58 results on '"Christine Mias"'
Search Results
2. Éducation et intervention sociale : quels enjeux pour demain ?
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Christine Mias and Véronique Bordes
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General Earth and Planetary Sciences ,General Environmental Science - Abstract
Ce numéro a pour objectif de mettre en lumière des travaux de recherche s'intéressant à l'intervention sociale et à la place de l'éducation dans ce champ pris au sens le plus large. Qu'entend-t-on par éducation et intervention sociale ? L'éducation est une préoccupation de la société qui peut être considérée comme un processus permettant d'acquérir des savoirs de saveurs différentes. Le Conseil de l'Europe, en posant la Recommandation 1437 en 2000, met en lumière l'idée d'une éducation qui po...
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- 2022
3. Modélisation d’un processus de professionnalisation : l’implication professionnelle
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Christine Mias
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Multiréférentialité, regard pluriel, polyglottisme disciplinaire, mais aussi braconnage, nomadisme, sont au fondement des sciences de l’éducation. Ces « licences », diraient quelques irréductibles de la pureté disciplinaire, autorisent les chercheurs de notre communauté à emprunter aux théories, concepts, méthodologies, outils, issus de divers lieux disciplinaires. C’est en quelque sorte opter pour le refus du sectarisme, d’un localisme fermé et pour une approche plus « cosmopolite » ne rédui...
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- 2022
4. Réflexivité
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Marie-France Carnus and Christine Mias
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- 2022
5. Symptom Network Analysis and Unsupervised Clustering of Oncology Patients Identifies Drivers of Symptom Burden and Patient Subgroups With Distinct Symptom Patterns
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Brandon H. Bergsneider, Terri S. Armstrong, Yvette P. Conley, Bruce Cooper, Marilyn Hammer, Jon D. Levine, Steven Paul, Christine Miaskowski, and Orieta Celiku
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Gaussian graphical models ,network analysis ,precision medicine ,quality of life ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
ABSTRACT Background Interindividual variability in oncology patients' symptom experiences poses significant challenges in prioritizing symptoms for targeted intervention(s). In this study, computational approaches were used to unbiasedly characterize the heterogeneity of the symptom experience of oncology patients to elucidate symptom patterns and drivers of symptom burden. Methods Severity ratings for 32 symptoms on the Memorial Symptom Assessment Scale from 3088 oncology patients were analyzed. Gaussian Graphical Model symptom networks were constructed for the entire cohort and patient subgroups identified through unsupervised clustering of symptom co‐severity patterns. Network characteristics were analyzed and compared using permutation‐based statistical tests. Differences in demographic and clinical characteristics between subgroups were assessed using multinomial logistic regression. Results Network analysis of the entire cohort revealed three symptom clusters: constitutional, gastrointestinal‐epithelial, and psychological. Lack of energy was identified as central to the network which suggests that it plays a pivotal role in patients' overall symptom experience. Unsupervised clustering of patients based on shared symptom co‐severity patterns identified six patient subgroups with distinct symptom patterns and demographic and clinical characteristics. The centrality of individual symptoms across the subgroup networks differed which suggests that different symptoms need to be prioritized for treatment within each subgroup. Age, treatment status, and performance status were the strongest determinants of subgroup membership. Conclusions Computational approaches that combine unbiased stratification of patients and in‐depth modeling of symptom relationships can capture the heterogeneity in patients' symptom experiences. When validated, the core symptoms for each of the subgroups and the associated clinical determinants may inform precision‐based symptom management.
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- 2024
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6. Stability and consistency of symptom clusters in younger versus older patients receiving chemotherapy
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Lisa Morse, Bruce A. Cooper, Christine S. Ritchie, Melisa L. Wong, Kord M. Kober, Carolyn Harris, Joosun Shin, Kate Oppegaard, Marilyn J. Hammer, Alejandra Calvo Schimmel, Steven M. Paul, Yvette P. Conley, Jon D. Levine, and Christine Miaskowski
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Cancer ,Chemotherapy ,Exploratory factor analysis ,Older adults ,Patient reported outcomes ,Symptoms ,Geriatrics ,RC952-954.6 - Abstract
Abstract Background By 2035, the number of newly diagnosed cancer cases will double and over 50% will be in older adults. Given this rapidly growing demographic, a need exists to understand how age influences oncology patients’ symptom burden. The study purposes were to evaluate for differences in the occurrence, severity, and distress of 38 symptoms in younger (
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- 2024
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7. Vieilles racines et jeunes pousses : nouvelles contributions au triptyque recherche-ingénierie-formation
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Christine Mias, Emmanuelle Brossais, Jean-Luc Rinaudo, Education, Formation, Travail, Savoirs (EFTS), École Nationale Supérieure de Formation de l'Enseignement Agricole de Toulouse-Auzeville (ENSFEA)-Université Toulouse - Jean Jaurès (UT2J), Centre interdisciplinaire de recherche normand en éducation et formation (CIRNEF), Institut de Recherche Interdisciplinaire Homme et Société (IRIHS), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Université Toulouse - Jean Jaurès (UT2J)-École Nationale Supérieure de Formation de l'Enseignement Agricole de Toulouse-Auzeville (ENSFEA), and Normandie Université (NU)-Institut de Recherche Interdisciplinaire Homme et Société (IRIHS)
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[SHS.EDU]Humanities and Social Sciences/Education ,05 social sciences ,enseignement ,050301 education ,ingénierie de formation ,health ,General Medicine ,tension ,research engineering ,teaching ,training engineering ,0501 psychology and cognitive sciences ,ingénierie de recherche ,santé ,0503 education ,ComputingMilieux_MISCELLANEOUS ,050107 human factors - Abstract
La métaphore végétale souligne le caractère vivace des liens recherche-formation, au fondement de la création de la discipline des sciences de l’éducation. Les jeunes pousses sont à la fois les nouveaux travaux explorant ces liens et les ingénieries, qui peuvent être de recherche et de formation. Notre parti pris est, dans cet article, scientifique et expérientiel. Il s’agit de présenter les éléments de problématisation qui ont mis au travail les contributeurs du symposium, de faire état des différentes communications ayant alimenté nos échanges, mais aussi de donner à voir nos modalités de travail et notre analyse de la circulation du terme ingénierie dans nos débats, entre apparition et disparition. Using vegetal metaphor underlines the lively nature of research-training links, which is at the origin of the creation of “sciences de l’éducation” as a French research field. Young shoots are both new studies exploring these links and engineering, understood as research and training ones. Point of view is scientifically and experientially focused. Presented elements of problematization put at work contributors of the symposium and therefore are reported the various communications which enhance our exchanges. Working modalities are also exposed, while analysing « engineering » term circulation within our debates, between appearance and disappearance.
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- 2018
8. Patients’ and Clinicians’ Perceptions of the Clinical Utility of Predictive Risk Models for Chemotherapy-Related Symptom Management: Qualitative Exploration Using Focus Groups and Interviews
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Morven Miller, Lisa McCann, Liane Lewis, Christine Miaskowski, Emma Ream, Andrew Darley, Jenny Harris, Grigorios Kotronoulas, Geir V Berg, Simone Lubowitzki, Jo Armes, Elizabeth Patiraki, Eileen Furlong, Patricia Fox, Alexander Gaiger, Antonella Cardone, Dawn Orr, Adrian Flowerday, Stylianos Katsaragakis, Simon Skene, Margaret Moore, Paul McCrone, Nicosha De Souza, Peter T Donnan, and Roma Maguire
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Computer applications to medicine. Medical informatics ,R858-859.7 ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundInterest in the application of predictive risk models (PRMs) in health care to identify people most likely to experience disease and treatment-related complications is increasing. In cancer care, these techniques are focused primarily on the prediction of survival or life-threatening toxicities (eg, febrile neutropenia). Fewer studies focus on the use of PRMs for symptoms or supportive care needs. The application of PRMs to chemotherapy-related symptoms (CRS) would enable earlier identification and initiation of prompt, personalized, and tailored interventions. While some PRMs exist for CRS, few were translated into clinical practice, and human factors associated with their use were not reported. ObjectiveWe aim to explore patients’ and clinicians’ perspectives of the utility and real-world application of PRMs to improve the management of CRS. MethodsFocus groups (N=10) and interviews (N=5) were conducted with patients (N=28) and clinicians (N=26) across 5 European countries. Interactions were audio-recorded, transcribed verbatim, and analyzed thematically. ResultsBoth clinicians and patients recognized the value of having individualized risk predictions for CRS and appreciated how this type of information would facilitate the provision of tailored preventative treatments or supportive care interactions. However, cautious and skeptical attitudes toward the use of PRMs in clinical care were noted by both groups, particularly in relationship to the uncertainty regarding how the information would be generated. Visualization and presentation of PRM information in a usable and useful format for both patients and clinicians was identified as a challenge to their successful implementation in clinical care. ConclusionsFindings from this study provide information on clinicians’ and patients’ perspectives on the clinical use of PRMs for the management of CRS. These international perspectives are important because they provide insight into the risks and benefits of using PRMs to evaluate CRS. In addition, they highlight the need to find ways to more effectively present and use this information in clinical practice. Further research that explores the best ways to incorporate this type of information while maintaining the human side of care is warranted. Trial RegistrationClinicalTrials.gov NCT02356081; https://clinicaltrials.gov/study/NCT02356081
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- 2024
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9. IMPLICATION PROFESSIONNELLE DANS LE TRAVAIL SOCIAL
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Christine Mias and Christine Mias
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- 1999
10. Common and distinct risk factors that influence more severe and distressing shortness of breath profiles in oncology outpatients
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Joosun Shin, Marilyn Hammer, Mary E. Cooley, Bruce A. Cooper, Steven M. Paul, Frances Cartwright, Kord M. Kober, Yvette P. Conley, Jon D. Levine, and Christine Miaskowski
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cancer ,chemotherapy ,distress ,dyspnea ,shortness of breath ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Shortness of breath occurs in 10%–70% of oncology patients. Very little is known about interindividual variability in its severity and distress and associated risk factors. Using latent profile analyses (LPAs), purpose was to identify subgroups of patients with distinct severity and distress profiles for shortness of breath as single symptom dimensions. In addition, a joint LPA was done using patients' severity AND distress ratings. For each of the three LPAs, differences among the shortness of breath classes in demographic, clinical, symptom, stress, and resilience characteristics were evaluated. Methods Patients completed ratings of severity and distress from shortness of breath a total of six times over two cycles of chemotherapy. All of the other measures were completed at enrollment (i.e., prior to the second or third cycle of chemotherapy). Separate LPAs were done using ratings of severity and distress, as well as a joint analysis using severity AND distress ratings. Differences among the latent classes were evaluated using parametric and nonparametric tests. Results For severity, two classes were identified (Slight to Moderate [91.6%] and Moderate to Severe [8.4%]). For distress, two classes were identified (A Little Bit to Somewhat [83.9%] and Somewhat to Quite a Bit [16.1%]). For the joint LPA, two classes were identified (Lower Severity and Distress [79.9%] and Higher Severity and Distress [20.1%]). While distinct risk factors were associated with each of the LPAs, across the three LPAs, the common risk factors associated with membership in the worse class included: a past or current history of smoking, poorer functional status, and higher comorbidity burden. In addition, these patients had a higher symptom burden and higher levels of cancer‐specific stress. Conclusions Clinicians can use the information provided in this study to identify high‐risk patients and develop individualized interventions.
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- 2024
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11. Quality of life of older gynecologic oncology patients at the initiation of chemotherapy
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Anne Grethe Kleven, Christine Miaskowski, Ann Helen Torstveit, Christine Seel Ritchie, Marie Ellström Engh, Elin Andersen, and Inger Utne
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Nursing ,RT1-120 - Abstract
Abstract Aim To evaluate older gynecologic oncology patients' quality of life (QOL) at the initiation of chemotherapy and compare their QOL scores with a female age‐matched general population (GP) sample. Design Cross‐sectional. Methods Older (n = 122) gynecologic oncology patients completed the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (QLQ‐C30) that evaluates global health and five functional scales (range from 0 to 100). Differences in QOL scores between our sample and the GP were evaluated using one‐sample t‐tests and effect sizes were calculated using Cohen's d. Results Patients' mean age was 70.7 years (±6.6). Mean scores for the function scales ranged from 58.5 (±31.1) for role function to 86.1 (±17.0) for cognitive function. Compared to the GP, our sample reported significantly lower scores for global health status, social, role and physical functioning, and a significantly higher score for cognitive functioning. No differences were found in emotional functioning scores. Patient or Public Contribution No patient or public contribution.
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- 2023
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12. Age-related differences in the occurrence, severity, and distress of symptoms in older patients at the initiation of chemotherapy
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Marlen Sunde Johannessen, Christine Miaskowski, Anne Grethe Kleven, Christine Seel Ritchie, Steven M. Paul, Ellen Karine Grov, Martine Hareide, Henrik Gaudernack, and Inger Utne
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Cancer ,Chemotherapy ,Older adults ,Symptoms ,Symptom assessment ,Geriatrics ,RC952-954.6 - Abstract
Abstract Background Evaluate for differences in occurrence, severity, and distress ratings for 32 symptoms between younger older adults (YOA,
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- 2023
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13. Autobiographie raisonnée
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Christine Mias and Lucile Courtois
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- 2019
14. Accounting for the interplay of interpersonal and structural trauma in the treatment of chronic non-cancer pain, opioid use disorder, and mental health in urban safety-net primary care clinics
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Stacy Castellanos, Alexis Cooke, Sedona Koenders, Neena Joshi, Christine Miaskowski, Margot Kushel, and Kelly Ray Knight
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Chronic non-cancer pain ,Opioids ,Primary care ,Safety-net ,Structural factors ,Trauma ,Mental healing ,RZ400-408 ,Public aspects of medicine ,RA1-1270 - Abstract
While the epidemiological literature recognizes associations between chronic non-cancer pain (CNCP), opioid use disorder (OUD), and interpersonal trauma stemming from physical, emotional, sexual abuse or neglect, the complex etiologies and interplay between interpersonal and structural traumas in CNCP populations are under-examined. Research has documented the relationship between experiencing multiple adverse childhood experiences (ACEs) and the likelihood of developing an OUD as an adult. However, the ACEs framework is criticized for failing to name the social and structural contexts that shape ACE vulnerabilities in families. Social scientific theory and ethnographic methods offer useful approaches to explore how interpersonally- and structurally-produced traumas inform the experiences of co-occurring CNCP, substance use, and mental health. We report findings from a qualitative and ethnographic longitudinal cohort study of patients with CNCP (n = 48) who received care in safety-net settings and their primary care providers (n = 23). We conducted semi-structured interviews and clinical and home-based participant observation from 2018 to 2020. Here we focus our analyses on how patients and providers explained and situated the role of patient trauma in the larger clinical context of reductions in opioid prescribing to highlight the political landscape of the United States opioid overdose crisis and its impact on clinical interactions. Findings reveal the disproportionate burden structurally-produced, racialized trauma places on CNCP, substance use and mental health symptoms that shapes patients’ embodied experiences of pain and substance use, as well as their emotional experiences with their providers. Experiences of trauma impacted clinical care trajectories, yet providers and patients expressed limited options for redress. We argue for an adaptation of trauma-informed care approaches that contextualize the structural determinants of trauma and their interplay with interpersonal experiences to improve clinical care outcomes.
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- 2023
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15. Telehealth for management of chronic non-cancer pain and opioid use disorder in safety net primary care
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Alexis Cooke, Stacy Castellanos, Celeste Enriquez, Pamela Olsen, Christine Miaskowski, Margot Kushel, and Kelly Ray Knight
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Chronic non-cancer pain ,Opioids ,Pain management ,Primary care ,Qualitative ,Telehealth ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background The SARS-CoV-2 (COVID-19) pandemic increased use of telehealth for the management of opioid use disorder and chronic non-cancer pain in primary care safety net clinical systems. Significant barriers to telehealth exist, little is known about how these barriers impact urban safety net, primary care providers and their patients. The objective of this study was to qualitatively assess the benefits and challenges of telehealth for management of chronic non-cancer pain, opioid use disorder, and multi-morbidity in primary care, safety net clinical systems. Methods We interviewed patients with chronic non-cancer pain and history of substance use (n = 22) and their primary care clinicians (n = 7) in the San Francisco Bay Area, March-July 2020. We recorded, transcribed, coded, and content analyzed interviews. Results COVID-19 shelter-in-place orders contributed to increases in substance use and uncontrolled pain, and posed challenges for monitoring opioid safety and misuse through telehealth. None of the clinics used video visits due to low digital literacy/access. Benefits of telehealth included decreased patient burden and missed appointments and increased convenience and control of some chronic conditions (e.g., diabetes, hypertension). Telehealth challenges included loss of contact, greater miscommunication, and less comprehensive care interactions. Conclusions This study is one of the first to examine telehealth use in urban safety net primary care patients with co-occurring chronic non-cancer pain and substance use. Decisions to continue or expand telehealth should consider patient burden, communication and technology challenges, pain control, opioid misuse, and medical complexity.
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- 2023
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16. Perturbations in common and distinct inflammatory pathways associated with morning and evening fatigue in outpatients receiving chemotherapy
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Kord M. Kober, Carolyn Harris, Yvette P. Conley, Anand Dhruva, Vasuda Dokiparthi, Marilyn J. Hammer, Jon D. Levine, Kate Oppegaard, Steven Paul, Joosun Shin, Anatol Sucher, Fay Wright, Brian Yuen, Adam B. Olshen, and Christine Miaskowski
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cancer ,chemotherapy ,cytokines ,fatigue ,gene expression ,inflammation ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Moderate to severe fatigue occurs in up to 94% of patients with cancer. Recent evidence suggests that morning and evening fatigue are distinct dimensions of physical fatigue. The purposes of this study were to evaluate the transcriptome for common and distinct perturbed inflammatory pathways in patients receiving chemotherapy who reported low versus high levels of morning or low versus high levels of evening cancer‐related fatigue. Methods Patients completed questionnaires during the week prior to their chemotherapy treatment. Severity of morning and evening fatigue was evaluated using the Lee Fatigue Scale. Gene expression and pathway impact analyses (PIA) were performed in two independent samples using RNA‐sequencing (n = 357) and microarray (n = 360). Patterns of interactions between and among these perturbed pathways were evaluated using a knowledge network (KN). Results Across the PIA, nine perturbed pathways (FDR
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- 2023
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17. La formation « à » et « par » la recherche : une voie de professionnalisation ? Examen de représentations d’étudiants en master « Recherche »
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Christine Mias and Alain Piaser
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professionnalisation ,research ,social representations ,professionalization ,enseignement ,recherche ,représentations sociales ,teaching ,master - Abstract
Cette contribution se propose d’examiner les représentations d’étudiants à propos de leur professionnalisation en cours dans un master « Recherches » en Sciences humaines et Sociales, dont la finalité est de se former à et par la recherche dans les domaines de l’éducation et de la formation. L’article s’appuiera d’abord sur des données recueillies auprès d’étudiants inscrits en maîtrise en 2003-2004 (N =78), puis étudiera le vécu de ces « étudiants professionnels » dans le master « Recherche » (N =13), via l’une des modalités pédagogiques qui y est centrale : les ateliers coopératifs. This contribution suggests examining students’representations about their current professionalization in a Master’s degree « Recherches » in Human and social Sciences the end of which is to form in and by the research in the domains of the education and the training. The article is first based on numerical data collected among students in master in 2003-2004 (N=78). Then, the contribution studies the place of these « professional trainees » within the Research master (N=13), with of the main educational method: cooperative workshops.
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- 2015
18. Les étudiants face à la professionnalisation à l’université
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Bruno Gachassin, Sabrina Labbé, and Christine Mias
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05 social sciences ,050301 education ,0501 psychology and cognitive sciences ,0503 education ,050107 human factors ,Education - Abstract
L’universite francaise connait une intensification de la professionnalisation de son offre de formation. De leur cote, les etudiants favorisent une orientation vers des filieres plus explicitement professionnalisantes. Dans ce contexte, notre travail s’attache a reperer les caracteristiques qui construisent l’image de « la professionnalisation a l’universite » chez des etudiants en licence. Nos resultats montrent une representation sociale globalement positive, dans laquelle le stage occupe une place privilegiee. Il apparait toutefois une attente insatisfaite chez les etudiants interroges.
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- 2013
19. Network analysis to identify symptoms clusters and temporal interconnections in oncology patients
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Elaheh Kalantari, Samaneh Kouchaki, Christine Miaskowski, Kord Kober, and Payam Barnaghi
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Medicine ,Science - Abstract
Abstract Oncology patients experience numerous co-occurring symptoms during their treatment. The identification of sentinel/core symptoms is a vital prerequisite for therapeutic interventions. In this study, using Network Analysis, we investigated the inter-relationships among 38 common symptoms over time (i.e., a total of six time points over two cycles of chemotherapy) in 987 oncology patients with four different types of cancer (i.e., breast, gastrointestinal, gynaecological, and lung). In addition, we evaluated the associations between and among symptoms and symptoms clusters and examined the strength of these interactions over time. Eight unique symptom clusters were identified within the networks. Findings from this research suggest that changes occur in the relationships and interconnections between and among co-occurring symptoms and symptoms clusters that depend on the time point in the chemotherapy cycle and the type of cancer. The evaluation of the centrality measures provides new insights into the relative importance of individual symptoms within various networks that can be considered as potential targets for symptom management interventions.
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- 2022
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20. Recherche professionnelle, recherche scientifique : quel statut pour les recherches en travail social ?
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Christine Mias and Michel Lac
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Sociology and Political Science - Abstract
Dans cet article, nous proposons d’aborder plusieurs points relatifs a l’epistemologie sous-jacente a la construction des connaissances « de l’interieur » scientifiquement « revisitees » dans le champ du travail social. Necessairement se poseront au fil du discours les questions de la necessite (ou non), de l’opportunite legitime (ou non), de la creation d’une discipline propre au travail social dans son projet de legitimation des recherches menees dans ce champ professionnel. Y seront confrontes les postures differentes (acteur/chercheur) et leurs apports mutuels a partir d’une reflexion sur l’implication de l’acteur dans la construction d’un objet de recherche. Deux modelisations complementaires seront discutees : l’une visant essentiellement la differenciation epistemologiquement incontournable entre questions de terrain et questions de recherche, l’autre la question d’une distanciation productive dans la mise a plat du rapport au terrain et a l’objet de recherche.
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- 2012
21. Des processus différenciés pour des investissements collectifs
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Christine Mias
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dissenssion ,sémantique ,intérêt ,implication professionnelle ,espace professionnel ,engagement ,Education - Abstract
Fédérer les projets de chacun, amener des individus à travailler ensemble sur des bases communes, construire des référentiels communs d’action, demande a minima que les apparents accords sur les actions à mener soient (ré)interrogés en levant les ambiguïtés sémantiques, possibles freins à la construction collective de savoirs partagés. C’est la place que peut occuper le chercheur quand il est invité à répondre à des offres formatives sur la demande de professionnels. Nous proposons ici de réfléchir sur la proximité de notions toutes utiles à la réalisation de ces projets en prenant des exemples issus du secteur médico-social et de l’entreprise. Federating individual projects, making individuals work together on common basis, constructing common systems of reference for action, require at least that the seeming agreements on the actions which are to be led, should be re-questioned while the semantic ambiguities which may possibly curb the collective construction of shared knowledge are cleared up. This is the place researchers may hold when they are asked by professionals to answer formative offers. In this paper we suggest reflecting on the proximity of notions which are all useful to the achievement of these projects by taking examples from the social, medical and corporate sectors. Federar los proyectos de cada uno, inducir a individuos a que trabajen juntos sobre bases comunes, construir referenciales de acción comunes, requiere a minima que los aparentes acuerdos sobre las acciones que hay que llevar a cabo sean (de nuevo)interrogados haciendo desaparecer las ambigüedades semánticas, posibles frenos a la construcción colectiva de saberes compartidos. Es el lugar que puede ocupar el investigador cuando se le pide que conteste a propuestas formativas a la demanda de profesionales. Proponemos aquí reflexionar sobre la proximidad de nociones todas útiles a la realización de esos proyectos tomando ejemplos sacados del sector médico-social y de la empresa. Die Projekte von jedem vereinigen, Individuen dazu bringen, auf gemeinsamen Grundlagen zusammen zu arbeiten, gemeinsame Aktionsbezugssysteme entwickeln, verlangt wenigstens, dass die scheinbaren Zustimmungen zu den durchzuführenden Aktionen erneut untersucht werden und dass dabei die semantischen Zweideutigkeiten aufgehoben werden, die die kollektive Entwicklung von geteilten Kenntnissen bremsen können. Diesen Platz kann der Forscher einnehmen, wenn er auf den Wunsch von Fachleuten hin auf formative Angebote eingehen soll. Hier schlagen wir vor, über die Nähe von Begriffen nachzudenken, die alle der Verwirklichung dieser Projekte nützlich sind und dabei führen wir Beispiele aus dem medizinisch-sozialen und betrieblichen Bereich an.
- Published
- 2008
22. ShinyGAStool: A user-friendly tool for candidate gene association studies
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Thomas J. Hoffmann, Christine Miaskowski, and Kord M. Kober
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Genetic association ,Regression analysis ,Single nucleotide polymorphism ,R shiny ,Computer software ,QA76.75-76.765 - Abstract
A major barrier to the analysis of genotyping and sequencing data is the relative complexity of the tools needed to perform the analysis. We developed shinyGAStool, an open source tool that enables the user to perform a candidate gene association analysis from large datasets in an easy to use tool from a web browser. With a 3-step workflow, shinyGAStool allows the user to (1) identify and explore distributions of the phenotype and covariates, (2) select genes and variants to evaluate, and (3) run an association analysis linking the two.
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- 2023
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23. Age‐related differences in self‐report and objective measures of cognitive function in older patients prior to chemotherapy
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Inger Utne, Borghild Løyland, Ellen Karine Grov, Hege Lund Rasmussen, Ann Helen Torstveit, Steven M. Paul, Christine Ritchie, Kristina Lindemann, Ingvild Vistad, Claudia Rodríguez‐Aranda, and Christine Miaskowski
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cancer ,cognitive function ,older adult ,patient‐reported outcomes ,performance‐based outcomes ,Nursing ,RT1-120 - Abstract
Abstract Aim Evaluate for differences in demographic and clinical characteristics and subjective and objective measures of cognitive function (CF) between younger older adults (YOA, 60–69 years) and older adults (OA, ≥70 years). Design Cross‐sectional. Methods Older oncology patients (n = 139) completed subjective (Attentional Function Index, European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (EORTC) CF scale) and objective (Montreal Cognitive Assessment, Trail Making Test (TMT) A & B) measures of CF prior to chemotherapy. Data were analyzed using parametric and nonparametric tests. Results No differences were found between the two groups for any of the subjective or objective CF measures, except that OA patients had higher TMT B scores. Compared with the general population, OAs had significantly higher EORTC CF scores and YOAs had significantly worse scores for all of the objective tests. Clinically meaningful difference between group differences was found for the TMT B test.
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- 2022
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24. L’autobiographie raisonnée, outil des analyses de pratiques en formation
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Christine Mias
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Points of reference ,Meaning ,Reasoned autobiography ,Social Psychology ,Memory ,Signification ,Developmental and Educational Psychology ,Sens ,Autobiographie raisonnée ,Mémoire ,Repères ,Implication ,Education - Abstract
Pour (ré)interroger les analyses de pratiques professionnelles, nous évoquerons celle menée dans le cadre d’une formation universitaire s’inscrivant dans une méthodologie de recherche-action : le D.U.E.P.S. (Diplôme Universitaire d’Études des Pratiques Sociales), et plus particulièrement les prémices de cette formation. Le choix de cet exemple provient d’une de ses originalités : les interrogations initiales portant sur les liens existant entre un questionnement de recherche scientifique et le cheminement personnel et socioprofessionnel des stagiaires. La particularité réside dans le fait que les stagiaires, à l’entrée en formation, « soutiennent » une autobiographie raisonnée et doivent ainsi faire un effort de distanciation pour trouver sens et signification à leur parcours de recherche. L’expérience de cette « mise à plat » leur permet de regarder autrement leurs pratiques anciennes ou plus actuelles pour mieux appréhender la construction de leur objet de recherche. This article re-investigates the issue of professional practices’ analyses by referring to those carried out during the initial stages of a university course (the University Diploma of social practices). An action research methodology was used. One of the particularities of this course was that it involved initial investigations into the links between a research question and the personal and socio-professional developments of the students. During course enrolment, students must present their personal biography in a clear thought-out way and must therefore make an effort to distance themselves from this autobiography in order to make sense of their research option. The act of “laying bare” their project allowed them to consider their previous or current practices differently in order to better comprehend the elaboration of their research project.
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- 2005
25. Les emplois-jeunes : la stabilité dans le mouvement. Une circulation entre transférabilité, actualisation et contextualisation des compétences
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Christine Mias
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Education - Abstract
The question of the professionalisation of youth jobs (emplois jeunes) raises specific problems, considering on the one hand, the frequent vagueness of the functions they are assigned, and on the other hand, consequently, the training sessions which they are attributed in this changing context. One can wonder whether these emerging jobs are not part of a permanant adjustment of services to needs, in the long term. Which amounts to putting the question of the perpetuation of the, La question de la professionnalisation des emplois-jeunes pose des problèmes spécifiques, en particulier celui de leur professionnalisation, eu égard d'une part au caractère souvent flou des fonctions qui leur sont attribuées, et d'autre part, corrélativement, aux formations qui leur sont proposées dans ce contexte mouvant. On peut se demander si ces métiers émergents ne s'inscrivent pas durablement dans un ajustement permanent des services aux besoins, ce qui revient à poser la question d'une pérennisation dans le mouvement, et en fin de compte d'une transformation continue. L'interrogation sur leur qualification rejoint cette problématique centrale d'une forme d'installation dans le mouvement. Une étude actuellement en cours en Ariège vise à recueillir les représentations en construction (pour reprendre des concepts étudiés dans notre équipe REPERE/ CREFI, représentations professionnelles, socioprofessionnelles, pré-professionnelles...) et à analyser, en rapport avec ces représentations, les dimensions de l'implication de ces acteurs émergents dans le développement local., Mias Christine. Les emplois-jeunes : la stabilité dans le mouvement. Une circulation entre transférabilité, actualisation et contextualisation des compétences. In: Recherche & Formation, N°37, 2001. Les emplois-jeunes : entre emploi, formation et professionnalisation, sous la direction de Michel Bataille et Joël Clanet. pp. 27-40.
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- 2001
26. Distinct employment interference profiles in patients with breast cancer prior to and for 12 months following surgery
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Raymond Javan Chan, Bruce Cooper, Louisa Gordon, Nicolas Hart, Chia Jie Tan, Bogda Koczwara, Kord M. Kober, Alexandre Chan, Yvette P. Conley, Steven M. Paul, and Christine Miaskowski
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Female breast cancer ,Employment interference ,Fatigue ,Patient-reported outcomes ,Quality of life ,Sleep disturbance ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Purpose To identify subgroups of female breast cancer patients with distinct self-reported employment interference (EI) profiles and determine which demographic, clinical, and symptom characteristics, and quality of life outcomes were associated with subgroup membership. Methods Women with breast cancer (n = 385) were assessed for changes in EI over ten times, from prior to, through 12 months after breast cancer surgery. Latent profile analysis (LPA) was used to identify subgroups of patients with distinct EI profiles. Results Three distinct EI profiles (i.e., None – 26.2% (n = 101), Low – 42.6% (n = 164), High – 31.2% (n = 120)) were identified. Compared to the None and Low groups, patients in the High group were more likely to be younger. Higher proportions in the High group were non-White, pre-menopausal prior to surgery, had more advanced stage disease, had received an axillary lymph node dissection, had received neoadjuvant chemotherapy, had received adjuvant chemotherapy, and had a re-excision or mastectomy on the affected breast within 6 months after surgery. In addition, these patients had lower quality of life scores. Compared to the None group, the High group had higher levels of trait and state anxiety, depressive symptoms, fatigue and sleep disturbance and lower levels of cognitive function. Conclusions This study provides new knowledge regarding EI profiles among women in the year following breast cancer surgery. The non-modifiable risk factors (e.g., younger age, being non-White, having more advanced stage disease) can inform current screening procedures. The potentially modifiable risk factors can be used to develop interventions to improve employment outcomes of breast cancer patients.
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- 2021
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27. Implication professionnelle
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Christine Mias
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- 2013
28. Réflexivité
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Marie-France Carnus and Christine Mias
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- 2013
29. Partager des références sur la professionnalisation
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Christine Mias
- Published
- 2013
30. Vers une évaluation scolaire inclusive ?
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Laetitia Branciard, Christine Mias, Hervé Benoit, École Nationale Supérieure de Formation de l'Enseignement Agricole de Toulouse-Auzeville (ENSFEA), Université Toulouse - Jean Jaurès (UT2J), Groupe de recherche sur le handicap, l’accessibilité, les pratiques éducatives et scolaires (EA 7287 Grhapes) (Grhapes), Institut national supérieur de formation et de recherche pour l'éducation des jeunes handicapés et les enseignements adaptés (INSHEA), and Gono, Aurélie
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[SHS.SOCIO]Humanities and Social Sciences/Sociology ,[SHS.SOCIO] Humanities and Social Sciences/Sociology ,[SHS.EDU]Humanities and Social Sciences/Education ,[SHS.EDU] Humanities and Social Sciences/Education - Abstract
International audience; Dix ans après le vote de la loi française du 11 février 2005 « pour l’égalité des droits et des chances, la participation et la citoyenneté des personnes handicapées », l’UMR Éducation formation travail savoirs (EFTS) de l’université Jean Jaurès de Toulouse et de l’École nationale de formation agronomique (ENFA) a organisé, en février 2015, un colloque consacré aux questions particulières que soulèvent les pratiques d’évaluation des élèves dans le cadre de l’école inclusive, sous le titre : Éducation inclusive, la question de l’évaluation : des représentations aux pratiques évaluatives . Cette manifestation a réuni des chercheurs dans le domaine de l’éducation inclusive, de l’évaluation et du handicap, mais également des professionnels de terrain (enseignants, formateurs, éducateurs spécialisés, médecins, maître de stage, directeurs d’établissement) qui ont mis en œuvre des dispositifs d’évaluation adaptés pour des publics en situation de handicap.
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- 2016
31. L’accompagnement de l’implication dans le projet issu du bilan de compétences des salariés en activité
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Michel Bataille, Christine Mias, and Michèle Saint-Jean
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Projet ,Points of reference ,Skills assessment test ,Social Psychology ,Project ,Repères ,Education ,Bilan de compétences ,Contrôle ,Control ,Direction/meaning ,Developmental and Educational Psychology ,Représentations ,Sens ,Accompagnement ,Implication ,Accompaniment support - Abstract
Notre recherche nous a amenés à élaborer un protocole permettant de faire émerger les caractéristiques individuelles des bénéficiaires d’un bilan de compétences et d’introduire un accompagnement spécifique du projet, fondé sur l’activation des composantes Sens/Repères/sentiment de Contrôle du modèle de l’implication professionnelle, développé dans notre laboratoire. Notre recherche a pour but de mesurer les effets de l’accompagnement sur la concrétisation des projets par rapport à un échantillon de comparaison. Les analyses statistiques démontrent un lien significatif entre accompagnement et concrétisation du projet. This study allowed us to elaborate a protocol that made it possible to reveal individual traits of participants having taken a skills assessment test and to introduce a personalized support program for the duration of a project. This accompaniment throughout the project was based on activating certain components: Direction/Meaning, Points of reference, Feelings of control from the professional implication model developed in our laboratory. Using a control group, this study aimed to measure the implications that being accompanied, throughout a project, had on the project achievement itself. Statistical findings demonstrated a significant link between being accompanied and project achievement.
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- 2011
32. Co-occurring Fatigue and Lymphatic Pain Incrementally Aggravate Their Negative Effects on Activities of Daily Living, Emotional Distress, and Overall Health of Breast Cancer Patients
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Mei Rosemary Fu PhD, RN, FAAN, Melissa L. McTernan PhD, Jeanna M. Qiu A.B., Christine Miaskowski RN, PhD, FAAN, Yvette P. Conley PhD, FAAN, Eunjung Ko MSN, RN, AGPCNP-BC, Deborah Axelrod MD, Amber Guth MD, Tamara J. Somers PhD, Lisa J. Wood PhD, RN, FAAN, and Yao Wang PhD
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background: Fatigue and lymphatic pain are the most common and debilitating long-term adverse effects of breast cancer treatment. Fatigue and pain independently have negative effects on quality of life, physical functions, and cancer recurrence-free survival. The interactions between fatigue and pain may aggravate their negative effects. Objectives: Examine the effects of co-occurring fatigue and lymphatic pain on activities of daily living (ADLs), emotional distress, and overall health of breast cancer patients. Methods: A cross-sectional and observational design was used to enroll 354 breast cancer patients. Valid and reliable instruments were used to assess fatigue, lymphatic pain, ADLs, emotional distress, and overall health. Descriptive statistics and multivariable regression models were used for data analysis. Results: After controlling for demographic and clinical factors, patients with co-occurring fatigue and lymphatic pain had higher odds of having impaired ADLs (OR = 24.43, CI = [5.44-109.67], P
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- 2022
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33. Differences in Circulating Extracellular Vesicle and Soluble Cytokines in Older Versus Younger Breast Cancer Patients With Distinct Symptom Profiles
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Dilorom Sass, Wendy Fitzgerald, Brian S. Wolff, Isaias Torres, Glorivee Pagan-Mercado, Terri S. Armstrong, Christine Miaskowski, Leonid Margolis, Leorey Saligan, and Kord M. Kober
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extracellular vesicles ,cytokines ,breast cancer ,symptoms ,latent class ,Genetics ,QH426-470 - Abstract
Because extracellular vesicle (EV)-associated cytokines, both encapsulated and surface bound, have been associated with symptom severity, and may vary over the lifespan, they may be potential biomarkers to uncover underlying mechanisms of various conditions. This study evaluated the associations of soluble and EV-associated cytokine concentrations with distinct symptom profiles reported by 290 women with breast cancer prior to surgery. Patients were classified into older (≥60 years, n = 93) and younger (< 60 years, n = 197) cohorts within two previously identified distinct symptom severity profiles, that included pain, depressive symptoms, sleep disturbance, and fatigue (i.e., High Fatigue Low Pain and All Low). EVs were extracted using ExoQuick. Cytokine concentrations were determined using Luminex multiplex assay. Mann Whitney U test evaluated the differences in EV and soluble cytokine levels between symptom classes and between and within the older and younger cohorts adjusting for Karnofsky Performance Status (KPS) score, body mass index (BMI), and stage of disease. Partial correlation analyses were run between symptom severity scores and cytokine concentrations. Results of this study suggest that levels of cytokine concentrations differ between EV and soluble fractions. Several EV and soluble pro-inflammatory cytokines had positive associations with depressive symptoms and fatigue within both age cohorts and symptom profiles. In addition, in the older cohort with High Fatigue Low Pain symptom profile, EV GM-CSF concentrations were higher compared to the All Low symptom profile (p < 0.05). Albeit limited by a small sample size, these exploratory analyses provide new information on the association between cytokines and symptom profiles of older and younger cohorts. Of note, unique EV-associated cytokines were found in older patients and in specific symptom classes. These results suggest that EVs may be potential biomarker discovery tools. Understanding the mechanisms that underlie distinct symptom class profiles categorized by age may inform intervention trials and offer precision medicine approaches.
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- 2022
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34. Feasibility and Acceptability of a Physical Activity Tracker and Text Messages to Promote Physical Activity During Chemotherapy for Colorectal Cancer: Pilot Randomized Controlled Trial (Smart Pace II)
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Erin L Van Blarigan, Anand Dhruva, Chloe E Atreya, Stacey A Kenfield, June M Chan, Alexandra Milloy, Iris Kim, Paige Steiding, Angela Laffan, Li Zhang, Sorbarikor Piawah, Yoshimi Fukuoka, Christine Miaskowski, Frederick M Hecht, Mi-Ok Kim, Alan P Venook, and Katherine Van Loon
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
BackgroundWe conducted a pilot 2-arm randomized controlled trial to assess the feasibility of a digital health intervention to increase moderate-to-vigorous physical activity in patients with colorectal cancer (CRC) during chemotherapy. ObjectiveThis study aimed to determine whether a digital health physical activity intervention is feasible and acceptable during chemotherapy for CRC. MethodsPotentially eligible patients with CRC expected to receive at least 12 weeks of chemotherapy were identified in person at the University of California, San Francisco, and on the web through advertising. Eligible patients were randomized 1:1 to a 12-week intervention (Fitbit Flex, automated SMS text messages) versus usual care. At 0 and 12 weeks, patients wore an Actigraph GT3X+ accelerometer for 7 days and completed surveys, body size measurements, and an optional 6-minute walk test. Participants could not be masked to their intervention arm, but people assessing the body size and 6-minute walk test outcomes were masked. The primary outcomes were adherence (eg, Fitbit wear and text response rate) and self-assessed acceptability of the intervention. The intervention would be considered feasible if we observed at least 80% complete follow-up and 70% adherence and satisfaction, a priori. ResultsFrom 2018 to 2020, we screened 240 patients; 53.3% (128/240) of patients were ineligible and 26.7% (64/240) declined to participate. A total of 44 patients (44/240, 18%) were randomized to the intervention (n=22) or control (n=22) groups. Of these, 57% (25/44) were women; 68% (30/44) identified as White and 25% (11/44) identified as Asian American or Pacific Islander; and 77% (34/44) had a 4-year college degree. The median age at enrollment was 54 years (IQR 45-62 years). Follow-up at 12 weeks was 91% (40/44) complete. In the intervention arm, patients wore Fitbit devices on a median of 67 out of 84 (80%) study days and responded to a median of 17 out of 27 (63%) questions sent via SMS text message. Among 19 out of 22 (86%) intervention patients who completed the feedback survey, 89% (17/19) were satisfied with the Fitbit device; 63% (12/19) were satisfied with the SMS text messages; 68% (13/19) said the SMS text messages motivated them to exercise; 74% (14/19) said the frequency of SMS text messages (1-3 days) was ideal; and 79% (15/19) said that receiving SMS text messages in the morning and evening was ideal. ConclusionsThis pilot study demonstrated that many people receiving chemotherapy for CRC are interested in participating in digital health physical activity interventions. Fitbit adherence was high; however, participants indicated a desire for more tailored SMS text message content. Studies with more socioeconomically diverse patients with CRC are required. Trial RegistrationClinicalTrials.gov NCT03524716; https://clinicaltrials.gov/ct2/show/NCT03524716
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- 2022
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35. Les prises de décision dans les groupes : exemple d'une action collective, un remembrement communal
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Christine Mias
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Social representation ,Local Development ,local development ,territory ,commitment ,involvement ,social representation ,Sociology ,territoire ,développement local ,engagement ,implication ,représentation sociale ,Humanities - Abstract
The example of a land consolidation in a given small town enables to propose in this paper an illustration of the theory developed by Serge Moscovici & Willem Doise in their book "Dissensions et Consensus". This empirical reading of their popositions leads to think over the existing link between social representation (tags for action) and social involvement (its transformation in the confrontation of heterogeneous landmarks)., L'exemple d'un remembrement communal permet dans cet article de proposer une illustration de la théorie développée par Serge Moscovici et Willem Doise dans leur ouvrage "Dissensions et consensus". Cette lecture empirique de leurs propositions permet de réfléchir au lien existant entre représentations sociales (repères pour l'action) et implication sociale (sa transformation dans la confrontation de repères hétérogènes)., Mias Christine. Les prises de décision dans les groupes : exemple d'une action collective, un remembrement communal. In: Les dossiers des sciences de l'éducation, N°4, 2000. Représentations et engagements: des repères pour l’action. pp. 99-110.
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- 2000
36. A review of the literature on the accuracy, strengths, and limitations of visual, thoracic impedance, and electrocardiographic methods used to measure respiratory rate in hospitalized patients
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Linda K. Bawua, Christine Miaskowski, Xiao Hu, George W. Rodway, and Michele M. Pelter
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electrocardiography ,hospitalized patients ,impedance pneumography ,respiratory rate ,sensitivity/specificity ,visual assessment ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Background Respiratory rate (RR) is one of the most important indicators of a patient's health. In critically ill patients, unrecognized changes in RR are associated with poorer outcomes. Visual assessment (VA), impedance pneumography (IP), and electrocardiographic‐derived respiration (EDR) are the three most commonly used methods to assess RR. While VA and IP are widely used in hospitals, the EDR method has not been validated for use in hospitalized patients. Additionally, little is known about their accuracy compared with one another. The purpose of this systematic review was to compare the accuracy, strengths, and limitations of VA of RR to two methods that use physiologic data, namely IP and EDR. Methods A systematic review of the literature was undertaken using prespecified inclusion and exclusion criteria. Each of the studies was evaluated using standardized criteria. Results Full manuscripts for 23 studies were reviewed, and four studies were included in this review. Three studies compared VA to IP and one study compared VA to EDR. In terms of accuracy, when Bland–Altman analyses were performed, the upper and lower levels of agreement were extremely poor for both the VA and IP and VA and EDR comparisons. Conclusion Given the paucity of research and the fact that no studies have compared all three methods, no definitive conclusions can be drawn about the accuracy of these three methods. The clinical importance of accurate assessment of RR warrants new research with rigorous designs to determine the accuracy, and clinically meaningful levels of agreement of these methods.
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- 2021
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37. The Effects of Kinect-Enhanced Lymphatic Exercise Intervention on Lymphatic Pain, Swelling, and Lymph Fluid Level
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Mei R. Fu PhD, RN, FAAN, Melissa L. McTernan PhD, Jeanna M. Qiu AB, Eunjung Ko MSN, RN, AGPCNP-BC, Simay Yazicioglu Undergraduate Research Assistant, Deborah Axelrod MD, Amber Guth MD, Zhipeng Fan PhD Student, Anna Sang Undergraduate Research Assistant, Christine Miaskowski RN, PhD, FAAN, and Yao Wang PhD
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background: The-Optimal-Lymph-Flow (TOLF) intervention aims to promote lymph flow through therapeutic lymphatic exercises to relieve lymphatic pain, swelling, lymphedema symptoms, and to decrease lymph fluid levels among breast cancer survivors. To enhance the efficacy of the TOLF intervention, an innovative, intelligent, Kinect-enhanced lymphatic exercise intervention (Kinect-TOLF) was developed to teach patients to perform the lymphatic exercises correctly. Objectives: This feasibility trial aimed to determine the feasibility, usability, and effects of the Kinect-TOLF on lymphatic pain, swelling, lymphedema symptoms, and lymph fluid levels. Methods: A single-arm feasibility trial with a pre- and post-test design was employed to recruit 30 breast cancer survivors with persistent lymphatic pain or swelling. Patients received a single training session to learn how to perform the lymphatic exercises using the Kinect-TOLF program. Descriptive statistics, Wilcoxon signed-rank tests, t -test, Spearman’s rank correlation coefficients, linear regressions, and Cohen’s d were performed for data analysis. Qualitative data were assessed for common themes. Results: The Kinect-TOLF was effective in training patients to perform the lymphatic exercises correctly with high user satisfaction. Significant reductions were found in scores of lymphatic pain ( Med Δ = −1.00, CI = [−1.5, −0.1], P = .004), arm/hand swelling ( Med Δ = −1.00, CI = [−1.5, −0.5], P = .004), total swelling ( Med Δ = −1.5, CI = [−2.0, −1.0], P = .003), number of lymphedema symptoms ( M Δ = −3.8, CI = [−5.5, −2.1], P
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- 2021
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38. Self-monitoring and reminder text messages to increase physical activity in colorectal cancer survivors (Smart Pace): a pilot randomized controlled trial
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Erin L. Van Blarigan, Hilary Chan, Katherine Van Loon, Stacey A. Kenfield, June M. Chan, Emily Mitchell, Li Zhang, Alan Paciorek, Galen Joseph, Angela Laffan, Chloe E. Atreya, Yoshimi Fukuoka, Christine Miaskowski, Jeffrey A. Meyerhardt, and Alan P. Venook
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Fitbit ,Digital health ,Exercise ,Accelerometer ,Lifestyle ,Intervention ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Over 1.3 million people live with colorectal cancer in the United States. Physical activity is associated with lower risk of colorectal cancer recurrence and mortality. Interventions are needed to increase physical activity in colorectal cancer survivors. Methods We conducted a 2-arm non-blinded pilot randomized controlled trial at the University of California, San Francisco among 42 individuals who had completed curative-intent treatment for colorectal cancer to determine the feasibility and acceptability of a 12-week (84 days) physical activity intervention using a Fitbit Flex™ and daily text messages. Participants were randomized 1:1 to receive the intervention with print educational materials or print educational materials alone. We explored the impact of the intervention versus usual care on physical activity using ActiGraph GT3X+ accelerometers pre−/post-intervention. Results We screened 406 individuals and randomized 42 to intervention (n = 21) or control (n = 21) groups. During the 12-week study, the intervention arm wore their Fitbits a median of 74 days [88% of days in study period, interquartile range: 23–83 days] and responded to a median of 34 (out of 46) text messages that asked for a reply (interquartile range: 13–38 text messages). Among the 16 intervention participants who completed the feedback survey, the majority (88%) reported that the intervention motivated them to exercise and that they were satisfied with their experience. No statistically significant difference in change in moderate-to-vigorous physical activity was found from baseline to 12 weeks between arms. Conclusion A 12-week physical activity intervention with a Fitbit and text messages was feasible and acceptable among colorectal cancer patients after curative treatment. Larger studies are needed to determine whether the intervention increases physical activity. Trial registration Clinicaltrials.gov Identifier NCT02966054. Registered 17 November 2016, retrospectively registered.
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- 2019
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39. Testing a pain self-management intervention by exploring reduction of analgesics’ side effects in cancer outpatients and the involvement of family caregivers: a study protocol (PEINCA-FAM)
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Sabine Valenta, Rebecca Spirig, Christine Miaskowski, Kathrin Zaugg, and Elisabeth Spichiger
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Neoplasms ,Pain management ,Adverse effects ,Caregivers ,Health behaviour ,Self-care ,Nursing ,RT1-120 - Abstract
Abstract Background Pain is one of cancer patients’ most frequent and distressing symptoms; however, analgesics’ side effects often increase symptom burden. Further, with the home rapidly becoming the primary cancer care setting, family caregivers (FCs) commonly play central roles in patients’ pain self-management, but with little or no preparation. One US-tested intervention, the PRO-SELF© Plus Pain Control Program (PCP), designed to support cancer outpatients and their FCs in pain self-management, is currently being tested in the Swiss multi-centre PEINCA study. The current PEINCA-FAM study is a sub-study of PEINCA. The aims of PEINCA-FAM are: a) to test the efficacy of the adapted German PRO-SELF © Plus PCP to reduce side effects of analgesics; b) to enhance patients’/FCs’ knowledge regarding cancer pain; and c) to explore FCs’ involvement in patients’ pain self-management. Methods This mixed methods project combines a multi-centre randomized controlled clinical trial with qualitative data collection techniques and includes 210 patients recruited from three oncology outpatient clinics. FCs involved in patients’ pain self-management are also invited to participate. After baseline evaluation, eligible participants are randomized to a 6-week intervention group and a control group. Both groups complete a daily pain and symptom diary. Intervention group patients/FCs receive the weekly psychoeducational PRO-SELF© Plus PCP interventions; control group patients receive usual care. After completing the six-week study procedures, a subsample of 7–10 patients/FCs per group and hospital (N = 42–60) will be interviewed regarding their pain management experiences. Data collection will take place from April 2016 until December 2018. An intent-to-treat analysis and generalized linear mixed models will be applied. Qualitative data will be analysed by using interpretive description. Quantitative and qualitative results will be combined within a mixed method matrix. Discussion In clinical practice, specially trained oncology nurses in outpatient clinics could apply the intervention to reduce side effects and to enhance patients’/FCs’ self-efficacy and pain management knowledge. Trial registration The PEINCA study is registered in the Clinical Trials.gov site (code: NCT02713919, 08 March 2016).
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- 2018
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40. A 4-Month Whole-Systems Ayurvedic Medicine Nutrition and Lifestyle Intervention Is Feasible and Acceptable for Breast Cancer Survivors: Results of a Single-Arm Pilot Clinical Trial
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Anand Dhruva MD, Cairn Wu BA, Christine Miaskowski RN, PhD, Wendy Hartogensis Phd, MPH, Hope S Rugo MD, Shelley R Adler PhD, Ted J Kaptchuk, Rucha Kelkar BAMS, PT, DPT, Sangeeta Agarawal RN, MS, CAS, Amisha Vadodaria BA, Ellen Garris CAS, and Frederick M Hecht MD
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Medicine (General) ,R5-920 ,Public aspects of medicine ,RA1-1270 - Abstract
Purpose Ongoing symptoms and impairments in quality of life (QOL) among breast cancer survivors remain a significant problem. We tested the feasibility and acceptability of a manualized Ayurvedic nutrition and lifestyle intervention for breast cancer survivors. Methods Eligible participants had Stage I–III breast cancer, underwent treatment within the past year that included chemotherapy, and were without active disease. The 4-month individualized Ayurvedic intervention included counseling on nutrition, lifestyle, yoga, and marma (like acupressure) during 8 one-on-one visits with an Ayurvedic practitioner. Feasibility and acceptability were the primary outcomes. QOL (European Organization for Research and Treatment of Cancer Quality of Life Questionnaire [EORTC QLQ C30]) and symptoms—sleep disturbance (General Sleep Disturbance Scale [GSDS]), fatigue (Lee Fatigue Scale [LFS]), depressive symptoms (Center for Epidemiological Studies—Depression Scale [CES-D]), anxiety (Spielberger State-Trait Anxiety Inventory [STAI-S, STAI-T]), and stress (Perceived Stress Scale [PSS])—were measured prior to, at midpoint, and at the end of the 4-month intervention. Effect sizes (Cohen’s d ) were calculated along with paired t tests comparing baseline to end of month 4 time points. Mixed effects models were used for repeated measures analyses. Results Participants ( n = 32) had a mean age of 48 years ( SD = 10). Retention at the end of the intervention was 84%. Among those who completed the intervention ( n = 27), adherence was high (99.5% of visits with practitioners attended). Large improvements were seen in QLQ-C30 emotional functioning ( d = 0.84, P
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- 2020
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41. Association between changes in body fat and disease progression after breast cancer surgery is moderated by menopausal status
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Li-Ni Liu, Yung-Chang Lin, Christine Miaskowski, Shin-Cheh Chen, and Mei-Ling Chen
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Breast cancer ,Menopausal status ,Body fat ,Disease progression ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Obesity is linked to poor disease outcomes in breast cancer patients. However, this link was mostly based on body weight or BMI rather than body-fat. The purpose of this study was to evaluate the relationship between body-fat gain and disease progression in Taiwanese women after breast cancer surgery and how this relationship is influenced by menopausal status. Methods Body fat percentage was measured 1 day before and 6 months after surgery in 131 women with stages 0–III breast cancer. Disease outcomes (metastasis and death) were assessed by chart review and telephone contact 7 to 8 years after diagnosis. These data were analyzed by multivariate Cox proportional hazard model analysis. Results The percentage of women with over 5% gain in body-fat was 56% for premenopausal and 42% for postmenopausal. Rates of distant metastasis and all-cause mortality were 17.6 and 9.9%, respectively over the follow-up period. Distant metastases were predicted in postmenopausal but not premenopausal women with breast cancer by increased body fat percentage (HR = 1.3, p = 0.035), after controlling other potential covariates, including disease severity, estrogen receptor expression, progesterone receptors expression, age, and exercise habit before diagnosis. Survival was not significantly associated with body-fat percentage gains. Conclusions Our results suggest that increased body fat percentage 6 months after breast surgery is an important predictor of distant metastasis in postmenopausal Taiwanese women with breast cancer. Clinicians may need to measure patients’ body fat periodically. Our findings should be validated in studies with a longer follow-up time.
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- 2017
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42. Proceedings of Patient Reported Outcome Measure’s (PROMs) Conference Oxford 2017: Advances in Patient Reported Outcomes Research
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Galina Velikova, Jose M. Valderas, Caroline Potter, Laurie Batchelder, Christine A’Court, Matthew Baker, Jennifer Bostock, Angela Coulter, Ray Fitzpatrick, Julien Forder, Diane Fox, Louise Geneen, Elizabeth Gibbons, Crispin Jenkinson, Karen Jones, Laura Kelly, Michele Peters, Brendan Mulhern, Alexander Labeit, Donna Rowen, Keith Meadows, Jackie Elliott, John Brazier, Emma Knowles, Anju Keetharuth, Janice Connell, Jill Carlton, Lizzie Taylor Buck, Thomas Ricketts, Michael Barkham, Pushpendra Goswami, Sam Salek, Tatyana Ionova, Esther Oliva, Adele K. Fielding, Marina Karakantza, Saad Al-Ismail, Graham P. Collins, Stewart McConnell, Catherine Langton, Daniel M. Jennings, Roger Else, Jonathan Kell, Helen Ward, Sophie Day, Elizabeth Lumley, Patrick Phillips, Rosie Duncan, Helen Buckley-Woods, Ahmed Aber, Gerogina Jones, Jonathan Michaels, Ian Porter, Jaheeda Gangannagaripalli, Antoinette Davey, Ignacio Ricci-Cabello, Kirstie Haywood, Stine Thestrup Hansen, Jose Valderas, Deb Roberts, Anil Gumber, Bélène Podmore, Andrew Hutchings, Jan van der Meulen, Ajay Aggarwal, Sujith Konan, Andrew Price, William Jackson, Nick Bottomley, Michael Philiips, Toby Knightley-Day, David Beard, Joanne Greenhalgh, Kate Gooding, Chema Valderas, Judy Wright, Sonia Dalkin, David Meads, Nick Black, Carol Fawkes, Robert Froud, Dawn Carnes, Jonathan Cook, Helen Dakin, James Smith, Sujin Kang, The ACHE Study Team, Catrin Griffiths, Ella Guest, Diana Harcourt, Mairead Murphy, Sandra Hollinghurst, Chris Salisbury, Anqi Gao, Agnieszka Lemanska, Tao Chen, David P. Dearnaley, Rajesh Jena, Matthew Sydes, Sara Faithfull, A. E. Ades, Daphne Kounali, Guobing Lu, Ines Rombach, Alastair Gray, Oliver Rivero-Arias, Patricia Holch, Marie Holmes, Zoe Rodgers, Sarah Dickinson, Beverly Clayton, Susan Davidson, Jacqui Routledge, Julia Glennon, Ann M. Henry, Kevin Franks, Roma Maguire, Lisa McCann, Teresa Young, Jo Armes, Jenny Harris, Christine Miaskowski, Grigorios Kotronoulas, Morven Miller, Emma Ream, Elizabeth Patiraki, Alexander Geiger, Geir V. Berg, Adrian Flowerday, Peter Donnan, Paul McCrone, Kathi Apostolidis, Patricia Fox, Eileen Furlong, Nora Kearney, Chris Gibbons, Felix Fischer, Joel Coste, Jose Valderas Martinez, Matthias Rose, Alain Leplege, Sarah Shingler, Natalie Aldhouse, Tamara Al-Zubeidi, Andrew Trigg, Helen Kitchen, Colin Green, Joanna Coast, Sarah Smith, Jolijn Hendriks, Koonal Shah, Juan-Manuel Ramos-Goni, Simone Kreimeier, Mike Herdman, Nancy Devlin, Aureliano Paolo Finch, John E. Brazier, Clara Mukuria, Bernarda Zamora, David Parkin, Yan Feng, Andrew Bateman, Thomas Patton, and Nils Gutacker
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Computer applications to medicine. Medical informatics ,R858-859.7 - Published
- 2017
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43. Factors that can predict pain with walking, 12 months after total knee arthroplasty: A trajectory analysis of 202 patients
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Maren Falch Lindberg, Christine Miaskowski, Tone RustøEn, Leiv Arne Rosseland, Bruce A Cooper, and Anners Lerdal
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Orthopedic surgery ,RD701-811 - Abstract
Background and purpose — Functional limitations after total knee arthroplasty (TKA) are common. In this longitudinal study, we wanted to identify subgroups of patients with distinct trajectories of pain-related interference with walking during the first year after TKA and to determine which demographic, clinical, symptom-related, and psychological characteristics were associated with being part of this subgroup. Patients and methods — Patients scheduled for primary TKA for osteoarthritis (n = 202) completed questionnaires that evaluated perception of pain, fatigue, anxiety, depression, and illness on the day before surgery. Clinical characteristics were obtained from the medical records. Interference of pain with walking was assessed preoperatively, on postoperative day 4, and at 6 weeks, 3 months, and 12 months after TKA. Results — Using growth mixture modeling, 2 subgroups of patients were identified with distinct trajectories of pain-related interference with walking over time. Patients in the Continuous Improvement class (n = 157, 78%) had lower preoperative interference scores and reported a gradual decline in pain-related interference with walking over the first 12 months after TKA. Patients in the Recurrent Interference class (n = 45, 22%) reported a high degree of preoperative pain-related interference with walking, initial improvement during the first 3 months after TKA, and then a gradual increase—returning to preoperative levels at 12 months. Patients in the Recurrent Interference class had higher preoperative pain, fatigue, and depression scores, and poorer perception of illness than the Continuous Improvement class. Interpretation — 1 in 5 patients did not improve in pain-related interference with walking at 12 months after TKA. Future studies should test the efficacy of interventions designed to modify preoperative characteristics.
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- 2016
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44. Colposcopic characteristics and Lugol׳s staining differentiate anal high-grade and low-grade squamous intraepithelial lesions during high resolution anoscopy
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Naomi Jay, J. Michael Berry, Christine Miaskowski, Misha Cohen, Elizabeth Holly, Teresa M. Darragh, and Joel M. Palefsky
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Infectious and parasitic diseases ,RC109-216 - Abstract
Background: Anal squamous intraepithelial lesions (SIL) and cancers are increased in immunocompromised populations. Based upon anatomic and histologic similarities, the cervix is used as the model for anal screening. During cervical colposcopy, acetic acid (AA) and Lugol׳s staining (LS) result in characteristic changes that help distinguish low-grade (L)SIL from high-grade (H)SIL. Lesion characteristics were evaluated for their ability to distinguish anal (a)LSIL from anal (a)HSIL during high-resolution anoscopy after application of AA and LS. Methods: AA-stained lesions were described using standard cervical colposcopic criteria. LS was then applied and lesions were characterized as Lugol׳s-negative (L−), Lugol׳s-partial (L+/−), or Lugol׳s positive (L+) and then biopsied. Biopsies were characterized as benign, squamous atypia, LSIL or HSIL. Results: 835 anal lesions were analyzed. Sensitivity and positive predictive value (PPV) for aHSIL were highest for characteristics associated with cervical (c)HSIL. L− was independently associated with aHSIL (OR=4.7, 95% CI=3.4–6.7). In multiple logistic regression analysis, significant predictors of aHSIL were flat contour (OR=2.24, 95% CI=1.3–3.8), mosaic pattern (OR=2.0, 95% CI=1.4–2.9), vascular punctation (OR=1.5, 95% CI=1.1–2.1) and L− (OR=2.3, 95% CI=1.5–3.4). L− staining improved the PPV of aHSIL almost twofold in lesions that otherwise had a colposcopic impression of LSIL. Conclusions: Evaluating acetowhite lesions for contour, surface, vascularity, and LS may maximize the likelihood of identifying aHSIL. Keywords: Anal, HSIL, High resolution anoscopy, Lugol׳s staining
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- 2015
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45. Learning from data to predict future symptoms of oncology patients.
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Nikolaos Papachristou, Daniel Puschmann, Payam Barnaghi, Bruce Cooper, Xiao Hu, Roma Maguire, Kathi Apostolidis, Yvette P Conley, Marilyn Hammer, Stylianos Katsaragakis, Kord M Kober, Jon D Levine, Lisa McCann, Elisabeth Patiraki, Eileen P Furlong, Patricia A Fox, Steven M Paul, Emma Ream, Fay Wright, and Christine Miaskowski
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Medicine ,Science - Abstract
Effective symptom management is a critical component of cancer treatment. Computational tools that predict the course and severity of these symptoms have the potential to assist oncology clinicians to personalize the patient's treatment regimen more efficiently and provide more aggressive and timely interventions. Three common and inter-related symptoms in cancer patients are depression, anxiety, and sleep disturbance. In this paper, we elaborate on the efficiency of Support Vector Regression (SVR) and Non-linear Canonical Correlation Analysis by Neural Networks (n-CCA) to predict the severity of the aforementioned symptoms between two different time points during a cycle of chemotherapy (CTX). Our results demonstrate that these two methods produced equivalent results for all three symptoms. These types of predictive models can be used to identify high risk patients, educate patients about their symptom experience, and improve the timing of pre-emptive and personalized symptom management interventions.
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- 2018
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46. Preoperative Pain, Symptoms, and Psychological Factors related to Higher Acute Pain Trajectories during Hospitalization for Total Knee Arthroplasty.
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Maren Falch Lindberg, Christine Miaskowski, Tone Rustøen, Leiv Arne Rosseland, Steven M Paul, and Anners Lerdal
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Medicine ,Science - Abstract
OBJECTIVES:Unrelieved postoperative pain after total knee arthroplasty (TKA) is a significant problem. This longitudinal study investigated how preoperative pain intensity, as well as a comprehensive list of preoperative and perioperative factors, influenced the severity of acute average and worst pain after TKA. METHODS:Prior to surgery, 203 patients completed a demographic questionnaire, Lee Fatigue Scale, Fatigue Severity Scale, Hospital Anxiety and Depression Scale, and Brief Illness Perception Questionnaire. Brief Pain Inventory was completed prior to surgery as well as through postoperative days (POD) 0 to 4. Clinical data were extracted from medical records. RESULTS:Several factors were associated with higher levels of preoperative and postoperative pain. Lower preoperative average and worst pain intensity scores were associated with increases in average and worst postoperative pain from POD1 to POD4. A higher number of comorbidities, higher C-reactive protein values, and higher pain interference with function were associated with higher preoperative levels of average pain. Older age, higher fatigue levels, and higher scores on identity and emotional responses to osteoarthritis (OA) were associated with higher preoperative levels of worst pain. Lower perceived consequences of OA were associated with higher pain from POD1 to POD4. Males and patients with lower preoperative scores for average pain had higher worst pain following surgery. DISCUSSION:Patients at higher risk for more severe postoperative pain can be identified through an assessment of pain and other risk factors identified in this study. Future research needs to test the efficacy of interventions that modify patients' perceptions of living with OA and pain intensity before surgery on short and long term postoperative outcomes.
- Published
- 2016
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47. Enabling symptom self-management via use of an electronic patient-reported outcomes (ePRO) system to increase self-efficacy of patients with cancer receiving active chemotherapy treatment
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Grigorios Kotronoulas, Eileen Furlong, Jo Armes, Christine Miaskowski, Elisabeth Patiraki, and Kathi Apostolidis
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Technology ,Cancer ,chemotherapy ,self-efficacy ,self-management ,randomized controlled trial ,empowerment ,patient-reported outcomes ,ePRO system ,Public aspects of medicine ,RA1-1270 - Abstract
Background: In recent years, the shift in cancer services from traditional tertiary care to care delivered within communities has increased the need for patients to engage in self-care activities in order to prevent or reduce the severity of numerous and complex-side effects (McCorkle et al., 2011) and make important health decisions when at home in the absence of clinicians (Butow et al., 2012). The actual degree of engagement in self-management may be dependent on patients’ perceived competence or self-efficacy to perform such activities (Fenlon et al., 2015). Self-efficacy has been defined as “a person’s belief to execute courses of action required to deal with a prospective situation” (Bandura, 1977, 2001). One’s beliefs in their capability to successfully manage tasks and consequently influence situations that impact their lives constitutes a central part of human agency, and can be influenced by performance accomplishments (Bandura, 1989, 2001). Whilst self-efficacy can enable engagement in self-management, actual participation in self-management activities can further increase one’s perceived ability to undertake such activities; it is thus obvious that a bi-directional association between self-management and self-efficacy exists. Supporting a shift in clinical practice with innovative technological systems affords a solution to the increasing demands placed on acute care by enabling the delivery of care in the home and community setting (Basch et al., 2011; Carpenter et al., 2008). Such remote monitoring systems facilitate the provision of clear lines of real-time communication between patients and their health care providers (Basch et al., 2011), and can deliver organised self-management advice tailored to the individual’s clinical characteristics and severity/distress of symptoms of anti-cancer treatment. Aim(s): Funded by the European Union (FP7 programme), a multi-centre European project (the eSMART study) has been designed to investigate the effects of an electronic patient-reported outcomes (ePRO) system, the Advanced Symptom Management System (ASyMS), on patient outcomes including improvement in self-efficacy, symptom management, supportive care needs, psychological status, work presenteeism, and well-being; health system costs; and the current clinical practice. The primary aim of eSMART is to evaluate the short and long term impact of the ASyMS technology on patient reported outcomes in people with breast cancer, colorectal cancer or haematological malignancies receiving first-line chemotherapy. In addition, eSMART will evaluate the cost-benefit of remote patient-monitoring and changes in clinical practice as a result of the application of the ASyMS intervention in different European healthcare settings. The study is currently recruiting patients, thus no data will be available for presentation. This presentation will nonetheless aim to present and discuss the hypothesis that provision of symptom self-management advice may be an important mechanism to improve patient self-efficacy, which may establish a self-sustained cycle where self-care advice provision enables patient self-efficacy and this in turn further increases patient involvement in self-management that can ultimately lead to improved patient outcomes. Method(s)/Results: The current study has been informed by the Medical Research Council Complex Interventions Framework (Anderson, 2008; Craig and Petticrew, 2012; Mackenzie et al., 2010), and the Holistic Framework to improve the Uptake and Impact of e-Health Technologies (van Gemert-Pijnen et al., 2011). The eSMART programme of work comprises two parts that will take place over a period of five years. The first part consists of preparatory work to refine the ASyMS intervention for use in a multi-national context, and concludes with a feasibility testing period to establish the technological readiness of the system prior to its use in the second part. The second part will employ a repeated-measures, parallel-group, stratified randomised controlled trial methodology to demonstrate the effects of the ASyMS intervention in supporting patients who receive chemotherapy treatment through individualised symptom management. The second part will test the short- (i.e. during the treatment phase) and long-term effects (i.e. at one-year follow-up) of the ASyMS intervention versus standard care across the participating countries (Austria, Greece, Ireland, Norway and the UK). The ASyMS intervention comprises use of a mobile phone (i.e. ASyMS patient handset) and a tympanic thermometer. The patient handset will enable participants on the intervention group to enter symptom/temperature data on a dedicated, electronic symptom questionnaire daily and whenever they feel unwell. Upon successful submission of their data, patients will immediately receive automated, evidence-based self-care advice based on their symptom reports. Patients will also have access to a self-care library, symptom graphs (detailing trends in individual symptoms experienced) and contact numbers of care teams and patient support organisations in their country, available within the ASyMS patient handset. Via dedicated tablet PCs, all participants will complete an electronic version of the Communication and Attitudinal Self-Efficacy scale for cancer (CASE-Cancer) (Wolf et al., 2005) at baseline; after each CTx; and 3, 6, 9 and 12 months post-chemotherapy treatment. The CASE-Cancer is a validated, 12-item measure that yields scores on three factors: understanding and participating in care, maintaining a positive attitude, and seeking and obtaining information. In accordance with latest recommendations for pragmatic research in healthcare (Oakley et al., 2006; Treweek and Zwarenstein, 2009), the longitudinal nature of the trial will aid to establish sustainability of intervention effects and further stress its benefits when compared to standard care. Conclusions: This anticipatory model of care supports symptom management within the patient’s home, where the early toxicities of chemotherapy can be managed, utilising self-care and local community services. This model is also expected to contribute to the health literacy of patients with cancer in relation to early identification, report and self-management of their most common symptoms. As part of the project’s objectives, we will aim to show improved self-efficacy (as shown by statistically significantly higher self-efficacy scores) during active chemotherapy for breast cancer, colorectal cancer, or haematological malignancies, and/or at one-year follow-up. It is hoped that an enhanced self-efficacy (evidenced by patients’ greater understanding and participation in care, positive attitude, and engagement in seeking health-related information) will in turn enable a smoother rehabilitation process for patients in the post-treatment survivorship period and beyond. EU FP7 Programme Grant agreement No. 602289. Trial registration identifier (clinicaltrials.gov) NCT02356081.
- Published
- 2015
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48. De quelles représentations souffrent les métiers en mal de main d’œuvre : Projet SHS bis 2007 du Conseil Régional Midi-Pyrénées
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Sabrina Labbé, Michel Bataille, Christine Mias, Michel Lac, Pierre Ratinaud, Alain Piaser, Patrice Bouyssières, Université Toulouse - Jean Jaurès (UT2J), and Université Toulouse - Jean Jaurès
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[SHS]Humanities and Social Sciences - Abstract
This collaborative research was conducted from 2007 to 2009 in response to a social commission of an industrial cluster, Mecanic Vallée having difficulty recruiting and training. The study focuses on the social representations of work, industry and ideal professions and aims to understand the representational mechanisms at play in professional choices, to highlight the representations of the professions in the industry and to identify communication channels that could enable the sector to no longer "suffer" from an image unfavourable to professional engagement.; Cette recherche collaborative a été menée de 2007 à 2009 en réponse à une commande sociale d'un cluster industriel, la Mecanic Vallée ayant des difficultés à recruter et à former. L'étude porte sur les représentations sociales du travail, des métiers de l'industrie et du métier idéal et vise à comprendre les mécanismes représentationnels en jeu dans les choix professionnels, à mettre en lumière les représentations des métiers de l'industrie et permet de dégager des voies de communications susceptibles de permettre au secteur de ne plus "souffrir" d'une image peu propice à l'engagement professionnel.
49. Lymphatic and angiogenic candidate genes predict the development of secondary lymphedema following breast cancer surgery.
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Christine Miaskowski, Marylin Dodd, Steven M Paul, Claudia West, Deborah Hamolsky, Gary Abrams, Bruce A Cooper, Charles Elboim, John Neuhaus, Brian L Schmidt, Betty Smoot, and Bradley E Aouizerat
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Medicine ,Science - Abstract
The purposes of this study were to evaluate for differences in phenotypic and genotypic characteristics in women who did and did not develop lymphedema (LE) following breast cancer treatment. Breast cancer patients completed a number of self-report questionnaires. LE was evaluated using bioimpedance spectroscopy. Genotyping was done using a custom genotyping array. No differences were found between patients with (n = 155) and without LE (n = 387) for the majority of the demographic and clinical characteristics. Patients with LE had a significantly higher body mass index, more advanced disease and a higher number of lymph nodes removed. Genetic associations were identified for four genes (i.e., lymphocyte cytosolic protein 2 (rs315721), neuropilin-2 (rs849530), protein tyrosine kinase (rs158689), vascular cell adhesion molecule 1 (rs3176861)) and three haplotypes (i.e., Forkhead box protein C2 (haplotype A03), neuropilin-2 (haplotype F03), vascular endothelial growth factor-C (haplotype B03)) involved in lymphangiogensis and angiogenesis. These genetic associations suggest a role for a number of lymphatic and angiogenic genes in the development of LE following breast cancer treatment.
- Published
- 2013
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50. Evidence of associations between cytokine genes and subjective reports of sleep disturbance in oncology patients and their family caregivers.
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Christine Miaskowski, Bruce A Cooper, Anand Dhruva, Laura B Dunn, Dale J Langford, Janine K Cataldo, Christina R Baggott, John D Merriman, Marylin Dodd, Kathryn Lee, Claudia West, Steven M Paul, and Bradley E Aouizerat
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Medicine ,Science - Abstract
The purposes of this study were to identify distinct latent classes of individuals based on subjective reports of sleep disturbance; to examine differences in demographic, clinical, and symptom characteristics between the latent classes; and to evaluate for variations in pro- and anti-inflammatory cytokine genes between the latent classes. Among 167 oncology outpatients with breast, prostate, lung, or brain cancer and 85 of their FCs, growth mixture modeling (GMM) was used to identify latent classes of individuals based on General Sleep Disturbance Scale (GSDS) obtained prior to, during, and for four months following completion of radiation therapy. Single nucleotide polymorphisms (SNPs) and haplotypes in candidate cytokine genes were interrogated for differences between the two latent classes. Multiple logistic regression was used to assess the effect of phenotypic and genotypic characteristics on GSDS group membership. Two latent classes were identified: lower sleep disturbance (88.5%) and higher sleep disturbance (11.5%). Participants who were younger and had a lower Karnofsky Performance status score were more likely to be in the higher sleep disturbance class. Variation in two cytokine genes (i.e., IL6, NFKB) predicted latent class membership. Evidence was found for latent classes with distinct sleep disturbance trajectories. Unique genetic markers in cytokine genes may partially explain the interindividual heterogeneity characterizing these trajectories.
- Published
- 2012
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