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Context: The rice-wheat (RW) system, spanning 13.5 million hectares in South Asia, is crucial for food security and livelihoods. However, intensive conventional tillage-based practices have harmed soil and environmental health, decreased productivity trends and increased greenhouse gas emissions. Objective: This study aims to develop resilient, climate-smart cropping systems within the RW system, focusing on soil and crop productivity, economic viability, and reduced greenhouse gas (GHG) emissions. Methods: Over eight years, the study evaluated diverse parameters compared to farmer practices (FP) in seven scenarios (Sc), including one representing FP (Sc1) and six based on conservation agriculture (CA) principles. The study assessed system crop productivity, economic returns, soil quality (organic carbon; OC, nitrogen; N, phosphorus; P, potassium; K contents, bulk density; BD, soil aggregation, infiltration rates, microbial counts, and earthworm density), and GHG emissions. Results: CA-based scenarios (Sc2 to Sc7) showed improved soil quality, lower bulk density, enhanced soil aggregation, and increased infiltration rates compared to Sc1. In the 0–15 cm layer, surface soil organic carbon (OC) and C stock were 63.7 % and 49.6 % higher, respectively, in CA-based scenarios. Additionally, available N, P and K contents in the surface layer increased by 10.2 %, 28.6 %, and 21.8 % under CA-based scenarios. Adoption of CA in intensified maize-based scenarios (Sc4 and Sc5) led to the increased system and economic yields, higher soil quality index (SQI), reduced GHG emissions and increased C stock compared to Sc1. Implications: The study highlights that Conservation Agriculture (CA) practices and diversified crop rotations can address issues like falling crop productivity, reduced economic returns, soil degradation, and increasing environmental impacts in northwestern India's traditional rice-wheat system. However, widespread adoption requires government policies, including C credit payments and guaranteed markets with supportive pricing.

BackgroundWith the emergence of SARS-CoV-2 variants resistant to monoclonal antibody therapies and limited global access to therapeutics, the evaluation of novel therapeutics to prevent progression to severe COVID-19 remains a critical need.MethodsSafety, clinical and antiviral efficacy of inhaled interferon-β1a (SNG001) were evaluated in a phase II randomized controlled trial on the ACTIV-2/A5401 platform (ClinicalTrials.govNCT04518410). Adult outpatients with confirmed SARS-CoV-2 infection within 10 days of symptom onset were randomized and initiated either orally inhaled nebulized SNG001 given once daily for 14 days (n = 110) or blinded pooled placebo (n = 110) between February 10 and August 18, 2021.FindingsThe proportion of participants reporting premature treatment discontinuation was 9% among SNG001 and 13% among placebo participants. There were no differences between participants who received SNG001 or placebo in the primary outcomes of treatment emergent Grade 3 or higher adverse events (3.6% and 8.2%, respectively), time to symptom improvement (median 13 and 9 days, respectively), or proportion with unquantifiable nasopharyngeal SARS-CoV-2 RNA at days 3 (28% [26/93] vs. 39% [37/94], respectively), 7 (65% [60/93] vs. 66% [62/94]) and 14 (91% [86/95] vs. 91% [83/81]). There were fewer hospitalizations with SNG001 (n = 1; 1%) compared with placebo (n = 7; 6%), representing an 86% relative risk reduction (p = 0.07). There were no deaths in either arm.InterpretationIn this trial, SNG001 was safe and associated with a non-statistically significant decrease in hospitalization for COVID-19 pneumonia.FundingThe ACTIV-2 platform study is funded by the NIH. Research reported in this publication was supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under Award Number UM1 AI068634, UM1 AI068636 and UM1 AI106701. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Soil provides essential nutrients for plant growth, but excess salts hinder development, making crops more vulnerable under climate change conditions. Soil microorganisms play a significant role in nutrient cycling. However, limited information is available on microbial behavior/community changes, and functional diversity in different soil types (normal, sodic, and highly sodic) and cropping systems [rice-wheat (RW); rice-wheat-mungbean (RWMb); maizewheat-mungbean (MWMb)] and management practices in the north-western Indo-Gangetic Plains of India. We investigated the influence of different soil types on physical and chemical properties at the surface level (0-15 cm) in relation to soil microbial population, activities, and functional diversity, focusing on community-level physiological profiling (CLPP) under different agriculture systems. Seven treatment combinations of soil types, cropping systems, and management practices were evaluated. Soil pHs were found to be lower in zerotill (ZT)-based sodic soil than in conventional-till (CT) sodic soil. Soil organic carbon (SOC) (0.91 and 0.90%) content and available N (154.46 and 132.74 kg ha-1) were higher with the ZT-based system under normal (N) soils (ZT-RWMb-N and ZT-MWMb-N) than in CT-based normal soil (0.67 and 121.04 kg ha-1). Similarly, higher SOC and N (0.85 and 76.11 kg ha-1) were found under ZT management in sodic soils (S) than under CT management (0.73% and 121.05 kg ha-1). Substrate utilization (amino acids, amines, carbohydrates, carboxylic acids, phenolic compounds, and polymers) increased with the incubation period. During 0-120 h of incubation, the highest utilization of amino acids, amines, carboxylic acids, phenolic compounds, and polymers was observed for ZT-MWMb-S soils, while the lowest was recorded for ZT-MWMb-N soils. Under high salt conditions, soil enzymatic activities (dehydrogenase, acid phosphatase, alkaline phosphatase, etc.) declined significantly compared to normal soils, affecting soil chemical and physical conditions. Microbial population and enzyme activities decreased with increasing salt stress across all cropping systems. These findings suggest that adopting efficient crop management practices can help mitigate the adverse effects of soil salinity on microbial diversity and soil health, thereby enhancing sustainable agricultural productivity in salt-affected regions. [ABSTRACT FROM AUTHOR]

Continuous rice-wheat (RW) rotation with conventional agronomic practices has resulted in declining factor productivity and degrading soil resources. A farmer's participatory research trial was conducted in Karnal, India to evaluate 8 combinations of cropping systems, tillage, crop establishment method and residue management effects on key soil physico-chemical and biological properties. Treatments (T) 1–4 involved RW and 5–8 maize-wheat (MW) with conventional tillage (CT) and zero tillage (ZT) with (+ R) and without (− R) residue recycling. Residue was either incorporated (Ri) or mulched (Rm). Treatment 1 (RW/CT − R) had the highest bulk density (BD) (1.47 Mg m−3) and T8 (MW/ZT + Rm), the lowest (1.34 Mg m−3). After 3 years of cropping, soil accumulated more organic C in (a) MW (9.33 Mg ha−1) than RW (8.5 Mg ha−1), (b) ZT (9.25 Mg ha−1) than CT (8.58 Mg ha−1), and (c) + R (10.18 Mg ha−1) than –R (7.65 Mg ha−1). MW system with ZT and residue (T8: MW/ZT + Rm) registered 208, 263, 210 and 48% improvement in soil microbial biomass C (MBC) and N, dehydrogenase activity (DHA) and alkaline phosphatase activity (APA), whereas RW system in T4 (RW/ZT + Rm) registered 83, 81, 44 and 13%, respectively as compared with T1 (RW/CT − R), the business as usual scenario. Treatment 8 (MW/ZT + Rm) recorded the highest microbial population viz. bacteria, fungi and actinomycetes. The most abundant micro-arthropods present in the soil of experimental plot were Collembola, Acari and Protura which varied with treatments. Soil MBC, APA, BD and micro-arthropod population were identified as the key indicators and contributed significantly towards soil quality index (SQI). MW system with ZT and Rm (T8) recorded the highest SQI (1.45) followed by T6 (1.34) and the lowest score (0.29) being in T1 (RW/CT − R). The SQI was higher by 90% in MW compared to RW, 22% in ZT compared to CT, and 100% in residue recycling compared with residue removal. System yield was strongly related to key soil quality indicators and also positively correlated with SQI. Longer-term studies are essential to realize maximal effects of improvements in soil health on crop yields.