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387 results on '"Christensson, Birger"'

1. SOX11 is a novel binding partner and endogenous inhibitor of SAMHD1 ara-CTPase activity in mantle cell lymphoma

Author

Abdelrazak Morsy, Mohammad Hamdy, Lilienthal, Ingrid, Lord, Martin, Merrien, Magali, Wasik, Agata Magdalena, Sureda-Gómez, Marta, Amador, Virginia, Johansson, Henrik J., Lehtiö, Janne, Garcia-Torre, Beatriz, Martin-Subero, Jose Ignacio, Tsesmetzis, Nikolaos, Tao, Sijia, Schinazi, Raymond F., Kim, Baek, Sorteberg, Agnes L., Wickström, Malin, Sheppard, Devon, Rassidakis, Georgios Z., Taylor, Ian A., Christensson, Birger, Campo, Elias, Herold, Nikolas, and Sander, Birgitta

Published
2024
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5. SOX11 is a novel binding partner and endogenous inhibitor of SAMHD1 ara-CTPase activity in mantle cell lymphoma.

Author

Morsy, Mohammad Hamdy Abdelrazak, primary, Lilienthal, Ingrid, additional, Lord, Martin, additional, Merrien, Magali, additional, Wasik, Agata Magdalena, additional, Amador, Virginia, additional, Sureda-Gómez, Marta, additional, Johansson, Henrik J, additional, Lehtiö, Janne, additional, García-Torre, Beatriz, additional, Martin-Subero, Jose Ignacio, additional, Tsesmetzis, Nikolaos, additional, Tao, Sijia, additional, Schinazi, Raymond F, additional, Kim, Baek, additional, Sorteberg, Agnes L, additional, Wickström, Malin, additional, Sheppard, Devon, additional, Rassidakis, Georgios Z, additional, Taylor, Ian A, additional, Christensson, Birger, additional, Campo, Elías, additional, Herold, Nikolas, additional, and Sander, Birgitta, additional

Published
2024
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6. Supplementary Materials and Methods from T Cells in Tumors and Blood Predict Outcome in Follicular Lymphoma Treated with Rituximab

Author

Wahlin, Björn Engelbrekt, primary, Sundström, Christer, primary, Holte, Harald, primary, Hagberg, Hans, primary, Erlanson, Martin, primary, Nilsson-Ehle, Herman, primary, Lindén, Ola, primary, Nordström, Marie, primary, Østenstad, Bjørn, primary, Geisler, Christian H., primary, Brown, Peter de Nully, primary, Lehtinen, Tuula, primary, Maisenhölder, Martin, primary, Tierens, Anne M., primary, Sander, Birgitta, primary, Christensson, Birger, primary, and Kimby, Eva, primary

Published
2023
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9. Specific properties of shRNA-mediated CCR5 downregulation that enhance the inhibition of HIV-1 infection in combination with shRNA targeting HIV-1 rev

Author

Cardona Gomez, Maria Eugenia, Hinkula, Jorma, Gustafsson, Kristin, Christensson, Birger, Wahren, Britta, Mohamed, Abdalla J., Smith, C. I. Edvard, Arteaga, H. Jose, Cardona Gomez, Maria Eugenia, Hinkula, Jorma, Gustafsson, Kristin, Christensson, Birger, Wahren, Britta, Mohamed, Abdalla J., Smith, C. I. Edvard, and Arteaga, H. Jose

Abstract

Treatment with RNAi against HIV-1 transcripts efficiently inhibits viral replication but induces selection of escape mutants; therefore, the CCR5 coreceptor was suggested as an additional target. Blocking viral and host transcripts improved the antiviral effect. We have used short hairpin RNA (shRNA) targeting the human CCR5 (shCCR5) or the HIV-1 rev (shRev) transcripts to demonstrate distinctive properties of anti-CCR5 shRNA: shCCR5 induced more sustained protection than shRev; partial reduction in CCR5 expression substantially decreased HIV-1 infection, and shCCR5 performed better than shRev in the mixed shRNA-treated and untreated cultures. These observations indicate that CCR5 inhibitors should be conveniently included in HIV-1 gene silencing treatment schedules when only a certain cell fraction is protected to further reduce endogenous virus in a properly ART-treated HIV-1 infected individual., Funding Agencies|Corporacion para el Desarrollo de la Ciencia y la Tecnologia

Published
2022
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14. Clinical and biological impact of SAMHD1 expression in mantle cell lymphoma

Author

Merrien, Magali, primary, Wasik, Agata M., additional, Ljung, Elin, additional, Morsy, Mohammad H. A., additional, de Matos Rodrigues, Joana, additional, Carlsten, Mattias, additional, Rassidakis, Georgios Z., additional, Christensson, Birger, additional, Kolstad, Arne, additional, Jerkeman, Mats, additional, Ek, Sara, additional, Herold, Nikolas, additional, Wahlin, Björn E., additional, and Sander, Birgitta, additional

Published
2021
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19. Downregulation of bactericidal peptides in enteric infections: A novel immune escape mechanism with bacterial DNA as a potential regulator

Author

Islam, Dilara, Bandholtz, Lisa, Nilsson, Jakob, Wigzell, Hans, Christensson, Birger, Agerberth, Birgitta, and Gudmundsson, Gudmundur H.

Abstract

Antibacterial peptides are active defense components of innate immunity. Several studies confirm their importance at epithelial surfaces as immediate barrier effectors in preventing infection. Here we report that early in Shigella spp. infections, expression of the antibacterial peptides LL-37 and human [beta]-defensin-1 is reduced or turned off. The downregulation is detected in biopsies from patients with bacillary dysenteries and in Shigella- infected cell cultures of epithelial and monocyte origin. This downregulation of immediate defense effectors might promote bacterial adherence and invasion into host epithelium and could be an important virulence parameter. Analyses of bacterial molecules causing the downregulation indicate Shigella plasmid DNA as one mediator., Author(s): Dilara Islam [1]; Lisa Bandholtz [2]; Jakob Nilsson [4]; Hans Wigzell [2]; Birger Christensson [5]; Birgitta Agerberth [3]; Gudmundur H. Gudmundsson (corresponding author) [2] Antibacterial peptides are important bactericidal [...]

Published
2001
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26. Expression of GNAZ, encoding the G alpha(z) protein, predicts survival in mantle cell lymphoma

Author

Mundt, Filip, Merrien, Magali, Nygren, Lina, Sutton, Lesley Ann, Christensson, Birger, Wahlin, Bjorn E., Rosenquist, Richard, Sander, Birgitta, Wasik, Agata M., Mundt, Filip, Merrien, Magali, Nygren, Lina, Sutton, Lesley Ann, Christensson, Birger, Wahlin, Bjorn E., Rosenquist, Richard, Sander, Birgitta, and Wasik, Agata M.

Abstract

Mantle cell lymphoma (MCL), a malignancy of B-lymphocytes, has a poor prognosis. It is thus necessary to improve the understanding of the pathobiology of MCL and identify factors contributing to its aggressiveness. Our studies, based on Affymetrix data from 17 MCL biopsies, real-time quantitative polymerase chain reaction data from 18 sorted primary MCL cells and 108 MCL biopsies compared to non-malignant tissue, reveals that GNAZ expression predicts poor clinical outcome of MCL patients (Cox regression, P = 0 center dot 014) and lymphocytosis (Mann-Whitney, P = 0 center dot 011). We show that GNAZ translates to G alpha(z) protein - a signalling molecule within the G-protein coupled receptor network. Our findings suggest that GNAZ/G alpha(z) contribute to the MCL pathobiology.

Published
2019
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34. High expression of 5-lipoxygenase in normal and malignant mantle zone B lymphocytes

Author

Sander Birgitta, Björkholm Magnus, Christensson Birger, Flygare Jenny, Spanbroek Rainer, Wang Xiao, Lisy Marcus-René, Mahshid Yilmaz, Habenicht Andreas JR, and Claesson Hans-Erik

Subjects
Immunologic diseases. Allergy, RC581-607
Abstract

Abstract Background Human B lymphocytes can produce leukotriene B4 but the biological function of the 5-lipoxygenase (5-LO) pathway in B cells is unclear. In order to better understand and define the role of 5-LO in B cells, we investigated the expression of 5-LO mRNA and protein in subsets of B cells from human tonsils and different types of B cell lymphoma. Results Based on RT-PCR and western blot/immunohistochemical staining, with a polyclonal antibody raised against 5-LO, high expression of 5-LO was found in mantle zone B cells from tonsils. By contrast, only a weak expression of 5-LO was detected in germinal centre cells and no expression in plasma cells from tonsils. This pattern of 5-LO expression was preserved in malignant lymphoma with high expression in mantle B cell lymphoma (MCL) and weak or no expression in follicular lymphoma. Primary leukemized MCL, so called B-prolymphocytic leukaemia cells, and MCL cell lines also expressed 5-LO and readily produced LTB4 after activation. Conclusion The present report demonstrates the expression of 5-LO mainly in normal and malignant mantle zone B cells while the expression is low or absent in germinal centre B cells and plasma cells, indicating a role of the 5-LO pathway in B cells before the cells finally differentiate to plasma cells.

Published
2009
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46. Expression of GNAZ, encoding the Gαz protein, predicts survival in mantle cell lymphoma.

Author

Mundt, Filip, Merrien, Magali, Nygren, Lina, Sutton, Lesley A., Christensson, Birger, Wahlin, Björn E., Rosenquist, Richard, Sander, Birgitta, and Wasik, Agata M.

Subjects
MANTLE cell lymphoma, G protein coupled receptors, POLYMERASE chain reaction, PROTEINS
Abstract

Summary: Mantle cell lymphoma (MCL), a malignancy of B‐lymphocytes, has a poor prognosis. It is thus necessary to improve the understanding of the pathobiology of MCL and identify factors contributing to its aggressiveness. Our studies, based on Affymetrix data from 17 MCL biopsies, real‐time quantitative polymerase chain reaction data from 18 sorted primary MCL cells and 108 MCL biopsies compared to non‐malignant tissue, reveals that GNAZ expression predicts poor clinical outcome of MCL patients (Cox regression, P = 0·014) and lymphocytosis (Mann‐Whitney, P = 0·011). We show that GNAZ translates to Gαz protein – a signalling molecule within the G‐protein coupled receptor network. Our findings suggest that GNAZ/Gαz contribute to the MCL pathobiology. [ABSTRACT FROM AUTHOR]

Published
2019
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47. Susceptibility to infections, without concomitant hyper-IgE, reported in 1976, is caused by hypomorphic mutation in the phosphoglucomutase 3 (PGM3) gene

Author

Lundin, Karin E, Hamasy, Abdulrahman, Backe, Paul Hoff, Moens, Lotte N, Falk-Sörqvist, Elin, Elgstøen, Katja B, Mørkrid, Lars, Bjørås, Magnar, Granert, Carl, Norlin, Anna-Carin, Nilsson, Mats, Christensson, Birger, Stenmark, Stephan, Smith, C I Edvard, Lundin, Karin E, Hamasy, Abdulrahman, Backe, Paul Hoff, Moens, Lotte N, Falk-Sörqvist, Elin, Elgstøen, Katja B, Mørkrid, Lars, Bjørås, Magnar, Granert, Carl, Norlin, Anna-Carin, Nilsson, Mats, Christensson, Birger, Stenmark, Stephan, and Smith, C I Edvard

Abstract

Phosphoglucomutase 3 (PGM3) is an enzyme converting N-acetyl-glucosamine-6-phosphate to N-acetylglucosamine-l-phosphate, a precursor important for glycosylation. Mutations in the PGM3 gene have recently been identified as the cause of novel primary immunodeficiency with a hyper-IgE like syndrome. Here we report the occurrence of a homozygous mutation in the PGM3 gene in a family with immunodeficient children, described already in 1976. DNA from two of the immunodeficient siblings was sequenced and shown to encode the same homozygous missense mutation, causing a destabilized protein with reduced enzymatic capacity. Affected individuals were highly prone to infections, but lack the developmental defects in the nervous and skeletal systems, reported in other families. Moreover, normal IgE levels were found. Thus, belonging to the expanding group of congenital glycosylation defects, PGM3 deficiency is characterized by immunodeficiency, with or without increased IgE levels, and with variable forms of developmental defects affecting other organ systems.

Published
2015
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49. Phosphorylation of serine 523 on 5-lipoxygenase in human B lymphocytes

Author

Mahshid, Yilmaz, primary, Markoutsa, Stavroula, additional, Dincbas-Renqvist, Vildan, additional, Sürün, Duran, additional, Christensson, Birger, additional, Sander, Birgitta, additional, Björkholm, Magnus, additional, Sorg, Bernd L., additional, Rådmark, Olof, additional, and Claesson, Hans-Erik, additional

Published
2015
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