly impossible feat of further intensifying the already anguished relations [...]

Published
2021

35. DISPROPORTIONATE VERSUS PROPORTIONATE FUNCTIONAL MITRAL REGURGITATION EVALUATION BY MAGNETIC RESONANCE IMAGING AND PROGNOSTIC IMPLICATIONS

Author

Wang, Tom Kai Ming, primary, Kocyigit, Duygu, additional, Choi, Harry, additional, Chan, Nicholas, additional, Anthony, Chris, additional, Bullen, Jennifer, additional, Cavalcante, Joao, additional, Popovic, Zoran, additional, Tang, Wai Hong, additional, Kapadia, Samir, additional, Griffin, Brian, additional, Flamm, Scott, additional, and Kwon, Deborah, additional

Published
2021
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36. CLASSIFICATION OF FUNCTIONAL MITRAL REGURGITATION BY MAGNETIC RESONANCE IMAGING: PROGNOSTIC UTILITY AND OPTIMAL THRESHOLDS

Author

Wang, Tom Kai Ming, primary, Kocyigit, Duygu, additional, Chan, Nicholas, additional, Anthony, Chris, additional, Choi, Harry, additional, Bullen, Jennifer, additional, Cavalcante, Joao, additional, Popovic, Zoran, additional, Tang, Wai Hong, additional, Kapadia, Samir, additional, Griffin, Brian, additional, Flamm, Scott, additional, and Kwon, Deborah, additional

Published
2021
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37. Hybridization chain reaction enables a unified approach to multiplexed, quantitative, high-resolution immunohistochemistry and in situ hybridization

Author

Schwarzkopf, Maayan, Liu, Mike C., Schulte, Samuel J., Ives, Rachel, Husain, N., Choi, Harry M. T., Pierce, Niles A., Schwarzkopf, Maayan, Liu, Mike C., Schulte, Samuel J., Ives, Rachel, Husain, N., Choi, Harry M. T., and Pierce, Niles A.

Abstract

RNA in situ hybridization (RNA-ISH) based on the mechanism of hybridization chain reaction (HCR) enables multiplexed, quantitative, high-resolution RNA imaging in highly autofluorescent samples including whole-mount vertebrate embryos, thick brain slices, and formalin-fixed paraffin-embedded (FFPE) tissue sections. Here, we extend the benefits of 1-step, multiplexed, quantitative, isothermal, enzyme-free HCR signal amplification to immunohistochemistry (IHC), enabling accurate and precise protein relative quantitation with subcellular resolution in an anatomical context. More-over, we provide a unified framework for simultaneous quantitative protein and RNA imaging with 1-step HCR signal amplification performed for all target proteins and RNAs simultaneously.

Published
2021

40. HIDDEN REALMS.

Author

Buzzi, Valentina, Choi, Harry C. H., Hayoung Chung, Elliott, David, Sooyoung Leam, Kelly Ma, SeoHyung, Diana, and Yvonne Wang

Published
2024

41. Programming biomolecular self-assembly pathways

Author

Yin, Peng, Choi, Harry M. T., Calvert, Colby R., and Pierce, Niles A.

Subjects
Biomolecules -- Structure -- Properties -- Research -- Usage, Molecular computing -- Usage -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation, Structure, Usage, Research, Properties
Abstract

Author(s): Peng Yin [1, 2]; Harry M. T. Choi [1]; Colby R. Calvert [1]; Niles A. Pierce (corresponding author) [1, 3] In nature, self-assembling and disassembling complexes of proteins and [...]

Published
2008
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42. Multiplexed Quantitative In Situ Hybridization with Subcellular or Single-Molecule Resolution Within Whole-Mount Vertebrate Embryos: qHCR and dHCR Imaging (v3.0)

Author

Nielsen, Boye Schnack, Jones, Julia, Choi, Harry M. T., Schwarzkopf, Maayan, Pierce, Niles A., Nielsen, Boye Schnack, Jones, Julia, Choi, Harry M. T., Schwarzkopf, Maayan, and Pierce, Niles A.

Abstract

In situ hybridization based on the mechanism of hybridization chain reaction (HCR) enables multiplexed quantitative mRNA imaging in the anatomical context of whole-mount vertebrate embryos. Third-generation in situ HCR (v3.0) provides automatic background suppression throughout the protocol, dramatically enhancing performance and ease of use. In situ HCR v3.0 supports two quantitative imaging modes: (1) qHCR imaging for analog mRNA relative quantitation with subcellular resolution in an anatomical context and (2) dHCR imaging for digital mRNA absolute quantitation with single-molecule resolution in an anatomical context. Here, we provide protocols for qHCR and dHCR imaging in whole-mount zebrafish, chicken, and mouse embryos.

Published
2020

43. Multiplexed Quantitative In Situ Hybridization for Mammalian or Bacterial Cells in Suspension: qHCR Flow Cytometry (v3.0)

Author

Nielsen, Boye Schnack, Jones, Julia, Schwarzkopf, Maayan, Choi, Harry M. T., Pierce, Niles A., Nielsen, Boye Schnack, Jones, Julia, Schwarzkopf, Maayan, Choi, Harry M. T., and Pierce, Niles A.

Abstract

In situ hybridization based on the mechanism of hybridization chain reaction (HCR) enables high-throughput expression profiling of mammalian or bacterial cells via flow cytometry. Third-generation in situ HCR (v3.0) provides automatic background suppression throughout the protocol, dramatically enhancing performance and ease of use. In situ HCR v3.0 supports analog mRNA relative quantitation via qHCR flow cytometry. Here, we provide protocols for multiplexed qHCR flow cytometry for mammalian or bacterial cells in suspension.

Published
2020

44. Multiplexed Quantitative In Situ Hybridization for Mammalian Cells on a Slide: qHCR and dHCR Imaging (v3.0)

Author

Nielsen, Boye Schnack, Jones, Julia, Schwarzkopf, Maayan, Choi, Harry M. T., Pierce, Niles A., Nielsen, Boye Schnack, Jones, Julia, Schwarzkopf, Maayan, Choi, Harry M. T., and Pierce, Niles A.

Abstract

In situ hybridization based on the mechanism of hybridization chain reaction (HCR) enables multiplexed quantitative mRNA imaging in diverse sample types. Third-generation in situ HCR (v3.0) provides automatic background suppression throughout the protocol, dramatically enhancing performance and ease of use. In situ HCR v3.0 supports two quantitative imaging modes: (1) qHCR imaging for analog mRNA relative quantitation with subcellular resolution and (2) dHCR imaging for digital mRNA absolute quantitation with single-molecule resolution. Here, we provide protocols for qHCR and dHCR imaging in mammalian cells on a slide.

Published
2020

45. 'Sea Change': RATIO 3/NONAKA-HILL

Author

Choi, Harry C.H.

Subjects
Pottery -- Exhibitions -- Criticism and interpretation, Art, Japanese -- Exhibitions -- Criticism and interpretation, Arts, visual and performing
Abstract

For a group exhibition that focused primarily on contemporary Japanese ceramics, 'Sea Change' strangely commenced with Octopi 4, 1990, an eerie atmospheric photograph by Kunie Sugiura. The print features two [...]

Published
2021

46. Application of machine learning to determine top predictors of noncalcified coronary burden in psoriasis: An observational cohort study

Author

Munger, Eric, primary, Choi, Harry, additional, Dey, Amit K., additional, Elnabawi, Youssef A., additional, Groenendyk, Jacob W., additional, Rodante, Justin, additional, Keel, Andrew, additional, Aksentijevich, Milena, additional, Reddy, Aarthi S., additional, Khalil, Noor, additional, Argueta-Amaya, Jenis, additional, Playford, Martin P., additional, Erb-Alvarez, Julie, additional, Tian, Xin, additional, Wu, Colin, additional, Gudjonsson, Johann E., additional, Tsoi, Lam C., additional, Jafri, Mohsin Saleet, additional, Sandfort, Veit, additional, Chen, Marcus Y., additional, Shah, Sanjiv J., additional, Bluemke, David A., additional, Lockshin, Benjamin, additional, Hasan, Ahmed, additional, Gelfand, Joel M., additional, and Mehta, Nehal N., additional

Published
2020
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47. Abstract P405: Visceral Adipose Tissue Volume is Associated With Prevalent Coronary Plaque Independent of Total Adiposity in Psoriasis

Author

Uceda, Domingo E, primary, Reddy, Aarthi, additional, Choi, Harry, additional, Lateef, Sundus S, additional, Abdelrahman, Khaled M, additional, Dey, Amit K, additional, Aksentijevich, Milena, additional, Scott, Colin, additional, Shukla, Parag, additional, Akbar, Mohammed D, additional, Argueta-Amaya, Jenis, additional, Rodante, Justin, additional, Teague, Heather, additional, Keel, Andrew, additional, Chen, Marcus Y, additional, Yao, Jianhua, additional, Zhou, Wunan, additional, Playford, Martin P, additional, and Mehta, Nehal N, additional

Published
2020
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48. Association Between Soluble Lectinlike Oxidized Low-Density Lipoprotein Receptor-1 and Coronary Artery Disease in Psoriasis

Author

Dey, Amit K., primary, Gaddipati, Ranjitha, additional, Elnabawi, Youssef A., additional, Ongstad, Emily, additional, Goyal, Aditya, additional, Chung, Jonathan H., additional, Teague, Heather L., additional, Rodante, Justin A., additional, Sajja, Aparna A., additional, Sorokin, Alexander V., additional, Lateef, Sundus S., additional, Aksentijevich, Milena, additional, Choi, Harry, additional, Reddy, Aarthi S., additional, Varghese, Nevin J., additional, Groenendyk, Jacob, additional, Belur, Agastya D., additional, Genovese, Leonard, additional, Rivers, Joshua P., additional, Lerman, Joseph, additional, Kabbany, Mohammad Tarek, additional, Harrington, Charlotte, additional, Ortiz, Jenis, additional, Khalil, Noor, additional, Keel, Andrew, additional, Baumer, Yvonne, additional, Chen, Marcus Y., additional, Bluemke, David A., additional, Joshi, Aditya A., additional, Kaplan, Mariana J., additional, Remaley, Alan T., additional, Playford, Martin P., additional, Karathanasis, Sotirios K., additional, Gelfand, Joel M., additional, Gupta, Ruchi, additional, and Mehta, Nehal N., additional

Published
2020
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49. Young-jun Tak: ATELIER HERMÈS.

Author

Choi, Harry C. H.

Subjects
*ART exhibitions
Abstract

The article reviews the art exhibition "Love Your Clean Feet on Thursday" by Young-jun Tak held at Atelier Hermès in Seoul, Korea.

Published
2024

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