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2. RIPPLE-VT study: Multicenter prospective evaluation of ventricular tachycardia substrate ablation by targeting scar channels to eliminate latest scar potentials without direct ablation

Author

Katritsis, George, Kailey, Balrik, Jamil-Copley, Shahnaz, Luther, Vishal, Koa-Wing, Michael, Cortez-Dias, Nuno, Carpinteiro, Luis, de Sousa, Joao, Martin, Ruairidh, Murray, Stephen, Das, Moloy, Whinnett, Zachary, Lim, Phang Boon, Peters, Nicholas S., Ng, Fu S., Chow, Anthony W., Linton, Nick W.F., and Kanagaratnam, Prapa

Published
2024
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5. Long-Term Impact of Body Mass Index on Survival of Patients Undergoing Cardiac Resynchronization Therapy: A Multi-Centre Study

Author

Papageorgiou, Nikolaos, Briasoulis, Alexandros, Barra, Sergio, Sohrabi, Catrin, Lim, Wei-Yao, Agarwal, Sharad, Oikonomou, Evaggelos, Duehmke, Rudolf, Roubicek, Tomas, Polasek, Rostislav, Behar, Jonathan M., Rinaldi, Christopher A., Neto, Micaela, Goncalves, Mariana, Adragao, Pedro, Tousoulis, Dimitris, Creta, Antonio, Rowland, Edward, Ahsan, Syed, Schilling, Richard J., Lambiase, Pier D., Lowe, Martin, Chow, Anthony W., and Providencia, Rui

Published
2021
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6. 2024 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Complicated Intra-abdominal Infections: Risk Assessment in Adults and Children.

Author

Bonomo, Robert A, Chow, Anthony W, Abrahamian, Fredrick M, Bessesen, Mary, Dellinger, E Patchen, Edwards, Morven S, Goldstein, Ellie, Hayden, Mary K, Humphries, Romney, Kaye, Keith S, Potoski, Brian A, Rodríguez-Baño, Jesús, Sawyer, Robert, Skalweit, Marion, Snydman, David R, Tamma, Pranita D, Donnelly, Katelyn, Kaur, Dipleen, and Loveless, Jennifer

Subjects
*MEDICAL protocols, *COMMUNICABLE diseases, *RISK assessment, *DIAGNOSTIC imaging, *PATIENTS, *HOSPITAL admission & discharge, *INTRA-abdominal infections, *PREGNANT women, *SEVERITY of illness index, *HOSPITAL mortality, *INTENSIVE care units, *DISEASE risk factors
Abstract

This paper is part of a clinical practice guideline update on the risk assessment, diagnostic imaging, and microbiological evaluation of complicated intra-abdominal infections in adults, children, and pregnant people, developed by the Infectious Diseases Society of America. In this paper, the panel provides a recommendation for risk stratification according to severity of illness score. The panel's recommendation is based on evidence derived from systematic literature reviews and adheres to a standardized methodology for rating the certainty of evidence and strength of recommendation according to the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) approach. [ABSTRACT FROM AUTHOR]

Published
2024
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7. 2024 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Complicated Intra-abdominal Infections: Risk Assessment, Diagnostic Imaging, and Microbiological Evaluation in Adults, Children, and Pregnant People.

Author

Bonomo, Robert A, Chow, Anthony W, Edwards, Morven S, Humphries, Romney, Tamma, Pranita D, Abrahamian, Fredrick M, Bessesen, Mary, Dellinger, E Patchen, Goldstein, Ellie, Hayden, Mary K, Kaye, Keith S, Potoski, Brian A, Rodríguez-Baño, Jesús, Sawyer, Robert, Skalweit, Marion, Snydman, David R, Pahlke, Sarah, Donnelly, Katelyn, and Loveless, Jennifer

Subjects
*MEDICAL protocols, *RISK assessment, *INTRA-abdominal infections, *DISEASE risk factors, *CHILDREN, *ADULTS, *PREGNANCY
Abstract

As the first part of an update to the clinical practice guideline on the diagnosis and management of complicated intra-abdominal infections in adults, children, and pregnant people, developed by the Infectious Diseases Society of America, the panel presents 21 updated recommendations. These recommendations span risk assessment, diagnostic imaging, and microbiological evaluation. The panel's recommendations are based on evidence derived from systematic literature reviews and adhere to a standardized methodology for rating the certainty of evidence and strength of recommendation according to the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) approach. [ABSTRACT FROM AUTHOR]

Published
2024
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8. 2024 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Complicated Intra-abdominal Infections: Diagnostic Imaging of Suspected Acute Intra-abdominal Abscess in Adults, Children, and Pregnant People.

Author

Bonomo, Robert A, Tamma, Pranita D, Abrahamian, Fredrick M, Bessesen, Mary, Chow, Anthony W, Dellinger, E Patchen, Edwards, Morven S, Goldstein, Ellie, Hayden, Mary K, Humphries, Romney, Kaye, Keith S, Potoski, Brian A, Rodríguez-Baño, Jesús, Sawyer, Robert, Skalweit, Marion, Snydman, David R, Donnelly, Katelyn, and Loveless, Jennifer

Subjects
COMMUNICABLE disease diagnosis, MEDICAL protocols, COMMUNICABLE diseases, ABDOMINAL abscess, COMPUTED tomography, INTRA-abdominal infections, ULTRASONIC imaging, MAGNETIC resonance imaging, PREGNANT women, PREGNANCY complications
Abstract

This article is part of a clinical practice guideline update on the risk assessment, diagnostic imaging, and microbiological evaluation of complicated intra-abdominal infections in adults, children, and pregnant people, developed by the Infectious Diseases Society of America. In this article, the panel provides recommendations for diagnostic imaging of suspected acute intra-abdominal abscess. The panel's recommendations are based on evidence derived from systematic literature reviews and adhere to a standardized methodology for rating the certainty of evidence and strength of recommendation according to the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach. [ABSTRACT FROM AUTHOR]

Published
2024
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9. 2024 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Complicated Intra-abdominal Infections: Utility of Intra-abdominal Fluid Cultures in Adults, Children, and Pregnant People.

Author

Bonomo, Robert A, Humphries, Romney, Abrahamian, Fredrick M, Bessesen, Mary, Chow, Anthony W, Dellinger, E Patchen, Edwards, Morven S, Goldstein, Ellie, Hayden, Mary K, Kaye, Keith S, Potoski, Brian A, Rodríguez-Baño, Jesús, Sawyer, Robert, Skalweit, Marion, Snydman, David R, Tamma, Pranita D, Donnelly, Katelyn, and Loveless, Jennifer

Subjects
MEDICAL protocols, COMMUNICABLE diseases, RISK assessment, MEDICAL personnel, INTRA-abdominal infections, PREGNANT women, EXTRACELLULAR fluid, PREGNANCY complications, PSYCHOSOCIAL factors, DISEASE risk factors, CHILDREN, ADULTS, PREGNANCY
Abstract

This paper is part of a clinical practice guideline update on the risk assessment, diagnostic imaging, and microbiological evaluation of complicated intra-abdominal infections in adults, children, and pregnant people, developed by the Infectious Diseases Society of America. In this paper, the panel provides recommendations for obtaining cultures of intra-abdominal fluid in patients with known or suspected intra-abdominal infection. The panel's recommendations are based on evidence derived from systematic literature reviews and adhere to a standardized methodology for rating the certainty of evidence and strength of recommendation according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. [ABSTRACT FROM AUTHOR]

Published
2024
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10. 2024 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Complicated Intra-abdominal Infections: Utility of Blood Cultures in Adults, Children, and Pregnant People.

Author

Bonomo, Robert A, Humphries, Romney, Abrahamian, Fredrick M, Bessesen, Mary, Chow, Anthony W, Dellinger, E Patchen, Edwards, Morven S, Goldstein, Ellie, Hayden, Mary K, Kaye, Keith S, Potoski, Brian A, Rodríguez-Baño, Jesús, Sawyer, Robert, Skalweit, Marion, Snydman, David R, Tamma, Pranita D, Pahlke, Sarah, Donnelly, Katelyn, and Loveless, Jennifer

Subjects
COMMUNICABLE disease diagnosis, MEDICAL protocols, COMMUNICABLE diseases, BLOOD, INTRA-abdominal infections, PREGNANT women, CELL culture, PREGNANCY complications, CHILDREN, ADULTS, PREGNANCY
Abstract

This article is part of a clinical practice guideline update on the risk assessment, diagnostic imaging, and microbiological evaluation of complicated intra-abdominal infections in adults, children, and pregnant people, developed by the Infectious Diseases Society of America. In this guideline, the panel provides recommendations for obtaining blood cultures in patients with known or suspected intra-abdominal infection. The panel's recommendations are based on evidence derived from systematic literature reviews and adhere to a standardized methodology for rating the certainty of evidence and strength of recommendation according to the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach. [ABSTRACT FROM AUTHOR]

Published
2024
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11. 2024 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Complicated Intra-abdominal Infections: Diagnostic Imaging of Suspected Acute Diverticulitis in Adults and Pregnant People.

Author

Bonomo, Robert A, Tamma, Pranita D, Abrahamian, Fredrick M, Bessesen, Mary, Chow, Anthony W, Dellinger, E Patchen, Edwards, Morven S, Goldstein, Ellie, Hayden, Mary K, Humphries, Romney, Kaye, Keith S, Potoski, Brian A, Rodríguez-Baño, Jesús, Sawyer, Robert, Skalweit, Marion, Snydman, David R, Donnelly, Katelyn, and Loveless, Jennifer

Subjects
COMMUNICABLE disease diagnosis, COMMUNICABLE diseases, MEDICAL protocols, RISK assessment, COMPUTED tomography, MAGNETIC resonance imaging, DIVERTICULITIS, PREGNANCY complications, MICROBIOLOGICAL techniques, DISEASE risk factors, DISEASE complications, CHILDREN, ADULTS, PREGNANCY
Abstract

This paper is part of a clinical practice guideline update on the risk assessment, diagnostic imaging, and microbiological evaluation of complicated intra-abdominal infections in adults, children, and pregnant people, developed by the Infectious Diseases Society of America. In this paper, the panel provides recommendations for diagnostic imaging of suspected acute diverticulitis. The panel's recommendations are based on evidence derived from systematic literature reviews and adhere to a standardized methodology for rating the certainty of evidence and strength of recommendation according to the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach. [ABSTRACT FROM AUTHOR]

Published
2024
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12. 2024 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Complicated Intraabdominal Infections: Diagnostic Imaging of Suspected Acute Cholecystitis and Acute Cholangitis in Adults, Children, and Pregnant People.

Author

Bonomo, Robert A, Edwards, Morven S, Abrahamian, Fredrick M, Bessesen, Mary, Chow, Anthony W, Dellinger, E Patchen, Goldstein, Ellie, Hayden, Mary K, Humphries, Romney, Kaye, Potoski, Brian A, Rodríguez-Baño, Sawyer, Robert, Skalweit, Marion, Snydman, David R, Tamma, Pranita D, Donnelly, Katelyn, and Loveless, Jennifer

Subjects
ULTRASONIC imaging of the abdomen, MEDICAL protocols, RISK assessment, CHOLANGITIS, COMPUTED tomography, INTRA-abdominal infections, MAGNETIC resonance imaging, CHOLECYSTITIS, MICROBIOLOGICAL techniques, ENDOSCOPIC retrograde cholangiopancreatography, DISEASE complications, CHILDREN, ADULTS, PREGNANCY
Abstract

This article is part of a clinical practice guideline update on the risk assessment, diagnostic imaging, and microbiological evaluation of complicated intraabdominal infections in adults, children, and pregnant people, developed by the Infectious Diseases Society of America. In this article, the panel provides recommendations for diagnostic imaging of suspected acute cholecystitis and acute cholangitis. The panel's recommendations are based on evidence derived from systematic literature reviews and adhere to a standardized methodology for rating the certainty of evidence and strength of recommendation according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. [ABSTRACT FROM AUTHOR]

Published
2024
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13. 2024 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Complicated Intra-abdominal Infections: Diagnostic Imaging of Suspected Acute Appendicitis in Adults, Children, and Pregnant People.

Author

Bonomo, Robert A, Tamma, Pranita D, Abrahamian, Fredrick M, Bessesen, Mary, Chow, Anthony W, Dellinger, E Patchen, Edwards, Morven S, Goldstein, Ellie, Hayden, Mary K, Humphries, Romney, Kaye, Keith S, Potoski, Brian A, Rodríguez-Baño, Jesús, Sawyer, Robert, Skalweit, Marion, Snydman, David R, Donnelly, Katelyn, and Loveless, Jennifer

Subjects
APPENDICITIS diagnosis, COMMUNICABLE disease diagnosis, MEDICAL protocols, COMMUNICABLE diseases, DIAGNOSTIC imaging, INTRA-abdominal infections, PREGNANCY complications, DISEASE risk factors, CHILDREN, ADULTS, PREGNANCY
Abstract

This paper is part of a clinical practice guideline update on the risk assessment, diagnostic imaging, and microbiological evaluation of complicated intra-abdominal infections in adults, children, and pregnant people, developed by the Infectious Diseases Society of America (IDSA). In this paper, the panel provides recommendations for diagnostic imaging of suspected acute appendicitis. The panel's recommendations are based on evidence derived from systematic literature reviews and adhere to a standardized methodology for rating the certainty of evidence and strength of recommendation according to the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Catheter ablation for fascicular ventricular tachycardia: A systematic review

Author

Creta, Antonio, Chow, Anthony W., Sporton, Simon, Finlay, Malcolm, Papageorgiou, Nikolaos, Honarbakhsh, Shohreh, Dhillon, Gurpreet, Graham, Adam, Patel, Kiran H.K., Dhinoja, Mehul, Earley, Mark J., Hunter, Ross J., Lowe, Martin, Rowland, Edward, Segal, Oliver R., Calabrese, Vito, Ricciardi, Danilo, Lambiase, Pier D., Schilling, Richard J., and Providência, Rui

Published
2019
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23. PO-03-103 OMNIPOLAR VOLTAGE MAPPING DURING AF EFFECTIVELY OVERCOMES THE IMPACT WAVEFRONT COLLISION AND FRACTIONATION HAS ON BIPOLAR VOLTAGE MAPS AND MORE EFFECTIVELY IDENTIFIES SITES OF PV RECONNECTION AT PREVIOUS WIDE AREA CIRCUMFERENTIAL LINES COMPARED TO BIPOLAR VOLTAGE MAPS

Author

Butcher, Charles, primary, Roney, Caroline H., additional, Ahluwalia, Nikhil, additional, Wharmby, Amy L., additional, Chow, Anthony W., additional, Lambiase, Pier D., additional, Hunter, Ross J., additional, and Honarbakhsh, Shohreh, additional

Published
2023
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24. EN-452414-1 IMPACT OF MULTI-DIRECTIONAL PACING ON LATE SIGNAL ACTIVATION, ACTIVATION SLOWING AND REPOLARIZATION GRADIENTS TO LOCALIZE RE-ENTRANT VENTRICULAR TACHYCARDIA CIRCUITS IN A PORCINE INFARCT MODEL.

Author

Dennis, Adam S., primary, Orini, Michele, additional, Hesselkilde, Eva Melis, additional, Saljic, Arnela, additional, Linz, Benedikt M., additional, Sattler, Stefan M., additional, Tfelt-Hansen, Jacob, additional, Jespersen, Thomas, additional, Chow, Anthony W., additional, and Lambiase, Pier D., additional

Published
2023
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26. PO-03-070 RIPPLE-VT STUDY: MULTICENTRE, PROSPECTIVE EVALUATION OF VENTRICULAR TACHYCARDIA SUBSTRATE ABLATION BY TARGETING SCAR CHANNEL ENTRANCES TO ELIMINATE LATEST SCAR POTENTIALS WITHOUT DIRECT ABLATION

Author

Katritsis, George, primary, Jamil-Copley, Shahnaz, additional, Luther, Vishal, additional, Koa-Wing, Michael, additional, Cortez-Dias, Nuno, additional, Santos Carpinteiro, Luis Manuel Ribeiro dos, additional, De Sousa, Joao, additional, MARTIN, RUAIRIDH, additional, Murray, Stephen, additional, Das, Moloy, additional, Whinnett, Zachary I., additional, Lim, Phang Boon, additional, Peters, Nicholas S., additional, Ng, Fu Siong, additional, Chow, Anthony W., additional, Linton, Nick, additional, and Kanagaratnam, Prapa, additional

Published
2023
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27. Full blood count as potential predictor of outcomes in patients undergoing cardiac resynchronization therapy

Author

Papageorgiou, Nikolaos, Falconer, Debbie, Ioannou, Adam, Wongwarawipat, Tanakal, Barra, Sergio, Tousoulis, Dimitris, Lim, Wei Yao, Khan, Fakhar Z., Ahsan, Syed, Muthumala, Amal, Hunter, Ross J., Finlay, Malcolm, Creta, Antonio, Rowland, Edward, Lowe, Martin, Segal, Oliver R., Schilling, Richard J., Lambiase, Pier D., Chow, Anthony W., and Providência, Rui

Published
2019
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28. Maturation of the Immune Response

Author

Savelkoul, Huub F J, Cameron, Scott B, Chow, Anthony W, Assenmacher, Mario, Avraham, Hava Karsenty, Avraham, Shalom, Bala, Shukal, Barnett, John, Basketter, David, Ben-David, Yaacov, Berek, Claudia, Blümel, Jörg, Bolliger, Anne Provencher, Bolon, Brad, Bradley, S Gaylen, Brundage, Kathleen M, Brunner, Georg, Bugelski, Peter J, Burchiel, Scott W, Burns-Naas, Leigh Ann, Bussiere, Jeanine L., Cameron, Scott B, Carey, Michelle, Cederbrant, Karin, Chow, Anthony W, Cohen, Mitchell D., Colagiovanni, Dorothy, Contreras, Marcela, Cornacoff, Joel B, Corsini, Emanuela, Crevel, René, Cuff, Christopher, Czuprynski, Charles J, Damoiseaux, Jan G M C, Daniels, Geoff, Dayan, Anthony D, Dearman, Rebecca J, Dodson, Sarah V. M., Ebringer, Alan, Engel, Andrea, Esser, Charlotte, Fairley, Kimberly J, Fernandez-Botran, Rafael, Flaherty, Dennis K, Frings, Werner, Gad, Shayne Cox, Gardner, Donald E, Gardner, Susan C, Garssen, Johan, Gashev, Anatoliy A, Geffner, Jorge, Geginat, Gernot, Gemsa, Diethard, Gerberick, Frank, Germolec, Dori, Gilbert, Kathleen M., Giles-Komar, Jill, Gore, Elizabeth R, Griem, Peter, Hagelschuer, Ina, Haggerty, Helen G., Hall, Andrew, Hanneken, S., Hastings, Kenneth L, Havelaar, Arie H, Heisler, Eckhart, Helm, Ricki M, Henschler, Reinhard, Herrmann, Thomas, Herzyk, Danuta J, Higgins, Rachel R., Hitzfeld, Bettina, Holladay, Steven, Holsapple, Michael, House, Robert V, Hughes, Lucy, Jeong, Tae Cheon, Johnson, Victor J, de Jong, Wim H, de Jonge, Rob, Kamath, Arati, Kaminski, Norbert E, Kaminsky, Ronald, Karol, Meryl, Kashon, Michael L, Kerkvliet, Nancy I, Kimber, Ian, Knight, David M, Knulst, A C, Koren, Eugen, Kraal, Georg, Kretz-Rommel, Anke, Kuper, C Frieke, Ladics, Gregory, Laiosa, Michael, Landreth, Kenneth S., Lawrence, B Paige, Lawrence, David A, Lee, Byeong-Chel, Lee, William, Leino, Lasse, Lemke, Hilmar, Lewis, J G, Liebau, Jutta, Lollini, Pier-Luigi, van Loveren, Henk, Luebke, Bob, Luster, Michael I, Mage, Rose G, Maier, Curtis C., Martin, Michael U., Maurer, Thomas, McKarns, Susan C, Meade, B Jean, Moser, Bernhard, Nagata, Shigekazu, Nain, Marianne, Neumann, Norbert J., Novicki, Deborah L, Olsen, John L, Pauluhn, Jürgen, Pichler, Werner, Pieters, Raymond, Pollard, K Michael, Preissner, Klaus T, Pruett, Stephen B, Pumford, Neil R., Rashid, Taha, Ratajczak, Helen V, Redegeld, Frank A M, Regal, Jean F, Resch, Klaus, Rodgers, Kathleen, Roman, Danielle, Rose, Noel R, Rosenthal, Gary J., Sali, Tina, Samsom, Janneke N, Savelkoul, Huub F J, Schafer, Rosana, Schatz, Mark, Schild, Hansjoerg, Shepherd, David, Shiohara, Tetsuo, Silverstone, Allen, Simeonova, Petia P, Smialowicz, Ralph J, Smith, K G C, Soos, Jeanne M, Stittelaar, Koert J, Straube, Frank, Sulentic, Courtney E W, Swart, B, Takumi, Katsuhisa, Tarkowski, Maciej, Tervaert, Jan Willem Cohen, Thomas, Peter T, Tinkle, Sally S, Treacy, George, Trouba, Kevin, Tryphonas, Helen, Uguccioni, Mariagrazia, Ulrich, Peter, van der Heijden, Maurice W, Van Loveren, H, Vandebriel, Rob J, Vleminckx, Kris, Vohr, Hans-Werner, Weinbauer, Gerhard F, Weinstein, I Bernard, Weltzien, Hans Ulrich, Weston, Ainsley, White, Kimber L., Wilson, Clyde, Wing, Mark, Wolf, Anna Maria, Yaqoob, Parveenn, Yucesoy, Berran, Zawieja, David C, Zelikoff, Judith T, Zola, H, and van Zwieten, P A

Published
2005
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32. Dual‐site right ventricular pacing in patients undergoing cardiac resynchronization therapy: Results of a multicenter propensity‐matched analysis

Author

Providencia, Rui, Barra, Sergio, Papageorgiou, Nikolaos, Ioannou, Adam, Rogers, Dominic, Wongwarawipat, Tanakal, Falconer, Debbie, Duehmke, Rudolf, Colicchia, Martina, Babu, Girish, Segal, Oliver R., Sporton, Simon, Dhinoja, Mehul, Ahsan, Syed, Ezzat, Vivienne, Rowland, Edward, Lowe, Martin, Lambiase, Pier D., Agarwal, Sharad, and Chow, Anthony W.

Published
2017
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37. PO-684-03 CHARACTERISATION OF FASCICULAR ACTIVATION IN THE POST-INFARCT VENTRICLE USING RIPPLE MAPPING

Author

Katritsis, George, primary, Luther, Vishal, additional, Kailey, Balrik, additional, Jamil-Copley, Shahnaz, additional, Koa-Wing, Michael, additional, Malcolme-Lawes, Louisa, additional, Qureshi, Norman A., additional, Lim, Phang Boon, additional, Ng, Fu Siong, additional, Dias, Nuno Cortez, additional, Ribeiro dos Santos Carpinteiro, Luis Manuel, additional, De Sousa, Joao, additional, MARTIN, RUAIRIDH, additional, Das, Moloy, additional, Murray, Stephen, additional, Chow, Anthony W., additional, Peters, Nicholas S., additional, Linton, Nick F., additional, and Kanagaratnam, Prapa, additional

Published
2022
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39. Diagnosis and Management of Complicated Intra-abdominal Infection in Adults and Children: Guidelines by the Surgical Infection Society and the Infectious Diseases Society of America

Author

Solomkin, Joseph S., Mazuski, John E., Bradley, John S., Rodvold, Keith A., Goldstein, Ellie J. C., Baron, Ellen J., O'Neill, Patrick J., Chow, Anthony W., Dellinger, E. Patchen, Eachempati, Soumitra R., Gorbach, Sherwood, Hilfiker, Mary, May, Addison K., Nathens, Avery B., Sawyer, Robert G., and Bartlett, John G.

Published
2010

44. Electrocardiographic imaging demonstrates electrical synchrony improvement by dynamic atrioventricular delays in patients with left bundle branch block and preserved atrioventricular conduction.

Author

Waddingham, Peter H, Mangual, Jan O, Orini, Michele, Badie, Nima, Muthumala, Amal, Sporton, Simon, McSpadden, Luke C, Lambiase, Pier D, and Chow, Anthony W C

Abstract

Aims Cardiac resynchronization therapy programmed to dynamically fuse pacing with intrinsic conduction using atrioventricular (AV) timing algorithms (e.g. SyncAV) has shown promise; however, mechanistic data are lacking. This study assessed the impact of SyncAV on electrical dyssynchrony across various pacing modalities using non-invasive epicardial electrocardiographic imaging (ECGi). Methods and results Twenty-five patients with left bundle-branch block (median QRS duration (QRSd) 162.7 ms) and intact AV conduction (PR interval 174.0 ms) were prospectively enrolled. ECGi was performed acutely during biventricular pacing with fixed nominal AV delays (BiV) and using SyncAV (optimized for the narrowest QRSd) during: BiV + SyncAV, LV-only single-site (LVSS + SyncAV), MultiPoint pacing (MPP + SyncAV), and LV-only MPP (LVMPP + SyncAV). Dyssynchrony was quantified via ECGi (LV activation time, LVAT; RV activation time, RVAT; LV electrical dispersion index, LVEDi; ventricular electrical uncoupling index, VEU; and biventricular total activation time, VVtat). Intrinsic conduction LVAT (124 ms) was significantly reduced by BiV pacing (109 ms) (P = 0.001) and further reduced by LVSS + SyncAV (103 ms), BiV + SyncAV (103 ms), LVMPP + SyncAV (95 ms), and MPP + SyncAV (90 ms). Intrinsic RVAT (93 ms), VVtat (130 ms), LVEDi (36 ms), VEU (50 ms), and QRSd (163 ms) were reduced by SyncAV across all pacing modes. More patients exhibited minimal LVAT, VVtat, LVEDi, and QRSd with MPP + SyncAV than any other modality. Conclusion Dynamic AV delay programming targeting fusion with intrinsic conduction significantly reduced dyssynchrony, as quantified by ECGi and QRSd for all evaluated pacing modes. MPP + SyncAV achieved the greatest synchrony overall but not for all patients, highlighting the value of pacing mode individualization during fusion optimization. [ABSTRACT FROM AUTHOR]

Published
2023
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47. Risk factors for developing pacing induced LV dysfunction: Experience from a tertiary center in the UK

Author

Kanthasamy, Vijayabharathy, primary, Papageorgiou, Nikolaos, additional, Bajomo, Tomi, additional, Monkhouse, Christopher, additional, Creta, Antonio, additional, Finlay, Malcolm, additional, Lambiase, Pier D, additional, Moore, Phil, additional, Sporton, Simon, additional, Earley, Mark J., additional, Schilling, Richard J., additional, Hayward, Carl, additional, Providência, Rui, additional, Hunter, Ross J., additional, Chow, Anthony W., additional, and Muthumala, Amal, additional

Published
2022
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