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209 results on '"Chow, Wan Cheng"'

2. SAT-383 Rapid analysis of HBV-specific T cell secretomes reveals distinct antiviral immune profiles among chronic HBV patients

Author

Bert, Nina Le, primary, Koffas, Apostolos, additional, Tan, Anthony, additional, Kumar, Rajneesh, additional, Mak, Lung-Yi, additional, Miao, Tizong, additional, Lei, Yu, additional, Hariharaputran, Smrithi, additional, Hang, Shou Kit, additional, Guo, Yifei, additional, Chen, Qi, additional, Gill, Upkar, additional, Chow, Wan Cheng, additional, Bertoletti, Antonio, additional, and Kennedy, Patrick, additional

Published
2024
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5. Use of Expression Profiles of HBV-DNA Integrated Into Genomes of Hepatocellular Carcinoma Cells to Select T Cells for Immunotherapy

Author

Tan, Anthony Tanoto, Yang, Ninghan, Lee Krishnamoorthy, Thinesh, Oei, Vincent, Chua, Alicia, Zhao, Xinyuan, Tan, Hui Si, Chia, Adeline, Le Bert, Nina, Low, Diana, Tan, Hiang Keat, Kumar, Rajneesh, Irani, Farah Gillan, Ho, Zi Zong, Zhang, Qi, Guccione, Ernesto, Wai, Lu-En, Koh, Sarene, Hwang, William, Chow, Wan Cheng, and Bertoletti, Antonio

Published
2019
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6. Prevalence and risk factors for impaired renal function among Asian patients with nonalcoholic fatty liver disease

Author

Sun, Chao, primary, Goh, George Boon-Bee, additional, Chow, Wan-Cheng, additional, Chan, Wah-Kheong, additional, Wong, Grace Lai-Hung, additional, Seto, Wai-Kay, additional, Huang, Yi-Hsiang, additional, Lin, Han-Chieh, additional, Lee, I-Cheng, additional, Lee, Hye Won, additional, Kim, Seung Up, additional, Wong, Vincent Wai-Sun, additional, and Fan, Jian-Gao, additional

Published
2023
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7. P1- HIGH VIRAL SUPPRESSION AND IMPROVED SAFETY PROFILE OF TENOFOVIR ALAFENAMIDE RELATIVE TO TENOFOVIR DISOPROXIL FUMARATE IN CHRONIC HEPATITIS B PATIENTS TREATED FOR 5 YEARS

Author

Seto, Wai Kay, primary, Chang, Ting-Tsung, additional, Chowdhry, Abhijit, additional, Chen, Chi-Yi, additional, Celen, Mustafa Kemal, additional, Ma, Xiaoli, additional, Ma, Mang, additional, Duseja, Ajay, additional, Yoon, Ki Tae, additional, Chow, Wan Cheng, additional, Yee, Leland, additional, Weber, Gregor, additional, Youn, Ms Jin, additional, Flaherty, John F., additional, Gaggar, Anuj, additional, Gao, Bing, additional, Camus, Gregory, additional, Bassetti, Eric, additional, Hwang, Jae Seok, additional, Inokuma, Tetshuro, additional, Lin, Young- Suk, additional, and Gane, Edward J., additional

Published
2023
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8. Hepatic steatosis and metabolic risk factors among patients with chronic hepatitis B: The multicentre, prospective CAP‐Asia study

Author

Leow, Yong‐Wen, primary, Chan, Wah‐Kheong, additional, Goh, George Boon‐Bee, additional, Wong, Vincent Wai‐Sun, additional, Fan, Jian Gao, additional, Kim, Young Seok, additional, Kim, Seung Up, additional, Nakajima, Atsushi, additional, Seto, Wai‐Kay, additional, Lee, I‐Cheng, additional, Huang, Yi‐Hsiang, additional, Kim, Yoon Jun, additional, Young, Jang Jae, additional, and Chow, Wan Cheng, additional

Published
2023
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9. Virtual monitoring for stable chronic hepatitis B patients does not reduce adherence to medications: A randomised controlled study.

Author

Kumar, Rajneesh, Yee, Mei-Ling, Goh, George BB, Chia, Pei-Yuh, Lee, Hwei-Ling, Xin, X, Teo, Pek SE, Ekstrom, Victoria SM, Tan, Jin YT, Cheah, Mark CC, Wang, Yu T, Chang, Jason PE, Tan, Chee-Keat, Tan, Hiang Keat, Krishnamoorthy, Thinesh L, and Chow, Wan-Cheng

Subjects
PATIENT compliance, CHRONIC hepatitis B, PATIENTS' attitudes, LIKERT scale, RACE
Abstract

Introduction: Chronic hepatitis B (CHB) remains common in endemic regions, causing significant healthcare burden. Patients with CHB may need to be adherent to nucleoside analogue (NA) for a long period of time to prevent complications. This study aims to investigate the safety, efficacy and patient experience of a virtual monitoring clinic (VMC) in monitoring stable patients taking NA for CHB. Methods: Patients on NA and regular follow-up were randomised to either VMC alternating with doctors' clinic visit or to a control group in which they continued standard follow-up by doctors. Therapy adherence was measured by medication possession ratio (MPR) for NA therapy, incidence of virological breakthrough and hepatocellular carcinoma (HCC) development at two years of follow-up. Patient acceptance was measured on a Likert scale of 1–10. Results: A total 192 patients completed follow-up: 94 and 98 patients in the VMC and control groups, respectively. Mean age was 60.6 ± 10.8 years, with 95.3% Chinese ethnicity and 64.1% males. Age, gender, race, educational, employment and financial status were similar in both groups. Upon study completion, the majority of patients – 76 (80.9%) in VMC group and 74 (75.5%) in control group – had MPR ≥0.8; 88.8% were satisfied and rated VMC better than a traditional follow-up clinic with doctors only. More than 85% of patients rated ≥8/10 on the Likert scale for VMC, and preferred VMC over traditional clinic visits. Clinical outcomes observed were HCC development in one (1.1%) in the VMC group and four (4.1%) in the control group (p = 0.369). Two (2.1%) and one (1.0%) virological breakthroughs were observed in the VMC and control groups, respectively (p = 0.615). No incidence of HCC or abnormal blood tests were missed in the VMC arm. Discussion: VMC is a viable and safe clinical model for monitoring stable CHB patients on NA therapy without compromising patients' adherence to medications and is preferred by patients. [ABSTRACT FROM AUTHOR]

Published
2023
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10. The utility of non‐invasive tests to assess advanced fibrosis in Asian subjects with chronic hepatitis B and concomitant hepatic steatosis.

Author

Lin, Kenneth W., Kumar, Rajneesh, Shen, Feng, Chan, Henry L.‐Y., Wong, Grace L.‐H., Kumar, Rahul, Chow, Wan Cheng, Lin, Su, Wong, Vincent W.‐S., Fan, Jian‐Gao, and Goh, George B.‐B.

Subjects
FATTY liver, CHRONIC hepatitis B, FIBROSIS, NON-alcoholic fatty liver disease
Abstract

Background: Chronic hepatitis B (CHB) is endemic to Asia and is a leading cause of liver‐related morbidity. The prevalence of concomitant CHB and hepatic steatosis (HS) is increasing in Asia. Non‐invasive tests (NITs) including FIB‐4, NFS and APRI assess fibrosis in populations with a single aetiology, but not in subjects with concomitant CHB and HS. Aim: To explore the accuracy of NITs in predicting advanced fibrosis in patients with concomitant CHB and HS. Methodology: This multicentre study of CHB patients who underwent liver biopsy explored clinical characteristics of these subjects, stratified by presence of HS. Fibrosis scores from NITs were compared against histological fibrosis stage in CHB subjects with and without HS. Results: 2262 subjects were enrolled, 74.5% were males, and the mean age was 39.5 years ±11.8 SD. 984 (44.4%) had HS, 824 (36.4%) had advanced fibrosis. In the CHB group, the AUROC for advanced fibrosis were 0.65 (95% CI 0.62–0.69) for FIB‐4 and 0.63 (95% CI 0.60–0.66) for APRI. The specificities were 0.94 for FIB‐4 greater than 3.25 and 0.81 for APRI greater than 1.5. In the CHBHS group, the AUROC for advanced fibrosis were 0.67 (95% CI 0.63–0.71) for FIB‐4, 0.60 (95% CI 0.56–0.64) for APRI and 0.65 (95% CI 0.61–0.69) for NFS. The specificities were 0.95 for FIB‐4 greater than 3.25, 0.88 for APRI greater than 1.5 and 0.99 for NFS greater than 0.675. Conclusion: The performance of NITs to exclude advanced fibrosis did not differ greatly regardless of HS. FIB‐4 and NFS have the best negative predictive values of 0.80 and 0.78, respectively, to exclude advanced fibrosis in CHBHS subjects. [ABSTRACT FROM AUTHOR]

Published
2023
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18. Immunosuppressive Drug‐Resistant Armored T‐Cell Receptor T Cells for Immune Therapy of HCC in Liver Transplant Patients

Author

Hafezi, Morteza, primary, Lin, Meiyin, additional, Chia, Adeline, additional, Chua, Alicia, additional, Ho, Zi Zong, additional, Fam, Royce, additional, Tan, Damien, additional, Aw, Joey, additional, Pavesi, Andrea, additional, Krishnamoorthy, Thinesh Lee, additional, Chow, Wan Cheng, additional, Chen, Wenjie, additional, Zhang, Qi, additional, Wai, Lu‐En, additional, Koh, Sarene, additional, Tan, Anthony T., additional, and Bertoletti, Antonio, additional

Published
2021
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19. Severity of gastric intestinal metaplasia predicts the risk of gastric cancer: a prospective multicentre cohort study (GCEP)

Author

Lee, Jonathan W J, primary, Zhu, Feng, additional, Srivastava, Supriya, additional, Tsao, Stephen KK, additional, Khor, Christopher, additional, Ho, Khek Yu, additional, Fock, Kwong Ming, additional, Lim, Wee Chian, additional, Ang, Tiing Leong, additional, Chow, Wan Cheng, additional, So, Jimmy Bok Yan, additional, Koh, Calvin J, additional, Chua, Shijia Joy, additional, Wong, Andrew S Y, additional, Rao, Jaideepraj, additional, Lim, Lee Guan, additional, Ling, Khoon Lin, additional, Chia, Chung-King, additional, Ooi, Choon Jin, additional, Rajnakova, Andrea, additional, Yap, Wai Ming, additional, Salto-Tellez, Manuel, additional, Ho, Bow, additional, Soong, Richie, additional, Chia, Kee Seng, additional, Teo, Yik Ying, additional, Teh, Ming, additional, and Yeoh, Khay-Guan, additional

Published
2021
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22. Clinical and economic evaluation of a surveillance protocol to manage hepatitis B virus (HBV) reactivation among lymphoma patients with resolved HBV infection receiving rituximab

Author

Tan, Chia Jie, primary, Kumar, Rajneesh, additional, Koomanan, Narendran, additional, Loo, Wei Sheng, additional, Farid, Mohamad, additional, Tao, Miriam, additional, Somasundaram, Nagavalli, additional, Poon, Eileen, additional, Chan, Jason Yongsheng, additional, Yang, Valerie Shiwen, additional, Chang, Esther, additional, Lim, Soon Thye, additional, Chow, Wan Cheng, additional, Chan, Alexandre, additional, and Tang, Tiffany, additional

Published
2021
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24. Virtual monitoring for stable chronic hepatitis B patients does not reduce adherence to medications: A randomised controlled study

Author

Kumar, Rajneesh, primary, Yee, Mei-Ling, additional, Goh, George BB, additional, Chia, Pei-Yuh, additional, Lee, Hwei-Ling, additional, Xin, X, additional, Teo, Pek SE, additional, Ekstrom, Victoria SM, additional, Tan, Jin YT, additional, Cheah, Mark CC, additional, Wang, Yu T, additional, Chang, Jason PE, additional, Tan, Chee-Keat, additional, Tan, Hiang Keat, additional, Krishnamoorthy, Thinesh L, additional, and Chow, Wan-Cheng, additional

Published
2021
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25. Empower to connect and connect to empower: experience in using a humanistic approach to improve patients’ access to, and experience of, care in isolation wards during the COVID-19 outbreak in Singapore

Author

Woong, Natalie Liling, primary, Ekstrom, Victoria Sze Min, additional, Xin, Xiaohui, additional, Lim, Crystal, additional, Boon, Evelyn Swee Kim, additional, Teo, Shaun Wei Jie, additional, Ng, Patrick Chee Sang, additional, Ang, Tricia Pei Shin, additional, Lim, Shu Hui, additional, Lam, Amanda Yun Rui, additional, Fan, Esther Monica Peijin, additional, Ang, Shin Yuh, additional, and Chow, Wan Cheng, additional

Published
2021
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27. Unhealthy lifestyle habits and physical inactivity among Asian patients with non‐alcoholic fatty liver disease

Author

Zhang, Xinrong, primary, Goh, George B.‐B., additional, Chan, Wah‐Kheong, additional, Wong, Grace L.‐H., additional, Fan, Jian‐Gao, additional, Seto, Wai‐Kay, additional, Huang, Yi‐Hsiang, additional, Lin, Han‐Chieh, additional, Lee, I‐Cheng, additional, Lee, Hye Won, additional, Kim, Seung Up, additional, Chow, Wan Cheng, additional, and Wong, Vincent W.‐S., additional

Published
2020
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29. Hepatitis C virus antigen detection is an appropriate test for screening and early diagnosis of hepatitis C virus infection in at‐risk populations and immunocompromised hosts

Author

Kumar, Rajneesh, primary, Chan, Kwai Peng, additional, Ekstrom, Victoria Sze Min, additional, Wong, Judith Chui Ching, additional, Lim, Kun Lee, additional, Ng, Wee Ching, additional, Woo, Shi Min, additional, Chan, Kian Sing, additional, Thangaraju, Sobhana, additional, Kee, Terence Yi Shern, additional, Gan, Sheryl Shien Wen, additional, Foo, Marjorie Wai Yin, additional, Oon, Lynette Lin Ean, additional, and Chow, Wan Cheng, additional

Published
2020
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30. Hepatitis C virus antigen detection as a tool for diagnosis of acute hepatitis C in patients with negative hepatitis C virus antibody

Author

Kumar, Rajneesh, primary, Chan, Kwai Peng, additional, Ekstrom, Victoria, additional, Gan, Sheryl, additional, Thangaraju, Sobhana, additional, Kee, Terence, additional, Woo, Shi Min, additional, Foo, Marjorie, additional, Chan, Kian Sing, additional, Lim, Kun Lee, additional, Lin Ean, Lynette Oon, additional, and Chow, Wan Cheng, additional

Published
2020
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47. Hepatitis C virus antigen detection is an appropriate test for screening and early diagnosis of hepatitis C virus infection in at‐risk populations and immunocompromised hosts.

Author

Kumar, Rajneesh, Chan, Kwai Peng, Ekstrom, Victoria Sze Min, Wong, Judith Chui Ching, Lim, Kun Lee, Ng, Wee Ching, Woo, Shi Min, Chan, Kian Sing, Thangaraju, Sobhana, Kee, Terence Yi Shern, Gan, Sheryl Shien Wen, Foo, Marjorie Wai Yin, Oon, Lynette Lin Ean, and Chow, Wan Cheng

Subjects
HEPATITIS C virus, IMMUNOCOMPROMISED patients, CHRONIC active hepatitis, VIRUS diseases, HEPATITIS B, CHRONIC hepatitis C, HEPATITIS C
Abstract

Early diagnosis remains key for effective prevention and treatment. Unfortunately, current screening with anti‐hepatitis C virus antibody (anti‐HCV Ab) test may have limited utility in the diagnosis of HCV infection and reinfection. This is of special concern to at‐risk population, such as immunocompromised hosts and end‐stage renal failure patients on hemodialysis. HCV antigen (Ag) could be useful in identifying the ongoing infection in such clinical scenarios. Hence, we aimed to study the utility of HCV Ag testing for the diagnosis of acute and chronic hepatitis C. Of 89 samples studied, 19 were from acute hepatitis C patients who were immunocompromised or were on hemodialysis, 43 were from active chronic hepatitis C patients and 27 were from patients treated for chronic hepatitis C. All samples were tested for HCV Ag using the Abbott ARCHITECT HCV Ag assay. HCV Ag was reactive in 19/19 samples from acute hepatitis C patients and 42/43 samples from active chronic hepatitis C patients. It was nonreactive in all samples from treated patients. The test showed a sensitivity and specificity of 98.4% and 100.0%, respectively. The positive and negative predictive values were 100.0% and 96.4%, respectively. The HCV antigen test has high clinical sensitivity and specificity and is useful for the diagnosis of acute and chronic hepatitis C infection in at‐risk and immunocompromised patients. Its short turnaround time and relatively low cost are advantageous for use in patients on hemodialysis and other at‐risk patients who require monitoring of HCV infection and reinfection. Highlights: ‐ Anti HCV antibody is used as screening test/ ‐ Anti HCV antibody test is falsely negative in immunocompromised hosts. ‐ HCV antigen testing can be used as screening test in this group. [ABSTRACT FROM AUTHOR]

Published
2021
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49. A randomised clinical trial of the safety, cost effectiveness and patient experience of nurse‐led telemonitoring of chronic hepatitis B patients

Author

Kumar, Rajneesh, primary, Teo, Pek Siang Edmund, additional, Tan, Wee Boon, additional, Choi, Xinyi, additional, Chia, Pei Yuh, additional, Lee, Hwei Ling, additional, Tan, Chee-Kiat, additional, Chang, Jason Pik‐Eu, additional, Krishnamoorthy, Thinesh L., additional, Tan, Hiang Keat, additional, Goh, George Boon‐Bee, additional, Wang, Yu Tien, additional, Xin, Xiaohui, additional, and Chow, Wan Cheng, additional

Published
2019
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