1. A PILOT STUDY OF PREOPERATIVE AND POSTOPERATIVE CHEMOTHERAPY IN PATIENTS WITH OPERABLE GASTRIC CANCER: AUSTRALASIAN GASTROINTESTINAL TRIALS GROUP STUDY 9601
- Author
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Peter Johnston, S Archer, Michael Findlay, G Cullingford, P Truskett, David Goldstein, D. Storey, Gary Richardson, J Trotter, J Yuen, Christine Hargreaves, Haryana M. Dhillon, A Davidson, S Della-Fiorentina, Michael Boyer, and Gebski
- Subjects
Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Pilot Projects ,Sudden death ,Stomach Neoplasms ,Antineoplastic Combined Chemotherapy Protocols ,Humans ,Medicine ,Stomach cancer ,Laparoscopy ,Aged ,Epirubicin ,Neoplasm Staging ,Aged, 80 and over ,Chemotherapy ,Performance status ,medicine.diagnostic_test ,business.industry ,Australia ,Cancer ,General Medicine ,Middle Aged ,medicine.disease ,Combined Modality Therapy ,Chemotherapy regimen ,Surgery ,Treatment Outcome ,Chemotherapy, Adjuvant ,Female ,Fluorouracil ,Cisplatin ,business ,medicine.drug - Abstract
Background: With poor cure rates in gastric cancer using surgery alone, the safety, efficacy and feasibility of preoperative and postoperative chemotherapy was investigated. Methods: Patients with advanced but operable gastric or cardio-oesophageal adenocarcinoma were staged using endoscopy, computed tomography scan and laparoscopy. If considered potentially resectable, they received chemotherapy (epirubicin, cisplatin and 5-fluorouracil) for 9 weeks before and after surgery. Results: Of 59 participants entered, two were found to have metastatic disease and were excluded from the analysis. Of the participants, 10 were women and 47 men; their median age was 58 years (range 27–83 years) and median performance status 0 (range 0–1). Two of the 57 participants commencing chemotherapy did not undergo surgery (one sudden death, one new liver metastases). Grade 3 and 4 preoperative and postoperative toxicity rates were, respectively, neutropenia 22 and 18%, emesis 12 and 14% and other non-haematological toxicity
- Published
- 2007
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