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Most prior research on culture and the dynamics of social support has focused on the emotional outcomes for social support recipients. Though an existing body of research has identified cross-cultural differences in the emotional correlates of receiving different types of social support, researchers have seldom examined possible cultural differences in the experience of social support providers. This study used the Day Reconstruction Method to examine cultural differences in the emotional correlates of the provision of solicited and unsolicited and emotional and informational social support in the daily lives of Singaporean (n = 79) and American (n = 88) participants. Singaporean participants reported providing more social support overall. Regardless of culture, participants reported more positive emotion (affection, happiness) and less negative emotion (anger, anxiety) when they provided emotional social support. Also, multilevel modeling analyses revealed a 3-way interaction between culture, social support provision, and social support solicitation, indicating cultural differences in negative emotional responses to providing solicited social support. Specifically, results suggest that attempts to provide more solicited social support were associated with more negative emotions in the U.S. In contrast, provider negative emotions were highest in Singapore when the provider did not meet the recipient's request for support. Patterns of cultural differences in social support provision are dissimilar to-rather than simply mirroring-those found in published research on social support receipt, highlighting the importance of studying social support provision as a distinct phenomenon.

Interferon inducible protein kinase PKR is an essential component of innate immunity. It is activated by long stretches of dsRNA and provides the first line of host defense against pathogens by inhibiting translation initiation in the infected cell. Many cellular and viral transcripts contain nucleoside modifications and/or tertiary structure that could affect PKR activation. We have previously demonstrated that a 5'-end triphosphate-a signature of certain viral and bacterial transcripts-confers the ability of relatively unstructured model RNA transcripts to activate PKR to inhibit translation, and that this activation is abrogated by certain modifications present in cellular RNAs. In order to understand the biological implications of native RNA tertiary structure and nucleoside modifications on PKR activation, we study here the heavily modified cellular tRNAs and the unmodified or the lightly modified mitochondrial tRNAs (mt-tRNA). We find that both a T7 transcript of yeast tRNA(Phe) and natively extracted total bovine liver mt-tRNA activate PKR in vitro, whereas native E. coli, bovine liver, yeast, and wheat tRNA(Phe) do not, nor do a variety of base- or sugar-modified T7 transcripts. These results are further supported by activation of PKR by a natively folded T7 transcript of tRNA(Phe)in vivo supporting the importance of tRNA modification in suppressing PKR activation in cells. We also examine PKR activation by a T7 transcript of the A14G pathogenic mutant of mt-tRNA(Leu), which is known to dimerize, and find that the misfolded dimeric form activates PKR in vitro while the monomeric form does not. Overall, the in vitro and in vivo findings herein indicate that tRNAs have an intrinsic ability to activate PKR and that nucleoside modifications and native RNA tertiary folding may function, at least in part, to suppress such activation, thus serving to distinguish self and non-self tRNA in innate immunity.

Background: Low back pain (LBP) is a common musculoskeletal disorder, that significantly impedes productivity. This study aims to ascertain the risk factors responsible for developing low back pain and the impact on personal workplace service delivery among Anesthetist's practicing in Rivers and Bayelsa States of Nigeria. Methodology: A cross-sectional survey was conducted, A self-administered questionnaire reflecting the modified Oswestry Disability Index (ODI) was used to detect the risk factors and assess the severity and impact of low back pain on this group of professionals. The prevalence of low back pain was calculated and described by using frequency tables. A multivariate logistic regression model was fitted to identify factors associated with the prevalence of low back pain. Significance was considered at p<0.05 with a 95% confidence interval. Results: A total of 65 anesthetist's responded, giving a response rate of 90%. There were more males (52.3%) than females (47.7%). The majority (69.2%) of those who responded had low back pain, more in females (53.3%) compared to males (46.7%) although not significant. (P=0.994); Majority had moderate pain 58.6%, 22.7% severe and 20.5% mild pain. There was no association between low back pain and age (P=0.130), gender(P=0.994), marital status (P=0.333) and BMI (P=0.164). Bending (P=0.032), lifting (P=0.024), and standing(P=0.016) were predictive variables for low back pain and were statistically significant P<0.05. Conclusion: Using the Oswestry pain assessment tool for LBP, the estimated prevalence of low back pain was more than fifty percent among the respondents. In this study, frequent bending and twisting, prolonged standing, and lifting were important significant associated factors in the development of LBP among anesthetist's. [ABSTRACT FROM AUTHOR]

We examined factors related to attitudes toward marriage and the importance of having children in both the US and Singapore. Path analysis indicated that life dissatisfaction leads to materialism, and both of these factors lead to favorable attitudes toward marriage, which leads to greater desire for children. Further analysis indicated this model was effective in explaining the difference in desire for children between Singaporeans and Americans, whereby Singaporeans have lower life satisfaction, higher materialism, and lower attitudes toward marriage and children. Materialistic standards of success were also related to the emphasis women placed on potential marriage partners' earning capacity. As Singaporean women had higher materialistic standards, they also placed higher emphasis on potential mates' earning capacity. Results suggest a consideration of psychological variables such as life satisfaction, materialism, and mate preferences may lead to a better understanding of larger-scale socioeconomic issues, including low fertility rates among developed East Asian countries.

Abstract Children who are HIV-exposed but uninfected have increased infectious mortality compared to HIV-unexposed children, raising the possibility of immune abnormalities following exposure to maternal viraemia, immune dysfunction, and co-infections during pregnancy. In a secondary analysis of the SHINE trial in rural Zimbabwe we explored biological pathways underlying infant mortality, and maternal factors shaping immune development in HIV-exposed uninfected infants. Maternal inflammation and cytomegalovirus viraemia were independently associated with infant deaths: mortality doubled for each log10 rise in maternal C-reactive protein (adjusted hazard ratio (aHR) 2.09; 95% CI 1.33–3.27), and increased 1.6-fold for each log10 rise in maternal cytomegalovirus viral load (aHR 1.62; 95% CI 1.11–2.36). In girls, mortality was more strongly associated with maternal C-reactive protein than cytomegalovirus; in boys, mortality was more strongly associated with cytomegalovirus than C-reactive protein. At age one month, HIV-exposed uninfected infants had a distinct immune milieu, characterised by raised soluble CD14 and an altered CD8 + T-cell compartment. Alterations in immunophenotype and systemic inflammation were generally greater in boys than girls. Collectively, these findings show how the pregnancy immune environment in women with HIV underlies mortality and immune development in their offspring in a sex-differentiated manner, and highlights potential new intervention strategies to transform outcomes of HIV-exposed children. ClinicalTrials.gov/NCT01824940.

I. INTRODUCTION The United States has not shied away from speaking out about human right abuses that take place across the globe. (1) However, in assuming the role of human [...]

Participants included 46 European American, 33 Asian American, 91 Japanese, 160 Indian, and 80 Hispanic students (N = 416). Discrete emotions, as well as pleasant and unpleasant emotions, were assessed: (a) with global self-report measures, (b) using an experience-sampling method for 1 week, and (c) by asking participants to recall their emotions from the experience sampling week. Cultural differences emerged for nearly all measures. The inclusion of indigenous emotions in India and Japan did not alter the conclusions substantially, although pride showed a pattern across cultures that differed from the other positive emotions. In all five cultural groups and for both pleasant and unpleasant emotions, global reports of emotion predicted retrospective recall even after controlling for reports made during the experience sampling period, suggesting that individuals' general conceptions of their emotional lives influenced their memories of emotions. Cultural differences emerged in the degree to which recall of frequency of emotion was related to experience sampling reports of intensity of emotions. Despite the memory bias, the three methods led to similar conclusions about the relative position of the groups. Keywords: culture; emotion; experience sampling methodology; memory for emotions