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42 results on '"Choline Kinase chemistry"'

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1. Genetic diseases of the Kennedy pathways for membrane synthesis.

2. Synthesis, biological evaluation, in silico modeling and crystallization of novel small monocationic molecules with potent antiproliferative activity by dual mechanism.

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3. ChoK-ing the Pathogenic Bacteria: Potential of Human Choline Kinase Inhibitors as Antimicrobial Agents.

4. Molecular basis for the interaction between human choline kinase alpha and the SH3 domain of the c-Src tyrosine kinase.

5. Computation-aided rational design of a halophilic choline kinase for cytidine diphosphate choline production in high-salt condition.

6. Identification of a Unique Inhibitor-Binding Site on Choline Kinase α.

7. Molecular structure and differential function of choline kinases CHKα and CHKβ in musculoskeletal system and cancer.

8. Plasmodium falciparum Choline Kinase Inhibition Leads to a Major Decrease in Phosphatidylethanolamine Causing Parasite Death.

9. Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase α1 (ChoKα1).

10. Evolutionary Ancestry of Eukaryotic Protein Kinases and Choline Kinases.

11. In Silico Exploration for New Antimalarials: Arylsulfonyloxy Acetimidamides as Prospective Agents.

12. Pharmacophore-Based Virtual Screening to Discover New Active Compounds for Human Choline Kinase α1.

13. Structural and enzymatic characterization of the choline kinase LicA from Streptococcus pneumoniae.

14. New more polar symmetrical bipyridinic compounds: new strategy for the inhibition of choline kinase α1.

15. Composite aromatic boxes for enzymatic transformations of quaternary ammonium substrates.

16. Discovery of a new binding site on human choline kinase α1: design, synthesis, crystallographic studies, and biological evaluation of asymmetrical bispyridinium derivatives.

17. Choline kinase active site provides features for designing versatile inhibitors.

18. Antiplasmodial activity and mechanism of action of RSM-932A, a promising synergistic inhibitor of Plasmodium falciparum choline kinase.

19. Determination of potential scaffolds for human choline kinase α1 by chemical deconvolution studies.

20. Kinetic and mechanistic characterisation of Choline Kinase-α.

21. The mechanism of allosteric coupling in choline kinase α1 revealed by the action of a rationally designed inhibitor.

22. A novel small molecule antagonist of choline kinase-α that simultaneously suppresses MAPK and PI3K/AKT signaling.

23. Involvement of human choline kinase alpha and beta in carcinogenesis: a different role in lipid metabolism and biological functions.

24. Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity.

25. Comparison of the cellular and biochemical properties of Plasmodium falciparum choline and ethanolamine kinases.

26. Potential choline kinase inhibitors: a molecular modeling study of bis-quinolinium compounds.

27. Elucidation of human choline kinase crystal structures in complex with the products ADP or phosphocholine.

28. Insight into the inhibition of human choline kinase: homology modeling and molecular dynamics simulations.

29. Generation and characterization of monoclonal antibodies against choline kinase alpha and their potential use as diagnostic tools in cancer.

30. Molecular characterization and localization of Plasmodium falciparum choline kinase.

31. Choline kinase: an important target for cancer.

32. Phosphorylation of the yeast choline kinase by protein kinase C. Identification of Ser25 and Ser30 as major sites of phosphorylation.

33. Structure and function of choline kinase isoforms in mammalian cells.

34. Identification of critical residues of choline kinase A2 from Caenorhabditis elegans.

35. A CDP-choline pathway for phosphatidylcholine biosynthesis in Treponema denticola.

36. The crystal structure of choline kinase reveals a eukaryotic protein kinase fold.

37. Phosphorylation of Saccharomyces cerevisiae choline kinase on Ser30 and Ser85 by protein kinase A regulates phosphatidylcholine synthesis by the CDP-choline pathway.

38. Structure and characterization of the genes for murine choline/ethanolamine kinase isozymes alpha and beta.

39. Complementary DNA sequence for a 42 kDa rat kidney choline/ethanolamine kinase.

40. Choline kinase from yeast.

41. Evolutionary comparison of enzyme activities of phosphatidylcholine metabolism in the nervous system of an invertebrate (Loligo pealei), lower vertebrate (Mustelus canis) and the rat.

42. Choline/ethanolamine kinase from rat brain.