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310 results on '"Chouker, A."'

1. How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?

Author

Willis, Craig R. G., Calvaruso, Marco, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Chouker, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Herranz, Raúl, Hellweg, Christine, Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Risaliti, Chiara, Santucci, Daniela, Sperl, Matthias, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Monici, Monica, and Szewczyk, Nathaniel J.

Published
2024
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2. How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?

Author

Craig R. G. Willis, Marco Calvaruso, Debora Angeloni, Sarah Baatout, Alexandra Benchoua, Juergen Bereiter-Hahn, Daniele Bottai, Judith-Irina Buchheim, Eugénie Carnero-Diaz, Sara Castiglioni, Duccio Cavalieri, Gabriele Ceccarelli, Alexander Chouker, Francesca Cialdai, Gianni Ciofani, Giuseppe Coppola, Gabriella Cusella, Andrea Degl’Innocenti, Jean-Francois Desaphy, Jean-Pol Frippiat, Michael Gelinsky, Giada Genchi, Maria Grano, Daniela Grimm, Alain Guignandon, Raúl Herranz, Christine Hellweg, Carlo Saverio Iorio, Thodoris Karapantsios, Jack van Loon, Matteo Lulli, Jeanette Maier, Jos Malda, Emina Mamaca, Lucia Morbidelli, Andreas Osterman, Aleksandr Ovsianikov, Francesco Pampaloni, Elizabeth Pavezlorie, Veronica Pereda-Campos, Cyrille Przybyla, Petra Rettberg, Angela Maria Rizzo, Kate Robson-Brown, Leonardo Rossi, Giorgio Russo, Alessandra Salvetti, Chiara Risaliti, Daniela Santucci, Matthias Sperl, Kevin Tabury, Sara Tavella, Christiane Thielemann, Ronnie Willaert, Monica Monici, and Nathaniel J. Szewczyk

Subjects
Biotechnology, TP248.13-248.65, Physiology, QP1-981
Abstract

Abstract Periodically, the European Space Agency (ESA) updates scientific roadmaps in consultation with the scientific community. The ESA SciSpacE Science Community White Paper (SSCWP) 9, “Biology in Space and Analogue Environments”, focusses in 5 main topic areas, aiming to address key community-identified knowledge gaps in Space Biology. Here we present one of the identified topic areas, which is also an unanswered question of life science research in Space: “How to Obtain an Integrated Picture of the Molecular Networks Involved in Adaptation to Microgravity in Different Biological Systems?” The manuscript reports the main gaps of knowledge which have been identified by the community in the above topic area as well as the approach the community indicates to address the gaps not yet bridged. Moreover, the relevance that these research activities might have for the space exploration programs and also for application in industrial and technological fields on Earth is briefly discussed.

Published
2024
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7. The kidney, volume homeostasis and osmoregulation in space: current perspective and knowledge gaps

Author

Rik H. G. Olde Engberink, Paula J. van Oosten, Tobias Weber, Kevin Tabury, Sarah Baatout, Keith Siew, Stephen B. Walsh, Giovanna Valenti, Alexander Chouker, Pierre Boutouyrie, Martina Heer, Jens Jordan, and Nandu Goswami

Subjects
Biotechnology, TP248.13-248.65, Physiology, QP1-981
Abstract

Abstract Although we have sent humans into space for more than 50 years crucial questions regarding kidney physiology, volume regulation and osmoregulation remain unanswered. The complex interactions between the renin-angiotensin-aldosterone system, the sympathetic nervous system, osmoregulatory responses, glomerular function, tubular function, and environmental factors such as sodium and water intake, motion sickness and ambient temperature make it difficult to establish the exact effect of microgravity and the subsequent fluid shifts and muscle mass loss on these parameters. Unfortunately, not all responses to actual microgravity can be reproduced with head-down tilt bed rest studies, which complicates research on Earth. Better understanding of the effects of microgravity on kidney function, volume regulation and osmoregulation are needed with the advent of long-term deep space missions and planetary surface explorations during which orthostatic intolerance complaints or kidney stone formation can be life-threatening for astronauts. Galactic cosmic radiation may be a new threat to kidney function. In this review, we summarise and highlight the current understandings of the effects of microgravity on kidney function, volume regulation and osmoregulation and discuss knowledge gaps that future studies should address.

Published
2023
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13. Breath Gas Analysis

Author

Dolch, Michael, Praun, Siegfried, Villiger, Johannes, Choukér, Alexander, Schelling, Gustav, and Choukèr, Alexander, editor

Published
2020
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18. Entering a New Era of Holistic Research in Establishing Groundwork for Future Human Space Exploration: Perspectives from the ESA-Topical Team 'Stress and Immunity'

Author

Choukér, Alexander, Baatout, Sarah, Campolongo, Patrizia, Frippiat, Jean-Pol, Gopalakrishnan, Jay, Kaufmann, Ines, Montano, Nicola, Praun, Siegfried, de Quervain, Dominique, Roozendaal, Benno, Schelling, Gustav, Thiel, Manfred, Thieme, Detlef, Viola, Antoine, Buchheim, Judith-Irina, Salam, Alex, Guo, Anne, and Choukèr, Alexander, editor

Published
2020
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19. Immunology

Author

Buchheim, Judith-Irina, Crucian, Brian, Choukér, Alexander, Norsk, Peter, Section editor, Young, Laurence R., editor, and Sutton, Jeffrey P., editor

Published
2021
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23. How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?

Author

Willis, Craig R G, Calvaruso, Marco, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Chouker, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Herranz, Raúl, Hellweg, Christine, Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Risaliti, Chiara, Santucci, Daniela, Sperl, Matthias, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Monici, Monica, Szewczyk, Nathaniel J, Willis, Craig R G, Calvaruso, Marco, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith-Irina, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Chouker, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl'Innocenti, Andrea, Desaphy, Jean-Francois, Frippiat, Jean-Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Herranz, Raúl, Hellweg, Christine, Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Risaliti, Chiara, Santucci, Daniela, Sperl, Matthias, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Monici, Monica, and Szewczyk, Nathaniel J

Abstract

Periodically, the European Space Agency (ESA) updates scientific roadmaps in consultation with the scientific community. The ESA SciSpacE Science Community White Paper (SSCWP) 9, "Biology in Space and Analogue Environments", focusses in 5 main topic areas, aiming to address key community-identified knowledge gaps in Space Biology. Here we present one of the identified topic areas, which is also an unanswered question of life science research in Space: "How to Obtain an Integrated Picture of the Molecular Networks Involved in Adaptation to Microgravity in Different Biological Systems?" The manuscript reports the main gaps of knowledge which have been identified by the community in the above topic area as well as the approach the community indicates to address the gaps not yet bridged. Moreover, the relevance that these research activities might have for the space exploration programs and also for application in industrial and technological fields on Earth is briefly discussed.

Published
2024

24. How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?

Author

Zorgeenheid Orthopaedie Medisch, Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Willis, Craig R.G., Calvaruso, Marco, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith Irina, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Chouker, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean Francois, Frippiat, Jean Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Herranz, Raúl, Hellweg, Christine, Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Risaliti, Chiara, Santucci, Daniela, Sperl, Matthias, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Monici, Monica, Szewczyk, Nathaniel J., Zorgeenheid Orthopaedie Medisch, Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, Willis, Craig R.G., Calvaruso, Marco, Angeloni, Debora, Baatout, Sarah, Benchoua, Alexandra, Bereiter-Hahn, Juergen, Bottai, Daniele, Buchheim, Judith Irina, Carnero-Diaz, Eugénie, Castiglioni, Sara, Cavalieri, Duccio, Ceccarelli, Gabriele, Chouker, Alexander, Cialdai, Francesca, Ciofani, Gianni, Coppola, Giuseppe, Cusella, Gabriella, Degl’Innocenti, Andrea, Desaphy, Jean Francois, Frippiat, Jean Pol, Gelinsky, Michael, Genchi, Giada, Grano, Maria, Grimm, Daniela, Guignandon, Alain, Herranz, Raúl, Hellweg, Christine, Iorio, Carlo Saverio, Karapantsios, Thodoris, van Loon, Jack, Lulli, Matteo, Maier, Jeanette, Malda, Jos, Mamaca, Emina, Morbidelli, Lucia, Osterman, Andreas, Ovsianikov, Aleksandr, Pampaloni, Francesco, Pavezlorie, Elizabeth, Pereda-Campos, Veronica, Przybyla, Cyrille, Rettberg, Petra, Rizzo, Angela Maria, Robson-Brown, Kate, Rossi, Leonardo, Russo, Giorgio, Salvetti, Alessandra, Risaliti, Chiara, Santucci, Daniela, Sperl, Matthias, Tabury, Kevin, Tavella, Sara, Thielemann, Christiane, Willaert, Ronnie, Monici, Monica, and Szewczyk, Nathaniel J.

Published
2024

33. The Immune System in Evolution

Author

Yi, Buqing, Thiel, Manfred, Choukèr, Alexander, Ruyters, Günter, Series editor, Braun, Markus, Series editor, Choukèr, Alexander, and Ullrich, Oliver

Published
2016
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41. Breath Gas Analysis

Author

Dolch, Michael, Praun, Siegfried, Villiger, Johannes, Choukèr, Alexander, Schelling, Gustav, and Chouker, Alexander, editor

Published
2012
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48. Stress Induced Immune Dysregulation: A Continuum Spanning Antarctica Winterover, Spaceflight, and Terrestrial Patients

Author

Krieger, Stephanie, Makedonas, George, Mehta, Satish, Nelman, Mayra, Pierson, Duane, Tyring, Stephen, Chouker, Alexander, Feuerecker, Matthias, Strewe, Claudia, Sams, Clarence, and Crucian, Brian

Subjects
Life Sciences (General)
Abstract

Spaceflight is a unique environment characterized by stress, microgravity, isolation, circadian misalignment, and radiation exposure and impacts immune health. Planned long duration missions to Mars are a top priority for NASA and mitigating the negative health consequences of spaceflight is particularly important. Terrestrial analogs are a vital aspect of spaceflight research since data from astronauts is limited and it is costly to receive samples from ISS. The most relevant ground analog would include station lifestyle, stress, disrupted circadian rhythms and isolation. This analysis compares various aspects of immune dysregulation in astronauts during long-duration orbital spaceflight to groundanalogs. Astronaut data were also compared to a clinical immunodeficiency population, shingles patients, to help interpret clinical risks during deep space missions. A comprehensive evaluation was performed across hypoxic interior Antarctica, normoxic coastal Antarctica, HERA, and astronauts which included plasma and mitogen stimulated cytokine profiles, T-cell function, and peripheral leukocyte distribution. A cross platform analysis was then performed to define in-flight immune alterations, determine analog appropriateness, and interpret clinical risk.

Published
2019

49. Update: Antarctic Winterover as an Analog for Spaceflight Immune Dysregulation

Author

Makedonas, George, Mehta, Satish K, Krieger, Stephanie S, Chouker, Alexander, Basner, Mathias, Stahn, Alexnder, Pierson, Duane L, and Crucian, Brian E

Subjects
Aerospace Medicine
Abstract

Orbital spaceflight perturbs the human immune system significantly; Natural Killer (NK) and T-lymphocyte (T) cell functions are most susceptible to spaceflight-induced impairment. This loss of function may manifest in persistent latent virus reactivation (CMV, EBV, VZV), which does occur at a higher frequency in astronauts compared to earthlings.

Published
2019

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