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In recent years, with the development of exoskeleton technology, it has been widely applied in the area of rehabilitation. However, in the rehabilitation of neurological diseases such as cerebral stroke, the rehabilitation of hands exists multifaceted difficulties. Long treatment period, choices of therapeutic schedule and costly treatment are common factors that affect the efficiency of rehabilitation. To improve hands exoskeleton’s therapeutic effect in the neurological rehabilitation. A considerable number of papers have been studied and the development trend of hands exoskeleton was revealed. This review focuses on the wearing comfort of hands exoskeleton, since wearing comfort is an essential factor when launching arm exoskeleton on the market. This article elaborates on the methods of improving exoskeleton’s wearing comfort based on rigid mechanism design and soft or flexible hand exoskeleton design. This article mainly discusses the improving control system and adapted materials, aiming at finding the similarities and differences among various solutions. Pictures concerning each method are also provided for better understanding. Besides, this article provides conclusive perspectives on the existing design and expectations for the further studies.

Inflammatory bowel disease (IBD) is an important high-risk factor that promotes the occurrence and development of colon cancer. Research on the mechanism of regulating NLRP3 can provide potential targets for treating NLRP3 inflammasome–related diseases and changing the inflammatory potential of immune cells. In this study, the effects of atractylenolide I on colitis-associated CRC (caCRC) and inflammasome activation were investigated both in vivo and in vitro. Furthermore, the role of atractylenolide I on Drp1-mediated mitochondrial fission was analyzed via Western blotting and transmission electron microscopy (TEM). Moreover, the Drp1 overexpression lentiviral vector was used to study the role of Drp1 on the signaling mechanisms of atractylenolide I. Atractylenolide I treatment significantly reduced the cell viability of human HCT116 and SW480 cells and induced apoptosis, and effectively inhibited colon tumors in the AOM/DSS mouse model. The reduction of NLRP3 inflammasome activation and excessive fission of mitochondria mediated by Drp1 were associated with the administration of atractylenolide I. Upregulation of Drp1 reversed the inhibitory effect of atractylenolide I on the activation of NLRP3 inflammasomes. Overexpressing the Drp1 expression counteracted the restraint of atractylenolide I on the release of IL-1β of LPS/DSS-stimulated BMDMs. Atractylenolide I inhibited NLRP3 and caspase-1 expression in mice BMDMs, with no influence in the Drp1-overexpressed BMDMs. These results demonstrated that atractylenolide I inhibits NLRP3 inflammasome activation in colitis-associated colorectal cancer via suppressing Drp1-mediated mitochondrial fission.

Laser drilling is of great significance for metal parts production, aerospace parts processing, precision chip manufacturing, etc. In recent years, drilling technology based on new laser devices has become an international research hotspot for its advantages of high speed, high accuracy and low thermal damage. In this paper, the laser drilling is compared with other drilling methods, and the influencing factors and application trends are introduced. At the same time paper introduced the main research on the model and theory of laser drilling at home and abroad. The important effects of thermal effect and molten material on drilling and the latest research progress are introduced.

When using the finite element software ANSYS to numerically simulate the thermal effect of laser irradiation, the calculation results will show some differences with the different ways of meshing. The thermal effect of finite element model under different meshing modes when loaded in the form of heat flux is studied, which is based on the process of laser irradiation of metal circular plates. The effects of element size ratio and mesh density on the simulation result are analysed. By comparing the theoretical analytical solutions with the calculation results under different element size ratio conditions, the overall scheme of meshing is determined first, and then the influence of mesh density is further explored. The calculation results show that when the element size ratio is 1 and the overall element size is 0.25mm, the finite element simulation solution gets high precision, which is consistent with the actual.

The functionally graded carbon nanotubes reinforced composites (FG-CNTRC) plates have excellent properties and broad application prospects. In the analysis of low velocity impact response of functionally graded carbon nanotubes reinforced composite plates, innovative numerical formulations are urgently needed. As a new high-order numerical method, the weak form quadrature element method (QEM) has its unique advantages and has been widely used in the engineering structural field. In this paper, the nonlinear Hertzian contact law is employed to describe the impact process between a rigid impactor and the rectangular FG-CNTRC plate, that was modelled with the Reddy’s high-order shear deformation theory. By using the weak form QEM, the calculation model for the impact system is established, and the numerical solution is carried out with the help of Newmark-β step-by-step time domain integration method and Newton-Raphson iteration technology. The effectiveness and accuracy of the weak form QEM formulation were verified through the comparison with the existing literature and the relevant low velocity impact properties of FG-CNTRC plate are explored.

Constructing a more than 1,000 m long bridge across a deep canyon with rocky terrain and limited access would present challenges to engineering and construction professionals anywhere. But for the team designing and building a new crossing in central China, whirling winds and deep caves beneath the tower foundations added complications that even the most experienced engineers may never have encountered. Their solutions included a complex pulley system to lift the deck sections, an innovative cable anchoring system—and a rocket launcher.