Search

Psychopathology : international journal of descriptive and experimental psychopathology, phenomenology and clinical diagnostics (2022). doi:10.1159/000525760, Published by Karger, Basel

Patients with pulmonary embolism (PE) and contraindications for or failed thrombolysis are at the highest risk for PE-related fatal events. These patients may benefit from surgical embolectomy, but data concerning this approach are still limited.The method used here was retrospective data analysis of 103 patients who underwent surgical embolectomy from 2002 to 2020 at our department.Mean age was 58.4 (±15.1) years. Fifty-eight (56.3%) patients had undergone recent surgery; the surgery was tumor associated in 32 (31.1%) cases. Thirty (29.1%) patients had to be resuscitated due to PE, and 13 (12.6%) patients underwent thrombolysis prior to pulmonary embolectomy. Fifteen (14.5%) patients were placed on extra corporeal membrane oxygenation (ECMO) peri-operatively. Five patients (4.9%) died intra-operatively. Neurological symptoms occurred in four patients (3.9%). Thirty-day mortality was 23.3% ( n = 24). Re-thoracotomy due to bleeding was necessary in 12 (11.6%) patients. This parameter was also identified as an independent risk factor for mortality.Surgical pulmonary embolectomy resulted in survival of the majority of patients with PE and contraindications for or failed thrombolysis. Given the excessive mortality when left untreated, an operative approach should become a routine part of discussions concerning alternative treatment options for these patients.

Background Post-stroke delirium (POD) in patients on stroke units (SU) is associated with an increased risk for complications and poorer clinical outcome. The objective was to reduce the severity of POD by implementing an interprofessional delirium-management. Methods Multicentric quality-improvement project on five SU implementing a delirium-management with pre/post-comparison. Primary outcome was severity of POD, assessed with the Nursing Delirium Screening Scale (Nu-DESC). Secondary outcome parameters were POD incidence, duration, modified Rankin Scale (mRS), length of stay in SU and hospital, mortality, and others. Results Out of a total of 799 patients, 59.4% (n = 475) could be included with 9.5% (n = 45) being delirious. Implementation of a delirium-management led to reduced POD severity; Nu-DESC median: pre: 3.5 (interquartile range 2.6–4.7) vs. post 3.0 (2.2–4.0), albeit not significant (p = 0.154). Other outcome parameters were not meaningful different. In the post-period, delirium-management could be delivered to 75% (n = 18) of delirious patients, and only 24 (53.3%) of delirious patients required pharmacological treatments. Patients with a more severe stroke and POD remained on their disability levels, compared to similar affected, non-delirious patients who improved. Conclusions Implementation of delirium-management on SU is feasible and can be delivered to most patients, but with limited effects. Nursing interventions as first choice could be delivered to the majority of patients, and only the half required pharmacological treatments. Delirium-management may lead to reduced severity of POD but had only partial effects on duration of POD or length of stay. POD hampers rehabilitation, especially in patients with more severe stroke. Registry DRKS, DRKS00021436. Registered 04/17/2020, www.drks.de/DRKS00021436.

Pneumocystis pneumonia (PCP) is a life-threatening opportunistic infectious disease of immunocompromised patients. Its incidence has decreased worldwide in the past, but data concerning its recent epidemiology are lacking.We retrospectively analyzed all German inpatient cases from January 1, 2014 to December 31, 2019, to describe the recent epidemiology, incidence, clinical course, mortality and underlying diseases of PCP. Simultaneously, we conducted a retrospective multi-center study at two German university hospitals, and analyzed PCP cases treated there to gain deeper insights on the basis of primary patient data.The incidence of PCP significantly increased from 2·3 to 2·6 per 100,000 population from 2014 to 2019 (1,857 to 2,172 cases, +17·0%,The incidence of PCP has reversed its trend, showing a significant increase in mortality on population level. Patients who were not previously considered in prophylactic measures are increasingly affected by PCP. This development deserves further investigation, and additional comprehensive guidelines for the use of chemoprophylaxis in new risk groups are needed.Department of Nephrology and Hypertension, University Hospital Schleswig-Holstein, Kiel.

Background Delirium is a common complication in patients in Intensive Care Units (ICU). Interventions such as mobilization are effective in the prevention and treatment of delirium, although this is usually completed during the daytime. Aim The aim of this study was to assess the feasibility of mobilization in the evening to prevent and treat ICU patients from delirium by an additional mobility team over 2 weeks. Methods The design was a pilot, multi-centre, randomized, controlled trial in four mixed ICUs over a period of 2 weeks. The mobility team consisted of trained nurses and physiotherapists. Patients in the intervention group were mobilized onto the edge of the bed or more between 21.00 and 23.00. Patients in the control group received usual care. The primary outcome parameter was the feasibility of the study, measured as recruitment rate, delivery rate, and safety. Secondary outcomes were duration and incidence of delirium, mortality, duration of mechanical ventilation (MV), and hospital length of stay for 28 days follow-up, and power calculation for a full trial. Results Out of 185 patients present in the ICUs, 28.6% (n = 53) were eligible and could be recruited, of which 24.9% (n = 46, Intervention = 26, Control = 20) were included in the final analysis. In the intervention group, mobilization could be delivered in 75% (n = 54) of 72 possible occasions; mobilization-related safety events appeared in 16.7% (n = 9) without serious consequences. Secondary parameters were similar, with less delirium in the intervention group albeit not significant. With an association of Cramer's V = 0.237, a complete study reaching statistical significance would require at least 140 patients, last 6 weeks, and cost >30 000 €. Conclusions In a mixed ICU population, mobilization in the evening was feasible in one-quarter of patients with a low rate of safety events. Future trials seem to be feasible and worth conducting.

The COVID-19 pandemic challenges hospital clinicians by additional burdens. Key questions are whether hospital clinicians have experienced more stress in the care of COVID-19 patients and whether patient safety and quality of care have changed.Cross-sectional study using an online survey with clinicians in German hospitals on working conditions and quality of care during the COVID-19 pandemic, comparing clinicians with (MmK) vs. without direct contact (MoK) to COVID-19 patients.In total, 2122 clinicians participated. Most clinicians were physicians (15.4%, n = 301) or nurses (77.0%, n = 1505) working in major acute care hospitals (46.0%, n = 899). Every second respondent stated that they worked more than usual (46.4%, n = 907) and took on additional activities (47.7%, n = 932). A quarter of the participants did not receive any training or get instructions in devices (21.5%, n = 421). Only 51.5% (n = 1006) of the respondents were provided with sufficient personal protective equipment. More than 30% (32.7%, n = 639) were more satisfied than usual. The comparing clinicans with vs. without direkt contact to Covid-19 patients worked more shifts than usual ( 2 shifts: 24.1%, n = 306 vs. 13.7%, n = 63, p 0.001) and without instruction (27.9%, n = 364 vs. 17.1%), n = 57, p 0.001). In terms of patient safety, there were more deficiencies in the care, mechanical ventilation and nursing (all p 0.001).The cross-sectional study indicates an increased burden on clinicians and a restricted quality of care for patients with COVID-19. A risk to patients or clinicians cannot be excluded.HINTERGRUND: Die COVID-19-Pandemie stellt Mitarbeiter im Kontext der klinischen Versorgung stationärer Patienten vor zusätzliche Belastungen. Zentrale Fragen sind, ob Gesundheitspersonal in der Versorgung von COVID-19-Patienten mehr Belastungen erlebt und die Patientensicherheit und Versorgungsqualität sich verändert haben.Querschnittsstudie mittels einer Online-Umfrage von Ärzten, Pflegenden, Therapeuten in Krankenhäusern zu Arbeitsbedingungen und Versorgungsqualität während der COVID-19-Pandemie sowie Vergleich von Mitarbeitern mit (MmK) vs. ohne direkten Kontakt (MoK) mit infizierten COVID-19-Patienten.Insgesamt nahmen 2122 Personen an der Online-Umfrage teil. Die meisten Teilnehmer arbeiteten in Maximalversorgern (46,0 %, n = 899), waren Ärzte (15,4 %, n = 301) und Pflegende (77,0 %, n = 1505). Jeder zweite Befragte gab an, mehr als sonst gearbeitet (46,4 %, n = 907) und zusätzliche Tätigkeiten übernommen (47,7 %, n = 932) zu haben, ein Viertel ohne Einarbeitung bzw. Geräteeinweisung (21,5 %, n = 421). Lediglich 51,5 % (n = 1006) der Befragten wurde ausreichend Schutzkleidung gestellt. Ein Drittel (32,7 %, n = 639) war mehr als sonst zufrieden. Mitarbeiter mit vs. ohne direkten Kontakt mit infizierten Covid-19 Patienten gaben mehr Belastungen an, es wurde mehr ( 2 Schichten: 24,1 %, n = 306 vs. 13,7 %, n = 63, p 0,001) und ohne Einweisung (27,9 %, n = 364 vs. 17,1 %, n = 57, p 0,001) gearbeitet; in der Patientensicherheit gab es mehr Mängel in der Betreuung, Beatmung und Pflege (alle p 0,001).Die Querschnittsstudie weist auf eine erhöhte Belastung der Mitarbeiter hin, sowie auf eine eingeschränkte Versorgungsqualität von mit COVID-19 infizierten Patienten. Eine Patienten- bzw. Mitarbeitergefährdung kann nicht ausgeschlossen werden.

Background Medical progress, economization of healthcare systems, and scarcity of resources raise fundamental ethical issues. Physicians are exposed to increasing moral conflict situations, which may cause Moral Distress (MD). MD occurs when someone thinks he or she might know the morally correct action but cannot act upon this knowledge because of in- or external constraints. Correlations of MD among residents to job changes and burn-out have been shown previously. There are, however, hardly any quantitative studies about MD among physicians in Germany. The aim of this study was to investigate the frequency of occurrence, the level of disturbance, and reasons for MD among neurological residents in German hospitals. Methods 1st qualitative phase: Open interviews on workload and ethical conflicts in everyday clinical practice were conducted with five neurological residents. Ethical principles of medical action and potential constraints that could cause MD were identified and a questionnaire designed. 2nd quantitative phase: A preliminary questionnaire was tested and evaluated by five further neurological residents. The final questionnaire consisted of 12 items and was conducted online and anonymously via e-mail or on-site as part of an unrelated resident training event at 56 sites. Results One hundred seven neurological residents from 56 university/acute care and rehabilitation hospitals throughout Germany were examined (response rate of those requesting the questionnaire: 75.1%). 96.3% of the participants had experienced MD weekly (3.86, SD 1.02), because they were unable to invest the necessary time in a patient or relative consultation. Errors in medical care, which could not be communicated adequately with patients or relatives, were rated as most distressing. The most common reasons for MD were the growing numbers of patients, expectations of patient relatives, fears of legal consequences, incentives of the DRG-system, and the increasing bureaucratization requirement. 43.0% of participants mentioned they considered leaving the field of inpatient-care. 65.4% stated they would like more support in conflict situations. Conclusion MD plays an important role for neurological residents in German hospitals and has an impact on participants’ consideration of changing the workplace. Important aspects are rationing (time/beds) and incentives for overdiagnosis as well as lack of internal communication culture and mentoring.

Background Previous studies have shown that not only pain intensity but also impairment of quality of life and functionality are important parameters for the evaluation of treatment of chronic low back pain patients. The aim of the study was to validate a specific self-questionnaire for symptom assessment and their influence on quality of life and functionality of chronic low back pain patients (Questionnaire for Symptom Assessment in Pain disorders for back pain patients, Q-SAP). Methods The self-questionnaire consists of two parts (for back and if applicable leg symptoms) and was tested in 152 chronic low back pain patients with and without radiculopathy. Test-retest reliability, exploratory factor analysis, convergent validity, criterion-related validity and the sensitivity to detect patient reported changes were investigated. Results The questionnaire showed a good to excellent test-retest reliability. In the factor analysis nociceptive and neuropathic pain components could be separated and the highest convergent validities were shown for the painDETECT, EQ-5D-3L and the FFbH-R. The criterion-related validity showed concordance of QST and the Q-SAP Back for warmth induced pain and numbness. Regarding the sensitivity to patient-reported changes, a moderate correlation was found for both parts of the questionnaire. Conclusions The Q-SAP was tested as a useful, valid and reliable tool. This new questionnaire records classical nociceptive and neuropathic pain symptoms of chronic low back pain patients depending on their local distribution. Furthermore, the questionnaire records the intensity of these symptoms and their influence on quality of life and functionality and can be used for the evaluation of treatment. Significance The Q-SAP Back/Leg is a new self-questionnaire for CLBP patients with or without radiating leg pain that precisely assesses neuropathic and nociceptive symptoms. In contrast to other questionnaires, the Q-SAP Back/Leg evaluates not only symptom intensities but also their impact on the patient's quality of life and functionality. Furthermore, this questionnaire requests the symptoms depending on their anatomical distribution.

Making routine clinical-care-data available for medical research requires adequate consent to legitimize use and exchange. While, public interest in supporting medical research is increasing, individuals often find it difficult to actively enable researchers to access their data. In addition to broad consent, the idea of (consent-free) data donation has been brought into play as another way to legitimize secondary research use of medial data. However, flanking the implementation of broad consent policies or data donation, the attitude of patients, and the general public toward different aspects of these approaches needs to be assessed. We conducted two empirical studies to this end among Dutch patients (n = 7430) and representative German citizens (n = 1006). Wide acceptance of broad consent was observed among Dutch patients (92.3%), corroborating previous findings among German patients (93.0%). Moreover, 28.8% of the Dutch patients generally approved secondary data-use for non-academic research, 42.3% would make their decision dependent upon the type of institution in question. In the German survey addressing the general population, 78.8% approved data donation without explicit consent as an alternative model of legitimization, the majority of those who approved (96.7%) would allow donated data to be used by universities and public research institutions. This willingness to support contrasted sharply with the fact that only 16.6% would allow access to the data by industry. Our findings thus not only add empirical evidence to the debate about broad consent and data donation, but also suggest that widespread public discussion and education about the role of industry in medical research is necessary in that context.

European eating disorders review 29(3), 427-442 (2021). doi:10.1002/erv.2755 special issue: "Special Issue: Value of Treatment / Issue edite by: Janet Treasure, Philip Gorwood, Fernando Fernandez-Aranda", Published by Wiley, Chichester

Background: High mobility group A proteins are involved in chromatin remodeling, thereby influencing multiple fundamental biological processes. HMGA2 has been linked to oncogenic traits among a variety of malignancies. Objective: To determine the prognostic implications of subcellular distribution patterns of HMGA2 in breast cancer. Methods: Nuclear and cytoplasmic HMGA2 was evaluated in 342 breast cancer specimens and matched with clinico-pathological parameters. Results: Overall and cytoplasmic, but not nuclear, levels of HMGA2 correlated with better survival prognoses in our collective (hazard ratio (HR) 0.34, P = 0.001 and HR 0.34, P < 0.001, respectively). The protective effect of cytoplasmic HMGA2 persisted in the Luminal A and triple negative breast cancer subgroups. Evaluating Luminal A and B subgroups jointly, only cytoplasmic, but not overall or nuclear HMGA2 levels were associated with better survival (HR 0.42, 95% confidence interval 0.21, 0.86, P = 0.017), irrespective of tumor size and node status. The addition of HMGA2 overall and cytoplasmic scores strengthened the prognostic selectivity in a model of conventional breast cancer risk factors. No predictive significance with regard to endocrine or chemoendocrine therapies was observed. Conclusion: Unexpectedly, we found a favorable survival probability upon overall levels of HMGA2 in our breast cancer collective, which was predominantly determined by the presence of HMGA2 in the cytoplasm.

Ein Delir bei kardiochirurgischen Patienten ist haufig und erhoht die Beatmungs- und Verweildauer sowie die Mortalitat. Protokolle konnen das Outcome verbessern. Delirante Patienten einer kardiochirurgischen Intensivstation (ITS) wurden bislang nicht standardisiert behandelt. Bei Patienten auf kardiochirurgischen ITS bewirkt ein standardisiertes Delirmanagement nach 4‑wochiger Einfuhrungsphase im Vergleich zu einer nichtstandardisierten Behandlung eine Reduktion der Delirdauer. Prospektive Vorher-Nachher-Studie zur Evaluation einer Qualitatsverbesserungsmasnahme zum Delirmanagement uber 12 Wochen mit 140 Patienten. Einschlusskriterien: a) ≥18 Jahre alt, b) Zustimmung zur Forschung mit ihren Daten. Ausschlusskriterien: a) prafinaler Status, b) Anwesenheit wahrend der Vorher‑/Nachherphase, c) Schwangerschaft, d) Einschluss in konkurrierender Studie, e) nicht auf Delir untersuchbar. Die Implementierung beinhaltet die Einfuhrung eines Protokolls mit interprofessionellem Training und Bedside Teaching, Pocket Cards, Postern und Erinnerungshilfen. Primarer Outcomeparameter ist die Delirdauer, die 4‑mal pro Tag mit einem validierten Instrumenten erfasst wird. Sekundare Outcomeparameter sind Delirinzidenz, Dauer von Beatmung, Intensiv‑, Krankenhaustage, Mortalitat, pflege‑/therapeutische Interventionen, kumulative Dosen von delirrelevanten Medikamenten und Komplikationen eines Delirs fur die Dauer eines Follow-ups von 28 Tagen. Die erhobenen Daten werden sowohl deskriptiv als auch inferenzstatistisch analysiert. Die Absicht der Studie ist es, die Delirdauer und -haufigkeit kardiochirurgischer Intensivpatienten zu reduzieren und Hinweise auf die Effektstarke der Einfuhrung eines Delirmanagements zu geben.

Bone metastasis in breast cancer has been linked to activity of c-Src kinase, one of the extensively explored tyrosine kinases in cell biology. The impact of TNF-related apoptosis inducing ligand (TRAIL) and TRAIL receptors has just recently been integrated into this conception. An osteotropic clone of MDA-MB-231 cells simulated a model for bone metastasis of triple-negative breast cancer (TNBC). The effects of Dasatinib, a clinically established inhibitor of Src kinases family and Abl were evaluated in vitro and in vivo. In vivo effects of Dasatinib treatment on the occurrence of skeletal metastases were tested in a xenograft mouse model after intra-cardiac injection of osteotropic MDA-MB-231-cells. Ex vivo analyses of the bone sections confirmed intraosseous growth of metastases and allowed determination of osteoclastic activity. Treatment of osteotropic MDA-MB-231 cells with Dasatinib inhibited proliferation rates in vitro. A shift in TRAIL-receptor expression towards an induction of oncogenic TRAIL-R2 was observed. In vivo, 15 of 30 mice received an intra-peritoneal treatment with Dasatinib. These mice showed significantly less skeletal metastases in bioluminescence scans. Moreover, a pronounced increase in bone volume was observed in the treatment group, as detected by µ-Computed Tomography. Dasatinib treatment also led to a greater increase in bone density in tibiae without metastatic affection, which was accompanied by reduced recruitment of osteoclasts. Our observations support the concept of utilizing Dasatinib in targeting early-stage bone metastatic TNBC and sustaining bone health.

Grit can be viewed as a facet of conscientiousness consisting of the two sub-facets perseverance of effort and consistency of interest. Although ample research illustrates the importance of grit for educational attainment, little is known about its developmental trajectories. The goal of the present study was to examine the development of self-perceptions in the two grit facets during educational stays abroad in young adulthood. We measured grit in a sample of 179 German sojourners, who went abroad for some type of educational stay, immediately before the start of their stay abroad (T1), 3 months afterwards (T2), and 15 months afterwards (T3). We compared the developmental trajectories across T1 and T2 with a control group of 112 Germans staying at home during this period. Multivariate latent change score models showed an increase in perseverance of effort between T1 and T2 in the group of sojourners, which did not emerge in the control group and persisted throughout T3. Consistency of interest did not change between T1 and T2, but sojourners showed an increase in consistency of interest between T1 and T3. This change was positively predicted by the time sojourners had spent abroad. Although we found different developmental trajectories for perseverance of effort and consistency of interest, substantial correlated change between these facets indicated similar processes to account for change in both traits. We discuss implications for research on the development of grit as well as the role of educational stays abroad.

Seizure 96, 18-21 (2022). doi:10.1016/j.seizure.2022.01.006, Published by Elsevier, Oxford [u.a.]

Purpose Every year, about 4.6 million people are diagnosed with cancer in Europe. However, based on preclinical changes and using appropriate examination procedures certain cancers can be detected in symptom-free patients at an early stage and treatment initiated. In Germany, various cancer screening examinations are currently offered to the relevant age groups and sexes free of charge. Participation rates are affected by a number of factors and barriers. The study aimed at identifying potential obstacles and barriers to uptake, taking into account demographic and socio-economic variables. Materials and methods Data collection was conducted in the context of routine examination appointments at the City of Kiel Occupational Health Department from September 2013 to September 2014 using an anonymised questionnaire. In addition to recording socio-demographic data and tobacco consumption, the questionnaire also catalogued participation in statutory health insurance cancer screening examinations using the “stages of change” from the Transtheoretical Model. Eight potential barriers to participation were recorded. Results The results are based on 718 completed questionnaires. It was found that women, older age, and non-smoking status were associated with a higher probability of participating in cancer screening. It was also found that various barriers affecting (regular) participation were perceived significantly different according to the individual stages of change. This influence of the stages was moderated by gender. Conclusion The results showed interesting trends in the different barriers and how they are influenced by socioeconomic factors and the stages of change. Especially the stages require different gender-specific approaches to mobilisation for cancer screening.

Background Early mobilization of patients in intensive care units (ICUs) improves patient recovery, but implementation remains challenging. Protocols may enhance the rate of out-of-bed mobilizations. Aim To evaluate the effect of implementing a protocol for early mobilization on the rate of out-of-bed mobilizations and other outcomes of ICU patients. Study design Multicentre, stepped-wedge, cluster-randomized pilot study. Methods After a control period, five ICUs were allocated to the implementation of an inter-professional protocol for early mobilization in a randomized, monthly order. Mobilization of ICU patients was evaluated by monthly 1-day point prevalence surveys using the ICU Mobility Scale. The primary outcome was the percentage of patients mobilized out of bed, defined as level 3 on the ICU Mobility Scale (sitting on edge of bed) or higher. Secondary outcomes were mechanical ventilation, delirium and ICU- and hospital-days, as well as unwanted safety events. Results Out-of-bed mobilizations increased non-significantly from 36·2% (n = 55) of 152 patients during the control period to 45·8% (n = 55) of 120 patients during the intervention period (difference 9·6%; 95% confidence interval -2·1 to 21·3%). Of 55 mobilized patients per group, more patients were mobilized once per day during the intervention period (intervention: n = 41 versus control: n = 23 patients). Multiple daily mobilizations decreased (control: n = 32 control versus intervention: n = 14 patients). Secondary outcomes, such as days with mechanical ventilation, delirium and in ICU and hospital, did not significantly differ. Adherence to the protocol was >90%; unwanted safety events were rare. Conclusions Implementing a protocol for early mobilization of ICU patients showed a trend towards more patients being mobilized. Without additional staff in participating ICUs, a significant increase in ICU mobilizations was not to be anticipated. More research should address whether more staff would increase the number of frequent mobilizations and if this is relevant to outcomes. Relevance to clinical practice Implementing inter-professional protocols for mobilization is feasible and safe and may contribute to an increase of ICU patients mobilized out of bed.

The research exemption implemented in the new EU General Data Protection Regulation (EU-GDPR) gives member states leeway in determining whether patient consent is required for secondary data use in medical research. However, even though broad consent has become common in data-rich medical research in many EU countries, giving up consent altogether is likely to be controversial. The aim of this study was to examine whether abolishing consent for secondary data use would be acceptable to patients. A questionnaire study was conducted among 700 outpatients of a northern German university hospital to assess their attitude towards use of clinical data for scientific research without consent. There was both strong willingness to give broad consent for secondary data use (468 of 503 responders, 93.0%) and strong approval of abolishing patient consent (n = 381, 75.7%) among study participants. The willingness to give consent was moderately associated with approval of the respective stipulations by the EU-GDPR. In research settings where broad consent is widely accepted (e.g. university hospitals), abolishing consent for secondary research use of clinical data will likely be acceptable to a large majority of patients.

Purpose In this in vitro study, the effectiveness and safety of four aspiration-based techniques for thrombectomy are evaluated for three types of thrombi in a flow model simulating the femoropopliteal segment. Material and Methods Red, white, and mixed thrombi were produced in a standardized manner and used to simulate occlusion of a superficial femoral artery using a pulsatile flow model. Four techniques were compared: aspiration alone, aspiration + stent retriever, exposing thrombus to laser by an excimer laser system and a laser catheter + aspiration, and aspiration + mechanical fragmentation by a separator. Rate of first-pass recanalization, embolic events, and number of embolized fragments > 1 mm were compared. Results Aspiration alone, stent retriever, laser, and separator differed in rates of first-pass recanalization (53.3%; 86.6%; 20%; and 100%) and embolic events (40%; 93.3%; 73.3%; and 60%). Number of embolized fragments was lowest with aspiration and higher with separator, laser, and stent retriever. Rates of first-pass-recanalization (75%; 75%; and 45%) and embolic events (65%; 60%; and 75%) differed for red, white, and mixed thrombi. The mixed thrombus caused the highest number of embolized fragments, which was particularly high using the stent retriever. Conclusion Additional use of mechanical techniques significantly enhances the effectiveness of thrombectomy but simultaneously provokes more embolism. Laser seems to negatively alter the structure of a thrombus and thus diminishes the effectiveness, while provoking embolism. All techniques had lowest effectiveness, but highest embolism with the mixed thrombus. This was particularly striking when a stent retriever was used with the mixed thrombus.

Background: Priority setting in healthcare that aims to achieve a fair and efficient allocation of limited resources is a worldwide challenge. Sweden has developed a sophisticated approach. Still, there is a need for a more detailed insight on how measures permeate clinical life. This study aimed to assess physicians’ views regarding (1) impact of scarce resources on patient care, (2) clinical decision-making, and (3) the ethical platform and national guidelines for healthcare by the National Board of Health and Welfare (NBHW). Methods: An online cross-sectional questionnaire was sent to two groups in Sweden, 2016 and 2017. Group 1 represented 331 physicians from different departments at one University hospital and group 2 consisted of 923 members of the Society of Cardiology. Results: Overall, a 26% (328/1254) response rate was achieved, 49% in group 1 (162/331), 18% in group 2 (166/923). Scarcity of resources was perceived by 59% more often than ‘at least once per month,’ whilst 60% felt less than ‘well-prepared’ to address this issue. Guidelines in general had a lot of influence and 19% perceived them as limiting decision-making. 86% professed to be mostly independent in decision-making. 36% knew the ethical platform ‘well’ and ‘very well’ and 64% NBHW’s national guidelines. 57% expressed a wish for further knowledge and training regarding the ethical platform and 51% for support in applying NBHW’s national guidelines. Conclusion: There was a need for more support to deal with scarcity of resources and for increased knowledge about the ethical platform and NBHW’s national guidelines. Independence in clinical decision-making was perceived as high and guidelines in general as important. Priority setting as one potential pathway to fair and transparent decision-making should be highlighted more in Swedish clinical settings, with special emphasis on the ethical platform.

Background Aggressive behaviour is a prevalent and harmful phenomenon in patients with borderline personality disorder (BPD). However, no short-term, low-cost programme exists that specifically focuses on aggression. Aims Attuning therapy modules to pathogenetic mechanisms that underlie reactive aggression in BPD, we composed a 6 week mechanism-based anti-aggression psychotherapy (MAAP) approach for the group setting, which we tested against a non-specific supportive psychotherapy (NSSP). Method A cluster-randomised two-arm parallel-group phase II trial of N = 59 patients with BPD and overt aggressive behaviour was performed (German Registry for Clinical Trials, DRKS00009445). The primary outcome was the externally directed overt aggression score of the Modified Overt Aggression Scale (M-OAS) post-treatment (adjusted for pre-treatment overt aggression). Secondary outcomes were M-OAS irritability, M-OAS response rate and ecological momentary assessment of anger post-treatment and at 6 month follow-up, as well as M-OAS overt aggression score at follow-up. Results Although no significant difference in M-OAS overt aggression between treatments was found post-treatment (adjusted difference in mean 3.49 (95% CI −5.32 to 12.31, P = 0.22), the MAAP group showed a clinically relevant decrease in aggressive behaviour of 65% on average (versus 33% in the NSSP group), with particularly strong improvement among those with the highest baseline aggression. Most notably, significant differences in reduction in overt aggression between MAAP and NSSP were found at follow-up. Conclusions Patients with BPD and aggressive behaviour benefited from a short group psychotherapy, with improvements particularly visible at 6 month follow-up. Further studies are required to show whether these effects are specific to MAAP.

Introduction. Non-invasive neuromodulation via transcranial direct current stimulation (tDCS) is a promising method for modulating plasticity. For the first time multichannel tDCS was used to investigate a larger number of children and young adolescents. Previous studies suggest that tDCS affects cognitive functions. It is assumed that the inferior frontal gyrus (IFG) has an important role in the process of response inhibition. Therefore, multichannel tDCS might has potential as therapy option for neurodevelopmental diseases such as attention deficit hyperactivity disorder (ADHD). The present study addressed the question whether tDCS could modulate this function. In addition, the study intended to investigate the most effective timing and tolerance of stimulation. Methods. The study was approved by the Ethic Committee of the Faculty of Medicine of Kiel university. 29 healthy participants (10-17 years old, mean age: 14,2 years, SD 2,14) were included in the analysis in a double-blinded and sham-controlled crossover study. The Flanker-task was used as target-task so that reaction time and accuracy were focused in the evaluation. Stimulation was scheduled prior (offline) or during (online) target task. After that the participants completed the n-back-task and the CPT-task as non-target-tasks. Resting state EEG was recorded before and after stimulation. Additionally, task related EEG was performed to expose changes at the neurophysiological level. For multichannel 2 mA tDCS over the right IFG we used a 6-channel solution (3.14 cm2 circular electrodes, positioned at F8 (1000 µA), FC6 (999 µA), P7 (−377 µA), T8 (−422 µA), C6 (−577 µA) and FPZ (−623 µA), filled with EEG electrode gel). Current was ramped up for 30 seconds at the beginning and the end in sham as well in verum stimulation. A linear mixed model was used for statistical evaluation. Results. There were only a few participants showing side effects such as itching, burning or fatigue. In a total of 112 sessions there were eight cases of adverse events such as headache. Our preliminary results at the behavioural level show no significant differences (p > 0.05) between tDCS and sham stimulation. There were no significant effects on accuracy or reaction time between online or offline stimulation neither. Conclusion. Our results show that tDCS was tolerated well by the participants. Based on preliminary results we could not confirm that tDCS could modulate the rIFG because response inhibition was not affected significantly. Further analysis could find out about possible reasons for our results such as ceiling effects. Analysis of resting EEG prior and after stimulation as well as task related EEG might yield neurophysiological explanation for the absence of behavioural improvement outcomes. The results provide a basis for future studies such as investigations of ADHD patients and might offer a compatible therapy option.

Background and Aims Elderly patients aged ≥65 years represent a growing population in the perioperative field, particularly orthopedic and vascular surgery. The higher degree of age‐related or comorbid‐dependent vascular alterations renders these patients at risk for hemodynamic complications and likely denote a possible limitation for modern, non‐invasive arterial pressure monitoring devices. The aim was to compare vascular unloading technique‐derived to invasive measurements of systolic (SAP), diastolic (DAP), and mean arterial pressure (MAP) in elderly perioperative patients. Methods This prospective observational study included patients aged ≥65 years scheduled for orthopedic and patients ≥50 years with peripheral artery disease Fontaine stage ≥ II scheduled for vascular surgery, respectively. Invasive radial artery and non‐invasive finger‐cuff (Nexfin system) arterial pressures were recorded before and after induction of general anesthesia and during surgery. Correlation, Bland‐Altman, and concordance analyses were performed. Measurements of arterial pressure were also compared during intraoperative hypotension (MAP 105 mm Hg). Results Sixty patients with orthopedic (N = 25, mean (SD) age 77 (5) years) and vascular surgery (N = 35, age 69 [10] years) were enrolled. Seven hundred data pairs of all patients were analysed and pooled bias and percentage error were: SAP: 14.43 mm Hg, 43.79%; DAP: −2.40 mm Hg, 53.78% and MAP: 1.73 mm Hg, 45.05%. Concordance rates were 84.01% for SAP, 77.87% for DAP, and 86.47% for MAP. Predefined criteria for interchangeability of absolute and trending values could neither be reached in the overall nor in the subgroup analyses orthopedic vs vascular surgery. During hypertension, percentage error was found to be lowest for all pressure values, still not reaching predefined criteria. Conclusion Arterial pressure monitoring with the vascular unloading technique did not reach criteria of interchangeability for absolute and trending values. Nevertheless, the putatively beneficial use of noninvasive arterial pressure measurements should be further evaluated in the elderly perioperative patient.

Background : Delirium is a common complication in patients on Intensive Care Units (ICU). Caring interventions such as early mobilization are effective in prevention and treatment of delirium, but are recommended during daytime. It may be effective in the night, too. Method : The aim of this study was to prove the effect of mobilization in the evening to prevent or treat ICU patients from delirium. The design was a multicentric, randomized, controlled trial in 5 mixed ICUs over a period of 2 weeks with max. 28 days follow-up. Patients in the intervention group were mobilized onto the edge of the bed or more between 9:00 and 11:00 p.m. by an additional mobilization team, following safety criteria. Patients in the control group received usual care. Primary outcome parameter was the duration of a delirium. Secondary parameters were presence of delirium, mortality, duration of mechanical ventilation (MV) and stay, feasibility, and mobilization-related complications. Results : In summary, n=69 patients could be analysed (intervention n=36, control n=33). Due to limited resources, the trial was stopped and reached 62% of targeted sample size. Mobilization in the evening did not significantly reduce duration of existing delirium, delirium presence, length of MV or days in ICU and hospital for 28 days follow-up. In an unplanned post-hoc analysis, mobilization in the evening prevented patients from delirium in the first four days (6 (16.7%) vs. 13 (39.4%), p=0.032), with a number needed to treat of 5. The intervention was feasible in 71.7% of eligible patients, with 13.6% unwanted safety events. Conclusions : In a mixed ICU population, mobilization in the evening did not show a reduction in duration of delirium, MV or length of stay, but a reduction in the incidence of early onset delirium. Mobilization between 9:00 and 11:00 pm. by an interprofessional mobilization team may prevent patients from delirium. The intervention was feasible, safe, and accepted by most patients.

BACKGROUND AND OBJECTIVES The personality construct grit is defined as the ability to be persistent in pursuit of long-term goals in spite of challenges or obstacles. Grit is an emerging concept in positive psychology and has gained much attention because of its relevance for success and well-being across different domains. The aim of the present study was to examine the prognostic value of grit for online game addiction. METHODS We surveyed German speaking online gamers (N = 305: 193 males and 112 females, Mage = 28.44 years, SDage = 8.88) in an online cross-sectional self-report study. We measured grit with the German version of the Short Grit Scale (BISS-8), online game addiction with the short version of the Game Addiction Scale (GAS), and participants' age and gender. RESULTS Structural equation modeling supported the higher-order factor structure of grit in our sample (χ2 [18] = 29.31, p

Intercultural competence (ICC) can be defined as a complex of abilities that are needed to interact with people from other cultures adequately and effectively. The goal of the present study was to investigate the development of ICC during international experiences. We conducted a quasi-experimental longitudinal study with a sample of N = 273 individuals. Whereas 199 participants went abroad for at least 3 months, the remaining 74 participants stayed in Germany during the same period. ICC was operationalized with the short version of the Test to Measure Intercultural Competence, which measures six facets of ICC multi-methodically with a self-appraisal test and a situational judgment test. We calculated regression analyses within the framework of change score models, thereby yielding significant increases in global ICC after 3 months abroad. Analyzing the six facets of ICC, we found the greatest increase for Cultural Identity Reflection, which is defined as intensively and constantly reflecting upon one’s o...

Objective: Successful treatment of chronic low back pain (LBP) is difficult in clinical practice and hard to measure in trials. One reason might be the use of insufficient outcome parameters. The aim was to investigate the importance of typical clinical characteristics of chronic LBP on QoL and functionality. Methods: A total of 51 patients with chronic LBP (19 with, 32 without radiculopathy) were investigated with different questionnaires. Results: Burdening symptoms differed in frequency, intensity and impairment of QoL and functionality between patients with and without radiculopathy and between the area of pain within the same patient, i.e. between back and leg. Symptoms of nerve affection such as prickling pain and numbness were rated higher in the area of radiating pain than on the back in radiculopathy, and typical neuropathic pain symptoms such as burning pain, prickling, spontaneous pain, and feeling of deep pressure and pain at the beginning of movement were rated with a higher impairment of QoL and functionality in patients with compared to those without radiculopathy. Furthermore, intensity, impairment of QoL, and functionality were not necessarily reported in association with one another: some patients were highly impaired in QoL or functionality, despite a moderate-to-low pain intensity, whereas others suffered from severe pain, but were less impaired in QoL or functionality. Conclusion: Results suggest the consideration of impairment of QoL and functionality in addition to symptom intensity for treatment evaluation of chronic LBP. This can help to improve overall well-being of the patients and enhance efficacy in clinical pain trials and patient-centered treatment.