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2. Correction: Antenatal steroids elicited neurodegenerative-associated transcriptional changes in the hippocampus of preterm fetal sheep independent of lung maturation

Author

Carter, Sean W. D., Fee, Erin L., Usuda, Haruo, Oguz, Gokce, Ramasamy, Adaikalavan, Amin, Zubair, Agnihotri, Biswas, Wei, Qin, Xiawen, Liu, Takahashi, Tsukasa, Takahashi, Yuki, Ikeda, Hideyuki, Kumagai, Yusaku, Saito, Yuya, Saito, Masatoshi, Mattar, Citra, Evans, Mark I., Illanes, Sebastián E., Jobe, Alan H., Choolani, Mahesh, and Kemp, Matthew W.

Published
2024
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3. Antenatal steroids elicited neurodegenerative-associated transcriptional changes in the hippocampus of preterm fetal sheep independent of lung maturation

Author

Carter, Sean W. D., Fee, Erin L., Usuda, Haruo, Oguz, Gokce, Ramasamy, Adaikalavan, Amin, Zubair, Agnihotri, Biswas, Wei, Qin, Xiawen, Liu, Takahashi, Tsukasa, Takahashi, Yuki, Ikeda, Hideyuki, Kumagai, Yusaku, Saito, Yuya, Saito, Masatoshi, Mattar, Citra, Evans, Mark I., Illanes, Sebastián E., Jobe, Alan H., Choolani, Mahesh, and Kemp, Matthew W.

Published
2024
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7. Implementation of First-Trimester Screening and Prevention of Preeclampsia: A Stepped Wedge Cluster-Randomized Trial in Asia

Author

Nguyen-Hoang, Long, Dinh, Linh Thuy, Tai, Angela S.T., Nguyen, Duy-Anh, Pooh, Ritsuko K., Shiozaki, Arihiro, Zheng, Mingming, Hu, Yali, Li, Bin, Kusuma, Aditya, Yapan, Piengbulan, Gosavi, Arundhati, Kaneko, Mayumi, Luewan, Suchaya, Chang, Tung-Yao, Chaiyasit, Noppadol, Nanthakomon, Tongta, Liu, Huishu, Shaw, Steven W., Leung, Wing Cheong, Mahdy, Zaleha Abdullah, Aguilar, Angela, Leung, Hillary H.Y., Lee, Nikki M.W., Lau, So Ling, Wah, Isabella Y.M., Lu, Xiaohong, Sahota, Daljit S., Chong, Marc K.C., Poon, Liona C., Wong, Iok Seng, Chen, Yunyu, Liu, Jiao, Lin, Jing, Tse, Ada W. T., Wong, Lo, Liu, Fangzi, Ma, Runmei, Min, Jiang Yan, Choolani, Mahesh A., Wataganara, Tuangsit, and Shimokawa, Osamu

Published
2024
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8. COVID-19 vaccination before or during pregnancy results in high, sustained maternal neutralizing activity to SARS-CoV-2 wild-type and Delta/Omicron variants of concern, particularly following a booster dose or infection

Author

Mahyuddin, Aniza P., Swa, Hannah L.F., Weng, Ruifen, Zhang, Jingxian, Dhanaraj, Janice P., Sesurajan, Binny P., Rauff, Mary, Dashraath, Pradip, Kanneganti, Abhiram, Lee, Rachel, Wang, Lin-Fa, Young, Barnaby E., Tambyah, Paul A., Lye, David C., Chai, Louis Y.A., Yee, Sidney, Choolani, Mahesh, and Mattar, Citra N.Z.

Published
2024
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17. Fetal Diagnosis and Therapy during the COVID-19 Pandemic: Guidance on Behalf of the International Fetal Medicine and Surgery Society

Author

Deprest, Jan, Choolani, Mahesh, Chervenak, Frank, Farmer, Diana, Lagrou, Katrien, Lopriore, Enrico, McCullough, Laurence, Olutoye, Olutoyin, Simpson, Lynn, Van Mieghem, Tim, and Ryan, Greg

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Conditions Affecting the Embryonic and Fetal Periods, Pediatric, Prevention, Perinatal Period - Conditions Originating in Perinatal Period, Clinical Research, Reproductive health and childbirth, Good Health and Well Being, Betacoronavirus, COVID-19, COVID-19 Testing, Clinical Laboratory Techniques, Consensus, Coronavirus Infections, Female, Host Microbial Interactions, Humans, Infant, Newborn, Infection Control, Infectious Disease Transmission, Patient-to-Professional, Infectious Disease Transmission, Vertical, Maternal Health Services, Occupational Health, Pandemics, Patient Safety, Pneumonia, Viral, Pregnancy, Risk Assessment, Risk Factors, SARS-CoV-2, Vertical transmission, Fetal anomaly, Fetal surgery, Fetoscopy, Fetal medicine, Paediatrics and Reproductive Medicine, Obstetrics & Reproductive Medicine, Paediatrics, Reproductive medicine
Abstract

The COVID-19 pandemic has stressed patients and healthcare givers alike and challenged our practice of antenatal care, including fetal diagnosis and therapy. This document aims to review relevant recent information to allow us to optimize prenatal care delivery. We discuss potential modifications to obstetric management and fetal procedures in SARS-CoV2-negative and SARS-CoV2-positive patients with fetal anomalies or disorders. Most fetal therapies are time sensitive and cannot be delayed. If personnel and resources are available, we should continue to offer procedures of proven benefit, acknowledging any fetal and maternal risks, including those to health care workers. There is, to date, minimal, unconfirmed evidence of spontaneous vertical transmission, though it may theoretically be increased with some procedures. Knowing a mother's preoperative SARS-CoV-2 status would enable us to avoid or defer certain procedures while she is contagious and to protect health care workers appropriately. Some fetal conditions may alternatively be managed neonatally. Counseling regarding fetal interventions which have a possibility of additional intra- or postoperative morbidity must be performed in the context of local resource availability. Procedures of unproven benefit should not be offered. We encourage participation in registries and trials that may help us to understand the impact of COVID-19 on pregnant women, their fetuses, and neonates.

Published
2020

21. Utilizing Continuous Glucose Monitoring for Early Detection of Gestational Diabetes Mellitus and Pregnancy Outcomes in an Asian Population.

Author

Lim, Beth S.Y., Yang, Qian, Choolani, Mahesh, Gardner, Daphne S.L., Chong, Yap Seng, Zhang, Cuilin, Chan, Shiao-Yng, and Li, Ling-Jun

Subjects
CONTINUOUS glucose monitoring, BLOOD sugar monitors, PREGNANCY outcomes, GESTATIONAL diabetes, PREGNANT women
Abstract

OBJECTIVE: We explored the potential value of continuous glucose monitoring (CGM) in early pregnancy in predicting gestational diabetes mellitus (GDM) and pregnancy outcomes. RESEARCH DESIGN AND METHODS: The study recruited 103 multiethnic Asian pregnant women with overweight or obesity from a hospital-based, prospective cohort. All of them had worn blinded CGM devices in early pregnancy and underwent the universal GDM screening at 24–28 gestation weeks. Models were selected based on early pregnancy risk factors and CGM-derived parameters to compare their respective predictive values for GDM and pregnancy outcomes. RESULTS: Eighteen GDM cases were ascertained. CGM-derived novel parameters demonstrated greater performance (e.g., area under the curve: 0.953 vs. 0.722) for predicting incident GDM compared with the model using traditional risks. Such novel CGM-derived parameters significantly differentiated primary cesarean and large-for-gestational age babies. CONCLUSIONS: Our data suggest CGM's potential clinical utility in the first trimester for predicting GDM and adverse pregnancy outcomes, particularly in individuals with overweight or obesity. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Validation of the first‐trimester machine learning model for predicting pre‐eclampsia in an Asian population.

Author

Nguyen‐Hoang, Long, Sahota, Daljit S., Pooh, Ritsuko K., Duan, Honglei, Chaiyasit, Noppadol, Sekizawa, Akihiko, Shaw, Steven W., Seshadri, Suresh, Choolani, Mahesh, Yapan, Piengbulan, Sim, Wen Shan, Ma, Runmei, Leung, Wing Cheong, Lau, So Ling, Lee, Nikki May Wing, Leung, Hiu Yu Hillary, Meshali, Tal, Meiri, Hamutal, Louzoun, Yoram, and Poon, Liona C.

Published
2024
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23. Antenatal corticosteroids in Singapore: a clinical and scientific assessment.

Author

Gosavi, Arundhati, Amin, Zubair, Carter, Sean William David, Choolani, Mahesh Arjandas, Fee, Erin Lesley, Milad, Mark Amir, Jobe, Alan Hall, and Kemp, Matthew Warren

Subjects
PREMATURE labor, REPRODUCTIVE technology, BODY mass index, GESTATIONAL diabetes, MATERNAL age
Abstract

Preterm birth (PTB; delivery prior to 37 weeks' gestation) is the leading cause of early childhood death in Singapore today. Approximately 9% of Singaporean babies are born preterm; the PTB rate is likely to increase given the increased use of assisted reproduction technologies, changes in the incidence of gestational diabetes/high body mass index and the ageing maternal population. Antenatal administration of dexamethasone phosphate is a key component of the obstetric management of Singaporean women who are at risk of imminent preterm labour. Dexamethasone improves preterm outcomes by crossing the placenta to functionally mature the fetal lung. The dexamethasone regimen used in Singapore today affords a very high maternofetal drug exposure over a brief period of time. Drawing on clinical and experimental data, we reviewed the pharmacokinetic profile and pharmacodynamic effects of dexamethasone treatment regimen in Singapore, with a view to creating a development pipeline for optimising this critically important antenatal therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Fetal Treatment 2017: The Evolution of Fetal Therapy Centers - A Joint Opinion from the International Fetal Medicine and Surgical Society (IFMSS) and the North American Fetal Therapy Network (NAFTNet).

Author

Moon-Grady, Anita J, Baschat, Ahmet, Cass, Darrell, Choolani, Mahesh, Copel, Joshua A, Crombleholme, Timothy M, Deprest, Jan, Emery, Stephen P, Evans, Mark I, Luks, Francois I, Norton, Mary E, Ryan, Greg, Tsao, Kuojen, Welch, Ross, and Harrison, Michael

Subjects
Humans, Fetal Therapies, Obstetrics, Pregnancy, Female, Advances in care, Ethics, Fetal therapy, Fetal therapy centers, Maternal autonomy and safety, State of the art, Pediatric, Perinatal Period - Conditions Originating in Perinatal Period, Reproductive health and childbirth, Good Health and Well Being, Paediatrics and Reproductive Medicine, Obstetrics & Reproductive Medicine
Abstract

More than 3 decades ago, a small group of physicians and other practitioners active in what they called "fetal treatment" authored an opinion piece outlining the current status and future challenges anticipated in the field. Many advances in maternal, neonatal, and perinatal care and diagnostic and therapeutic modalities have been made in the intervening years, yet a thoughtful reassessment of the basic tenets put forth in 1982 has not been published. The present effort will aim to provide a framework for contemporary redefinition of the field of fetal treatment, with a brief discussion of the necessary minimum expertise and systems base for the provision of different types of interventions for both the mother and fetus. Our goal will be to present an opinion that encourages the advancement of thoughtful practice, ensuring that current and future patients have realistic access to centers with a range of fetal therapies with appropriate expertise, experience, and subspecialty and institutional support while remaining focused on excellence in care, collaborative scientific discovery, and maternal autonomy and safety.

Published
2017

28. Insights of healthcare professionals regarding waterbirths and water immersion during labour: A mixed studies review.

Author

Chua, Joelle Yan Xin, Choolani, Mahesh, Lalor, Joan Gabrielle, Chong, Yap Seng, and Shorey, Shefaly

Subjects
*MEDICAL information storage & retrieval systems, *CINAHL database, *LABOR (Obstetrics), *HYDROTHERAPY, *DESCRIPTIVE statistics, *IMMERSION in liquids, *MEDLINE, *PRENATAL care, *ATTITUDES of medical personnel, *UNDERWATER childbirth, *ONLINE information services, *WOMEN'S health, *CHILDBIRTH, *PSYCHOLOGY information storage & retrieval systems, *NURTURING behavior, *PREGNANCY
Abstract

Aim: To consolidate healthcare professionals' insights about waterbirths and water immersion during labour. Design: Mixed studies review. Data Sources: Seven electronic databases were searched from their inception dates till June 2023: PubMed, Embase, CINAHL, PsycINFO, Web of Science, Scopus, ProQuest Dissertations and Theses Global. Methods: The Preferred Reporting Items for Systematic Reviews and Meta‐Analysis (PRISMA) guidelines and Pluye and Hong's mixed studies review framework guided this review. The quality of included studies was evaluated using the Mixed Methods Appraisal Tool. Findings were synthesized using the convergent qualitative synthesis method, and results were thematically analysed using Braun and Clarke's framework. Results: Three main themes were identified from the 22 included studies: (1) believing in waterbirths, (2) opposing forces and (3) plotting the course ahead. Conclusion: Healthcare professionals reported different views about waterbirths and water immersion practices; midwives were most likely to support these practices, followed by nurses and lastly, few physicians supported them. Reasons for opposing waterbirths include insufficient training and support from colleagues as well as concerns about work efficiency, waterbirth safety and litigation issues. Impact: The available evidence suggests the need to provide waterbirth training for healthcare professionals, equip healthcare facilities with necessary waterbirth‐related infrastructure and develop appropriate waterbirth policies/guidelines. Healthcare professionals could also consider providing antenatal waterbirth education to women and obtain women's feedback to improve current policies/guidelines. Future research should explore the views of different types of healthcare professionals from more diverse cultures. Reporting Method: The PRISMA guidelines. No Patient or Public Contribution: Systematic review. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Upregulation of hepatic nuclear receptors in extremely preterm ovine fetuses undergoing artificial placenta therapy

Author

Ikeda, Hideyuki, primary, Watanabe, Shimpei, additional, Sato, Shinichi, additional, Fee, Erin L., additional, Carter, Sean W. D., additional, Kumagai, Yusaku, additional, Takahashi, Tsukasa, additional, Kawamura, Shinichi, additional, Hanita, Takushi, additional, Illanes, Sebastian E., additional, Choolani, Mahesh A., additional, Saito, Masatoshi, additional, Kikuchi, Atsuo, additional, Kemp, Matthew W., additional, and Usuda, Haruo, additional

Published
2024
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32. ChatGPT outscored human candidates in a virtual objective structured clinical examination in obstetrics and gynecology

Author

Rauff, Mary, Biswas, Arijit, Low, Jeffrey J.H., Ng, Joseph S., Gosavi, Arundhati T., Huang, Zhongwei, Rajendran, Preethi, Ng, Kwok Weng Roy, Wong, Jeslyn J.L., Chan, Grace M.F., Lee, Kelvin Zhi Xing, Yap, Jeannie J.Y., Ahmad, Nurulhuda, Shanmugam, Shwetha, Kathirvel, Rajeswari, Mathur, Manisha, Lim, Whui Whui, Lim, Min Yu, Li, Sarah W., Kemp, Matthew W., Logan, Susan J.S., Dimri, Pooja Sharma, Singh, Navkaran, Mattar, Citra N.Z., Dashraath, Pradip, Ramlal, Harshaana, Mahyuddin, Aniza P., Kanayan, Suren, Carter, Sean W.D., Thain, Serene P.T., Fee, Erin L., Illanes, Sebastian E., and Choolani, Mahesh A.

Published
2023
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35. Healthcare in the era of climate change and the need for environmental sustainability.

Author

Chin Hock Tee, Nicholas, Yeo, Jo-Anne, Choolani, Mahesh, Kian Keong Poh, and Tiing Leong Ang

Abstract

Climate change is an existential threat to humanity. While the healthcare sector must manage the health-related consequences of climate change, it is a significant contributor to greenhouse gas emissions, responsible for up to 4.6% of global emission, aggravating global warming. Within the hospital environment, the three largest contributors to greenhouse gas emissions are the operating theatre, intensive care unit and gastrointestinal endoscopy. Knowledge of the health-related burden of climate change and the potential transformative health benefits of climate action is important to all health professionals, as they play crucial roles in effecting change. This article summarises the available literature on the impact of healthcare on climate change and efforts in mitigation, focusing on the intrinsic differences and similarities across the operating theatre complex, intensive care unit and gastrointestinal endoscopy unit. It also discusses strategies to reduce carbon footprint. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Chorioamnionitis: An Update on Diagnostic Evaluation

Author

Carter, Sean W. D., primary, Neubronner, Samantha, additional, Su, Lin Lin, additional, Dashraath, Pradip, additional, Mattar, Citra, additional, Illanes, Sebastián E., additional, Choolani, Mahesh A., additional, and Kemp, Matthew W., additional

Published
2023
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40. Identifying occult maternal malignancies from 1.93 million pregnant women undergoing noninvasive prenatal screening tests

Author

Ji, Xing, Li, Jia, Huang, Yonghua, Sung, Pi-Lin, Yuan, Yuying, Liu, Qiang, Chen, Yan, Ju, Jia, Zhou, Yafeng, Huang, Shujia, Chen, Fang, Han, Yuan, Yuan, Wen, Fan, Cheng, Zhao, Qiang, Wu, Haitao, Feng, Suihua, Liu, Weiqiang, Li, Zhihua, Chen, Jingsi, Chen, Min, Yao, Hong, Zeng, Li, Ma, Tao, Fan, Shushu, Zhang, Jinman, Yuen, Ka Yiu, Cheng, So Hin, Chik, Irene Wing Shan, Liu, Nien-Tzu, Zhu, Jianyu, Lin, Siyuan, Cao, Jeremy, Tong, Steve, Shan, Zhiyuan, Li, Wenyan, Hekmat, Mohammad Reza, Garshasbi, Masoud, Suela, Javier, Torres, Yaima, Cigudosa, Juan C., Ruiz, F. J. Pérez, Rodríguez, Laura, García, Mónica, Bernik, Janez, Traven, Eva, Reš, Uršula, Tul, Nataša, Tseng, Ching-Fong, Zhao, Depeng, Sun, Luming, Pan, Qiong, Shen, Li, Dai, Mengyao, Wang, Yuying, Wang, Jian, Yang, Huanming, Yin, Ye, Duan, Tao, Zhu, Baosheng, Choolani, Mahesh, Jin, Xin, Chen, Yingwei, and Mao, Mao

Published
2019
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41. Artificial placenta support of extremely preterm ovine fetuses at the border of viability for up to 336 hours with maintenance of systemic circulation but reduced somatic and organ growth

Author

Usuda, Haruo, primary, Ikeda, Hideyuki, additional, Watanabe, Shimpei, additional, Sato, Shinichi, additional, Fee, Erin L., additional, Carter, Sean W. D., additional, Kumagai, Yusaku, additional, Saito, Yuya, additional, Takahashi, Tsukasa, additional, Takahashi, Yuki, additional, Kawamura, Shinichi, additional, Hanita, Takushi, additional, Saito, Masatoshi, additional, Kikuchi, Atsuo, additional, Choolani, Mahesh A., additional, Yaegashi, Nobuo, additional, and Kemp, Matthew W., additional

Published
2023
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42. Third-Generation Single-Molecule Sequencing for Preimplantation Genetic Testing of Aneuploidy and Segmental Imbalances

Author

Tan, Vivienne J, primary, Liu, Timing, additional, Arifin, Zainul, additional, Pak, Beatrice, additional, Tan, Arnold S C, additional, Wong, Simin, additional, Khor, Chiea-Chuen, additional, Yang, Henry, additional, Lee, Caroline G, additional, Huang, Zhongwei, additional, Choolani, Mahesh A, additional, and Chong, Samuel S, additional

Published
2023
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47. Identifying Occult Maternal Malignancies From 1.93 Million Pregnant Women Undergoing Noninvasive Prenatal Screening Tests

Author

Ji, Xing, Li, Jia, Huang, Yonghua, Sung, Pi-Lin, Yuan, Yuying, Liu, Qiang, Chen, Yan, Ju, Jia, Zhou, Yafeng, Huang, Shujia, Chen, Fang, Han, Yuan, Yuan, Wen, Fan, Cheng, Zhao, Qiang, Wu, Haitao, Feng, Suihua, Liu, Weiqiang, Li, Zhihua, Chen, Jingsi, Chen, Min, Yao, Hong, Zeng, Li, Ma, Tao, Fan, Shushu, Zhang, Jinman, Yuen, Ka Yiu, Cheng, So Hin, Shan Chik, Irene Wing, Liu, Nien-Tzu, Zhu, Jianyu, Lin, Siyuan, Cao, Jeremy, Tong, Steve, Shan, Zhiyuan, Li, Wenyan, Hekmat, Mohammad Reza, Garshasbi, Masoud, Suela, Javier, Torres, Yaima, Cigudosa, Juan C., Pérez Ruiz, F. J., Rodríguez, Laura, García, Mónica, Bernik, Janez, Traven, Eva, Reš, Uršula, Tul, Nataša, Tseng, Ching-Fong, Zhao, Depeng, Sun, Luming, Pan, Qiong, Shen, Li, Dai, Mengyao, Wang, Yuying, Wang, Jian, Yang, Huanming, Yin, Ye, Duan, Tao, Zhu, Baosheng, Choolani, Mahesh, Jin, Xin, Chen, Yingwei, and Mao, Mao

Published
2020
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49. ChatGPT Outscored Human Candidates in a Virtual Objective Structured Clinical Examination (OSCE) in Obstetrics and Gynecology

Author

LI, Sarah W., primary, Kemp, Matthew W., additional, Logan, Susan J.S., additional, Dimri, Pooja Sharma, additional, Singh, Navkaran, additional, Mattar, Citra N.Z., additional, Dashraath, Pradip, additional, Ramlal, Harshaana, additional, Mahyuddin, Aniza P., additional, Kanayan, Suren, additional, Carter, Sean W.D., additional, Thain, Serene P.T., additional, Fee, Erin L., additional, Illanes, Sebastian E., additional, Choolani, Mahesh A., additional, Rauff, Mary, additional, Biswas, Arijit, additional, Low, Jeffrey J.H., additional, Ng, Joseph S., additional, Roy Ng, Kwok Weng, additional, Gosavi, Arundhati T., additional, Kathirvel, Rajeswari, additional, Huang, Zhongwei, additional, Wong, Jeslyn J.L., additional, Mathur, Manisha, additional, Lim, Whui Whui, additional, Lim, Min Yu, additional, Chan, Grace M.F., additional, Xing Lee, Kelvin Zhi, additional, Yap, Jeannie J.Y., additional, Ahmad, Nurulhuda, additional, Shanmugam, Shwetha, additional, and Rajendran, Preethi, additional

Published
2023
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50. LPCAT1 levels in the placenta, the maternal plasma and the fetal plasma do not predict fetal lung responses to glucocorticoids in a sheep model of pregnancy

Author

Takahashi, Tsukasa, primary, Fee, Erin L., additional, Takahashi, Yuki, additional, Usuda, Haruo, additional, Carter, Sean W.D., additional, Ikeda, Hideyuki, additional, Saito, Masatoshi, additional, Kumagai, Yusaku, additional, Bridges, James P., additional, Jobe, Alan H., additional, Choolani, Mahesh A., additional, and Kemp, Matthew W., additional

Published
2023
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