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20 results on '"Chong, Gaowei"'

8. Labeling Assembly of Hydrophilic Methionine into Nanoparticle for Mild‐Heat Mediated Immunometabolic Therapy

Author

Zheng, Xiao, primary, Liu, Ying, additional, Zhang, Tingting, additional, Zhao, Yuge, additional, Liu, Yiqiong, additional, Zang, Jie, additional, Chong, Gaowei, additional, Li, Yan, additional, Yang, Yushan, additional, Yang, Yan, additional, Gu, Jingjing, additional, He, Ruiqing, additional, Liu, Bingbing, additional, Yin, Weimin, additional, Dong, Haiqing, additional, and Li, Yongyong, additional

Published
2023
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11. CaCO3 powder-mediated biomineralization of antigen nanosponges synergize with PD-1 blockade to potentiate anti-tumor immunity.

Author

Su, Runping, Gu, Jingjing, Sun, Juanjuan, Zang, Jie, Zhao, Yuge, Zhang, Tingting, Chen, Yingna, Chong, Gaowei, Yin, Weimin, Zheng, Xiao, Liu, Bingbing, Huang, Li, Ruan, Shuangrong, Dong, Haiqing, Li, Yan, and Li, Yongyong

Subjects
T helper cells, BIOMINERALIZATION, CYTOTOXIC T cells, PROGRAMMED cell death 1 receptors, T cells, ANTIGENS, IMMUNITY
Abstract

Antigen self-assembly nanovaccines advance the minimalist design of therapeutic cancer vaccines, but the issue of inefficient cross-presentation has not yet been fully addressed. Herein, we report a unique approach by combining the concepts of "antigen multi-copy display" and "calcium carbonate (CaCO3) biomineralization" to increase cross-presentation. Based on this strategy, we successfully construct sub-100 nm biomineralized antigen nanosponges (BANSs) with high CaCO3 loading (38.13 wt%) and antigen density (61.87%). BANSs can be effectively uptaken by immature antigen-presenting cells (APCs) in the lymph node upon subcutaneous injection. Achieving efficient spatiotemporal coordination of antigen cross-presentation and immune effects, BANSs induce the production of CD4+ T helper cells and cytotoxic T lymphocytes, resulting in effective tumor growth inhibition. BANSs combined with anti-PD-1 antibodies synergistically enhance anti-tumor immunity and reverse the tumor immunosuppressive microenvironment. Overall, this CaCO3 powder-mediated biomineralization of antigen nanosponges offer a robust and safe strategy for cancer immunotherapy. [ABSTRACT FROM AUTHOR]

Published
2023
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14. CaCO 3 Powder-Mediated Biomineralization of Antigen Nanosponges Synergize with PD-1 Blockade to Potentiate Anti-Tumor Immunity

Author

Su, Runping, primary, Gu, Jingjing, additional, Sun, Juanjuan, additional, Zang, Jie, additional, Zhao, Yuge, additional, Zhang, Tingting, additional, Chen, Yingna, additional, Chong, Gaowei, additional, Yin, Weimin, additional, Zheng, Xiao, additional, Liu, Bingbing, additional, Huang, Li, additional, Ruan, Shuangrong, additional, Dong, Haiqing, additional, Li, Yan, additional, and Li, Yongyong, additional

Published
2022
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15. Nanofactory for Metabolic and Chemodynamic Therapy: Pro-Tumor Lactate Trapping and Anti-Tumor ROS Transition

Author

He, Ruiqing, primary, Zang, Jie, additional, Zhao, Yuge, additional, Liu, Ying, additional, Ruan, Shuangrong, additional, Zheng, Xiao, additional, Chong, Gaowei, additional, Xu, Dailin, additional, Yang, Yan, additional, Yang, Yushan, additional, Zhang, Tingting, additional, Gu, Jingjing, additional, Dong, Haiqing, additional, and Li, Yongyong, additional

Published
2021
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18. Catalytic Nanovaccine for Cancer Immunotherapy: A NADPH Oxidase-Inspired Fe-Polyphenol Network Nanovaccine for Enhanced Antigen Cross-Presentation

Author

Chong, Gaowei, primary, Su, Runping, additional, Gu, Jingjing, additional, Zhang, Tingting, additional, Zang, Jie, additional, Zhao, Yuge, additional, Zheng, Xiao, additional, Liu, Ying, additional, Ruan, Shuangrong, additional, He, Ruiqing, additional, Yin, Weimin, additional, Dong, Haiqing, additional, and Li, Yongyong, additional

Published
2021
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