Search

Your search keyword '"Christinet, A."' showing total 188 results
Start Over Author "Christinet, A."
188 results on '"Christinet, A."'

1. Safety and immunogenicity of CD40.HIVRI.Env, a dendritic cell-based HIV vaccine, in healthy HIV-uninfected adults: a first-in-human randomized, placebo-controlled, dose-escalation study (ANRS VRI06)

Author

Levy, Yves, Candotti, Fabio, Centlivre, Mireille, Desvallées, Mathilde, Diallo, Alpha, Durand, Mélany, Ding, Song, Hanot, Laurent, Hardel, Lucile, Hocini, Hakim, Lacabaratz, Christine, Lelièvre, Jean-Daniel, Levoyer, Léa, Moog, Christiane, Pantaleo, Giuseppe, Paul, Stéphane, Richert, Laura, Rieux, Véronique, Surgers, Laure, Wiedemann, Aurélie, Viard, Jean-Paul, Batteux, Frédéric, Grabar, Sophie, Pollard, Hélène, Lachatre, Marie, Mercier, Noémie, Molinari, Laura, Pinoges, Loretxu, Boston, Anaïs, Boilet, Valérie, Campion, Cécilia, Delahaye, Solenne, Dembélé, Mohamed, Guillochon, Quentin, Khalil, Youssra, Soutthiphong, Anne-Aygline, Taïeb, Ludivine, Wittkop, Linda, Thiebaut, Rodolphe, Foucat, Emile, Krief, Corinne, Ribeiro, Alexandre, Rodrigues, Cécile, Decoville, Thomas, Laumond, Géraldine, Li, Li-Yun, Schmidt, Sylvie, Fenwick, Craig, Gonzalo, Tapia, Kiehl, Philippe, Ben Rayana, Raida, Bouvier, Magali, Diombera, Harouna, Mehawej, Hanane, Verlinde-Carvalho, Muriel, Zatta, Marta, Launay, Odile, Tanah, Motolete Alaba, Cheref, Kahina, Durel-Maurisse, Aurélie, Favreau, Mathilde, Grange, Pascal, Guerin, Corinne, Luong, Liem Binh, Parfait, Béatrice, Christinet, Vanessa, Hottinger, Rosemary, Sommer, Isabelle, Tommasini, Francesco, Voidey, Aline, Salazar, Andres, Cardinaud, Sylvain, Zurawski, Sandra, Zurawski, Gerard, and Tomaras, Georgia D.

Published
2024
Full Text
View/download PDF

4. Rectal shedding of monkeypox virus in a patient coinfected with Chlamydia trachomatis and Neisseria gonorrhoeae: a case report

Author

Florian Desgranges, Emmanouil Glampedakis, Vanessa Christinet, Sara Encarnação, Cândida Fernandes, Gilbert Greub, Onya Opota, and Matthias Cavassini

Subjects
Monkeypox, Sexually transmitted infection, Proctitis, Shingles, Case report, Medicine
Abstract

Abstract Background Infection by the monkeypox virus classically causes a cutaneous rash that is preceded by fever and lymph node swelling, as well as other nonspecific systemic symptoms. A recent outbreak occurred and spread in Europe and other regions, especially among patients who declare themselves as men who have sex with men. Current reports have shown that cutaneous lesions may be limited to the anogenital area. We report on a case of proctitis caused by monkeypox virus, without visible typical lesions of this virus. Case presentation A 29-year-old Caucasian male presented with a monkeypox virus proctitis that recurred after treatment for a documented Neisseria gonorrhoeae and Chlamydia trachomatis coinfection, likely acquired at the same time. The proctitis was preceded by fever and a swollen inguinal lymph node, and was associated with a hemorrhoid. The monkeypox virus polymerase chain reaction of a rectal swab documented high viral loads, although no typical lesion was visible. After resolution of the rectitis, the patient developed a single dermatome herpes zoster, despite the absence of usual risk factors. The patient evolved well without further specific treatment. Conclusion This case shows that monkeypox virus can be responsible for proctitis, without any typical lesion, along with the important rectal shedding of the virus. It raises the concern of contagion during anal intercourse through body fluids and gives further credit that monkeypox virus can be a sexually transmitted infection. This should prompt routine rectal screening in patients with proctitis accompanied by fever and swollen lymph nodes, and in patients who have a history of unprotected receptive anal sex, even in presence of other sexually transmitted infections, and especially during a monkeypox virus outbreak. The potential link between monkeypox virus infection and shingles warrants further investigations.

Published
2023
Full Text
View/download PDF

5. Incidence of sexually transmitted infections and association with behavioural factors: Time-to-event analysis of a large pre-exposure prophylaxis (PrEP) cohort

Author

Hovaguimian, Frédérique; https://orcid.org/0000-0003-4181-2948, Kouyos, Roger D; https://orcid.org/0000-0002-9220-8348, Kusejko, Katharina; https://orcid.org/0000-0002-4638-1940, Schmidt, Axel J; https://orcid.org/0000-0002-6910-4399, Tarr, Philip E; https://orcid.org/0000-0002-1488-5407, Bernasconi, Enos; https://orcid.org/0000-0002-9724-8373, Braun, Dominique L; https://orcid.org/0000-0003-4036-1030, Calmy, Alexandra; https://orcid.org/0000-0002-1137-6826, Notter, Julia, Stoeckle, Marcel; https://orcid.org/0000-0002-0088-5078, Surial, Bernard; https://orcid.org/0000-0002-1402-974X, Christinet, Vanessa, Darling, Katharine E A; https://orcid.org/0000-0003-1449-3873, Depmeier, Carsten, Läuchli, Severin, Reinacher, Matthias, Rasi, Manuela, Nicca, Dunja; https://orcid.org/0000-0002-4133-8177, Bruggmann, Philip, Haerry, David, Bize, Raphaël; https://orcid.org/0000-0001-5626-4628, Low, Nicola; https://orcid.org/0000-0003-4817-8986, Vock, Florian, El Amari, Emmanuelle Boffi, Böni, Jürg; https://orcid.org/0000-0001-7925-4852, Bosshard, Philipp P; https://orcid.org/0000-0002-1154-2281, Fehr, Jan S, Hampel, Benjamin, SwissPrEPared Cohort Study, Hovaguimian, Frédérique; https://orcid.org/0000-0003-4181-2948, Kouyos, Roger D; https://orcid.org/0000-0002-9220-8348, Kusejko, Katharina; https://orcid.org/0000-0002-4638-1940, Schmidt, Axel J; https://orcid.org/0000-0002-6910-4399, Tarr, Philip E; https://orcid.org/0000-0002-1488-5407, Bernasconi, Enos; https://orcid.org/0000-0002-9724-8373, Braun, Dominique L; https://orcid.org/0000-0003-4036-1030, Calmy, Alexandra; https://orcid.org/0000-0002-1137-6826, Notter, Julia, Stoeckle, Marcel; https://orcid.org/0000-0002-0088-5078, Surial, Bernard; https://orcid.org/0000-0002-1402-974X, Christinet, Vanessa, Darling, Katharine E A; https://orcid.org/0000-0003-1449-3873, Depmeier, Carsten, Läuchli, Severin, Reinacher, Matthias, Rasi, Manuela, Nicca, Dunja; https://orcid.org/0000-0002-4133-8177, Bruggmann, Philip, Haerry, David, Bize, Raphaël; https://orcid.org/0000-0001-5626-4628, Low, Nicola; https://orcid.org/0000-0003-4817-8986, Vock, Florian, El Amari, Emmanuelle Boffi, Böni, Jürg; https://orcid.org/0000-0001-7925-4852, Bosshard, Philipp P; https://orcid.org/0000-0002-1154-2281, Fehr, Jan S, Hampel, Benjamin, and SwissPrEPared Cohort Study

Abstract

OBJECTIVES: Our objective was to obtain long-term data on the incidence of sexually transmitted infections (STIs) and their association with behavioural factors after widespread pre-exposure prophylaxis (PrEP) implementation. METHODS: This was a time-to-event analysis of a national PrEP cohort in Switzerland (SwissPrEPared study). Participants were people without HIV interested in taking PrEP with at least two STI screening visits. Primary outcomes were incidence rate of gonorrhoea, chlamydia, and syphilis. The association between behavioural factors and STI diagnosis was expressed using hazard ratios. We adjusted for testing frequency and calendar year. RESULTS: This analysis included 3907 participants enrolled between April 2019 and April 2022, yielding 3815.7 person-years of follow-up for gonorrhoea (15 134 screenings), 3802.5 for chlamydia (15 141 screenings), and 3858.6 for syphilis (15 001 screenings). The median age was 39 years (interquartile range [IQR] 32-47), 93.8% (n = 3664) identified as men who have sex with men (MSM). The incidence was 22.8 (95% confidence interval [CI] 21.3-24.4) per 100 person-years for gonorrhoea, 26.3 (95% CI 24.7-28.0) for chlamydia, and 4.4 (95% CI 3.8-5.1) for syphilis. Yearly incidence rates decreased between 2019 (all bacterial STIs: 81.6; 95% CI 59.1-109.9) and 2022 (all bacterial STIs: 49.8; 95% CI 44.6-55.3). Participants reporting chemsex substance use were at higher risk of incident STIs, as were those reporting multiple sexual partners. Younger age was associated with a higher risk of gonorrhoea and chlamydia. CONCLUSIONS: Incidence rates of bacterial STIs decreased over time. Young MSM, those with multiple partners, and those using chemsex substances were at increased risk of STIs.

Published
2024

7. Changes in mental and sexual health among MSM using HIV pre-exposure prophylaxis during the SARS-CoV-2 pandemic: longitudinal analysis of the SwissPrEPared cohort study

Author

Babette L. Winter, Frédérique Hovaguimian, Roger D. Kouyos, Axel Jeremias Schmidt, Enos Bernasconi, Dominique L. Braun, Alexandra Calmy, Julia Notter, Marcel Stoeckle, Bernard Surial, Vanessa Christinet, Matthias Cavassini, Carsten Depmeier, Severin Läuchli, Emmanuelle Boffi El Amari, Matthias Reinacher, Manuela Rasi, Philip Bruggmann, David Haerry, Raphaël Bize, Nicola Low, Andreas Lehner, Boris B. Quednow, Jan S. Fehr, and Benjamin Hampel

Subjects
Medicine
Abstract

BACKGROUND: Changes in mental and sexual health among men having sex with men (MSM) due to the SARS-CoV-2 pandemic remain unclear. METHODS: Design: Longitudinal analysis of an ongoing, multicentre, pre-exposure prophylaxis (PrEP) cohort (NCT03893188) in Switzerland. Participants: HIV-negative MSM aged ≥18 who completed at least one questionnaire before and one after the start of the SARS-CoV-2 pandemic. Outcomes: Primary: mental health, defined as anxiety and depression scores assessed by the Patient Health Questionnaire-4. Secondary: sexual behaviour, well-being, PrEP use and disruption of care. Outcomes were assessed over seven periods corresponding to different SARS-CoV-2 prevention measures in Switzerland. We performed pairwise comparisons between periods (Wilcoxon signed rank test). RESULTS: Data from 1,043 participants were included. Whilst anxiety scores remained stable over time, depression scores worsened in the second wave and the second lockdown period compared to pre-pandemic scores. This was confirmed by pairwise comparisons (pre-SARS-CoV-2/second wave and pre-SARS-CoV-2/second lockdown: p

Published
2022
Full Text
View/download PDF

8. The Swiss STAR trial – an evaluation of target groups for sexually transmitted infection screening in the sub-sample of men

Author

Axel J. Schmidt, Manuela Rasi, Cate Esson, Vanessa Christinet, Michael Ritzler, Thomas Lung, Christoph V. Hauser, Marcel Stoeckle, Florent Jouinot, Andreas Lehner, Katharina Lange, Torsten Konrad, and Pietro Vernazza

Subjects
sexually transmitted diseases, men, sexual and gender minorities, Hepatitis C, hepatitis B, HIV, Medicine
Abstract

OBJECTIVES In Switzerland, universal health insurance does not cover any routine testing for sexually transmitted infections (STIs), not even in individuals at high risk, and extra-genital swabbing is not standard of care. We determined the prevalence and incidence of human immunodeficiency virus (HIV), viral hepatitis and non-viral STIs in a multicentre prospective observational cohort of multi-partner men who have sex with men (MSM) and other men. MATERIALS AND METHODS Between January 2016 and June 2017, we offered free STI testing to all men with multiple sexual partners (three or more in the previous 12 months), with follow-up examinations every 6 months. We used multiplex polymerase chain-reaction testing (for Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis, Mycoplasma genitalium) on pooled swabs (pharynx, urethra/vagina, anus), and antibody tests for HIV and Treponema pallidum at every visit, and for hepatitis B/C at baseline. RESULTS We screened 779 multi-partner MSM and 92 other men. Previously undiagnosed HIV was found in 0.5% vs 0.0%, respectively and T. pallidum antibodies in 15.3% vs 1.1%. STIs requiring antibiotic treatment comprised: active syphilis 1.7% vs 0.0%; N. gonorrhoeae 10.3% vs 0.0%; C. trachomatis 8.7% vs 1.1%. One in four MSM versus 1 in 100 other multi-partner men had any of these three STIs at baseline. 10.4% vs 1.3% had a history of hepatitis B, 31.9% vs 47.3% had no immunity (HBs-AB 20). CONCLUSION Among MSM, but not among other multi-partner men, STIs, mostly asymptomatic, are common. Given the high risk of onward transmission, low-cost or free routine screening of multi-partner MSM is a public health priority.

Published
2020
Full Text
View/download PDF

9. Incidence of sexually transmitted infections and association with behavioural factors: Time‐to‐event analysis of a large pre‐exposure prophylaxis (PrEP) cohort.

Author

Hovaguimian, Frédérique, Kouyos, Roger D., Kusejko, Katharina, Schmidt, Axel J., Tarr, Philip E., Bernasconi, Enos, Braun, Dominique L., Calmy, Alexandra, Notter, Julia, Stoeckle, Marcel, Surial, Bernard, Christinet, Vanessa, Darling, Katharine E. A., Depmeier, Carsten, Läuchli, Severin, Reinacher, Matthias, Rasi, Manuela, Nicca, Dunja, Bruggmann, Philip, and Haerry, David

Subjects
SEXUALLY transmitted disease diagnosis, PREVENTION of sexually transmitted diseases, SYPHILIS epidemiology, EPIDEMIOLOGY of sexually transmitted diseases, CHLAMYDIA, GONORRHEA, CONFIDENCE intervals, TIME, HUMAN sexuality, HEALTH outcome assessment, MEDICAL screening, PRE-exposure prophylaxis, HUMAN services programs, RISK assessment, SEX customs, RESEARCH funding, HEALTH behavior, DESCRIPTIVE statistics, MEN who have sex with men, BACTERIAL diseases, DATA analysis software, LONGITUDINAL method, PROPORTIONAL hazards models
Abstract

Objectives: Our objective was to obtain long‐term data on the incidence of sexually transmitted infections (STIs) and their association with behavioural factors after widespread pre‐exposure prophylaxis (PrEP) implementation. Methods: This was a time‐to‐event analysis of a national PrEP cohort in Switzerland (SwissPrEPared study). Participants were people without HIV interested in taking PrEP with at least two STI screening visits. Primary outcomes were incidence rate of gonorrhoea, chlamydia, and syphilis. The association between behavioural factors and STI diagnosis was expressed using hazard ratios. We adjusted for testing frequency and calendar year. Results: This analysis included 3907 participants enrolled between April 2019 and April 2022, yielding 3815.7 person‐years of follow‐up for gonorrhoea (15 134 screenings), 3802.5 for chlamydia (15 141 screenings), and 3858.6 for syphilis (15 001 screenings). The median age was 39 years (interquartile range [IQR] 32–47), 93.8% (n = 3664) identified as men who have sex with men (MSM). The incidence was 22.8 (95% confidence interval [CI] 21.3–24.4) per 100 person‐years for gonorrhoea, 26.3 (95% CI 24.7–28.0) for chlamydia, and 4.4 (95% CI 3.8–5.1) for syphilis. Yearly incidence rates decreased between 2019 (all bacterial STIs: 81.6; 95% CI 59.1–109.9) and 2022 (all bacterial STIs: 49.8; 95% CI 44.6–55.3). Participants reporting chemsex substance use were at higher risk of incident STIs, as were those reporting multiple sexual partners. Younger age was associated with a higher risk of gonorrhoea and chlamydia. Conclusions: Incidence rates of bacterial STIs decreased over time. Young MSM, those with multiple partners, and those using chemsex substances were at increased risk of STIs. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

10. Liver transplant recipients with autoimmune hepatitis in the Swiss transplant cohort study have a higher risk of graft loss and vascular complications

Author

Rosat, Aurélie, primary, Terziroli, Benedetta, additional, Hoessly, Linard, additional, Stampf, Susanne, additional, Koller, Michael, additional, Goossens, Nicolas, additional, Christinet, Montserrat Fraga, additional, Berzigotti, Annalisa, additional, Semmo, Nasser, additional, Müllhaupt, Beat, additional, Semela, David, additional, Heim, Markus, additional, Brunner, Simon, additional, Pascual, Manuel, additional, Moradpour, Darius, additional, and Vionnet, Julien, additional

Published
2023
Full Text
View/download PDF

18. Changes in mental and sexual health among MSM using HIV pre-exposure prophylaxis during the SARS-CoV-2 pandemic: longitudinal analysis of the SwissPrEPared cohort study

Author

Winter, Babette L, Hovaguimian, Frédérique, Kouyos, Roger D, Schmidt, Axel Jeremias, Bernasconi, Enos, Braun, Dominique L, Calmy, Alexandra, Notter, Julia, Stoeckle, Marcel, Surial, Bernard, Christinet, Vanessa, Cavassini, Matthias, Depmeier, Carsten, Läuchli, Severin, Boffi El Amari, Emmanuelle, Reinacher, Matthias, Rasi, Manuela, Bruggmann, Philip, Haerry, David, Bize, Raphaël, Low, Nicola, Lehner, Andreas, Quednow, Boris B; https://orcid.org/0000-0001-7933-2865, Fehr, Jan S, Hampel, Benjamin, Winter, Babette L, Hovaguimian, Frédérique, Kouyos, Roger D, Schmidt, Axel Jeremias, Bernasconi, Enos, Braun, Dominique L, Calmy, Alexandra, Notter, Julia, Stoeckle, Marcel, Surial, Bernard, Christinet, Vanessa, Cavassini, Matthias, Depmeier, Carsten, Läuchli, Severin, Boffi El Amari, Emmanuelle, Reinacher, Matthias, Rasi, Manuela, Bruggmann, Philip, Haerry, David, Bize, Raphaël, Low, Nicola, Lehner, Andreas, Quednow, Boris B; https://orcid.org/0000-0001-7933-2865, Fehr, Jan S, and Hampel, Benjamin

Abstract

BACKGROUND Changes in mental and sexual health among men having sex with men (MSM) due to the SARS-CoV-2 pandemic remain unclear. METHODS Design: Longitudinal analysis of an ongoing, multicentre, pre-exposure prophylaxis (PrEP) cohort (NCT03893188) in Switzerland. Participants: HIV-negative MSM aged ≥18 who completed at least one questionnaire before and one after the start of the SARS-CoV-2 pandemic. Outcomes: Primary: mental health, defined as anxiety and depression scores assessed by the Patient Health Questionnaire-4. Secondary: sexual behaviour, well-being, PrEP use and disruption of care. Outcomes were assessed over seven periods corresponding to different SARS-CoV-2 prevention measures in Switzerland. We performed pairwise comparisons between periods (Wilcoxon signed rank test). RESULTS Data from 1,043 participants were included. Whilst anxiety scores remained stable over time, depression scores worsened in the second wave and the second lockdown period compared to pre-pandemic scores. This was confirmed by pairwise comparisons (pre-SARS-CoV-2/second wave and pre-SARS-CoV-2/second lockdown: p <0.001). Downward trends in sexual activity,sexualized substance use, and a switch from daily to "event-driven" PrEP were found. Disruption of care affected 42.6% (790/1856) of daily PrEP users' follow-up visits. CONCLUSION In this longitudinal analysis of a PrEP cohort enrolling MSM, depression scores worsened in the second wave and the second lockdown compared to the pre-pandemic period.

Published
2022

19. Participation, retention and uptake in a multicentre pre-exposure prophylaxis cohort using online, smartphone-compatible data collection

Author

Hovaguimian, Frédérique; https://orcid.org/0000-0003-4181-2948, Martin, Eileen Christiane, Reinacher, M, Rasi, M, Schmidt, A J, Bernasconi, E, Boffi El Amari, E, Braun, D L, Calmy, A, Darling, K; https://orcid.org/0000-0003-1449-3873, Christinet, V, Depmeier, C, Hauser, C, Läuchli, S, Notter, J, Stoeckle, M, Surial, B, Vernazza, P, Bruggmann, P, Tarr, P, Haerry, D, Bize, R, Low, N, Lehner, A, Böni, J, Kouyos, R D, Fehr, J S, Hampel, B, Hovaguimian, Frédérique; https://orcid.org/0000-0003-4181-2948, Martin, Eileen Christiane, Reinacher, M, Rasi, M, Schmidt, A J, Bernasconi, E, Boffi El Amari, E, Braun, D L, Calmy, A, Darling, K; https://orcid.org/0000-0003-1449-3873, Christinet, V, Depmeier, C, Hauser, C, Läuchli, S, Notter, J, Stoeckle, M, Surial, B, Vernazza, P, Bruggmann, P, Tarr, P, Haerry, D, Bize, R, Low, N, Lehner, A, Böni, J, Kouyos, R D, Fehr, J S, and Hampel, B

Abstract

OBJECTIVES: The aim of the study was to assess the feasibility of a national pre-exposure prophylaxis (PrEP) programme using smartphone-compatible data collection. METHODS: This was a multicentre cohort study (NCT03893188) enrolling individuals interested in PrEP in Switzerland. All centres participate in the SwissPrEPared programme, which uses smartphone-compatible data collection. Feasibility was assessed after centres had enrolled at least one participant. Participants were HIV-negative individuals presenting for PrEP counselling. Outcomes were participation (number enrolled/number eligible), enrolment rates (number enrolled per month), retention at first follow-up (number with first follow-up/number enrolled), and uptake (proportion attending first visit as scheduled). Participant characteristics were compared between those retained after baseline assessment and those who dropped out. RESULTS: Between April 2019 and January 2020, 987 individuals were assessed for eligibility, of whom 969 were enrolled (participation: 98.2%). The median enrolment rate was 86 per month [interquartile range (IQR) 52-137]. Retention at first follow-up and uptake were both 80.7% (782/969 and 532/659, respectively). At enrolment, the median age was 40 (IQR 33-47) years, 95% were men who have sex with men, 47% had a university degree, and 75.5% were already taking PrEP. Most reported multiple casual partners (89.2%), previous sexually transmitted infections (74%) and sexualized drug use (73.1%). At baseline, 25.5% tested positive for either syphilis, gonorrhoea or chlamydia. Participants who dropped out were at lower risk of HIV infection than those retained after baseline assessment. CONCLUSIONS: In a national PrEP programme using smartphone-compatible data collection, participation, retention and uptake were high. Participants retained after baseline assessment were at considerable risk of HIV infection. Younger, less educated individuals were underrepresented in the SwissPrEPared co

Published
2022

20. Changes in mental and sexual health among MSM using HIV pre-exposure prophylaxis during the SARS-CoV-2 pandemic: longitudinal analysis of the SwissPrEPared cohort study

Author

Winter, Babette L., primary, Hovaguimian, Frédérique, additional, Kouyos, Roger D., additional, Schmidt, Axel Jeremias, additional, Bernasconi, Enos, additional, Braun, Dominique L., additional, Calmy, Alexandra, additional, Notter, Julia, additional, Stoeckle, Marcel, additional, Surial, Bernard, additional, Christinet, Vanessa, additional, Cavassini, Matthias, additional, Depmeier, Carsten, additional, Läuchli, Severin, additional, Boffi El Amari, Emmanuelle, additional, Reinacher, Matthias, additional, Rasi, Manuela, additional, Bruggmann, Philip, additional, Haerry, David, additional, Bize, Raphaël, additional, Low, Nicola, additional, Lehner, Andreas, additional, Quednow, Boris B., additional, Fehr, Jan S., additional, and Hampel, Benjamin, additional

Published
2022
Full Text
View/download PDF

25. HIV-Prä-Expositionsprophylaxe in der Schweiz

Author

Dominique L Braun, Matthias Reinacher, Christoph Hauser, Marcel Stckle, Emanuelle Boffi El Amari, Benjamin Hampel, Enos Bernasconi, Vanessa Christinet, Dunja Nicca, Marc Weber, Jrg Bni, Andreas Lehner, Raphaël Bize, Manuela Rasi, Nicola Low, Alexandra Calmy, Carsten Depmeier, Matthias Cavassini, Axel J. Schmidt, Roger D. Kouyos, Jan Fehr, Pietro Vernazza, David Haerry, and Severin Luchli

Published
2021
Full Text
View/download PDF

26. HIV-Prä-Expositionsprophylaxe in der Schweiz

Author

Weber, Marc, Nicca, Dunja, Schmidt, Axel Jeremias, Reinacher, Matthias, Rasi, Manuela, Braun, Dominique, Kouyos, Roger, Hauser, Christoph, Calmy, Alexandra, Cavassini, Matthias, Vernazza, Pietro, Stöckle, Marcel, Bernasconi, Enos, Christinet, Vanessa, Depmeier, Carsten, Boffi El Amari, Emanuelle, Läuchli, Severin, Haerry, David, Bize, Raphael, Low, Nicola, Lehner, Andreas, Böni, Jürg, Fehr, Jan S, Hampel, Benjamin, and University of Zurich

Subjects
10234 Clinic for Infectious Diseases, 610 Medicine & health, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI)
Published
2021

27. Prophylaxie pré-exposition au VIH en Suisse

Author

Pietro Vernazza, Severin Luchli, David Haerry, Dominique L Braun, Axel J. Schmidt, Roger D. Kouyos, Jan Fehr, Enos Bernasconi, Andreas Lehner, Emanuelle Boffi El Amari, Christoph Hauser, Matthias Reinacher, Benjamin Hampel, Dunja Nicca, Manuela Rasi, Marcel Stckle, Vanessa Christinet, Nicola Low, Jrg Bni, Alexandra Calmy, Carsten Depmeier, Raphaël Bize, Matthias Cavassini, and Marc Weber

Subjects
Marketing, Organizational Behavior and Human Resource Management, Strategy and Management, Drug Discovery, Pharmaceutical Science, Pharmacology
Published
2021
Full Text
View/download PDF

28. Participation, retention and uptake in a multicentre pre‐exposure prophylaxis cohort using online, smartphone‐compatible data collection

Author

Hovaguimian, F, primary, Martin, E, additional, Reinacher, M, additional, Rasi, M, additional, Schmidt, AJ, additional, Bernasconi, E, additional, Boffi El Amari, E, additional, Braun, DL, additional, Calmy, A, additional, Darling, K, additional, Christinet, V, additional, Depmeier, C, additional, Hauser, C, additional, Läuchli, S, additional, Notter, J, additional, Stoeckle, M, additional, Surial, B, additional, Vernazza, P, additional, Bruggmann, P, additional, Tarr, P, additional, Haerry, D, additional, Bize, R, additional, Low, N, additional, Lehner, A, additional, Böni, J, additional, Kouyos, RD, additional, Fehr, JS, additional, and Hampel, B, additional

Published
2021
Full Text
View/download PDF

29. Prophylaxie pré-exposition au VIH en Suisse

Author

Weber, Marc, primary, Nicca, Dunja, additional, Schmidt, Axel Jeremias, additional, Reinacher, Matthias, additional, Rasi, Manuela, additional, Braun, Dominique, additional, Kouyos, Roger, additional, Hauser, Christoph, additional, Calmy, Alexandra, additional, Cavassini, Matthias, additional, Vernazza, Pietro, additional, Stckle, Marcel, additional, Bernasconi, Enos, additional, Christinet, Vanessa, additional, Depmeier, Carsten, additional, Boffi El Amari, Emanuelle, additional, Luchli, Severin, additional, Haerry, David, additional, Bize, Raphael, additional, Low, Nicola, additional, Lehner, Andreas, additional, Bni, Jrg, additional, Fehr, Jan, additional, and Hampel, Benjamin, additional

Published
2021
Full Text
View/download PDF

30. HIV-Prä-Expositionsprophylaxe in der Schweiz

Author

Weber, Marc, primary, Nicca, Dunja, additional, Schmidt, Axel Jeremias, additional, Reinacher, Matthias, additional, Rasi, Manuela, additional, Braun, Dominique, additional, Kouyos, Roger, additional, Hauser, Christoph, additional, Calmy, Alexandra, additional, Cavassini, Matthias, additional, Vernazza, Pietro, additional, Stckle, Marcel, additional, Bernasconi, Enos, additional, Christinet, Vanessa, additional, Depmeier, Carsten, additional, Boffi El Amari, Emanuelle, additional, Luchli, Severin, additional, Haerry, David, additional, Bize, Raphael, additional, Low, Nicola, additional, Lehner, Andreas, additional, Bni, Jrg, additional, Fehr, Jan, additional, and Hampel, Benjamin, additional

Published
2021
Full Text
View/download PDF

31. Empfehlungen für die Nachsorge von Patientinnen/Patienten mit ausgeheilter Hepatitis C

Author

Patrizia Künzler-Heule, Montserrat Fraga Christinet, David Semela, Daniel Lavanchy, A. Cerny, Olivia Keiser, Christophe Bösiger, Philip Bruggmann, F. Negro, Nasser Semmo, Darius Moradpour, Bettina Maeschli, Claude Scheidegger, Andri Rauch, Maria Christine Thurnheer, and Carina Bobzin

Abstract

Diese Empfehlungen wurden in Zusammenarbeit verschiedener Fachgesellschaften und Patientenorganisationen erarbeitet und dienen dazu, ein Nachsorgeprogramm fur erfolgreich behandelte Patientinnen und Patienten zu etablieren.

Published
2021
Full Text
View/download PDF

32. Recommandations pour le suivi des patients atteints d’hépatite C guérie

Author

Bettina Maeschli, Andri Rauch, Nasser Semmo, Claude Scheidegger, Montserrat Fraga Christinet, Daniel Lavanchy, Francesco Negro, David Semela, Darius Moradpour, Carina Bobzin, Christophe Bösiger, Philip Bruggmann, Maria Christine Thurnheer, Andreas Cerny, Olivia Keiser, and Patrizia Künzler-Heule

Subjects
respiratory system, human activities
Abstract

Ces recommandations ont ete elaborees par diverses societes professionnelles et organisations de patients pour assurer un programme de suivi pour les patients traites avec succes.

Published
2021
Full Text
View/download PDF

35. HIV-Pr��-Expositionsprophylaxe in der Schweiz: der Anfang vom Ende der HIV/AIDS-Pandemie

Author

Weber, Marc, Nicca, Dunja, Schmidt, Axel Jeremias, Reinacher, Matthias, Rasi, Manuela, Braun, Dominique L, Kouyos, Roger, Hauser, Christoph, Calmy, Alexandra, Cavassini, Matthias, Vernazza, Pietro, St��ckle, Marcel, Bernasconi, Enos, Christinet, Vanessa, Depmeier, Carsten, Boffi El Amari, Emanuelle, Laeuchli, Severin, Haerry, David, Bize, Raphael, Low, Nicola, Lehner, Andreas, B��ni, J��rg, Fehr, Jan, and Hampel, Benjamin

Published
2021
Full Text
View/download PDF

36. Recommandations pour le suivi des patients atteints d'hépatite C guérie

Author

Bobzin, Carina, Bsiger, Christophe, Bruggmann, Philip, Cerny, Andreas, Fraga Christinet, Montserrat, Keiser, Olivia, Knzler-Heule, Patrizia, Lavanchy, Daniel, Maeschli, Bettina, Moradpour, Darius, Negro, Francesco, Rauch, Andri, Scheidegger, Claude, Semela, David, Semmo, Nasser, and Thurnheer, Maria Christine

Subjects
ddc:616, ddc:616.07, ddc:613
Published
2021

37. Participation, retention and uptake in a multicentre pre-exposure prophylaxis cohort using online, smartphone-compatible data collection

Author

J Notter, Benjamin Hampel, S Läuchli, Bernard Surial, Pietro Vernazza, Manuela Rasi, Matthias Reinacher, Enos Bernasconi, E Martin, P Bruggmann, Vanessa Christinet, F Hovaguimian, Axel J. Schmidt, Dominique L Braun, Andreas Lehner, Roger D. Kouyos, Jan Fehr, EB El Amari, Philip E. Tarr, Christoph Hauser, Raphaël Bize, Marcel Stoeckle, Kea Darling, D Haerry, Jürg Böni, Nicola Low, Alexandra Calmy, Carsten Depmeier, University of Zurich, and Hovaguimian, Frédérique

Subjects
Adult, Male, 10028 Institute of Medical Virology, medicine.medical_specialty, Anti-HIV Agents, HIV Infections, 610 Medicine & health, Lower risk, Men who have sex with men, Cohort Studies, 10234 Clinic for Infectious Diseases, Sexual and Gender Minorities, Pre-exposure prophylaxis, 360 Social problems & social services, Interquartile range, Internal medicine, medicine, Humans, 2736 Pharmacology (medical), Pharmacology (medical), Homosexuality, Male, Chlamydia, business.industry, Data Collection, Health Policy, Anti-HIV Agents/therapeutic use, HIV Infections/drug therapy, HIV Infections/epidemiology, HIV Infections/prevention & control, Pre-Exposure Prophylaxis, Smartphone, HIV, cohort study, pre-exposure prophylaxis, prevention programme, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), 2725 Infectious Diseases, medicine.disease, 2719 Health Policy, Infectious Diseases, Cohort, Syphilis, business, Cohort study
Abstract

OBJECTIVES The aim of the study was to assess the feasibility of a national pre-exposure prophylaxis (PrEP) programme using smartphone-compatible data collection. METHODS This was a multicentre cohort study (NCT03893188) enrolling individuals interested in PrEP in Switzerland. All centres participate in the SwissPrEPared programme, which uses smartphone-compatible data collection. Feasibility was assessed after centres had enrolled at least one participant. Participants were HIV-negative individuals presenting for PrEP counselling. Outcomes were participation (number enrolled/number eligible), enrolment rates (number enrolled per month), retention at first follow-up (number with first follow-up/number enrolled), and uptake (proportion attending first visit as scheduled). Participant characteristics were compared between those retained after baseline assessment and those who dropped out. RESULTS Between April 2019 and January 2020, 987 individuals were assessed for eligibility, of whom 969 were enrolled (participation: 98.2%). The median enrolment rate was 86 per month [interquartile range (IQR) 52-137]. Retention at first follow-up and uptake were both 80.7% (782/969 and 532/659, respectively). At enrolment, the median age was 40 (IQR 33-47) years, 95% were men who have sex with men, 47% had a university degree, and 75.5% were already taking PrEP. Most reported multiple casual partners (89.2%), previous sexually transmitted infections (74%) and sexualized drug use (73.1%). At baseline, 25.5% tested positive for either syphilis, gonorrhoea or chlamydia. Participants who dropped out were at lower risk of HIV infection than those retained after baseline assessment. CONCLUSIONS In a national PrEP programme using smartphone-compatible data collection, participation, retention and uptake were high. Participants retained after baseline assessment were at high risk of HIV infection. Younger, less educated individuals were underrepresented in the SwissPrEPared cohort.

Published
2021
Full Text
View/download PDF

40. The Swiss STAR trial - an evaluation of target groups for sexually transmitted infection screening in the sub-sample of men

Author

Schmidt, Axel Jeremias, Rasi, Manuela, Esson, Cate, Christinet, Vanessa, Ritzler, Michael, Lung, Thomas, Hauser, Christoph V., Stöckle, Marcel, Jouinot, Florent, Lehner, Andreas, Lange, Katharina, Konrad, Torsten, and Vernazza, Pietro

Subjects
Male, 0303 health sciences, 030306 microbiology, Sexually Transmitted Diseases, virus diseases, 610 Medicine & health, HIV Infections, General Medicine, urologic and male genital diseases, 03 medical and health sciences, Sexual and Gender Minorities, 0302 clinical medicine, Seroepidemiologic Studies, Prevalence, Humans, Female, 030212 general & internal medicine, Prospective Studies, Homosexuality, Male, Switzerland
Abstract

OBJECTIVES In Switzerland, universal health insurance does not cover any routine testing for sexually transmitted infections (STIs), not even in individuals at high risk, and extra-genital swabbing is not standard of care. We determined the prevalence and incidence of human immunodeficiency virus (HIV), viral hepatitis and non-viral STIs in a multicentre prospective observational cohort of multi-partner men who have sex with men (MSM) and other men. MATERIALS AND METHODS Between January 2016 and June 2017, we offered free STI testing to all men with multiple sexual partners (three or more in the previous 12 months), with follow-up examinations every 6 months. We used multiplex polymerase chain-reaction testing (for Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis, Mycoplasma genitalium) on pooled swabs (pharynx, urethra/vagina, anus), and antibody tests for HIV and Treponema pallidum at every visit, and for hepatitis B/C at baseline. RESULTS We screened 779 multi-partner MSM and 92 other men. Previously undiagnosed HIV was found in 0.5% vs 0.0%, respectively and T. pallidum antibodies in 15.3% vs 1.1%. STIs requiring antibiotic treatment comprised: active syphilis 1.7% vs 0.0%; N. gonorrhoeae 10.3% vs 0.0%; C. trachomatis 8.7% vs 1.1%. One in four MSM versus 1 in 100 other multi-partner men had any of these three STIs at baseline. 10.4% vs 1.3% had a history of hepatitis B, 31.9% vs 47.3% had no immunity (HBs-AB 20). CONCLUSION Among MSM, but not among other multi-partner men, STIs, mostly asymptomatic, are common. Given the high risk of onward transmission, low-cost or free routine screening of multi-partner MSM is a public health priority.

Published
2020
Full Text
View/download PDF

41. Patients cirrhotiques sans projet de transplantation: qui admettre aux soins intensifs ? [Adequacy of intensive care admission in cirrhotic patients not eligible for transplantation]

Author

Rey, A., Christinet Fraga, M., Artru, F., Eckert, P., and Schneider, A.

Abstract

Decompensated cirrhosis corresponds to the end stage of chronic liver disease. It is associated with poor outcomes, in particular, in patients who are not candidate for a liver transplantation. Those patients require frequent hospital admissions to manage complications. In those situations, the adequacy of a potential intensive care unit admission is regularly discussed among care providers. This article reviews elements to be considered in such situations: available tools, decision timing and modulating factors such as trigger for admission.

Published
2020

42. The ATLAS semiconductor tracker end-cap module

Author

Abdesselam, A., Adkin, P.J., Allport, P.P., Alonso, J., Andricek, L., Anghinolfi, F., Antonov, A.A., Apsimon, R.J., Atkinson, T., Batchelor, L.E., Bates, R.L., Beck, G., Becker, H., Bell, P., Bell, W., Beneš, P., Bernabeu, J., Bethke, S., Bizzell, J.P., Blocki, J., Broklová, Z., Brož, J., Bohm, J., Booker, P., Bright, G., Brodbeck, T.J., Bruckman, P., Buttar, C.M., Butterworth, J.M., Campabadal, F., Campbell, D., Carpentieri, C., Carroll, J.L., Carter, A.A., Carter, J.R., Casse, G.L., Čermák, P., Chamizo, M., Charlton, D.G., Cheplakov, A., Chesi, E., Chilingarov, A., Chouridou, S., Chren, D., Christinet, A., Chu, M.L., Cindro, V., Ciocio, A., Civera, J.V., Clark, A., Colijn, A.P., Cooke, P.A., Costa, M.J., Costanzo, D., Dabrowski, W., Danielsen, K.M., Davies, V.R., Dawson, I., de Jong, P., Dervan, P., Doherty, F., Doležal, Z., Donega, M., D’Onofrio, M., Dorholt, O., Drásal, Z., Dowell, J.D., Duerdoth, I.P., Duxfield, R., Dwuznik, M., Easton, J.M., Eckert, S., Eklund, L., Escobar, C., Fadeyev, V., Fasching, D., Feld, L., Ferguson, D.P.S., Ferrari, P., Ferrere, D., Fleta, C., Fortin, R., Foster, J.M., Fowler, C., Fox, H., Freestone, J., French, R.S., Fuster, J., Gadomski, S., Gallop, B.J., García, C., García-Navarro, J.E., Gibson, S., Gilchriese, M.G.D., Gonzalez, F., Gonzalez-Sevilla, S., Goodrick, M.J., Gorisek, A., Gornicki, E., Greenall, A., Greenfield, D., Gregory, S., Grigorieva, I.G., Grillo, A.A., Grosse-Knetter, J., Gryska, C., Guipet, A., Haber, C., Hara, K., Hartjes, F.G., Hauff, D., Haywood, S.J., Hegeman, S.J., Heinzinger, K., Hessey, N.P., Heusch, C., Hicheur, A., Hill, J.C., Hodgkinson, M., Hodgson, P., Horažďovský, T., Hollins, T.I., Hou, L.S., Hou, S., Hughes, G., Huse, T., Ibbotson, M., Iglesias, M., Ikegami, Y., Ilyashenko, I., Issever, C., Jackson, J.N., Jakobs, K., Jared, R.C., Jarron, P., Johansson, P., Jones, R.W.L., Jones, T.J., Joos, D., Joseph, J., Jovanovic, P., Jusko, O., Jusko, V., Kaplon, J., Kazi, S., Ketterer, Ch., Kholodenko, A.G., King, B.T., Kodyš, P., Koffeman, E., Kohout, Z., Kohriki, T., Kondo, T., Koperny, S., Koukol, H., Král, V., Kramberger, G., Kubík, P., Kudlaty, J., Lacasta, C., Lagouri, T., Lee, S.C., Leney, K., Lenz, S., Lester, C.G., Liebicher, K., Limper, M., Lindsay, S., Linhart, V., LLosá, G., Loebinger, F.K., Lozano, M., Ludwig, I., Ludwig, J., Lutz, G., Lys, J., Maassen, M., Macina, D., Macpherson, A., MacWaters, C., Magrath, C.A., Malecki, P., Mandić, I., Mangin-Brinet, M., Martí-García, S., Matheson, J.P., Matson, R.M., McMahon, S.J., McMahon, T.J., Meinhardt, J., Mellado, B., Melone, J.J., Mercer, I.J., Messmer, I., Mikulec, B., Mikuž, M., Miñano, M., Mitsou, V.A., Modesto, P., Moed, S., Mohn, B., Moncrieff, S., Moorhead, G., Morris, F.S., Morris, J., Morrissey, M., Moser, H.G., Moszczynski, A., Muijs, A.J.M., Murray, W.J., Muskett, D., Nacher, J., Nagai, K., Nakano, I., Nickerson, R.B., Nisius, R., Oye, O.K., O’Shea, V., Paganis, E., Parker, M.A., Parzefall, U., Pater, J.R., Peeters, S.J.M., Pellegrini, G., Pelleriti, G., Pernegger, H., Perrin, E., Phillips, P.W., Pilavova, L.V., Poltorak, K., Pospíšil, S., Postranecky, M., Pritchard, T., Prokofiev, K., Rafí, J.M., Raine, C., Ratoff, P.N., Řezníček, P., Riadovikov, V.N., Richter, R.H., Robichaud-Véronneau, A., Robinson, D., Rodriguez-Oliete, R., Roe, S., Rudge, A., Runge, K., Saavedra, A., Sadrozinski, H.F.W., Sanchez, F.J., Sandaker, H., Saxon, D.H., Scheirich, D., Schieck, J., Seiden, A., Sfyrla, A., Slavíček, T., Smith, K.M., Smith, N.A., Snow, S.W., Solar, M., Sopko, B., Sopko, V., Sospedra, L., Spencer, E., Stanecka, E., Stapnes, S., Stastny, J., Strachko, V., Stradling, A., Stugu, B., Su, D.S., Sutcliffe, P., Szczygiel, R., Tanaka, R., Taylor, G., Teng, P.K., Terada, S., Thompson, R.J., Titov, M., Toczek, B., Tovey, D.R., Tratzl, G., Troitsky, V.L., Tseng, J., Turala, M., Turner, P.R., Tyndel, M., Ullán, M., Unno, Y., Vickey, T., Van der Kraaij, E., Viehhauser, G., Villani, E.G., Vitek, T., Vu Anh, T., Vorobiev, A.P., Vossebeld, J.H., Wachler, M., Wallny, R., Ward, C.P., Warren, M.R.M., Webel, M., Weber, M., Weidberg, A.R., Weilhammer, P., Wells, P.S., Wetzel, P., Whitley, M., Wiesmann, M., Wilhelm, I., Willenbrock, M., Wilmut, I., Wilson, J.A., Winton, J., Wolter, M., Wormald, M.P., Wu, S.L., Wu, X., Zhu, H., Bingefors, N., Brenner, R., and Ekelof, T.

Published
2007
Full Text
View/download PDF

44. Empfehlungen für die Nachsorge von Patientinnen/Patienten mit ausgeheilter Hepatitis C

Author

Bobzin, Carina, primary, Bsiger, Christophe, additional, Bruggmann, Philip, additional, Cerny, Andreas, additional, Fraga Christinet, Montserrat, additional, Keiser, Olivia, additional, Knzler-Heule, Patrizia, additional, Lavanchy, Daniel, additional, Maeschli, Bettina, additional, Moradpour, Darius, additional, Negro, Francesco, additional, Rauch, Andri, additional, Scheidegger, Claude, additional, Semela, David, additional, Semmo, Nasser, additional, and Thurnheer, Maria Christine, additional

Published
2021
Full Text
View/download PDF

45. Recommandations pour le suivi des patients atteints d’hépatite C guérie

Author

Bobzin, Carina, primary, Bsiger, Christophe, additional, Bruggmann, Philip, additional, Cerny, Andreas, additional, Fraga Christinet, Montserrat, additional, Keiser, Olivia, additional, Knzler-Heule, Patrizia, additional, Lavanchy, Daniel, additional, Maeschli, Bettina, additional, Moradpour, Darius, additional, Negro, Francesco, additional, Rauch, Andri, additional, Scheidegger, Claude, additional, Semela, David, additional, Semmo, Nasser, additional, and Thurnheer, Maria Christine, additional

Published
2021
Full Text
View/download PDF

48. THU-526 - Liver transplant recipients with autoimmune hepatitis in the Swiss transplant cohort study have a higher risk of graft loss and vascular complications

Author

Rosat, Aurélie, Terziroli, Benedetta, Hoessly, Linard, Stampf, Susanne, Koller, Michael, Goossens, Nicolas, Christinet, Montserrat Fraga, Berzigotti, Annalisa, Semmo, Nasser, Müllhaupt, Beat, Semela, David, Heim, Markus, Brunner, Simon, Pascual, Manuel, Moradpour, Darius, and Vionnet, Julien

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results