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324 results on '"Choi, So-Ra"'

12. Nasal instillation of povidone‐iodine ameliorates ongoing mucosal inflammation in a pre‐sensitized murine model of Der p1‐induced allergic rhinitis.

Author

Kang, Jae‐Yoon, Choi, Mi‐Ra, and Kim, Yong Min

Subjects
*ALLERGIC rhinitis, *HOUSE dust mites, *NASAL mucosa, *DERMATOPHAGOIDES pteronyssinus, *POVIDONE-iodine, *DEXAMETHASONE, *IMMUNOGLOBULIN E
Abstract

Background: Interleukin (IL)‐33, when cleaved into smaller fragments by proteases, becomes hyperactive, contributing to allergic inflammation. Povidone‐iodine (PVP‐I) is an iodine‐based compound that exhibits antimicrobial properties and inhibits proteases. This study aimed to investigate whether PVP‐I treatment inhibits IL‐33 cleavage, improves allergic rhinitis (AR) symptoms, and suppresses allergic inflammation in a mouse model. Methods: In vitro experiments using full‐length recombinant human IL‐33 and allergens, including house dust mites or Dermatophagoides pteronyssinus 1, were conducted using western blotting. Fifty BALB/c mice were divided into five groups: control (CON), AR with phosphate‐buffered saline treatment (AR), PVP‐I treatment (AR + PVP), trans‐epoxysuccinyl‐L‐leucylamido(4‐guanidino)butane (E64) treatment (AR + E64), and dexamethasone treatment (AR + Dexa). Nasal symptom scores, including rubbing and sneezing, were measured. The cytokine levels in the nasal lavage fluid (NLF) and the concentration of immunoglobulins in the blood serum were assessed. Nasal mucosa from each group was used for reverse transcriptase‐polymerase chain reaction (RT‐PCR) and histological analyses were conducted. Results: PVP‐I treatment reduced nasal symptoms, suppressed allergic inflammation, and decreased the levels of IL‐33, IL‐5, and IL‐13 in the NLF and total immunoglobulin E (IgE) and specific IgE in the serum. Histopathological analysis revealed a reduction in the number of eosinophils and goblet cells in the nasal mucosa of the AR + PVP group when compared to the AR group. RT‐PCR and immunofluorescence staining confirmed the downregulation of genes and proteins associated with allergic inflammation. Conclusions: These findings suggest that nasal irrigation with PVP‐I may be a promising therapeutic option for managing AR by inhibiting IL‐33 activation and suppressing allergic inflammation. [ABSTRACT FROM AUTHOR]

Published
2024
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30. A Study on the Priority of Advancing Hydrogen Fueling Infrastructure Using AHP

Author

Kim Sungu, Choi Hyeok-Ra, Kim Heaseon, and Kim Seon-Myung

Subjects
Hydrogen infrastructure, Rate of return, Hydrogen safety, Analytic hierarchy process, Subsidy, Public service, Business, Environmental economics, Hydrogen vehicle, Hydrogen production
Abstract

In this study, the solution to the problems raised in the hydrogen industry infrastructure construction was considered using the AHP analysis. This research model divided the major decision-making issues of hydrogen infrastructure construction into seven and evaluated the importance and priority of detailed items for each decision-making issue. The result of the analysis indicated that locations near existing gas stations were suitable for installing hydrogen refueling stations. To expand the supply of hydrogen refueling stations, safety concerns and acceptability of the refueling stations were evaluated as the biggest problems to be solved. It was evaluated that the location near the new mass demand was the most suitable location of the hydrogen production facility. Expanding public service advertisements related to hydrogen safety was found to be an appropriate technique for raising public awareness for the expansion of hydrogen infrastructure construction. Insufficient hydrogen infrastructure was evaluated as the most important factor for expanding the hydrogen industry ecosystem in Korea. Therefore, to expand the construction of hydrogen infrastructure, in addition to the subsidies for hydrogen vehicles, support policies from the government that guarantee a certain rate of return on the operation of hydrogen infrastructure facilities are necessary.

Published
2021

46. Deep neural network for automatic volumetric segmentation of whole-body CT images for body composition assessment

Author

Lee, Yoon Seong, primary, Hong, Namki, additional, Witanto, Joseph Nathanael, additional, Choi, Ye Ra, additional, Park, Junghoan, additional, Decazes, Pierre, additional, Eude, Florian, additional, Kim, Chang Oh, additional, Chang Kim, Hyeon, additional, Goo, Jin Mo, additional, Rhee, Yumie, additional, and Yoon, Soon Ho, additional

Published
2021
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