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195 results on '"Choi, Hyunchul"'

6. Immunochip Analysis Identification of 6 Additional Susceptibility Loci for Crohn's Disease in Koreans

Author

Yang, Suk-Kyun, Hong, Myunghee, Choi, Hyunchul, Zhao, Wanting, Jung, Yusun, Haritunians, Talin, Ye, Byong Duk, Kim, Kyung-Jo, Park, Sang Hyoung, Lee, Inchul, Kim, Won Ho, Cheon, Jae Hee, Kim, Young-Ho, Jang, Byung Ik, Kim, Hyun-Soo, Choi, Jai Hyun, Koo, Ja Seol, Lee, Ji Hyun, Jung, Sung-Ae, Shin, Hyoung Doo, Kang, Daehee, Youn, Hee-Shang, Taylor, Kent D, Rotter, Jerome I, Liu, Jianjun, McGovern, Dermot PB, and Song, Kyuyoung

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Digestive Diseases, Inflammatory Bowel Disease, Human Genome, Autoimmune Disease, Crohn's Disease, Genetics, Clinical Research, Aetiology, 2.1 Biological and endogenous factors, Adolescent, Adult, Asian People, Biomarkers, Case-Control Studies, Cohort Studies, Crohn Disease, Female, Follow-Up Studies, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Male, Odds Ratio, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide, Prognosis, Young Adult, Crohn's disease, genetics, ImmunoChip, Korean, Gastroenterology & Hepatology, Clinical sciences
Abstract

BackgroundCrohn's disease (CD) is an intractable inflammatory bowel disease of unknown cause. Recent genome-wide association studies of CD in Korean and Japanese populations suggested marginal sharing of susceptibility loci between Caucasian and Asian populations. As the 7 identified loci altogether explain 5.31% of the risk for CD, the objective of this study was to identify additional CD susceptibility loci in the Korean population.MethodsUsing the ImmunoChip custom single-nucleotide polymorphism array designed for dense genotyping of 186 loci identified through GWAS, we analyzed 722 individuals with CD and 461 controls for 96,048 SNP markers in the discovery stage, followed by validation in an additional 948 affected individuals and 977 controls.ResultsWe confirmed 6 previously reported loci in Caucasian: GPR35 at 2q37 (rs3749172; P = 5.30 × 10, odds ratio [OR] = 1.45), ZNF365 at 10q21 (rs224143; P = 2.20 × 10, OR = 1.38), ZMIZ1 at 10q22 (rs1250569; P = 3.05 × 10, OR = 1.30), NKX2-3 at 10q24 (rs4409764; P = 7.93 × 10, OR = 1.32), PTPN2 at 18p11 (rs514000; P = 9.00 × 10, OR = 1.33), and USP25 at 21q11 (rs2823256; P = 2.49 × 10, OR = 1.35), bringing the number of known CD loci (including 3 in the HLA) in Koreans to 15. The 6 additional loci increased the total genetic variance for CD risk from 5.31% to 7.27% in Koreans.ConclusionsAlthough the different genetic backgrounds of CD between Asian and Western countries has been well established for the major susceptibility genes, our findings of overlapping associations offer new insights into the genetic architecture of CD.

Published
2015

18. Real-Time Image Correction for Interactive Environment

Author

Choi, Hyunchul, Kyoung, Dongwuk, Jung, Keechul, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, and Stephanidis, Constantine, editor

Published
2007
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34. Optical configuration of a horizontal-switching liquid-crystal cell for improvement of the viewing angle

Author

Lee, Joun-Ho, Choi, Hyunchul, Lee, Seung Hee, Kim, Jae Chang, and Lee, Gi-Dong

Subjects
Dielectric films -- Optical properties, Thin films -- Optical properties, Liquid crystals -- Optical properties, Optics -- Research, Astronomy, Physics
Abstract

We propose an optical configuration of a horizontal-switching liquid-crystal cell, consisting of a splayed liquid-crystal cell and uniaxial films, to improve the viewing angle characteristics by compensating for the phase dispersion in a diagonal direction. The optical design of the proposed configuration was performed on a Poincare sphere with geometric calculations. By fabricating in-plane switching cells with the introduced configuration, we demonstrated their optical performances. As a result, we found that the diagonal viewing angle of the proposed horizontal-switching cell could be increased by 80% compared to a symmetrical viewing cone. OCIS codes: 230.3720, 230.0230, 220.0220.

Published
2006

46. Amino acid position 37 of HLA-DRβ1 affects susceptibility to Crohn’s disease in Asians

Author

Han, Buhm, primary, Akiyama, Masato, additional, Kim, Kyung-Kon, additional, Oh, Hyunjung, additional, Choi, Hyunchul, additional, Lee, Cue Hyunkyu, additional, Jung, Seulgi, additional, Lee, Ho-Su, additional, Kim, Emma E, additional, Cook, Seungho, additional, Haritunians, Talin, additional, Yamazaki, Keiko, additional, Park, Sang Hyoung, additional, Ye, Byong Duk, additional, McGovern, Dermot P B, additional, Esaki, Motohiro, additional, Kawaguchi, Takaaki, additional, Khor, Seik-Soon, additional, Taylor, Kent D, additional, Rotter, Jerome I, additional, Suzuki, Yasuo, additional, Matsui, Toshiyuki, additional, Motoya, Satoshi, additional, Bang, So-Young, additional, Kim, Tae-Hwan, additional, Momozawa, Yukihide, additional, Kamatani, Yoichiro, additional, Tokunaga, Katsushi, additional, Kubo, Michiaki, additional, Okada, Yukinori, additional, Yang, Suk-Kyun, additional, and Song, Kyuyoung, additional

Published
2018
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50. Tension-controlled single-crystallization of copper foils for roll-to-roll synthesis of high-quality graphene films

Author

Jo, Insu, primary, Park, Subeom, additional, Kim, Dongjin, additional, Moon, Jin San, additional, Park, Won Bae, additional, Kim, Tae Hyeong, additional, Kang, Jin Hyoun, additional, Lee, Wonbae, additional, Kim, Youngsoo, additional, Lee, Dong Nyung, additional, Cho, Sung-Pyo, additional, Choi, Hyunchul, additional, Kang, Inbyeong, additional, Park, Jong Hyun, additional, Lee, Jeong Soo, additional, and Hong, Byung Hee, additional

Published
2018
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